why lupron is used in ivf treatment
TRANSCRIPT
WHY LUPRON IS USED IN IVF TREATMENT
Introduction To Lupron
O Lupron (leuprolide) overstimulates the body's own production of certain hormones, which causes that production to shut down temporarily. Leuprolide reduces the amount of testosterone In men or estrogen in women.
O Lupron is used in men to treat the symptoms of prostate cancer. Lupron treats only the symptoms of prostate cancer and does not treat the cancer itself.
Why Lupron Is Used In IVF Treatment
O Lupron- Has several possible uses in assisted
reproduction: as the trigger injection prior to egg retrieval to reduce the risk of hyperstimulation
- As part of the “flare” protocol to help women who respond poorly to fertility medications.
- Suppression of the pituitary to prevent ovulation
How Lupron Works In IVFO Lupron acts by suppressing the pituitary gland (the
gland which is normally responsible for triggering ovulation). However, before suppression occurs, Lupron will briefly stimulate the pituitary causing an increase in the pituitary hormones LH (luteinizing hormone) and FSH (follicle stimulating hormone). This is called the agonist or flare phase (see picture). If the Lupron is continued, it will eventually stop the pituitary from producing LH and FSH. This is known as the suppression phase.
O Since it requires an extended period time to reach the suppression phase, Lupron is usually started a few weeks before starting the other medications needed for a particular treatment.
How Lupron Works In IVF
O This allows the patient to “get past” the stimulation phase and into the suppression or desensitization phase.
O During the suppression phase, spontaneous ovulation will not occur. You may hear the staff refer to the patient during this phase as being “down-regulated” or "suppressed". This suppression effect will even persist for a few weeks after the Lupron is stopped.
O Today, Lupron suppression is used primarily for frozen embryo transfer cycles and egg donation cycles. Some programs may still use Lupron for fresh IVF cycles .
How Lupron Works In IVF
O At IVF1, we use a newer class of medications to prevent premature ovulation in fresh IVF cycles. We like to use Cetrotide or Antagon instead of Lupron.
O The flare effect of Lupron can be used at the beginning of a fresh IVF cycle to help stimulate the development and maturation of eggs. Lupron is given for a few days and then injectable fertility medications are started. The flare protocol is rarely used anymore since it does not appear to produce any benefit over other simpler protocols.
How Lupron Works In IVFO The “flare effect” of Lupron can also be
used at the end of an IVF stimulation in place of the hCG trigger injection. This use of Lupron is primarily reserved for women who have responded too vigorously to the fertility medications and are at risk for ovarian hyperstimulation syndrome.
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O [email protected] Fax : 1-888-477-2365