workup and management of acute kidney injury...acute kidney injury (aki) in hospitalized patients 2....
TRANSCRIPT
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WorkupandManagementofAcuteKidneyInjury
MatthewRivara,MD,FASNAssistantProfessorofMedicine
DivisionofNephrologyUniversityofWashington
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Disclosures• Ihavenothingtodisclose
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Objectives
1. Reviewcommon(anduncommon)causesofacutekidneyinjury(AKI)inhospitalizedpatients
2. DiscusspracticaldiagnosticevaluationforthehospitalizedpatientwithAKI
3. DiscusspreventionandmanagementofselectAKIetiologies
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Case1
HPI:• 43y/owomanwithahistoryofchronicHCV,presentstoEDwithabdominalpain,vomitingx3days• Temp38,BP95/60,HR100• Examshowsabdominaltenderness,1+LEedema▫ Receives1literLR,vancomycinandcefepimex1▫ F/uBP105/70àadmittedtomedicine
PMH:• H/owristfracture1yearago,creatinine0.7mg/dL
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Laboratory/imagingevaluation
Urinalysis: 1+ RBCs, 1+ protein Urine protein/creat: 0.5 g/g 134
4.2 102
21
20
1.2 94
HCVviralload:800,000IU/LC3,C4bothlowINR:1.4Totalbilirubin:6.0mg/dL
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Case1,continued
0
0.5
1
1.5
2
2.5
3
0 2 4 6 8 10 12
SERU
MCRE
ATININE(M
G/DL
)
HOSPITALDAY
Trendinserumcreatinine
Vanco level 40
Vanco/cefepime
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Whatiscausingthispatient’sAKI?
AcuteKidneyInjury
Pre-renal(lowEABV)
Acutetubularinjury/necrosis
Hepatorenalsyndrome
Acuteinterstitialnephritis
Vancomycinnephrotoxicity
GN/MPGNrelatedtoHepatitisC
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“AcuteKidneyInjury"isaclinicalsyndrome
ElevatedCreatinine/DecreasedeGFR Lowurineoutput
KDIGO AKI Guidelines, 2012
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• AKIisnotasinglediseaseentity–itisaheterogeneousgroupofconditionswithdifferentcausesandpathophysiologicmechanisms
• Therearenopharmacologicagentsavailableforthepreventionortreatmentofacutekidneyinjury
• Thus,treatmentisalways▫ Identificationandmanagementofunderlyingdisorder▫ Managementofvolumeandmetaboliccomplications
TREATMENT OF AKI
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AKIiscommoninhospitalizedpatients!
Zeng et al, CJASN, 2014
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UrinarybiomarkersforAKI–NOTYET!
Ostermann M, et al.. Crit Care. 2016.
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Tubularfunctionasastresstest
77 patients with AKI who received FST à followed for development of stage 3 AKI, RRT, death FUROSEMIDE OUTPERFORMED URINARY BIOMARKERS FOR ALL OUTCOMES
Koyner et al, JASN, 2015
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CausesofAKI
Pre-renal Post-renalIntra-renal
• Volume depletion • Cardiorenal syndrome • Hepatorenal syndrome • Abdominal compartment
syndrome • Renal artery occlusion/ • Dissection • Renal vein thrombosis
• Acute tubular necrosis • Glomerular disorders • Microvascular disorders • Tubulointerstitial Disorders
• Ureteral obstruction • Bladder outlet
obstruction
DecreasedEABV/Renal
veincongestion
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Jefferson, Haseley. Comprehensive Clinical Nephrology. Chapter 66, Sixth edition.
CausesofAKI–AnAnatomicApproach
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Case2• 20y/omanhospitalizedforvolumedepletionafterreturningfromMexico• Reports5daysof6-10loosestools/day,nausea,poorPOintake• BPis80/50,dizzywithstanding• Creatinine1yearago0.9.
126 4.5
90
16
75
3.5 90
Urine: UNa 8 mEq/L Ucreat: 35 mg/dL Uosm: 560 mOsm/kg Fe Na 0.6% Urine sediment: Bland
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CausesofAKIinhospitalizedpatients
Nash et al., AJKD, 2002
55
39
2 4 30
10
20
30
40
50
60
ATN Decrease EABV Obstruction Parenchymal diseases not
ATN
Not classified
%
> 90% of all AKI!
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“Pre-renal” ATNUOP/creatininerespondquicklytofluids(ifgivenenough)
UOP/creatininedonotrespondtofluids
BUNoutofproportiontoCr BUN/Cr<20:1
UOP<15ml/hrbutnotanuric Canbeanuric
Courseimprovedwithintervention Courseunaffectedbyinterventionprovidedfurtherinsultavoided
Urinesodiumlow(<10meq/L),FeNalow(<1%)
UrinesodiumNOTlow(>20meq/L),FeNanotlow(>2%)
Somecaseshaveconsiderableoverlap
If volume status unclear: 1. Early therapeutic trial of withholding diuretics, give 500cc-1000cc isotonic fluid over 1-4 hours 2. Watch for UOP and serum creatinine over next 12-24 hours
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FENa
65%
20-25%
5-7%
2-5%
= Excreted Na Filtered Na = Urine Na x Serum Cr x 100 Serum Na x Urine Cr • FENa <1% prerenal azotemia
• Sensitivity: 90% Specificity: 93%
• FENa > 1% ATN • Sensitivity: 93%
Specificity: 90%
Espinel. JAMA. 1976:236(579-581) Miller et al. Ann Int Med. 1978;89(47-50)
Na
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ON DIURETICS? ✔FEUrea
65%
20-25%
5-7%
2-5%
= Excreted Urea Filtered Urea = Urine Urea x Serum Cr x 100 Serum Urea x Urine Cr • Normal FE Urea 50-65 %
• Prerenal Azotemia < 35%
Urea
Urea
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What’swrongwithfractionalexcretionmeasures?
Perazella et al. CJASN 2012
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• Restorerenalperfusion/treatunderlyingcondition
MANAGEMENT OF PRERENAL AKI
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DecreasedEABVAKI–morethan“pre-renal”
Intravascularvolumedepletion
Hemorrhage
GIorrenallosses
Reducedcardiacoutput
CHF/cardiogenicshock
Pericardialdiseases
Systemicvasodilation
Sepsis
Cirrhosis
Anaphylaxis
RenalVasoconstriction
Hepatorenalsyndrome
Acutehypercalcemia
Drugs–ACEI,NSAIDS,calcineurininhibitors
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Othercommonlow-EABVAKIconditions
Type1cardiorenalsyndrome
Hepatorenalsyndrome(HRS)
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MechanismsofCRS
Soni Clinical Queries: Nephrology 2014
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Clinicalconundrumwithacutecardiorenalsyndrome,type1
Heartfailureexacerbation
Fluidoverload
Venouscongestion
LowBP
Gentlediuresis?
Aggressivediuresis?
Mechanicalultrafiltration?
Worsevs.improvedkidney
function?
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Diureticdosing• DOSE trial • 308 patients with acute decompensated heart failure • Randomized to furosemide IV bolus q12 hours vs. infusion and at
either low dose (equivalent to home oral dose) vs. high dose (2.5x home oral dose)
Felker NEJM 2011
Take home message: diuretic dosing is flexible
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Ultrafiltration• CARRESS-HF trial • 188 patients with acute decompensated heart failure, AKI and persistent
congestion • Stepped pharmacologic therapy (IV diuretics) vs. ultrafiltration • No difference in weight loss between groups • Higher rate of adverse events and greater increase in Cr in UF group
Bart NEJM 2012
Take home message: diuresis is likely a safer strategy (vs. UF)
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HEPATORENAL SYNDROME (HRS)
Reversiblefunctionalrenalimpairmentthatoccursinpatientswithadvancedliverdisease.
LowGFR
Absenceofshock,currentinfection,fluidlosses,nephrotoxic
drugs
Noimprovementinrenalfunctionafter
diureticwithdrawalandexpansionofvolume
Proteinuria<500mg/d
Noobstruction
Nointrinsicrenaldisease(noATN,no
GN)
Typically IV albumin 1g/kg of body weight x 2 days
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PrecipitatingfactorsinHRS
3 interrelated pathways: 1. Splanchnic
vasodilation decreasing EABV
2. Renal sympathetic stimulation
3. Cardiac dysfunction leading to renal hypo-perfusion
Wadei et al, CJASN, 2006
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HRSTreatmentIncriticallyillpatients:• NorepinephrineIVtoraiseMAPby10mmHguntilnoresponseorresolutionofAKI(atleast2days)
Innon-criticallyillpatients:• Midodrine7.5-15mgTID• Octreotide100mcg-200mcgTID• Trialx2days
Innon-responders:• ConsiderTIPS(controversial)• Iflivertransplantcandidate,dialysisasbridgetotransplant
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Case3• 20y/omanhospitalizedforvolumedepletionafterreturningfromMexico• Reports5daysof6-10loosestools/day,nausea,poorPOintake• BPis80/50,dizzywithstanding• Creatinine1yearago0.9.
126 4.5
90
16
75
3.5 90
Urine: UNa 30 mEq/L Ucreat: 42 mg/dL Uosm: 300 mOsm/kg Fe Na 2%
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Case3:urinesediment
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ValueofUrineSediment
Perazella et al. CJASN 2012
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NEPHROTOXINS AND ATN
Endogenous Exogenous/Drugs Myoglobin(Rhabdomyolysis)Uricacid(TumorLysisSyndrome)Hemoglobin(Hemolysis)
AmphotericinAminoglycosidesCisplatinIfosfamideAcetaminophenSalicyclatesRadiocontrastagents(?)IntravenousimmunoglobulinZolendronateVancomycin
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Isvancomycinnephrotoxic?• Isitthis?
• Orisitthis?
Vanco levels Serum creatinine
causality
causality Serum creatinine Vanco levels
Notamenabletorandomizedcontrolledtrial!
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Vancomycinnephrotoxicity
7 randomized and controlled trials N = 4033 6 – vancomycin vs linezolid 1 – vancomycin vs certaroline 6/7 – vancomycin associated with higher risk of AKI
RR 2.45 (95% confidence interval, 1.69 to 3.55)
Ray et al, CJASN 2016
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Vancomycin-associatedcastnephropathy
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Vancomycinnephrotoxicityasafunctionoftroughlevel
Troughconcentration(mg/L) Toxicity
5–1010.1–1515.1–2020.1–35>35
5%3%11%23%82%
Horey et al. Ann Pharmacother. 2012;46:1477-83
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Whatabout“contrastnephropathy?”
• 6,000,000 hospitalized pts; no AKI on admit, LOS < 10 d
• Evaluated for hospital-acquired AKI Contrast No Contrast 5.5% 5.6% (unadjusted)
5.6% 5.1% (adjusted)
Conclusions: “…our analyses suggest that the incremental risk of AKI that can be attributed to radiocontrast is modest at worst, and almost certainly overestimated by patients, physicians, surgeons, radiologists, and other decision-makers.”
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Preventionofcontrast-nephropathy
Myapproach:• IfeGFR>45mL/min,nochangeinmanagementwithanyiodinatedcontrastscan• IfeGFR30-45mL/min,USUALLYnochangeinmanagementàevaluateforriskfactorsforAKI• IfeGFR<30▫ Ifcantoleratefluid,give1cc/kg/hrisotonicfluid(NSversusLR)for6hourspre-procedure,andfor6hourspost-procedure▫ DonotgiveNAC,donotwithholdACEI/ARB,statins
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• Restorerenalperfusion/treatunderlyingcondition• Avoidfurtherinsultsifpossible;ifdrug-related,withdrawntheoffendingdrug• Manageaccompanyingvolume/electrolyte/acid-baseabnormalities• Adjustrenally–excretedmedstocurrentlevelofkidneyfunction• Watchforuremicmanifestations,orotherindicationsforinitiationofdialysis
MANAGEMENT OF ATN
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Obstructivenephropathy,anuncommoncauseofAKI
• Evaluation:▫ Bladderscan,bladdercatheterization▫ Renalu/s
Intrarenalobstruction Ureteralobstruction Bladderoutletobstruction
• Stones • Transitional cell
carcinoma • Clots • Papillary necrosis
• Stones • Transitional cell
carcinoma • External compression
• Tumors • RP fibrosis • Lymph nodes
• BPH • Neurogenic bladder
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ShouldyougetarenalultrasoundinallAKI?
No,butyoushouldatleastconsider….• Largekidneys-amyloid(otherinfiltrativedisease),AIN,HIV,diabetes• Smallkidneys-likelychronicprocess,unlikelytobenefitfromtreatment• Polycystickidneydisease• Singlekidney
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Case4• 55y/omanhospitalizedforsepsis,foundtohaveMRSAbacteremia2/2severesofttissueinfection• TreatedwithIVvancomycin• Initiallabs:
134 4.5
100
20
20
1.5 90
Urine: UNa 20 mEq/L Fe Na 1% Urine sediment: dysmorphic RBCs
Creatinine subsequently climbed daily: 1.5 à 1.7 à 2.1 à 2.3 à 2.6 à 2.9
C3: low C4: WNL
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DYSMORPHIC RBCS
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GLOMERULONEPHRITIS/RPGN
SystemicDisease Mechanism Disease
Antibody-mediatedPauci-immuneImmunecomplex
Anti-GBMdiseaseSmallvesselvasculitis(GPA,MPA,Churg-Strauss)LupusnephritisCryoglobulinemia
Laboratory evaluation: Complement levels, ANCA group, anti GBM, ANA with reflexive panel, HCV PCR, cyroglobulinemia titers/cryocrit Definitive diagnosis: Kidney biopsy
PrimaryGlomerularDisease
Mechanism Disease
Immunecomplex
IgAnephropathyMPGN(HCV)Infection-relatedGN
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• NearlyalwaysassociatedwithCONCURRENTstaphinfection• Distinctfrompost-streptococcalGN▫ Post-strepGNoccursAFTERinfection• Canbeaccompaniedbyvasculitisskinrash• Serumcomplementslow▫ LowC3morecommonthanlowC4• Noserologictestavailable;definitivediagnosisrequireskidneybiopsy
INFECTION-RELATED GLOMERULONEPHRITIS
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Clinicalcluesthatshouldpromptnephrologyconsultation
RenalConsult
Nephroticsyndrome
Concernforpulmonary-
renalsyndromes
ConcernforAIN
AKIinkidneytransplant
PersistentoligoanuriawithAKI
![Page 49: Workup and Management of Acute Kidney Injury...acute kidney injury (AKI) in hospitalized patients 2. Discuss practical diagnostic evaluation for the hospitalized patient with AKI 3](https://reader036.vdocuments.net/reader036/viewer/2022071111/5fe6c32b3822934f96343267/html5/thumbnails/49.jpg)
Take-homepoints• >90%ofAKIinhospitalizedpatientsislowEABV(includingpre-renal,cardiorenal,hepatorenal)orATN
• Urinemicroscopyisasimpleandusefultool▫ Granularcastsàif>6/lpf,likelytobeATN▫ DysmorphicRBCsàalwaysglomerularpathology
• AKIinthecontemporaryhospitalizedpatientisoftenmultifactorialwithoverlappingcauses
![Page 50: Workup and Management of Acute Kidney Injury...acute kidney injury (AKI) in hospitalized patients 2. Discuss practical diagnostic evaluation for the hospitalized patient with AKI 3](https://reader036.vdocuments.net/reader036/viewer/2022071111/5fe6c32b3822934f96343267/html5/thumbnails/50.jpg)
Questions?