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WE´VE GOT CHLORONICOTINIC ACID AND ITS DERIVATIVES DOWN TO AN EXACT SCIENCE

2-Chloronicotinic acid (2-CNA) and 6-Chloronicotinic acid (6-CNA) are versatile building blocks in the preparation of agrochemical and pharmaceutical active ingredients.

Agrochemical and Pharmaceutical Applications2-Chloronicotinic acid (2-CNA) and 6-Chloronicotinic acid (6-CNA) are being used as intermediates in a broad variety of agrochemical and pharmaceutical active ingredients including the fungicide Boscalid from BASF and the antiviral drug Nevirapin from Boehringer Ingelheim.

API TRADE NAME APPLICATION ORIGINATOR

BOSCALID NICOBIFEN FUNGICIDE BASF

DIFLUFENICAN TIGREX HERBICIDE BAYER

NEVIRAPIN VIRAMUNEHIV ANITRETROVIRAL

TREATMENTBOEHRINGER INGELHEIM

FLUNIXIN FINADYNE NSAID SCHERING

NIFLUMIC ACID NIFLAMOL NSAID HEXACHIMIE

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Services on Chloronicotinic Acid AMRI is producing 2-CNA and 6-CNA in its large scale dedicated production facilities in Europe with a capacity of >1.000MT/year.

Various Chloronicotinic acid derivatives are available in pilot and commercial scale.

2-Chloronicotinic Acid (2-CNA) Derivatives 6-Chloronicotinic Acid (6-CNA) Derivatives

2-CHLORONICOTINIC ACID

CAS. NO 2942-59-8

EMPIRICAL FORMULA C6H4CLNO2

ASPECT WHITE TO OFF-WHITE POWDER

LOSS ON DRYING (105°C, 3 HOURS)

≤ 0.5% (W/W)

CHLORIDE TITRATION ≤ 0.5% (W/W)

ACIDIMETRIC TITRATION 98.0 – 102.0%

N-OXIDE NICOTINIC ACID CONTENT

≤ 0.1% (W/W)

6-CHLORONICOTINIC ACID CONTENT

≤ 0.15% (W/W)

2-HYDROXYNICOTINIC ACID CONTENT

≤ 0.1% (W/W)

IMPURITY 3078 (*) ≤ 0.1% (W/W)

OTHER IMPURITIES (EACH) ≤ 0.1% (W/W)

SUM OF IMPURITIES ≤ 0.5% (W/W)

6-CHLORONICOTINIC ACID

CAS. NO 5326-23-8

EMPIRICAL FORMULA C6H4CLNO2

ASPECT TAN POWDER

WATER CONTENT ≤ 0.5% (M/M)

CHLORIDE TITRATION ≤ 1.0% (M/M)

ACIDIMETRIC TITRATION 98.0 – 102.0%

6-HYDROXYNICOTINIC ACID CONTENT

≤ 1.0% (M/M)

2-CHLORONICOTINIC ACID CONTENT

≤ 1.0% (M/M)

2-HYDROXYNICOTINIC ACID CONTENT

≤ 1.0% (M/M)

IMPURITY 3078 (*) ≤ 1.0% (M/M)

RELATED IMPURITIES (HPLC) ≤ 1.0% (M/M)

*(NICOTINOYL-6 OXY)-2 NICOTINIC ACID