what we learn from breast cancer facts in hong kong 2008 ... · pdf filewhat we learn from...
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What we learn from
Breast Cancer Facts Breast Cancer Facts
in Hong Kong
2008 Report
30 May 2010
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Hong Kong Breast Cancer Registry
First-of-its-kind Territory-wide comprehensive information collection system on local breast cancer
Vision:
– To enhance effectiveness of preventive measures, diagnosis and treatment of breast cancer
– To help bring about changes in public policies and medical practice for improved breast healthcare in Hong Kong
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Hong Kong Breast Cancer Registry
Objectives:
– To analyze the causes and risk factors of local breast cancer cases
– To monitor the general situation of the disease and treatment trends in the local context
– To investigate the impact of breast screening in early detection
– To advocate and support people-oriented public healthcare policies
– To develop and improve the standard of care for breast cancer
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Collaborating Centres
Prince of Wales Hospital
Princess Margaret
North District
Hospital
Pok Oi Hospital
Tuen Mun
Hospital
United Christian
Hospital
Princess Margaret
Hospital
Queen Mary Hospital
Pamela Youde Nethersole
Eastern Hospital
Hong Kong Sanatorium & Hospital
Private
clinic
Private
clinic
Baptist
hospital
Private
clinicPrivate
clinic
2008 2009 2010
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471
542573
500
600
700
Nu
mb
er
of
su
bje
cts
in
th
e R
eg
istr
yOver 3000 breast cancer cases
participating the Registry
(as in Jan, 2010)
317
95 103
172
231
307
351
0
100
200
300
400
<=2000 2001 2002 2003 2004 2005 2006 2007 2008 2009
Nu
mb
er
of
su
bje
cts
in
th
e R
eg
istr
y
Year of first diagnosis
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Breast Cancer Facts in Hong
Kong 2008 Report in Chapters• Patient Demographics
• Lifestyle
• Health Background
• Clinical Characteristics• Clinical Characteristics
• Overall Cancer Characteristics
• Histological & Molecular Characteristics
• Treatment Methods
• Patients Status
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About the dataset
• 1006 cases
• Data collection period: Feb 2008 –Jan 2009Jan 2009
• Over 95% of breast cancer cases from private clinics
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Who is at risk for Breast Cancer?
• Age
• Socioeconomic profile
• Body built
Health profile• Health profile
• Life style and dietary habit
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44%
25% 25
30
35
40
45
50
% of the subjects
Age distribution
Breast cancer case in Hong Kong is characterized by early age of onset, showing a relatively
1%
17%
8%
4%
1% 0
5
10
15
20
Age <30 Age 30-39 Age 40-49 Age 50-59 Age 60-69 Age 70-79 Age 80 or above
% of the subjects
Age group
Source: Breast Cancer Facts in Hong Kong 2008 Report
onset, showing a relatively younger median age at diagnosis.
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Demographic data (1)
Percentage (%)
Occupation
Professional 17%
Clerical 33%
Housewife 30%
Self-employed 5%
Non-clerical/ Labor 4%
Retired/ Unemployed 11%
Education levelEducation level
No schooling/ Kindergarten 1%
Primary school 11%
Secondary school 60%
Matriculation or above 28%
Marital status
Never married 17%
Married 73%
Widowed/ cohabitating 10%
Monthly household income
<$10,000 9%
$10,000-29,999 33%
>$30,000 58%
Source: Breast Cancer Facts in Hong Kong 2008 Report
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Demographic data (2)
Districts Percentage (%)Hong Kong Island
Southern 6%
Central and Western 9%
Wan Chai 5%
Eastern 16%
Islands 2%
Kowloon
Kwun Tong 5%
Wong Tai Sin 4%
38%
Wong Tai Sin 4%
Yau Tsim Mong 5%
Sham Shui Po 4%
Kowloon City 9%
New Territories
Kwai Tsing 3%
Tsuen Wan 5%
Sai Kung 6%
Tai Po 3%
Sha Tin 9%
Yuen Long 4%
Tuen Mun 3%
North 2%
27%
35%
Source: Breast Cancer Facts in Hong Kong 2008 Report
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Who is at risk for Breast Cancer?
Body built
Mean BMI (SD) 22.1 (3.2)
Median BMI 21.6
Occurrence (%)
Obesity 17%Obesity 17%
Bra size
≤ 34 inches 64%
> 34 inches 36%
Cup size
Cup A or B 81%
Cup C or above 19%
BMI: body mass indexSource: Breast Cancer Facts in Hong Kong 2008 Report
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Are women with larger breast size at
higher risk for breast cancer?
• Some studies in western countries showed women with larger breasts had higher risk for breast cancer.1-2
• In Breast Cancer Facts in Hong Kong 2008 Report, breast cancer occurred in 81% with smaller cup size (cup size A or B) or in 64% with breast size <34 inches.
• Women with small breast size should also be on the alert of breast cancer risk.
Ref 1: Egan KM et al. Cancer Causes Control. 1999 Apr;10(2):115-8.
Ref 2: Hsieh CC et al. Eur J Cancer. 1991;27(2):131-5.
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Who is at risk for Breast Cancer?
Health backgroundOccurrence (%)
Personal history of breast cancer 20%
Previous breast disease 17%
Family history 19%
Early menarche (<12 years old) 17%Early menarche (<12 years old) 17%
Late menopause (>55 years old) 8%
No childbirth 21%
Childbirth >35 years old 7%
No breast feeding 64%
Oral contraceptives 38%
Hormone replacement therapy 14%
Source: Breast Cancer Facts in Hong Kong 2008 Report
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Who is at risk for Breast Cancer?
Life style and dietary habits
Occurrence (%)
Lack of physical exercise (<3 hours per week) 74%
Stress (high level of stress, >50% of time/wk) 40%
Dietary habit
Meat and dairy products rich diet 15%
Balanced diet 70%
Vegetable rich/ vegetarian 15%
Note: High level of stress defined as more than half the time or nearly all the time perceived stress
Source: Breast Cancer Facts in Hong Kong 2008 Report
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Summary of most common risk
factors in breast cancer patientsRisk factors Occurrence (%)
Lack of exercise (<3 hrs/ week) 74% No breast feeding 64%
High stress level 40%
Use of oral contraceptives 38%
Overweight/ obese 34% Overweight/ obese 34%
Nulliparious/ first childbirth >35 yrs of age 28%
Family history of breast cancer 19%
Early menarche (<12 years old) 17%
Meat/dairy product rich diet 15%
Use of hormonal replacement therapy 14%
Alcohol drinker 9%
Late menopause (>55 years old) 8%
Smoker 4%
Source: Breast Cancer Facts in Hong Kong 2008 Report
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Which risk factors are the most
common in breast cancer patients?
• 74% lacked regular physical exercises
• 64% had no breast feeding
• 40% perceived high stress level.
This observation warrants further research to study the relative risk of identifiable risk factors attributed to breast cancer.
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How many risk factors are present
among breast cancer patients?
Exogenous hormone risk
factors
Pre-existing health
Reproductive risk factors
health background risk factors
Life style risk factors
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14%
26% 26%
19%
15
20
25
30
% of the subjecrts
Percentage of subjects with
risk factors
Median # of risk factors: 3Mean # of risk factors (SD): 2.8 (1.4)
3% bear no
risk factors
3%
14%
7%
3%
1%
0
5
10
15
0 1 2 3 4 5 6 7
% of the subjecrts
Number of risk factors
Source: Breast Cancer Facts in Hong Kong 2008 Report
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Number of risk factors by category
Risk factors by category
Range
Mean number of risk factors (SD)
Median number of risk factors
Subjects bearing lifestyle risk factors1
0-5 1.1 (0.8) 1.0
Subjects bearing pre-Subjects bearing pre-existing health background risk factors2
0-2 0.5 (0.6) 0.0
Subjects bearing reproductive riskfactors3
0-4 0.9 (0.8) 1.0
Subjects bearing exogenous hormone risk factors4
0-2 0.4 (0.6) 0.0
1Lifestyle risk factors including smoker, drinker, diet, exercise and stress level2Pre-existing health background risk factors including obesity and family or personal history of breast cancer3Reproductive risk factors including early menarche, late menopause, first childbirth age >35 years old and no breast feeding
4Exogenous hormone risk factors including use of contraceptives and use of hormone replacement therapy
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Recommendations for
breast cancer preventionbreast cancer prevention
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• Maintain a healthy weight throughout life
– Balance calorie intake with physical activity
– Avoid excessive weight gain throughout life
– Achieve and maintain a healthy weight if currently overweight or obese
ACS 2002 recommendations: Nutrition & Physical
Activity Guidelines for Cancer Prevention
overweight or obese
• Adopt a physically active lifestyle
– Adults: Engage in at least 30 minutes of moderate to vigorous physical activity, above usual activities, on 5 or more days of the week; 45 to 60 minutes of intentional physical activity are preferable
Source: American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention 2002
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ACS 2002 recommendations: Nutrition & Physical
Activity Guidelines for Cancer Prevention
• Adopt a healthy diet, with emphasis on plant sources
– Choose foods and drinks in amounts that help achieve and maintain a healthy weight
– Eat 5 or more servings of a variety of vegetables – Eat 5 or more servings of a variety of vegetables and fruits each day
– Choose whole grains over processed (refined) grains
– Limit intake of processed and red meats
• Drink no more than 1 drink of alcoholic beverages per day for women or 2 per day for men
Source: American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention 2002
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Examples of moderate and vigorous
intensity physical activities
Moderate Activities Vigorous Activities
Exercise and Leisure Walking, dancing, leisurely bicycling, ice-skating or roller-skating, horseback riding, canoeing, yoga
Jogging or running, fast bicycling, circuit weight training, aerobic dance, martial arts, jump rope, swimming
Sports Volleyball, golfing, softball, baseball,
Soccer, field hockey or ice hockey, lacrosse,
Sportssoftball, baseball, badminton, doubles tennis, downhill skiing
ice hockey, lacrosse, singles tennis, racquetball, basketball, cross-country skiing
Home Activities Mowing the lawn, general lawn and garden maintenance
Digging, carrying and hauling, masonry, carpentry
Occupational Activity Walking and lifting as part of the job (custodial work, farming, auto or machine repair)
Heavy manual labor (forestry, construction, fire fighting)
Source: American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention 2002
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Breast Cancer Facts in Hong Kong
2008 Report in Chapters
• Patient Demographics
• Lifestyle
• Health Background
• Clinical Characteristics• Clinical Characteristics
• Overall Cancer Characteristics
• Histological & Molecular Characteristics
• Treatment Methods
• Patients Status
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80%
50
60
70
80
90
% of the subjects
Mode of first breast cancer detection
80% breast cancers are detected by incidental self-discovery whereas 20% are detected through breast screening.
�indicating low utilization rate of breast
screening in Hong Kong.
12%
4% 3% 1%
0
10
20
30
40
Incidental self-discovery
Mammography screening
Breast ultrasound Clinical breast examination
Regular breast self-examination
% of the subjects
Source: Breast Cancer Facts in Hong Kong 2008 Report
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3%
5%
91%
Pain
Nipple discharge
Lump
Major presenting symptoms among
subjects with incidental discovery of
breast cancer
-90% presented with painless lumps-2% presented with pain only
1%
1%
2%
3%
Other symptoms
Asymmetry
Nipple retraction
Pain-2% presented with pain only-1% presented with pain and lumps
Note:*= percentages added to more than 100% as more than one response could be checked
Other symptoms: breast discomfort and chest pain
Source: Breast Cancer Facts in Hong Kong 2008 Report
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Breast Cancer Facts in Hong Kong 2008 Report
Other countries
% incidental self-discovery
80%75% (Australia)1/80% (USA)2/
87% (Singapore)3
80% of subjects discovered breast cancer
incidentally with larger tumour size
discovery 87% (Singapore)3
Median tumoursize
Incidental self-discovered patients
2.2 cm 2.3 cm (Singapore)3
Screen-detected patients
1.7 cm 1.8 cm (Singapore)3
1 ANZ J Surg 2001; 71(7): 398-402; 2 Am J Surg 2006; 191(5): 635-40; 3 Breast J 2009: 15(2): 133-9
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49%
35%
30
40
50
60
% of the subjects
Duration from onset of symptoms to first
medical consultation
� 49% sought medical advice within 1 month from onset of symptoms
� 35% sought medical advice within 1-3 months from onset of symptoms
� 16% sought medical advice more than 3 months from onset of symptoms
5% 5% 6%
0
10
20
30
<1 mon 1-3 mon 4-6 mon 7-12 mon >12 mon
% of the subjects
Number of months
Source: Breast Cancer Facts in Hong Kong 2008 Report
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Breast Cancer Facts in Hong Kong
2008 Report in Chapters
• Patient Demographics
• Lifestyle
• Health Background
• Clinical Characteristics• Clinical Characteristics
• Overall Cancer Characteristics
• Histological & Molecular Characteristics
• Treatment Methods
• Patients Status
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Location of tumours
UIQ23%
UOQ43%
Central12%
UOQ53%
UIQ17%
Central10%
UOQ: upper outer quadrantUIQ: upper inner quadrantLOQ: lower outer quadrantLIQ: lower inner quadrantFigures include multicentric cancers
Right breast Left breast
LOQ15%
LIQ12%
LIQ7%
LOQ16%
Source: Breast Cancer Facts in Hong Kong 2008 Report
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Diagnostic results of mammography, breast
ultrasound and magnetic resonance imaging (MRI)
Diagnostic method Mammogram Breast
ultrasound MRI
% subjects using diagnostic
test979/1006 (97%) 963/1006 (96%) 96/1006 (9.5%)
Total no. 979 963 96
Normal (BI-RADS 1) 113 (12%) 33 (3%) 1 (1%)
Benign (BI-RADS 2) 112 (11%) 45 (5%) 2 (2%) Benign (BI-RADS 2) 112 (11%) 45 (5%) 2 (2%)
Probably benign (BI-RADS 3) 136 (14%) 143 (15%) 2 (2%)
Indeterminate (BI-RADS 4a) 367 (38%) 405 (42%) 28 (29%)
Suspicious (BI-RADS 4b) 13 (1%) 12 (1%) 3 (3%)
Diagnostic /malignant
(BI-RADS 5) 238 (24%) 325 (34%) 60 (63%)
Overall sensitivity (4&5) 618 (63%) 742 (77%) 91 (95%)
MRI: Magnetic resonance imaging
BI-RADS: Breast Imaging Reporting And Data System
Mammography, breast ultrasound and MRI: BI-RADS 4,5 are considered accurate
Source: Breast Cancer Facts in Hong Kong 2008 Report
Sensitivity of the test = No. of positive tests Total of the subjects performed
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Diagnostic results of fine needle aspiration (FNA),
core needle biopsy (CNB) and excisional biopsy
Diagnostic method FNA CNB Excisional
biopsy % subjects using diagnostic
test601/1006 (60%) 396/1006 (39%) 112/1006 (11%)
Total no. 601 396 112
Scanty benign (Class I) 6 (1%) 0 (0%) --
Benign (Class II) 31 (5%) 3 (1%) --Benign (Class II) 31 (5%) 3 (1%) --
Atypical (Class III) 50 (8%) 6 (2%) --
Suspicious (Class IV) 156 (26%) 20 (5%) --
Diagnostic/ malignant (Class V) 358 (60%) 367 (92.7%) 112 (100%)
Overall sensitivity (III,IV & V) 564 (94%) 393 (99%) 112 (100%)
FNA: Fine needle aspiration
CNB: Core needle biopsy
Fine needle aspiration (FNA), core needle biospy (CNB) and excisional biopsy: Class 3,4,5 are considered accurate
Source: Breast Cancer Facts in Hong Kong 2008 Report
Sensitivity of the test = No. of positive tests Total of the subjects performed
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Mammogram is the gold standard
in early detection especially for nonpalpable
cancersMammographic findings* Percentage (%)
Negative findings 13%
Mircocalcifications 48%
Opacity 27%
Architectural distortion 11%
Asymmetric density 8%
Other findings** 7%
Source: Breast Cancer Facts in Hong Kong 2008 Report
* Mammographic findings: more than one option can be checked, the percentage added up can be more than 100%**Other findings: skin thickening, lymph node metastasis
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40%
50%
60%
70%
80%
90%
% of the subjects
Breast density
Breasts become less dense over age
age <40 age 40-49 age 50-59 age 60-69 age 70+
fatty 5% 5% 8% 20% 28%
scattered density 11% 15% 17% 17% 17%
heterogeneous density 78% 75% 70% 61% 55%
extreme density 6% 5% 5% 2% 0%
0%
10%
20%
30%
Source: Breast Cancer Facts in Hong Kong 2008 Report
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Staging methods employed
Staging methods Percentage (%)
CXR and USG abd 73.2%
PET scan 22.8%
CXR or USG abd only 3.5%
The most common staging
CXR or USG abd only 3.5%
MRI whole body 0.5%
CTT, CTA and bone scan 0.1%
CXR: chest x-ray
USG abd: ultrasound abdomen
PET scan: positron emission tomography
MRI: magnetic resonance imaging
CTT: computed tomography thorax
CTA : computed tomography abdomen
Source: Breast Cancer Facts in Hong Kong 2008 Report
common staging method
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34%
26%
20
25
30
35
40
% of the subjects
Cancer stage at diagnosis
15%
12% 12%
1%
0
5
10
15
20
Stage 0 Stage I Stage IIA Stage IIB Stage III Stage IV
% of the subjects
Source: Breast Cancer Facts in Hong Kong 2008 Report
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Breast Cancer Facts in Hong Kong 2008 Report
Other countries
Cancer stage
Localized 60% 62% (USA SEER)
Regional 24% 31% (USA SEER)
Metastasized 1% 4% (USA SEER)
13% are advanced stage breast cancer
Metastasized 1% 4% (USA SEER)
Unstaged -- 3% (USA SEER)
Cancer stage (AJCC 2002)
Stage 0 15% --
Stage I 34% --
Stage II 38% --
Stage III 12% --
Stage IV 1% --
SEER Cancer Statistics Review 1975-2006, National Cancer Institute
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38% 40%
25
30
35
40
45
% of the subjects
Invasive breast cancer size
17%
5%
0
5
10
15
20
<1.0 1.0-2.0 2.01-5.0 >5.0
% of the subjects
Size (cm)
Source: Breast Cancer Facts in Hong Kong 2008 Report
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50%
60%
70%
80%
90%
100%
% of the subjects
More positive nodes observed
in bigger sized tumours
T1a: >0.1cm to <0.5cm; T1b: >0.5cm to ≤ 1.0cm; T1c: >1.0cm to ≤2.0cmT2: >2.0cm to ≤ 5.0cm; T3: >5.0cm; T4: Tumour of any size with direct extension to (a) chest wall or (b) skin.
T1a T1b T1c T2 T3 T4
0 93% 81% 65% 49% 0% 0%
1-3 7% 16% 28% 34% 50% 0%
4-9 0% 3% 4% 12% 19% 100%
10-19 0% 0% 2% 4% 12% 0%
20-29 0% 0% 0% 1% 12% 0%
30+ 0% 0% 0% 0% 8% 0%
0%
10%
20%
30%
40%
% of the subjects
Source: Breast Cancer Facts in Hong Kong 2008 Report
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3%
8% 7%
25%
30%
35%
40%
% of the subjects
80% of in situ cancer are
symptomaticasymptomatic
symptomatic
20%
27% 27%
6%
3%
2%
0%
5%
10%
15%
20%
<1.00 1.00-2.00 2.01-5.00 >5.00
% of the subjects
In situ tumours size (cm)
Source: Breast Cancer Facts in Hong Kong 2008 Report
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Breast Cancer Facts in Hong Kong
2008 Report in Chapters
• Patient Demographics
• Lifestyle
• Health Background
• Clinical Characteristics• Clinical Characteristics
• Overall Cancer Characteristics
• Histological & Molecular Characteristics
• Treatment Methods
• Patients Status
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Histological characteristics of invasive breast cancer
Histological type Percentage (%)
Ductal 82.7%
Lobular 5.3%
Mucinous (colloid) 3.4%
Microinvasive 1.8%
Mixed ductal & lobular 1.5%
Tubular 1.3%
Borderline/ malignant phyllodes 0.9%
The most common histological type of invasive cancer
Borderline/ malignant phyllodes 0.9%
Medullary 0.9%
Papillary 0.6%
Micropapillary 0.6%
Paget disease of nipple 0.1%
Cribiform carcinoma 0.3%
Neuroendocrine carcinoma 0.2%
Adenoid cystic carcinoma 0.2%
Inflammatory 0.1%
Metaplastic carcinoma 0.1%
Source: Breast Cancer Facts in Hong Kong 2008 Report
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83%
47%
41%
47%
57%
50%
60%
70%
80%
90%
% of the subjects
Grading of invasive breast cancer
by cancer stage
Grade 1
Grade 2
Grade 3
16%
23%
15%
6%
0%
37% 36%38% 37%
41%
17%
0%
10%
20%
30%
40%
Overall Stage I Stage II Stage III Stage IV
% of the subjects
Cancer stage
Source: Breast Cancer Facts in Hong Kong 2008 Report
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47%
85%
50%50%
60%
70%
80%
90%
% of the subjects
Lymphovascular invasion of
invasive breast cancer
39%
14%
0%
10%
20%
30%
40%
Overall Stage I Stage II Stage III Stage IV
% of the subjects
Cancer stage
Source: Breast Cancer Facts in Hong Kong 2008 Report
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Multifocality and multicentricity of invasive
breast cancer
Percentage (%)
Multifocality
Yes 19%
No 81%
Number of foci
2 51%2 51%
3-4 33%
≥5 16%
Multicentricity
Yes 5%
No 95%
Number of quadrants
2 81%
3 17%
4 2%
Source: Breast Cancer Facts in Hong Kong 2008 Report
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Molecular characteristics of invasive
breast cancer
Overall Stage I Stage II Stage III Stage IV
Estrogen Receptor (ER+) 77% 77% 78% 73% 71%
Progesterone Receptor (PR+) 62% 64% 63% 55% 57%
c-erbB2 (HER2+) 19% 21% 17% 22% 14%
Source: Breast Cancer Facts in Hong Kong 2008 Report
Overall Stage I Stage II Stage III Stage IV
Ki67 proliferative index
<12% 50% 57% 49% 39% 67%
12-50% 38% 32% 39% 47% 33%
>50% 12% 11% 12% 14% 0%
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Characteristics of molecular subtypes of ER, PR
and HER2 in invasive breast cancer
Overall Stage I Stage II Stage III Stage IV
ER+PR+HER2+ 6% 8% 5% 8% 0%
ER+PR+HER2- 55% 55% 57% 45% 58%
ER+PR-HER2+ 4% 4% 4% 5% 0%
ER+PR-HER2- 12% 10% 12% 15% 14%ER+PR-HER2- 12% 10% 12% 15% 14%
ER-PR+HER2+ 1% 1% 1% 1% 0%
ER-PR+HER2- 1% 1% 1% 2% 0%
ER-PR-HER2+ 8% 9% 7% 8% 14%
ER-PR-HER2- 13% 12% 13% 16% 14%
ER+: estrogen receptor positive; ER-: estrogen receptor negative; PR+: progesterone receptor positive; PR-: progesterone receptor negative HER2+: Human Epidermal growth factor Receptor 2 positive; HER2-: Human Epidermal growth factor Receptor 2 negative
Source: Breast Cancer Facts in Hong Kong 2008 Report
The most common subtype
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Histological type, necrosis and nuclear grade
of in situ breast cancer
Percentage
Histological type
Ductal 96.8%
Papillary 2.6%
Paget disease of nipple 0.6%
Necrosis
Yes 70%
No 30%
Nuclear Grade
Low 18%
Intermediate 37%
High 45%
Source: Breast Cancer Facts in Hong Kong 2008 Report
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Multifocality and multicentricity of
in situ breast cancer
Percentage
Multifocality
Yes 10%
No 90%
Number of foci
2 75%2 75%
3-4 17%
≥5 8%
Multicentricity
Yes 3%
No 97%
Number of quadrants
2 75%
3 25%
4 0%
Source: Breast Cancer Facts in Hong Kong 2008 Report
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59%
40
50
60
70
of subjects
Mammographic findings of
in situ breast cancer
16% 15%
6%
10%
6%
0
10
20
30
40
Normal Microcalcification Opacity Architectural distortion
Asymmetric density
Others
% of subjects
Note: * = percentages add to more than 100% because more than one response could be marked
Source: Breast Cancer Facts in Hong Kong 2008 Report
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Molecular characteristics of
in situ breast cancer
Positive Negative
Estrogen Receptor (ER) 77% 23%
Progesterone Receptor (PR) 67% 33%
c-erbB2 (HER2) 33% 67%
Source: Breast Cancer Facts in Hong Kong 2008 Report
<12% 12-50% >50%
Ki67 proliferative index 63% 34% 3%
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Comparing histological & molecular characteristics of
breast cancer in HK vs. in other countries
Invasive breast cancerBreast Cancer Facts in Hong Kong 2008
ReportOther countries
Histological types
Ductal 82.7% 91% (Canada) 1
Lobular 5.3% 8% (Canada) 1
Others 12% <2% (Canada) 1Others 12% <2% (Canada)
Molecular characteristics
ER+ 77% 69% (Canada) 1
PR+ 62% 46% (Canada) 1
HER2+ 19% 13% (Canada) 1
Ki67 index >12-16% 50% --
ER- PR- HER2- 13% 16% (Canada)2
Lymphovascular invasion 39% 43% (Canada) 1
ER+: estrogen receptor positive; ER-: estrogen receptor negative; PR+: progesterone receptor positive; PR-: progesterone receptor negative;
HER2+: human epidermal growth factor receptor 2 positive; HER2-: human epidermal growth factor receptor 2 negative1 JNCI 2009; 101(10): 736-750 ; 2 JAMA 2006; 295(21): 2492-2502
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Breast Cancer Facts in Hong Kong
2008 Report in Chapters
• Patient Demographics
• Lifestyle
• Health Background
• Clinical Characteristics• Clinical Characteristics
• Overall Cancer Characteristics
• Histological & Molecular Characteristics
• Treatment Methods
• Patients Status
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40.0%
50.0%
60.0%
70.0%
80.0%% of the subjects
99.8% had breast surgeryRate of BCS was higher in early stage compared with advanced
stage
Source: Breast Cancer Facts in Hong Kong 2008 Report BCS: breast conserving surgery
Overall Stage 0 Stage I Stage II Stage III Stage IV
No surgery 0.2% 0% 0% 0% 0% 29%
BCS 61% 73% 69% 56% 39% 29%
Mastectomy 29% 18% 24% 33% 41% 29%
Mastectomy+reconstruction 10% 9% 7% 11% 20% 13%
0.0%
10.0%
20.0%
30.0%
% of the subjects
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10%
17%
13%
10%
12%
14%
16%
18%
% of the subjects
Percentage of reconstruction in
mastectomy patients by age
Rate of reconstruction declined over age
Source: Breast Cancer Facts in Hong Kong 2008 Report
9%
3%
0%0%
2%
4%
6%
8%
10%
Overall <40 40-49 50-59 60-69 70+
% of the subjects
Age group
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40%
50%
60%
70%
80%% of the subjects
Choice of reconstruction by age
Increasing use of TRAM flap with age
Overall <40 40-49 50-59 60-69
Implant 32% 41% 31% 25% 33%
LD flap 4% 4% 4% 4% 0%
LD flap+ implant 12% 23% 12% 4% 0%
TRAM flap 53% 32% 53% 68% 67%
0%
10%
20%
30%
% of the subjects
Source: Breast Cancer Facts in Hong Kong 2008 Report
LD flap: Latissimus dorsi flapTRAM flap: Transverse Rectus Abdominis Myocutaneous flap
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27%
34%
25%
34% 33%
25%
30%
35%
40%
45%
50%
% of the subjects
Percentage of reconstruction in
mastectomy patients by cancer stage
21%
25%
0%
5%
10%
15%
20%
25%
Overall Stage 0 Stage I Stage II Stage III Stage IV
% of the subjects
Cancer stage
Source: Breast Cancer Facts in Hong Kong 2008 Report
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40%
50%
60%
70%
80%
% of the subjects
Axillary nodal surgery by cancer stageSentinel node biopsy widely used in early stage of cancer to examine whether tumours spread to lymph
nodes
0%
10%
20%
30%
Overall Stage 0 Stage I Stage II Stage III Stage IV
% of the subjects
Cancer stage
No nodal surgery Sentinel node biopsy Sentinel node biopsy & axillary dissection Axillary dissection
Source: Breast Cancer Facts in Hong Kong 2008 Report
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13%
0%5%
15%
39%
25%
4%
1%
1%4%
20%
0%
50%
60%
70%
80%
90%
100%
% of the subjects
Radiation therapy rate
71% treated with radiation therapy
54%61% 61%
52%
35%
50%
0%
10%
20%
30%
40%
Overall Stage 0 Stage I Stage II Stage III Stage IV
% of the subjects
Cancer stage
BCS Mastectomy Mastectomy+ reconstruction
Source: Breast Cancer Facts in Hong Kong 2008 Report BCS: breast conserving surgery
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23%
22%
35%
20
25
30
35
40
% of subjects
Radiated regions
8%
5%
3% 2%
2%
0
5
10
15
20
whole breast
local boost Chest wall SCF Axilla IMC Partial breast
Unclassified
% of subjects
Radiated regionSource: Breast Cancer Facts in Hong Kong 2008 Report
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40%
60%
80%
100%
% of the subjects
Chemotherapy rate
71% treated with chemotherapy
Source: Breast Cancer Facts in Hong Kong 2008 Report CT: chemotherapy
Overall Stage I Stage II Stage III Stage IV
No chemotherapy 29% 53% 16% 4% 14%
Adjuvant CT 67% 47% 82% 80% 0%
Neoadjuvant CT 3% 0% 2% 16% 0%
Palliative 1% 0% 0% 0% 86%
0%
20%
40%
% of the subjects
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20%
25%
30%
35%
40%
45%
50%
% of the subjects
Percentage use of chemotherapy
regimen in each cancer stage
Source: Breast Cancer Facts in Hong Kong 2008 Report
Overall Stage I Stage II Stage III Stage IV
CMF only 1% 0% 3% 0% 0%
AC only 19% 44% 17% 2% 33%
TC/ DC only 15% 23% 12% 13% 33%
FAC/ FEC only 19% 18% 22% 9% 34%
AC+T 33% 13% 35% 44% 0%
TAC 1% 0% 1% 2% 0%
FEC+T 3% 1% 3% 6% 0%
Others 9% 1% 7% 24% 0%
0%
5%
10%
15%
20%
% of the subjects
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58% 60%
69% 70%
60%
40%
50%
60%
70%
80%
% of the subjects
Endocrine therapy rate
17%
0%
10%
20%
30%
Overall Stage 0 Stage I Stage II Stage III Stage IV
% of the subjects
Cancer stage
Source: Breast Cancer Facts in Hong Kong 2008 Report
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77%
40
50
60
70
80
90
% of subjects
Forms of endocrine therapy
17%
1% 0%
6%
0
10
20
30
40
Tamoxifen Aromatase inhibitor
Ovarian suppression
Ovarian irradiation/
oophorectomy
Unclassified
% of subjects
Note: * = percentages add to more than 100% because more than one response could be marked
Source: Breast Cancer Facts in Hong Kong 2008 Report
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Targeted therapy11%
Targeted therapy rate
No targeted therapy89%
Source: Breast Cancer Facts in Hong Kong 2008 Report
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100%
60
70
80
90
100
% of subjects
Types of targeted therapy treated for
invasive breast cancer
0% 0%0
10
20
30
40
50
60
Trastuzamab Lapatinib Avastin
% of subjects
Source: Breast Cancer Facts in Hong Kong 2008 Report
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Alternative medicine
8%
Use of alternative medicine
No alternative medicine92%
Source: Breast Cancer Facts in Hong Kong 2008 Report
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89%
50
60
70
80
90
100
% of subjects
Type of alternative medicine
16%
0
10
20
30
40
50
Chinese medicine Health food
% of subjects
Note: * = percentages add to more than 100% because more than one response could be marked
Source: Breast Cancer Facts in Hong Kong 2008 Report
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Compare clinical management practice for
breast cancer in HK vs. in other countriesBreast Cancer Facts in Hong Kong 2008
ReportOther countries
Surgery 99.8% 98% (Canada)1/ 98% (UK)2
Breast conserving surgery 61% 44% (Canada)1/ 72% (UK)2
Mastectomy 39% 55% (Canada)1/ 26% (UK)2
Reconstruction among patients with mastectomy
26% 16.8% (USA)3
Radiotherapy 71% 81% (UK)4
Endocrine therapy 58% 83% (Australia)5
Chemotherapy 71% 78% (Australia)5
Targeted therapy 11% --
Alternative medicine 8% 28.1% (USA)6
1 JNCI 2009; 101(10): 736-750; 2 CancerStats-Breast Cancer- UK 2009 May; 3
JAMA 2006; 295(4):387-388; 4 PNAS 2003; 100(18): 10393-40398; 5 ANZ J Surg 2006: 76: 745-750; 6 NEJM 1999: 340(22): 1733-1739
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Breast Cancer Facts in Hong Kong
2008 Report in Chapters
• Patient Demographics
• Lifestyle
• Health Background
• Clinical Characteristics• Clinical Characteristics
• Overall Cancer Characteristics
• Histological & Molecular Characteristics
• Treatment Methods
• Patients Status
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Patient status
Total number of follow up cases N= 625
Mean follow-up period 12.6 months
Median follow-up period 12.0 months
Range (months) 0.1-89.0
No. of recurrence 8 (1.3%)
No. of local recurrence 5 (0.8%)
No. of distant metastasis 3 (0.5%)
No. of death from breast cancer 0 (0%)
No. of death from unrelated cause 0 (0%)
Source: Breast Cancer Facts in Hong Kong 2008 Report
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1.3% cancer relapse and no mortality
during follow up
Breast CancerFacts in Hong
Kong 2008 ReportOther countries
Mean follow up 12.6 months --
Recurrence 1.3% --
5-year local recurrence rate:
Local recurrence 0.8%
5-year local recurrence rate: 7% (France)1/
5-year local recurrence rate: 7.3% (Netherlands)2
Distant metastasis 0.5%
5-year distant metastasis rate: 8.5% (France)1/
5-year distant metastasisrate: 13% (Netherlands)2
Death from breast cancer 0% --
Death from unrelated cause 0% --
1Int J Radiat Oncol Bio Phy 1999; 43(1): 25-372N Eng J Med 2001; 345(19): 1378-1387
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Psychosocial impact to
breast cancer survivorsbreast cancer survivors
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87.7%
60%
70%
80%
90%
100%
% of the subjects
Less than 10% patients feel severe
discomfort/ intolerable after surgery
1. Wound pain2. Unacceptable to
change of appearance3. Weakness4. Sleepless5. Difficulty in lifting up
hand of surgical side
6.8% 5.4%
0%
10%
20%
30%
40%
50%
60%
Minimal/ tolerable Severe/ Intolerable No comments/ others
% of the subjects
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92%
82%79%
60%
70%
80%
90%
100%
% of the subjects
Level of physical sufferings
after surgery
Minimal/ tolerable
Severe/ Intolerable
No comment
P <0.001
3%
11%
17%
5%7%
4%
0%
10%
20%
30%
40%
50%
60%
Breast conserving treatment Mastectomy Mastectomy+reconstruction
% of the subjects
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54.4%
43.9%
40%
50%
60%
% of the subjects
About 40% patients feel severe
discomfort/ intolerable during
chemotherapy1. Nausea/ vomiting2. Hair loss3. Weakness4. Loss of appetite5. Psychological
problems
1.7%
0%
10%
20%
30%
Minimal/ Tolerable Severe/ Intolerable No comments/ Others
% of the subjects
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86.1%
70%
80%
90%
100%
% of the subjects
Less than 10% patients feel severe
discomfort/ intolerable during radiation
therapy1. Pain2. Skin peeling
off/swollen3. Feeling of
burning4. Itchiness
5.9% 8.1%
0%
10%
20%
30%
40%
50%
60%
Minimal/ Tolerable Severe/ Intolerable No comments/ Others
% of the subjects
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74.4%
50%
60%
70%
80%
% of the subjects
Less than 10% patients feel severe
discomfort/ intolerable during endocrine
therapy
1. Hot flushes2. Bone pain3. Menstrual
disorder
5.7%
19.9%
0%
10%
20%
30%
40%
50%
Minimal/ Tolerable Severe/ Intolerable No comments/ Others
% of the subjects
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66.7%
50%
60%
70%
80%
% of the subjects
Nearly 20% patients feel severe
discomfort/ intolerable during targeted
therapy
1. Vomiting2. Less appetite/
loss of appetite3. Dizziness4. Pain
17.9%15.4%
0%
10%
20%
30%
40%
50%
Minimal/ Tolerable Severe/ Intolerable No comments/ Others
% of the subjects
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45%44%
36%
50%
47%
54%
61%
65%
33%
40%
50%
60%
70%
% of the subjects
Change in outlook of life
Negative
Indifferent
Positive
P=0.017
8%
3% 3%
6%
17%
29%
33%
0%
10%
20%
30%
Stage 0 Stage I Stage II Stage III Stage IV
% of the subjects
Cancer stage
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60%
64%
60%
50%
83%
50%
60%
70%
80%
90%
% of the subjects
Change in self image
Negative
Indifferent
Positive
P=0.218
10%
6% 6%
13%
17%
30% 31%
34%37%
0%0%
10%
20%
30%
40%
Stage 0 Stage I Stage II Stage III Stage IV
% of the subjects
Cancer stage
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55.7%
31.4%
40%
50%
60%
How do patients cope with
negative emotions?
31.4%
11.1%
5.8%
0%
10%
20%
30%
Direct verbal expression
Direct focus Ignore it Feel depressed
% of the subjects
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54.5%
40%
50%
60%
% of the subjects
About 70% sometimes/ always
worry about recurrence
8.9%
21.6%
15.1%
0%
10%
20%
30%
Never Seldom Sometimes Always
% of the subjects
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60%
70%
80%
90%
100%
% of the subjects
Worry about cancer recurrence:
the younger the more worried
P<0.001
0%
10%
20%
30%
40%
50%
<40 40-49 50-59 60-69 70+
% of the subjects
Age group
Always
Sometimes
Never/seldom
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HKBCF recommends
• Engage in at least 30 mins of moderate to vigorous exercise for 5 or more days per week
• Encourage breast feeding
• Maintain ideal body weight & healthy diet
• Practice regular breast screening• Practice regular breast screening
Age Self-examination
Clinical examination
Mammogram
20-39 Every month Every 3 years -
40 and above Every month Every 2 years Every 2 years
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Acknowledgements
• Steering Committee
– Dr. Polly Cheung, Chairman
– Mrs. Veronica Bourke
– Dr. Emily Ying Yang Chan
– Dr. Keeng Wai Chan
– Dr. Sharon Wing Wai Chan
– Dr. Peter Choi
– Mrs. Joanna Choi
• IT Subcommittee
– Dr. Peter Choi
– Mr. Peter Kwan
– Dr. Chun Chung Yau
– Dr. Gary Yeoh
• All medical professionals, doctors, nurses and patients who participated and facilitated in data collection– Ms. Yvonne Chua
– Ms. Doris Kwan
– Dr. Wing Hong Kwan
– Dr. Stephen CK Law
– Dr. Lawrence Li
– Mrs. Sandra Mak
– Dr. Ting Ting Wong
– Dr. Chun Chung Yau
in data collection
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Hong Kong Breast Cancer Registry
promotion and data collection snapshots
Over 3000 participants
joined the Hong Kong
Breast Cancer Registry
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Patient participation – To support and Participate
in the Hong Kong Breast Cancer RegistryStep 1: Please download read the form thoroughly. If there you have
questions please do not hesitate to call us at the Foundation. It is important to
us that you understand why we need your information and how it will be used.
Step 2: Sign and return the Consent Form to HKBCF by mail or via your
doctors-in-charge. Please do not return the completed form via facsimile.
Your consent will give us permission to access and collect your medical and
treatment records from your doctors, and to use them in future statistical
analysis.analysis.
Step 3: Fill in the Personal Profile questionnaire that we will send you on
receipt of your consent. We urge you to complete this questionnaire as best as
you can as data collected here is of vital importance to provide for the most
accurate data for future research and analyses to be conducted.
Step 4: Once a year, we will contact you and/or your physicians updating your
status and collect latest medical information on your health status. Data
collection will be either by phone or by mail, whichever is convenient to you at
that time.
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For more details please visit:
www.hkbcf.org/breastcancerregistry