WT1 and Wilms’ TumorSarah DeHart

DNA-binding transcription factorProtein carries 4 C-terminal zinc fingers

36 different isoforms based on splicingSpecific isoforms can have different functions

WT1 Expression in Development

WT1 Pathway

WT1 Role in EMT/MET

WT1 inheritance patters

What’s wrong here?

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– http://www.projekt-koni.de/77.html?&L=1– http://radiology.rsna.org/content/early/2012/11/20/radiol.12120670/F1.expansion.html– http://practicalimaging.blogspot.com/2012/07/new-case-of-week.html– http://www.sciencedirect.com/science/article/pii/S0031395505705307