Program

Workshop

Workshop on Oral, Gastrointestinal and Pulmonary GvHD

November 17 – 18, 2017University Hospital RegensburgRegensburg, Germany

CME credits 7

Awarded with

3

Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4

Scientific Program . . . . . . . . . . . . . . . . . . . . . . . . . 6

List of Speakers . . . . . . . . . . . . . . . . . . . . . . . . . . . 9

Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12

7 credit hours (CME) have been awarded to the Workshop by the European Union of Medical Specialists (UEMS) – European Board of Gastroenterology (EBG).

4

Preface

Dear colleagues,

We are pleased to invite you to the Workshop on oral, gastrointestinal and pulmonary GvHD 2017 held in Regensburg. Acute and chronic GvHD continues to be associated with significant morbidity and mortality representing an ongoing challenge in clinical care. Recently, new insights in the pathophysiology of microbial changes associated with different organ GvHD (oral mucosa, gastrointestinal tract and lung) and their impact on immunoregulation have been achieved, their translation into clinical success remains challenging.

The workshop on oral, gastrointestinal & pulmonary GvHD will provide a comprehensive overview on pathophysiology including microbiological changes, and will provide an update on diagnosis, immunosuppressive and supportive treatment of the latter organ manifestations.

The workshop is supported by the Falk Foundation e.V.

E. Holler, M. Edinger, W. Herr, M. Evert, D. Weber, A. Gessner, D. Wolff (Regensburg, Germany)H. Greinix (Graz, Austria), A. Lawitschka (Vienna, Austria), J. Halter (Basel, Switzerland)G.C. Hildebrandt (Lexington, USA), S.Z. Pavletic (Bethesda, USA)

5

Workshop

Workshop on Oral, Gastrointestinal and Pulmonary GvHD

November 17 – 18, 2017University Hospital RegensburgRegensburg, Germany

Start of Registration:Friday, November 17, 201711.45 – 18.30 hat the congress offi ce

Congress Venue:University Hospital Regensburg-Großer Hörsaal-Franz-Josef-Strauß-Allee 1193053 RegensburgGermany

The Workshop is organized by Falk Foundation e.V.

Scientifi c Organization:Prof. Dr. Daniel WolffDepartment of Hematology and OncologyUniversity Hospital RegensburgFranz-Josef Strauss-Allee 1193053 Regensburg, GermanyTel: +49 (0)941-944-5531Fax: +49 (0)941-944-5543E-Mail: daniel.wolff@ukr.de

Scientifi c Co-Organization:H. Greinix, Graz (Austria)J. Halter, Basel (Switzerland)W. Herr, Regensburg (Germany)G.C. Hildebrandt, Lexington (USA)E. Holler, Regensburg (Germany)S.Z. Pavletic, Bethesda (USA)

Offi cial Language:English

6

Friday, November 17, 2017

12.45 Welcome W. Herr, Regensburg

Session I Pathophysiology of acute and chronic GvHD I

Chair: G.R. Hill, Brisbane; P.R. Reddy, Ann Arbor

13.00 Role of APC’s in GvHD G.R. Hill, Brisbane

13.30 Effector T cell programs in GvHD R. Chakraverty, London

14.00 Innate lymphoid cells in graft-versus-host disease M.-C. Brueggen, Zurich

14.20 CD4+CD25+ regulatory T cells in allogeneic stem M. Edinger, cell transplantation Regensburg

14.40 Coffee break

Session II Pathophysiology of acute and chronic GvHD II

Chair: R. Chakraverty, London; M. Edinger, Regensburg

15.00 The role of B cells in chronic GvHD T. Winkler, Erlangen

15.20 Innate immunity R. Zeiser, Freiburg

15.40 Role of antimicrobial peptides and Paneth cells J.L.M. Ferrara, New York

16.00 Pathophysiology of intestinal tolerance P.R. Reddy, Ann Arbor

16.30 Coffee break

7

Friday, November 17, 2017

Session III Lung GvHD

Chair: H. Greinix, Graz; A. Lawitschka, Vienna

17.00 Pathophysiology of lung GvHD G.C. Hildebrandt, Lexington

17.30 Diagnosis of lung GvHD J. Halter, Basel

18.00 Treatment of lung GvHD S.Z. Pavletic, Bethesda

18.30 End of afternoon session

8

Saturday, November 18, 2017

Session IV Oral GvHD

Chair: S. Elad, Rochester; D. Wolff, Regensburg

9.00 Microbiome in oral chronic GvHD M. Mravak-Stipetic, Zagreb

9.20 Immunosuppressive treatment of oral chronic GvHD S. Elad, Rochester

10.00 Supportive care E.M. Wagner, Mainz

10.20 Coffee break

Session V GI-GvHD

Chair: A. Gerbitz, Berlin; M.R.M. van den Brink, New York

10.50 Impact of microbiota in experimental GI-GvHD M.R.M. van den Brink, New York

11.20 Pathophysiology of microbial changes in clinical D. Weber, GI-GvHD Regensburg

11.50 Microbiota transfer as treatment of GvHD C. Högenauer, Graz

12.10 Diagnosis and treatment of gastrointestinal GvHD E. Holler, Regensburg

12.30 Panel Discussion: R. Chakraverty, London; H. Greinix, Graz; G.R. Hill, Brisbane; C. Högenauer, Graz; E. Holler, Regensburg; P.R. Reddy, Ann Arbor; M.R.M. van den Brink, New York

12.50 Summary and closing remarks E. Holler, Regensburg

13.00 Lunch

9

List of Speakers, Moderators and Scientific Organizers

Dr. Marie-Charlotte BrueggenDepartment of DermatologyUniversity Hospital ZurichGloriastrasse 318091 ZürichSwitzerlandmarie-charlotte.brueggen@usz.ch

Prof. Dr. Ronjon ChakravertyInst. of Immunity, Transplant.and Cancer School of MedicineRoyal Free HospitalRowland Hill StreetLondon NW3 2PFGreat Britainr.chakraverty@ucl.ac.uk

Prof. Dr. Matthias EdingerKlinik für Innere Medizin IIIUniversitätsklinikum RegensburgFranz-Josef-Strauß-Allee 1193053 RegensburgGermanymatthias.edinger@ukr.de

Sharon Elad, DMD, MScProfessor of DentistryDivision of Oral MedicineEastman Institute for Oral HealthUniversity of Rochester Medical Center625 Elmwood Ave.Rochester, NY 14620USAselad@urmc.rochester.edu

James L. M. Ferrara, M.D.Professor of MedicineHematologic MalignanciesTranslational Research CenterThe Tisch Cancer InstituteDivision of Hematology / Medical OncologyHess Center for Science and Medicine1470 Madison Avenue, 6th FloorNew York, NY 10029USAjames.ferrara@mssm.edu

Prof. Dr. Armin GerbitzAllogeneic Stem Cell TransplantationDep. of Hematology/OncologyCharité CVK I Mittelallee 1113353 BerlinGermanyarmin.gerbitz@charite.de

Prof. Dr. Hildegard GreinixKlinische Abteilung für HämatologieMedizinische Universität GrazLKH-Univ. Klinikum GrazAuenbruggerplatz 38 8036 GrazAustriahildegard.greinix@klinikum-graz.at

PD Dr. Jörg HalterHämatologieDepartment of MedicineUniversitätsspital BaselPetersgraben 44031 BaselSwitzerlandjoerg.halter@usb.ch

Prof. Dr. Wolfgang HerrKlinik für Innere Medizin IIIUniversitätsklinikum RegensburgFranz-Josef-Strauß-Allee 1193053 RegensburgGermanywolfgang.herr@ukr.de

Gerhard C. Hildebrandt, M.D.Professor of MedicineDivision of Hematology &Blood and Marrow TransplantationUniversity of Kentucky800 Rose StreetLexington, KY 40536USAgerhard.hildebrandt@uky.edu

10

Prof. Dr. Geoffrey R. HillBone Marrow Transplantation LaboratoryQIMR Berghofer Medical Research Institute300 Herston RdBrisbane, QLD 4006Australiageoff.hill@qimrberghofer.edu.au

Prof. Dr. Christoph Högenauer Division of Gastroenterology and HepatologyDepartment of Internal MedicineMedical University of GrazAuenbruggerplatz 158036 GrazAustriachristoph.hoegenauer@medunigraz.at

Prof. Dr. Ernst HollerKlinik für Innere Medizin IIIUniversitätsklinikum RegensburgFranz-Josef-Strauß-Allee 1193053 RegensburgGermanyernst.holler@ukr.de

Dr. Anita LawitschkaSCT-OUTPATIENT CLINICSt. Anna Children‘s HospitalKinderspitalgasse 6 1090 Wien-AlsergrundAustriaanita.lawitschka@stanna.at

Prof. Dr. Marinka Mravak-Stipetic Clinical Department of Oral MedicineUniversity Hospital Centre Zagreb University of ZagrebGunduliceva 510000 ZagrebCroatiammstipetic@gmail.com

Steven Z. Pavletic, M.D.Head of GvHD and Autoimmunity UnitExperimental Transplantation and Immunology BranchNational Cancer Institute10 Center DriveBethesda, MD 20892-1203USApavletis@mail.nih.gov

Pavan R. Reddy, M.D.Div. of Hematology/OncologyDept. of Internal MedicineS.C. Mott Children‘s Hospital1540 E. Hospital Dr - SPC 4257Ann Arbor, MI 48109USAreddypr@umich.edu

Marcel R. M. van den Brink, M.D., Ph.D.Professor of Medicine and ImmunologyDivision of Hematologic OncologyWeill Cornell Medical College1275 York Avenue, Box 111New York, NY 10065USAmuggeoc@mskcc.org

PD Dr. Eva M. WagnerIII. Medizinische KlinikUniversitätsmedizin der Johannes Gutenberg-Universität Langenbeckstr. 155131 Mainz Germanyeva.wagner@unimedizin-mainz.de

Dr. Daniela WeberKlinik für Innere Medizin IIIUniversitätsklinikum RegensburgFranz-Josef-Strauß-Allee 1193053 RegensburgGermanydaniela.weber@ukr.de

11

Prof. Dr. Thomas WinklerSektion HämatopoeseLehrstuhl GenetikNikolaus-Fiebiger-Zentrum Molekulare MedizinGlueckstrasse 691054 ErlangenGermanythomas.winkler@fau.de

Prof. Dr. Daniel WolffKlinik für Innere Medizin IIIUniversitätsklinikum RegensburgFranz-Josef-Strauß-Allee 1193053 RegensburgGermanydaniel.wolff@ukr.de

Prof. Dr. Robert ZeiserKlinik für Innere Medizin ISchwerpunkt Hämatologie, Onkologieund StammzelltransplantationUniversitätsklinikum FreiburgHugstetter Str. 5579106 FreiburgGermanyrobert.zeiser@uniklinik-freiburg.de

12

General InformationPrior to the opening of the Workshop in Regensburg

Falk Foundation e.V. Telephone: +49 (0)761/1514-125Congress Department Telefax: +49 (0)761/1514-359Leinenweberstr. 5 E-mail: symposia@falk-foundation-symposia.org79108 FreiburgGermany

Congress Office and RegistrationDuring the Workshop in Regensburg

Congress Office Telephone: +49 (0)175/7795327

Opening Hours:Friday, November 17, 2017 11.45 – 18.30 hSaturday, November 18, 2017 8.00 – 13.00 h

University Hospital RegensburgFranz-Josef-Strauss-Allee 1193053 RegensburgGermany

Congress FeesThe participation at the Workshop is free of charge. Please be aware that the number of participants is limited. Registration is mandatory.

Refreshments during the coffee breaks and lunch on November 17 – 18 and a copy of the abstract volume of the Workshop are also free of charge.

The event shall be held regardless of any decisions made by you or by your place of employment regarding the procurement, prescription or use of any products of our organization or associated companies. If you are a civil servant or salaried employee, please check whether you require permission from your employer to participate in the event. If you participate in the event, Falk Foundation e.V. presumes that you were granted permission from your employer prior to your participation.

13

Admission to Scientific EventsFor admission to scientific program your name badge should be clearly visible.

Conflicts of InterestMembers of the scientific committee declare following potential Conflicts of Interest: Daniel Wolff: Falk Pharma, Mallinckrodt; Hildegard Greinix: Incyte, Roche, Therakos Inc, Novartis, BMS; Ernst Holler: Incyte, Novartis, JAZZ Pharma, Neovii, Astellas.Jörg Halter, Wolfgang Herr, Gerhard C. Hildebrand and Steven Z. Pavletic declare no Conflicts of Interest.

Hotel Accommodation If you would like to do a hotel reservation, please contact:

Tourist-Information Altes RathausRathausplatz 493047 RegensburgGermany Tel: +49 (0)941/507-4410Tel: +49 (0)941/507-4418E-Mail: tourismus@regensburg.dewww.tourismus.regensburg.de

Airport International Franz-Josef-Strauß-Airport Munich

14

Directions to University Hospital Regensburg

Main Entrance

Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg

HALF A CENTURY OF PROMOTING MEDICAL EXCHANGEConferences that advance medicine and re-search: 50 years ago, Herbert Falk, MD, PhD, organized a week-long event in Freiburg devot-ed to the liver – it was his first symposium and the start of an extraordinary success story.Since then, 207 additional events have been held worldwide, featuring speakers who are pioneers in their fields. To date, more than 130,000 physicians and researchers from around the world have participated in our sym-posia, and the strong interest in our upcoming events shows that this concept remains appeal-ing. We take great pride in this! Since the very beginning, all of our events – whether large or small – have been based on the principle of providing neutral continuing medical education

that benefits research, treatment, and ultimate-ly the patient.We would like to offer our deepest thanks to everyone who has participated, and we look forward to further advancing scientific dialogue as we continue to advocate for more knowledge sharing and therapeutic progress!Allow us to welcome you to the Falk Foundation symposia – now and for many years to come!

Scientific Dialogue in the Interest of Therapeutic Progress

OF SYMPOSIAYears

PWSR

EG17

2-1

1/20

17/2

00

Stü

Organized by:

FALK FOUNDATION e.V.Leinenweberstr. 579108 FreiburgGermany

Congress DepartmentTelephone: +49 (0) 761/15 14-125Telefax: +49 (0) 761/15 14-359E-Mail: symposia@falk-foundation-symposia.orgwww.falk-foundation-symposia.org