Wyss Family Symposium on

Genetic Predisposition to Brain Cancer

May 11–12, 2015

Conference HostsNationwide Children’s Hospital Division of Hematology, Oncology and BMT

Nationwide Children’s Hospital Division of Neurology

Nationwide Children’s Hospital Personalized Medicine and Cancer Predisposition Program

Intended Audience:Adult and pediatric neurosurgeons, pediatric and medical neuro-oncologists and oncologists, neuro-radiologists, internists, pediatricians, geneticists, genetic counselors, at-risk families, and other pertinent healthcare providers.

Conference Planning CommitteeDaniel E. Barr, MHSA, FACHEElena Chiappinelli, MSW, MHATami DavisJennifer EnglishJonathan Finlay, MB, ChB

Elizabeth PottsSteve Roach, MDElizabeth Varga, MS, LGCTammi Young-Saleme, PhD

Wyss Family Symposium on Genetic Predisposition to Brain CancerMay 11–12, 2015

Hilton Columbus Downtown

Faculty

David H. Gutmann, MD, PhDDepartment of Neurology

Director, Neurofibromatosis CenterWashington University School of Medicine

Jeffrey R. Leonard, MDChief, Pediatric Neurosurgery

Nationwide Children’s HospitalProfessor of Clinical Neurosurgery

The Ohio State University College of Medicine

Russell R. Lonser, MDProfessor and Chairman

Department of Neurological SurgeryThe Ohio State University

David Malkin, PhDProfessor of Pediatrics and Medical Biophysics

University of TorontoDirector, Cancer Genetics Program

Senior Staff Oncologist, Division of Hematology/Oncology

Senior Scientist, Genetics and Genome Biology Program

The Hospital for Sick Children

Donald W. (“Will”) Parsons, MD, PhDAssistant Professor, Baylor College of Medicine

Departments of Pediatrics, Molecular & Human GeneticsTexas Children’s Cancer Center

Steve Roach, MDChief of Pediatric Neurology

Vice-Chair of Pediatrics Nationwide Children’s Hospital

Professor of Pediatrics and Neurology The Ohio State University College of Medicine

Joshua D. Schiffman, MDMedical Director, High Risk

Pediatric Cancer ClinicAssociate Professor,

Pediatric Hematology/OncologyAdjunct Associate Professor,

Oncological Sciences Investigator, Huntsman Cancer Institute

Uri Tabori, MDAssociate Professor of Pediatrics,

Institute of Medical Sciences, UofTStaff Neuro-Oncologist at

The Hospital for Sick Children Senior Scientist and Principal Investigator,

Genetic & Genomic Program, Research InstituteThe Hospital for Sick Children

Andrea F. Patenaude, PhDAssociate Professor, Department of Psychiatry, Harvard Medical School

Director of Psycho-Oncology Research in the Division of Pediatric Oncology, Dana-Farber Cancer Institute

Keynote:Carlo M. Croce, MD

Distinguished University ProfessorThe John W. Wolfe Chair

in Human Cancer GeneticsProfessor and Chair, Department of Molecular Virology, Immunology and Medical GeneticsDirector, Human Cancer Genetics Program

Director, Genetics Institute

Shahab Asgharzadeh, MDDivision of Hematology/Oncology

Associate Professor of PediatricsChildren’s Hospital Los Angeles

Jonathan L. Finlay, MB, ChBProfessor of Pediatrics

The Ohio State UniversityDirector, Neuro-Oncology Program

Division of Hematology/Oncology/BMTNationwide Children’s Hospital

Agenda Wyss Symposium on Genetic Predisposition to Brain CancerMay 11–12, 2015Hilton Columbus Downtown Monday, May 11, 20157 – 8 a.m. Breakfast and Check-in

8 – 8:05 a.m. Introduction Dr. John Barnard

8:05 – 8:10 a.m. Introduction Mr. Oliver Wyss

8:10 – 8:30 a.m. Overview Dr. Jonathan Finlay

8:30 – 9:05 a.m. Neurofibromatosis - Type 1 Dr. David Gutmann

9:05 – 9:15 a.m. Questions

9:15 – 9:50 a.m. Neurofibromatosis - Type 2 Dr. Jeffrey Leonard

9:50 – 10 a.m. Questions

10 – 10:35 a.m. Tuberous Sclerosis Complex Dr. Steve Roach

10:35 – 10:45 a.m. Questions

10:45 – 11:15 a.m. Break

11:15 a.m. – 12 p.m. Keynote Address: Micro RNAs in Cancer Genetics Dr. Carlo Croce

12 – 12:10 p.m. Questions

12:10 – 12:45 p.m. Von Hippel Lindau Syndrome Dr. Russell Lonser

12:45 – 1 p.m. Questions

1 – 2:30 p.m. Lunch

Family SymposiumHilton Columbus Downtown Monday, May 11, 20151:30 – 2:30 p.m. Check-in for Families

2:30 – 2:40 p.m. Mr. Oliver Wyss 2:40 – 2:55 p.m. Overview Dr. Jonathan Finlay

2:55 – 3:10 p.m. The Family Centric Cancer Genetics Clinic Dr. Joshua Schiffman

3:10 – 3:25 p.m. Advances in Understanding of Neurocutaneous Syndromes Dr. Steve Roach

3:25 – 3:40 p.m. Advances in Understanding of Cancer Predisposition Syndromes Dr. David Malkin

3:40 – 3:55 p.m. Psychological Issues Confronting At-Risk Families Dr. Andrea Patenaude

3:55 – 4:25 p.m. Break

4:25 – 4:40 p.m. The Pros & Cons of Genomic Screening Dr. Will Parsons

4:40 – 5:15 p.m. Round Table Questions Drs. Finlay, Roach, Schiffman, Malkin, Parsons & Patenaude

5:15 – 5:20 p.m. Adjourn

6:30 p.m. + Symposium Banquet

Tuesday, May 12, 20157:30 – 8 a.m. Breakfast and Check-in

8 – 8:35 a.m. Mismatched Repair Syndrome Dr. Uri Tabori 8:35 – 8:45 a.m. Questions

8:45 – 9:20 a.m. Li Fraumeni Cancer Predisposition Syndrome Dr. David Malkin

9:20 – 9:30 a.m. Questions

9:30 – 10:05 a.m. The Family Centric Cancer Genetics Clinic Dr. Joshua Schiffman

10:05 – 10:15 a.m. Questions

10:15 – 10:50 a.m. Psychological Issues Confronting At-Risk Families Dr. Andrea Patenaude

10:50 – 11 a.m. Questions

11 – 11:15 a.m. Break

11:15 – 11:50 a.m. Bioinformatic Perils of Cancer Genomics Dr. Shahab Asgharzadeh

11:50 a.m. – 12 p.m. Questions

12 – 12:35 a.m. Cancer - Genome Analysis Dr. Will Parsons

12:35 – 12:45 p.m. Questions

12:45 – 1:15 p.m. Lunch and Adjourn

Conference RegistrationAttendees may register via the web at www.nationwidechildrens.org/wyss-family-symposium or Nationwidechildrens.org/courses-conferences. Upon receipt of registration payment, each participant registering before May 1, 2015 will receive a confirmation letter via email. The registration fee includes the educational materials, which will be provided on a flash drive, breakfast, lunch and afternoon refreshments. Dinner registration fee is separate from the conference registration, but may be combined with the conference payment.

Physician – $175Nationwide Children’s Physician – $125Non-Physician Staff – $100Nationwide Children’s Non-Physician Staff – $75Residents, Fellows – ComplimentaryPatient/Family Members – ComplimentaryStudents – Complimentary

Dinner Day 1 – $60 (patient/family attendees complimentary)Late fee after May 1, 2015 – $25 (additional to registration)

Conference and Hotel AccommodationsHilton Columbus Downtown401 North High StreetColumbus, OH 43215www3.hilton.com

Enjoy a refreshing and comfortable stay in the Hilton Columbus Downtown hotel located in the heart of Columbus and near the Arena District, the Short North and the North Market. Relax and refresh in a comfortable modern guest room. Unwind with your favorite show on a 42-inch flat-screen TV and select from a range of premium TV channels. Catch up with work at the desk and benefit from high-speed internet access to keep in touch with family and business. Unwind after a day of business or sightseeing on a comfortable king- or queen-sized bed. Upgrade to a spacious suite with a separate sleeping area or indulge

in a stylish Executive room. Executive room guests enjoy access to the executive lounge with complimentary breakfast and additional food and drinks.

Meet friends for lunch or dinner and select from a diverse range of tantalizing cuisine in the inviting Gallerie Bar & Bistro. Enjoy a selection of tasty snacks and meals in the beautiful atrium setting. Maintain your fitness routine during your stay with an energizing workout in the fitness center, and enjoy a refreshing swim in the indoor pool. Make business easy in the 24-hour business center featuring a range of business-friendly facilities. Hold business meetings, conferences and elegant weddings in a choice of versatile meeting rooms accommodating any size of event. The Greater Columbus Convention Center provides extra meeting space and is linked to the hotel by a glass skywalk.

AirportPort Columbus International Airport, located just 10 minutes from the Hilton Columbus Downtown, is served by 10 airlines and their regional affiliates providing 350 daily arrivals and departures to 35 airports. Major carriers include AirTran, Air Canada Express, American, Delta, Southwest, United and US Airways. All ground transportation may be accessed via the terminal walkway or baggage claim level exits.

Taxi service is provided by many vendors. The average fare from Port Columbus International Airport to the Hilton Columbus Downtown is $35-$40.

Cancellation PolicyA refund, minus 30% for administrative costs, will be given for cancellations received in writing before May 1, 2015. After this date, no refunds will be available.

Faculty Disclosure of Commercial RelationshipsConsistent with ACCME guidelines, planning committee members and faculty for this conference are expected to disclose all relevant financial relationships with any commercial interests in the last 12

months that create, or may be perceived as creating, a conflict related to the material discussed. Any relationships identified will have been resolved prior to the delivery of the educational activity. Full disclosure of relationship(s) and steps taken to resolve (when relevant) will be made prior to the presentations.

Continuing EducationPhysician – The Nationwide Children’s Hospital is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The Nationwide Children’s Hospital designates this live activity for a maximum of 8.0 AMA PRA Category 1 Credit(s)TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Psychology – Please call (614) 355-0676 for information about psychology CE credit for this conference.

Questions? Nationwide Children’s Hospital Education

Professional Conferencing 700 Children’s Drive

Columbus, OH, 43205

Phone (614) 355-0676 | FAX (614) 355-0670NationwideChildrens.org/wyss-family-symposium

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