What is the state of the evidence What is the state of the evidence for omega-3s in Cardiovascular for omega-3s in Cardiovascular

Health?Health?

Omega-3 Centre Scientific Consensus Meeting 2010Omega-3 Centre Scientific Consensus Meeting 2010

Crowne Plaza Canberra Crowne Plaza Canberra

Omega-3 Centre Scientific Consensus Meeting 2010Omega-3 Centre Scientific Consensus Meeting 2010

Crowne Plaza Canberra Crowne Plaza Canberra

Assoc Prof David Colquhoun 11th November 2010Assoc Prof David Colquhoun 11th November 2010

University of Queensland, Wesley Hospital, Brisbane, Australia www.coreresearchgroup.com

d.colquhoun@uq.edu.au

Slides prepared by David Colquhoun & Jennefer Shields

University of Queensland, Wesley Hospital, Brisbane, Australia www.coreresearchgroup.com

d.colquhoun@uq.edu.au

Slides prepared by David Colquhoun & Jennefer Shields

Disclosures specific to EPA/DHADisclosures specific to EPA/DHA

I take 1800-2400 EPA&DHA in ethyl ester form dailyI take 1800-2400 EPA&DHA in ethyl ester form daily

I eat 200-600 gm fish per weekI eat 200-600 gm fish per week

I am the Chief Author of the National Heart Foundation I am the Chief Author of the National Heart Foundation Australia Position Statement on Fish, Fish oils, n-3 PUFA and Australia Position Statement on Fish, Fish oils, n-3 PUFA and CV Health CV Health www.heartfoundation.org.au

I presented a poster on the 2010 Update on NHFA marine n-3 I presented a poster on the 2010 Update on NHFA marine n-3 fatty acid at the CSANZ Meeting fatty acid at the CSANZ Meeting

Source of “fish oil” and ethyl Source of “fish oil” and ethyl EPA/DHAEPA/DHA

(A crustacean)(A crustacean)

““The Beginning”The Beginning” Krill eat planktonKrill eat plankton Fish eat Fish eat KrillKrill

PhytoplanktonPhytoplankton

Fish eat fishFish eat fish

CapsuleCapsuleEicosapentaenoic acid (C20:5n-3 [EPA] & Eicosapentaenoic acid (C20:5n-3 [EPA] &

Docosahexaenoic acid (C22:6n-3 [DHA])Docosahexaenoic acid (C22:6n-3 [DHA])

Almost NO fish (like humans) can make EPA/DHA Almost NO fish (like humans) can make EPA/DHA (exception – the Queensland Barramundi Cod)(exception – the Queensland Barramundi Cod)

Fish, Fish Oil and Long Chain Omega-Fish, Fish Oil and Long Chain Omega-3 Fatty Acids 3 Fatty Acids

NHFA Position NHFA Position StatementStatement

PRIMARY WRITERSPRIMARY WRITERS A/Prof D Colquhoun, Mr A Ferreira-JardimA/Prof D Colquhoun, Mr A Ferreira-Jardim

NHFA NUTRITION & METABOLISM COMMITTEENHFA NUTRITION & METABOLISM COMMITTEE Dr M Noakes (Chair), Prof P Barter, Prof M Ball, A/Prof D Colquhoun, Prof Dr M Noakes (Chair), Prof P Barter, Prof M Ball, A/Prof D Colquhoun, Prof D Crawford, A/Prof L Kritharides, Ms M Miller, A/Prof R O’Brien, A/Prof D Crawford, A/Prof L Kritharides, Ms M Miller, A/Prof R O’Brien, A/Prof L Simons, A/Prof D Sullivan, Dr D Topping. L Simons, A/Prof D Sullivan, Dr D Topping. NHFA Staff:NHFA Staff: Dr P Abernethy. Ms S Anderson, Ms C Cooper, Dr P Abernethy. Ms S Anderson, Ms C Cooper, Ms E Thompson, Ms B Eden, Ms E Thompson, Ms B Eden,

INTERNAL NHFA REVIEWINTERNAL NHFA REVIEW National Cardiovascular Health Advisory Committee National Cardiovascular Health Advisory Committee National Board of NHFANational Board of NHFA

EXTERNAL REVIEWERSEXTERNAL REVIEWERS A/Prof P Clifton, A/Prof R Gibson, Prof P Howe, Dr M James, A/Prof P Clifton, A/Prof R Gibson, Prof P Howe, Dr M James, A/Prof A Keech, A/Prof K Kostner, A/Prof T Mori, Prof P Nestel, A/Prof A Keech, A/Prof K Kostner, A/Prof T Mori, Prof P Nestel, Prof A Sinclair, Dr S Somerset, Prof AS Truswell, Prof A Sinclair, Dr S Somerset, Prof AS Truswell, Prof K O’DeaProf K O’Dea

20082008

www.heartfoundation.org.au

NHFA Health Professional advice NHFA Health Professional advice 20082008

www.heartfoundation.org.auwww.heartfoundation.org.au

NHFA Recommendations for All NHFA Recommendations for All Adult AustraliansAdult Australians

NHFA advice to Governments NHFA advice to Governments 20082008

NHFA Advice to the Food IndustryNHFA Advice to the Food Industry

NHFA Summary of Evidence 2008NHFA Summary of Evidence 2008

Mechanisms of ActionMechanisms of Action

Future Research Future Research

www.heartfoundation.org.auwww.heartfoundation.org.au

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Definition of Oily FishDefinition of Oily FishNHFA Position StatementNHFA Position Statement

LeanLean < < 1% Fat (body weight)1% Fat (body weight)

e.g. Cod, troute.g. Cod, trout

IntermediateIntermediate 1 - 10% Fat1 - 10% Fat

e.g. Trout, sea bass, breame.g. Trout, sea bass, bream

OilyOily >> 10% Fat10% Fat

e.g. Atlantic salmon, herring, swordfishe.g. Atlantic salmon, herring, swordfish