www.dendron.org.uk introducing dendron east anglia what is dendron? what does it do? what is the...
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www.dendron.org.uk
Introducing DeNDRoN East Anglia
What is DeNDRoN?
What does it do?
What is the evidence it is successful?
Where next?
www.dendron.org.uk
DeNDRoN is a managed network not an organisation
net·work / ‘net1wərk/n. 1. a group or system of interconnected people or organisations
www.dendron.org.uk
DeNDRoN
• Aims to:– Support development & delivery of clinical
research in dementia & neurodegenerative diseases
• By:– Providing leadership & administrative support to
allow the integration of health research & patient care
– Developing capacity & expertise to improve the speed & quality of research
www.dendron.org.uk
Through developing a strong network our vision is that...
All patients with a neurodegenerative disease* have the opportunity to
participate in and benefit from high quality clinical research
*Dementia
Parkinson’s Disease
Huntington’s Disease
Motor Neurone Disease
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The 7 DeNDRoNs
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East Anglia DeNDRoN
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Norwich
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Cambridge
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What does DeNDRoN do?
• LRN– Provide clinical leadership for research– Assist local researchers to undertake NIHR Portfolio studies– Develop new research sites & investigators– Patient & public involvement– Annual budget £500k / LRN
• National– Develop new studies (CSG, writing groups)– Adopt studies onto the NIHR Portfolio– Coordinate the strategic development of neurodegenerative
research in England– Promote collaboration between patients, carers, researchers,
academics, NHS trusts, funding bodies & industry– Support & guidance to LRNs
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DeNDRoN East Anglia – Strategy
• Support existing research active sites– Financial input & DeNDRoN research staff– Encourage involvement in complex studies
• Develop new sites & PIs– Active promotion of DeNDRoN in periphery– Targeting of potential PIs– Acting as “broker” between new sites / PIs & sponsor – DeNDRoN staff involvement throughout study– Facilitation & encouragement of local staff– Deploy DeNDRoN staff locally when research activity
justifies it
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What Has DeNDRoN East Anglia Achieved?
• Increased number of:– Studies– Research sites – Principal Investigators– Patients recruited into research
• Contributed to development of academic base in East Anglia– Closer working with local academic departments– Development of academic posts in Old Age
Psychiatry
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DeNDRoN PIs (2006)
0
2
4
6
Cambridge Norwich Ipswich Peterborough Gt Yarmouth
Public Health
OAP
Primary Care
MFE
Neurology
• 11 Studies• 9 Principal investigators
– 55% Neurologists– 11% Old Age Psychiatrists– 55% Cambridge-based
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Cumulative DeNDRoN PIs (2006 – 2010)
0
2
4
6
8
10
12
14
Cambridge Norwich Ipswich Peterborough Gt Yarmouth
Public Health
OAP
Primary Care
MFE
Neurology
• 39 Studies• 27 PIs
– 41% Neurologists– 37% Old Age Psychiatrists– 48% Cambridge-based
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New DeNDRoN PIs (2006 – 2010)
0
1
2
3
4
5
6
Cambridge Norwich Ipswich Peterborough Gt Yarmouth
Public Health
OAP
Primary Care
MFE
Neurology
• 16 New PIs– 25% Neurologists– 56% Old Age Psychiatrists– 25% Cambridge-based– 75% Outside Cambridge
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www.dendron.org.uk
www.dendron.org.uk
Where Next?• Increase locally-generated studies
– Local Research Directors– Local Dementia Research Interest Group (HIEC)– Local writing groups
• Improve recruitment (numbers & speed)– Development of “Entirely Research Active” demonstration site
• Integration of research into local care pathways• Routine invitation at first contact with service to participate in
research• Case registers / Recruitment & Facilitation Tools (RAFTs)
– Increase research capacity by developing further sites & PIs– Reduce time delays by closer working with CLRNs & NHS R&D
departments
www.dendron.org.uk
Thanks to the DeNDRoN East Anglia Team