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Masters Programme in Genomic Medicine Open Day Event

Tendering process

Anne Gilford, Head of Education and Quality, HEWM

3rd September 2014

Masters Programme in Genomic Medicine Open Day Event

MSc Genomic Medicine Curriculum

Val Davison, Scientific Advisor, National School of Healthcare Science

10 November 2015


HEE/GeL Masters (MSc) Programme in Genomic Medicine

Support 100,000 genomes

project and the research &

clinical opportunities it

provides

Transformation of both

specialist and general work

force

Wider education in

genomic medicine

Multiprofessional - build

sustainable capacity within

the NHS


Development of MSc

MSc – full curricula available

with tender

Developed by experts from both GE and

HEE

Academic and clinical input

Also out to consultation with patients and public


Commissioning

• MSc Genomic Medicine delivered in South West geographical footprint

• Track record of teaching at postgraduate level• Demonstrate potential partnerships with Genomic

Medicine Centres • Required to form a national network and work

collaboratively • 65 commissions to be allocated to successful for full

Master’s• 100 CPPD commissions to be allocated


Programme Structure

• A full time option delivered over 1 year • P/T – 2 years blended learning format • Access to individual modules CPD• Combinations of credit modules that can lead to PG Cert or

PG Diploma • A significant research component in the MSc• Flexibility delivered by core modules and optional modules


Programme Structure

Core Modules 15 credits

• An introduction to genomics• Omics techniques and their

application to medicine • Genomics of common and

rare disease • Molecular pathology of cancer • Pharmacogenetics and

stratified healthcare• Application of Genomics to

infectious disease• Bioinformatics interpretation • Research dissertation (60 /30

credits)

Optional Modules 15 credits

• ELSI• Counselling skills for

genomics• Economic models and

genomics• Workbased learning • Professional and research

skills • Epigenetics


Research modules

• Research project (60 credits)– Education and Training GeCIP led by HEE– In house project

• Clinical • Laboratory based

• Literary dissertation (30 credits)– Epigenetics – Clinical topics


Potential Module Combinations

Modules

Core modules 1-7

Research Module

Optional modules

Total Credits

Combination 1

7x15 = 105 credits

1x60=60credits

1x15=15credits

180 credits

Combination 2

7x15=105 credits

1x30 = 30 credits

3x15=45 credits

180 credits


• Discuss the human genome structure and the properties of DNA sequence

• Critique the regulation of gene expression, transcription and translation and the contribution of each to cellular phenotype

• Discuss critically epigenetic modifications and imprinting and role in disease

• Describe the correlation of genotype with phenotype for both dichotomous and quantitative traits

• Describe and evaluate the purpose, structures, use and storage of health records

An Introduction to Human Genetics and Genomics


Omics Techniques and application to genomic medicine

• Describe and critically evaluate a range of sequence technologies to targeted parts of the genome or whole genomes

• Discuss how these techniques and their applications in RNA expression, metabolomics and proteomic analysis

• Discuss and criticially appraise approaches to the bioinformatics analysis and interpretation of ‘omics’ data

• Critically evaluate the different ‘omics’ technologies and platforms in relation to genomic medicine


Genomics of common and rare disease

• Explain the principles of the genetic architecture of common and rare diseases

• Critique traditional and current approaches used to identify genes for common and rare diseases

• Discuss the Genomics England Programme and the Data Infrastructure

• Identify phenotype, select cases and relevant family information for whole exome or whole genome based approaches for hypothesis free whole exome or whole genome sequencing.


Pharmacogenomics & stratified health-care

• Discuss and evaluate the mechanism of several examples of genomically-determined differential drug response, and drug reaction

• Critique the strategies and analytical approaches for stratifying patients for adverse drug reactions or optimal drug response, including ethnic differences, and how these translate into ‘companion diagnostics’

• Discuss critically with examples, how genomic information can enable development of drugs targeted for particular genotypes

• With reference to examples, demonstrate an appreciation of the ELSI which could accompany patient

stratification for healthcare advice or intervention.


: Application of genomics in Infectious disease

• Demonstrate an in-depth knowledge of the differences between prokaryotes and eukaryotes genomes

• Discuss how the genome sequence of pathogens can be used to track cross infection and outbreaks of infections among the population

• Critique the molecular basis of organism drug resistance in some infections and how this directs drug research

• Evaluate how sequencing of the genome of infective organisms can be used in infectious disease for assessing: diagnosis, sub-classification & strain identity, pathogenicity, drug resistance and drug selection; and for epidemic control.


Clinical Bioinformatics • Discuss the principles applied to quality control of sequencing

data, alignment of sequence to the reference genome, pathogenic mutations in sequencing data

• the principles of informatics and bioinformatics applied to clinical data, and gain practical experience of the major national and international resources and standards which underpin them

• Discuss Iinterrogate major datasources, e.g. of genomic sequence, protein sequences, variation, pathways, (e.g. EVS, dbSNP, ClinVar, etc.) and be able to integrate with clinical data, to assess the pathogenic significance of genome result

• Acquire computational skills • Gain practical experience of the bioinformatics pipeline through

the Genomics England programme• Understand the place of Professional Best Practice Guidelines in the diagnostic setting for the reporting of genomic variation.


Making sense of the science……..


Cambridge LearnersBirmingham Learners

Southampton Learners

www.hee.nhs.uk masters programme in genomic medicine open day event tendering process anne gilford,...

Documents

genomic medicine centres

masters msc programme

masters programme

modules research project

optional modules

core modules

human genome structure

ukdevelopment of msc