wim jennes, sonja verheyden, julie w. mertens, makhtar camara, moussa seydi, tandakha n. dieye,...
TRANSCRIPT
Wim Jennes, Sonja Verheyden, Julie W. Mertens, Makhtar Camara, Moussa Seydi, Tandakha N. Dieye, Souleymane Mboup, Christian Demanet, Luc Kestens
Inhibitory KIR/HLA incompatibility between sexual partners confers protection
against HIV-1 transmission
Institute of Tropical Medicine Antwerp
University Hospital Brussels
Cheikh Anta Diop University of Dakar
Autoresponse: Natural killer cells kill founder HIV-1 infected CD4+ T-cells
Alloresponse: Natural killer cells kill partner HIV-1 infected CD4+ T-cells
How can NK cells protect against HIV-1 infection?
KIR/HLA typing in HIV-1 transmitting and non-transmitting married couples from Dakar, Senegal
Autoresponse
NK cell protection due to activating KIR and missing ligand combinations
Alloresponse
KIR/HLA mismatched stem cell transplants cure leukemia
Velardi et al, Curr Opin Immunol 2008; Moretta et al, Immunology Reviews 2008
KIR/HLA typing in HIV-1 transmitting and non-transmitting married couples from Dakar, Senegal
Autoresponse
NK cell protection due to activating KIR and missing ligand combinations
NK cell protection due to missing self alloreactive KIR/HLA combinations
Alloresponse
Summary and implications
Summaryo Lack of HIV-1 transmission in African couples is associated with
- NK cell activating KIR/HLA genotypes in the recipient partner- KIR/HLA missing self combinations between partners
o KIR/HLA missing self combinations correlate with alloreactive NK cell killing of HIV-1 patient-derived CD4+ T cells in vitro
Implicationso NK cells could be important in protection against HIV-1 infection
and may be suitable targets for future preventive therapies
o KIR/HLA mismatched stem cell transplants: revolution in leukemiaCan KIR/HLA mismatches be exploited in HIV prevention and cure?