what is apoptosis?? apoptosis is a morphological term apoptosis and programmed cell death frequently...

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What is apoptosis?? Apoptosis is a morphological term Apoptosis and programmed cell death frequent are used interchangeably Apoptotic death is characterized by: nuclear condensation membrane blebbing phosphotidylserine flipping DNA degradation into nucleosomal fragments new gene synthesis in some instances

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Page 1: What is apoptosis?? Apoptosis is a morphological term Apoptosis and programmed cell death frequently are used interchangeably Apoptotic death is characterized

What is apoptosis??

• Apoptosis is a morphological term

• Apoptosis and programmed cell death frequently are used interchangeably

• Apoptotic death is characterized by:nuclear condensationmembrane blebbingphosphotidylserine flippingDNA degradation into nucleosomal fragmentsnew gene synthesis in some instances

Page 2: What is apoptosis?? Apoptosis is a morphological term Apoptosis and programmed cell death frequently are used interchangeably Apoptotic death is characterized

Normalthymocyte

ApoptoticThymocyte

(induced todie by Dex)

Transmission EM Scanning EM

Morphological features of apoptosis

Page 3: What is apoptosis?? Apoptosis is a morphological term Apoptosis and programmed cell death frequently are used interchangeably Apoptotic death is characterized

Figure 9.18a The Biology of Cancer (© Garland Science 2007)

Apoptosis Involves Biochemical As Well As Morphological Changes

Page 4: What is apoptosis?? Apoptosis is a morphological term Apoptosis and programmed cell death frequently are used interchangeably Apoptotic death is characterized

Table 9.3 The Biology of Cancer (© Garland Science 2007)

Not in all cases

Page 5: What is apoptosis?? Apoptosis is a morphological term Apoptosis and programmed cell death frequently are used interchangeably Apoptotic death is characterized

Figure 9.19 The Biology of Cancer (© Garland Science 2007)

Page 6: What is apoptosis?? Apoptosis is a morphological term Apoptosis and programmed cell death frequently are used interchangeably Apoptotic death is characterized

Apoptosis plays a key role in regulating lymphocyte cell numbers

Page 7: What is apoptosis?? Apoptosis is a morphological term Apoptosis and programmed cell death frequently are used interchangeably Apoptotic death is characterized

How do we get rid of corpses??

Why do we get rid of corpses??

Page 8: What is apoptosis?? Apoptosis is a morphological term Apoptosis and programmed cell death frequently are used interchangeably Apoptotic death is characterized

Find me and eat me signal and phagocyte receptors

Lorenz & Ravichandran

LPC = lipid lysophosphatidylcholine

Page 9: What is apoptosis?? Apoptosis is a morphological term Apoptosis and programmed cell death frequently are used interchangeably Apoptotic death is characterized

Lorenz & Ravichandran

Engulfment of apoptotic cells requires cytoskeletal rearrangment

Page 10: What is apoptosis?? Apoptosis is a morphological term Apoptosis and programmed cell death frequently are used interchangeably Apoptotic death is characterized

Induction of Apoptosis – an Overview

Page 11: What is apoptosis?? Apoptosis is a morphological term Apoptosis and programmed cell death frequently are used interchangeably Apoptotic death is characterized

Figure 9.28 The Biology of Cancer (© Garland Science 2007)

The Apoptosome

Page 12: What is apoptosis?? Apoptosis is a morphological term Apoptosis and programmed cell death frequently are used interchangeably Apoptotic death is characterized

Caspase family tree**

**There are now at least twelve caspases

Caspases must be cleaved to be activated

Caspases

Page 13: What is apoptosis?? Apoptosis is a morphological term Apoptosis and programmed cell death frequently are used interchangeably Apoptotic death is characterized

Initiator & Effector Caspases

Page 14: What is apoptosis?? Apoptosis is a morphological term Apoptosis and programmed cell death frequently are used interchangeably Apoptotic death is characterized

Induction of Apoptosis – an Overview

Page 15: What is apoptosis?? Apoptosis is a morphological term Apoptosis and programmed cell death frequently are used interchangeably Apoptotic death is characterized

Figure 9.25a The Biology of Cancer (© Garland Science 2007)

The Bcl-2 Family – Key Modifiers of Apoptosis

Page 16: What is apoptosis?? Apoptosis is a morphological term Apoptosis and programmed cell death frequently are used interchangeably Apoptotic death is characterized

*

*

*

*

Bcl-2 family members play an important role inmany life and death decisions

Page 17: What is apoptosis?? Apoptosis is a morphological term Apoptosis and programmed cell death frequently are used interchangeably Apoptotic death is characterized

Figure 9.27c The Biology of Cancer (© Garland Science 2007)

Page 18: What is apoptosis?? Apoptosis is a morphological term Apoptosis and programmed cell death frequently are used interchangeably Apoptotic death is characterized

Engineering the Mice

Influence of Cooperation on Survival

Influence of anti-Apoptotic Gene on Outcome of Oncogene Challenge

Page 19: What is apoptosis?? Apoptosis is a morphological term Apoptosis and programmed cell death frequently are used interchangeably Apoptotic death is characterized

Exrinsic and Intrinsic Death Pathways

Page 20: What is apoptosis?? Apoptosis is a morphological term Apoptosis and programmed cell death frequently are used interchangeably Apoptotic death is characterized

Figure 9.31a The Biology of Cancer (© Garland Science 2007)

Death Receptors of the Extrinsic Pathway

Page 21: What is apoptosis?? Apoptosis is a morphological term Apoptosis and programmed cell death frequently are used interchangeably Apoptotic death is characterized

Figure 9.33 The Biology of Cancer (© Garland Science 2007)

Page 22: What is apoptosis?? Apoptosis is a morphological term Apoptosis and programmed cell death frequently are used interchangeably Apoptotic death is characterized

Figure 9.34 The Biology of Cancer (© Garland Science 2007)

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Chapter 18 Apoptosis Apoptosis is only one form of programmed cell death. In animal cells, cell necrosis is another form of programmed cell death

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Papers Apoptosis: cell ‘death’ reveals Creation · Papers Apoptosis: cell ‘death’ reveals Creation Philip Bell Apoptosis* (‘programmed cell death’) is a biologi- cally

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Programmed nuclear death and its relation to apoptosis and

Apoptosis (programmed cell death) plays many important ...mcb.berkeley.edu/courses/mcb142/lecture topics/Dernburg/Lecture9_CelegansII...Apoptosis (programmed cell death) plays many

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Apoptosis. Cell death Necrotic Caspase-dependentCaspase-independent receptor-caspase 8 mitochondria-caspase 9 Classification of cell death

Programmed Cell Death / Apoptosis - University of San Diegohome.sandiego.edu/.../376f09_lectures/Lect22-376F09(CellDeath).pdf · Programmed Cell Death / Apoptosis Cell Death in Development

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apoptosis€¦ · apoptosis (programmed cell death), necrosis and inflammation. The end result of all the pro-cesses involved in apoptosis eventually end in the caspases taking proteins

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Apoptosis - biochemistry-stanislaus.wdfiles.combiochemistry-stanislaus.wdfiles.com/local--files/biochemistry-ii/Apoptosis.pdf · Apoptosis THE PROCESS OF PROGRAMMED CELL DEATH IN

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Introduction to Apoptosis - Shodhgangashodhganga.inflibnet.ac.in/bitstream/10603/4226/7/07_chapter 1.pdf · Introduction to Apoptosis . 1.1 Cell death and apoptosis . In the life

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