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YALE UNIVERSITY

NEUROSCIENCE PROGRAM

HANDBOOK FOR GRADUATE STUDENTS

AND PARTICIPATING FACULTY 2006-2007

Directory 2 Students Faculty University Offices 7 Administrative Offices University Graduate School Offices Biological and Biomedical Sciences Medical Scientist Training Program

Special University Offices The Graduate Program in Neuroscience 10 Overview Curriculum 11 Outline Formal Courses Requirements for the Ph.D. Degree 12 Requirements for MD/PhD Students 16 Procedures for the Qualifying Examination,

Thesis Prospectus and the Dissertation 19

Registration 23 General Information Foreign Student Registration In Absentia Registration Leave of Absence Tuition Financial Aid 24 Lectures, Seminars and Journal Clubs 26 Off-Campus Neuroscience Courses 28 Campus Facilities 30 Recreational Opportunities 36 Faculty Research Interests 37 Committees 43 Neuroscience Courses 44

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Interdepartmental Neuroscience Program & BBS Students Name Advisor/Dept Campus Address Campus Phone Campus Fax Addy, Nii Picciotto/Psychiatry 301 Cedar 737-2042 737-2043 Bellemer, Andy Koelle/MB&B CE 30 SHM 737-2271 785-6404 Bender, Genevieve Small/JPL JPL 401-6210 624-4950 Berman, Rachel Blumenfeld/Neurology LCI 1007 785-6470 737-2538 Brown, Rebecca# Strittmatter/Neurology 301 Cedar St. 785-4173 785-5971 Carey, Allison* Carlson/MCDB KBT 1132 432-3542 432-6161 Casale, Amanda# Miesenbock/Cell Biology 785-5971 Colli, Christian# Zhong/MCDB 785-5971 Davis, Denise Strittmatter/Neurology 301 Cedar 785-5030 785-5098 Davis, Doug* Pieribone/Pierce JPL 401-6252 624-4950 Egan, Kathy Bordey/Neurosurgery FMB 429 737-2500 737-2159 Einstein, Emily# Yeckel/Neurobiology B 432 SHM 737-1032 785-5971 Englot, Dario* Blumenfeld/Neurology LCI1007 785-6470 737-2538 Frost, Adam* Unger/MB&B CE 16 SHM 785-5784 785-6404 Gamo, Nao# Arnsten/Neurobiology B428 SHM 785-3066 785-5971 Ghaznavi, Sharmin* Johnson/Psychology SSS 432-7132 432-4617 Gipson, Keith* Yeckel/Neurobiology B 432 SHM 737-1032 785-5263 Golomb, Julie Chun/Psychology 317 SSS 432-9621 432-7171 Gourley, Shannon Taylor/Psychiatry CMHC 3rd fl. 974-7729 974-7897 Gray, Sarah# Horvath/Comparative Medicine LSOG 785-5971 Guez, Danielle* Picciotto/Psychiatry 301 Cedar 737-2042 737-2043 Heath, Chris Picciotto/Psychiatry 301 Cedar 737-2042 737-2043 Horst, Nicole Laubach/Pierce JPL 401-6257 624-4950 Huebner, Eric* Strittmatter/Neurology 301 Cedar 785-5030 785-5098 Hunsberger, Josh Duman/Psychiatry CMHC 3rd fl 974-7734 974-7897 Johnson, Matt R.# Constable/Diagnostic Rad. TAC N135 737-2835 785-6534 Jones, Warren Klin/Child Study Center SHM G-132 785-3499 737-4197 Jung, Yon Woo# Koelle/MB&B CE 30 SHM 737-2271 785-5971 Kimchi, Eyal* Laubach/Pierce Lab JPL 401-6257 624-4950 Kinsler, Rebecca# Beech/Psychiatry 300 George St. 785-5971 Krause, Matt Mazer/Neurobiology I412 SHM 785-5263 Krueger, Dilja Nairn/Psychiatry CMHC 3rd fl. 974-7753 974-7897 Kwan, Ken Sestan/Neurobiology C320 SHM 737-1435 785-5263 Lacar, Ben Bordey/Neurosurgery FMB 429 737-2500 737-2159 Letinic, Kresimir Rakic/Neurobiology C319 SHM 785-5418 785-5263 Martushova, Katherine Strittmatter/Neurology 301 Cedar 785-5030 785-5098 Masurkar, Arjun* Chen/Neurobiology 236 FMB 785-5263 Maynard, Kristen# Lavik/Biomedical Engineering MEC 311 785-5971 Narayanan, Kumar* Laubach/Pierce JPL 401-6211 624-4950 Newhouse, Kristi Small/Pierce JPL 401-6210 624-4950 Park, James* Strittmatter/Neurology 301 Cedar 785-4971 785-5098 Rabenstein, Reba Picciotto/Psychiatry 301 Cedar 737-2042 737-2043 Robbins, Elissa Biederer/MB&B C129 SHM 737-1002 785-6404 Sears, Rob DiLeone/Psychiatry Basemt CMHC 974-7677 974-7897 Snyder, Derek Bartoshuk/Surgery (ENT) Strumbos, John Kaczmarek/Pharmacology B 316c SHM 785-7670 Thomas, Lisa Biederer/MB&B C 129 SHM 737-1002 785-6404 Trinko, Rich% DiLeone/Psychiatry Basemt CMHC 974-7677 974-7897 Ua Cruadhlaoich, Matt Richerson/Neurology LCI 712C 737-2893 785-5694 von Hehn, Christian Jordt/Pharmacology SHM B326a 785-5971 Williams, Cicely Lavik/Biomed Eng MEC 311 432-0030 Wiseman, Shari# Wells/MCDB KBT 226 785-5971 Yao, Andrea Carlson/MCDB 1132 KBT 432-3542

432-3545 432-5631

Yang, Yvonne* Strittmatter/Neurology 301 Cedar St. 785-4173 785-5098 Young, Stephanie Bordey/Neurosurgery FMB 429 737-2500 737-2159 *MD/PhD student # First year Neuroscience Track student % VAIR student

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Neurobiology Students

Bi, Linda* Matthews Ithaca, NY Brennan, Avis Arnsten B428 SHM 785-3066 785-5263 Breunig, Josh Rakic C324 SHM 737-1362 785-5263 Hagenston, Anna Yeckel B 436 SHM 737-1032 785-5263 Haider, Bilal McCormick C303 SHM 785-5263 Johnson, Matt Sestan B302 SHM 737-1435 785-5263 Kraus, Mike Bruce B435 SHM 785-5164 785-5263 McRae, Paulette Matthews Ithaca, NY Vijayraghavan, Susheel Arnsten B404 SHM 785-5711 785-5263 Whitman, Mary* Greer FMB 430 785-4230 737-2159 Zoncu, Roberto Rakic C303 SHM 785-5418 785-5263 *MD/PhD student

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FACULTY DIRECTORY First Name Last Name Title Department Address Phone Fax

Meenakshi Alreja Assoc. Prof. Psychiatry 335A CMHC 974-7762 974-7897 Amy Arnsten Professor Neurobiology B428 SHM 785-4431 785-5263 Thomas Biederer Asst Prof. MB&B C 127 SHM 785-5465 785-6404 Hal Blumenfeld Asst. Prof. Neurology LCI 1007 785-3928 737-2538 Angélique Bordey Assoc Prof Neurosurgery FMB 422 737-2515 737-2159 Walter Boron Professor Physiology B128 SHM 785-4070 785-4951 Charlie Bruce Assoc. Prof. Neurobiology B439 SHM 737-2727 785-5263 Benjamin Bunney Professor Psychiatry 300 George Ste 901 785-6396 785-6196 John Carlson Professor MCDB KBT 1132 432-3541 432-6161 Wei Chen Asst. Prof. Neurobiology FMB 231 785-5459 785-5263 Marvin Chun Professor Psychology KH/318 SSS 432-9620 432-7172 Larry Cohen Professor Physiology BE58 SHM 785-4047 785-4951 Todd Constable Professor Diag. Radiology TAC N135 737-2768 785-6534 Pietro De Camilli Professor Cell Biology 236 BCMM 737-4465 737-1762 Nihal DeLanerolle Professor Neurosurgery FMB 414 785-3258 737-2159 Sabrina Diano Asst Prof OB/Gyn LSOG 401 737-1216 785-4747 Ron Duman Professor Psychiatry S308 CMHC 974-7726 974-7724 Barbara Ehrlich Professor Pharmacology B207 SHM 737-1158 785-7670 Paul Forscher Professor MCDB KBT 222 432-6344 432-8999 Karyn Frick Asst. Prof. Psychology DL 210 432-4673 432-7172 Jeremy Gray Asst. Prof. Psychology SSS 212 432-9615 432-7172 Charles Greer Professor Neurosurgery FMB 412 785-4034 737-2159 Lise Heginbotham Assoc Prof. MB&B Bass 234 432-9803 432-5175 Tamas Horvath Chair Comparative Medicine LSOG 117 785-2525 785-4747 Jim Howe Assoc Prof Pharmacology B251a SHM 737-2398 785-7670 Marcia Johnson Professor Psychology KH; SSS 306c 432-6761 432-4617 Sven-Eric Jordt Asst. Prof. Pharmacology SHM B 163c 785-2159 785-7670 Len Kaczmarek Professor Pharmacology B316c SHM 785-4500 785-7670 Doug Kankel Professor MCDB KBT 1118 432-3532 432-6161 Haig Keshishian Professor MCDB KBT 640 432-3478 432-6161 Ken Kidd Professor Genetics I351 SHM 785-2654 785-6568 Jeff Kocsis Professor Neurology Bld 34 VAMC 937-3802 937-3801 Michael Koelle Assoc Prof MB&B SHM CE 28a 737-5808 785-6404 Tony Koleske Assoc Prof MB&B CE 31 SHM 785-5624 785-7979 Hür Koser Asst Prof Elect. Engineering BCT 507 432-9629 432-7769 Robert LaMotte Professor Anesthesiology BML 419 737-2720 737-5220 Mark Laubach Asst. Prof. Pierce Lab JPL 401-6202 624-4950 David LaVan Asst. Prof. Mech. Eng. Mason Labs M3 432-9662 432-7654 Erin Lavik Asst. Prof. Biomed Eng. MEC 311 432-4265 432-0030 Tom Lentz Professor Cell Biology C324 SHM 785-4565 785-7226 Michael Levene Asst. Prof. Biomed. Eng. MEC 313 432-4262 432-0030 Daeyeol Lee Assoc Prof Neurobiology C303 SHM 785-3527 785-5263 Jamie Mazer Asst. Prof. Neurobiology I412 SHM 737-5853 785-5263 Greg McCarthy Professor Psychology KH David McCormick Professor Neurobiology I409 SHM 785-4577 737-5223

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First Name Last Name Title Department Address Phone Fax Gero Miesenböck Assoc Prof Cell Biology 254C BCMM 785-3725 Mark Mooseker Professor MCDB KBT 352 432-3468 432-5059 Angus Nairn Professor Psychiatry CMHC S307 974-7725 974-7724 Dhasakumar Navaratnam Asst. Prof. Neurology LLCI 703 785-5755 785-5694 Michael Nitabach Asst Prof C&M Physiology BE 29 SHM 737-2939 785-4951 Marina Picciotto Assoc Prof Psychiatry 301 Cedar 737-2041 737-2043 Vincent Pieribone Assoc Prof Pierce Lab JPL 401-6214 624-4950 Maria M. Piñango Assoc Prof Linguistics 370 Temple 305 432-8289 432-4087 Pasko Rakic Professor Neurobiology C323a SHM 785-4330 785-5263 George Richerson Assoc Prof Neurology 712 LCI 737-1461

785-4085 785-5694

Robert Roth Professor Pharmacology 300 George 8300 785-4506 785-5275 Gary Rudnick Professor Pharmacology B326 SHM 785-4548 785-7670 Mark Saltzman Professor Biomedical Engineering MEC 413 432-4262

785-3202 432-0030

Laurie Santos Asst. Prof. Psychology KH; SSS 314e 432-4524 432-7172 Joseph Santos-Sacchi Professor Surgery (Otol.) BML 244 785-7566 737-2245 Glenn Schafe Asst. Prof. Psychology KH, DL 204 432-3461 432-7172 Ilsa Schwartz Professor Surgery (Otol.) 232 BML 785-6329 737-2245 Mike Schwartz Assoc Prof Neurobiology C327B SHM 785-4324 785-6331 Nenad Sestan Asst Prof Neurobiology C323C SHM 737-2190 737-1435 Gordon Shepherd Professor Neurobiology FMB 236 785-4336 785-6990 Fred Sigworth Professor Physiology BE 42 SHM 785-5773 785-4951 Dana Small Asst. Prof. Pierce Lab JPL 401-6204 624-4950 Matthew State Assoc Prof Child Study I383 SHM/

S341A TAC 737-4342 785-7560

Elke Stein Asst Prof MCDB KBT 232 432-8402 432-6161 Stephen Strittmatter Professor Neurology 184 Liberty CP 318 785-4878 785-5098 Jane Taylor Assoc Prof Psychiatry CMHC Room S307 974-7727 974-7724 Ning Tian Asst. Prof. Ophthalmology BML 212 785-2723 785-7401 Susumu Tomita Asst. Prof. C&M Physiology SHM BE11 785-7201 785-4951 Vinzenz Unger Asst. Prof. MB&B SHM CE 25 785-5652 785-6404 Flora Vaccarino Assoc Prof Child Study Ctr I266 SHM 737-4147 785-7611 Allan Wagner Professor Psychology KH 432-4691 432-7563 Xiao-Jing Wang Professor Neurobiology C303 SHM 785-6297 785-5263 Stephen Waxman Professor Neurology 708 LCI 785-5947 785-7826 David Wells Asst. Prof. MCDB KBT 226 432-3481 432-6161 Robert Wyman Professor MCDB KBT 610 432-3475 432-6161 Tian Xu Assoc Prof Genetics BCMM 236c 737-2623 737-1762 Mark Yeckel Asst. Prof. Neurobiology B436 SHM 785-5581 785-5263 David Zenisek Asst. Prof. Physiology B 114 SHM 785-6474 785-4951 Weimin Zhong Assoc Prof MCDB KBT 616B 432-9233 432-6161 Yufeng Zhou Asst. Prof. C&M Physiology SHM BE 07 785-7388 785-4951 Steven Zucker Professor Comp Science AKW 507 432-6434 432-0593 Affiliated Faculty Patrick Allen Asst. Prof. Psychiatry 335D CMHC 974-7763 974-7897 Bob Beech Asst. Prof. Psychiatry 300 George St.

8304C 737-1375 737-1031

Joel Black Res Sci. Neurology Bldg 34 VAMC 937-3802 937-3801 Hilary Blumberg Assoc. Prof. Psychiatry 470 Congress

Ste 120 785-6195 737-2513

Ted Carnevale Sr Res Sci. Psychology KH 432-8931 432-3440 Ralph DiLeone Asst Prof Psychiatry CMHC 3rd fl

Research 974-7684 974-7897

Albert Lo Asst. Prof. Neurology LCI 7 932.5711.5734

Laura Manuelidis Professor Surg (Neuropath) FMB 11 785-4442 785-6381 Rory McCrimmon Asst Prof Internal Medicine (Endoc.) LMP 1093/ TAC S130 785-4664 Sam Sathyanesan Asst Prof Psychiatry CMHC 3rd fl

Research 974-7723 974-7724

Robert Sherwin Professor Internal Medicine (Endoc.) LMP 1093 785-4183 James Swain Asst Prof Child Study Center NIHB 205 785-6973 785-7611 Michael Westerveld Asso. Prof. Neurosurgery TMP 4 562-4090 Anne Williamson Asso. Prof. Neurosurgery FMB 410 785-5327 737-2159

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NEUROSCIENCE TRACK ADMINISTRATIVE OFFICES Campus Address Phone Fax Number INP Co-Director Haig Keshishian 640 KBT 432-3478 432-6161 INP Co-Director Charles Greer FMB 412 785-4034 737-2159 Neurobiology DGS Amy Arnsten B428 SHM 785-4431 785-5263 Admissions Director

Charles Greer FMB 412 785-4034 737-2159

Student Services Officer

Carol Russo L200 SHM 785-5932 785-5971

Neurobiology Offfice Assistant

Lynne Baumgarten C303 SHM 785-4323 785-5263

UNIVERSITY OFFICES Yale Graduate School http://www.yale.edu/graduateschool/ Dean Jon Butler 112 HGS 432-2733 FAX 432-2442 Assistant to Dean Diane Hovey 112 HGS 432-2789 Associate Dean Richard Sleight 134 HGS 432-2744 FAX 432-6904 Assistant Dean 134 HGS 432-1884 Assistant to Dean Theresa Dio 134 HGS 432-2744 Admissions Office 117 HGS 432-2771 (questions related to admission or readmission to the Graduate School) Registrar 246 Church St. 432-2336 (registration; course schedules; grades; petitions for Master's Degrees; transcripts) http://www.yale.edu/sfas/registrar/ Graduate Registrar 113 HGS 432-2743 (applications for departmental transfer; leaves of absence, withdrawal) Financial Aid Office Jennifer Brinley 129 HGS 432-7980 (loan applications; administration and payment of fellowships) Information Office 140 HGS 432-2770 (general information; dissertation submission packets) http://www.yale.edu/graduateschool/academics/policies.html McDougal Center Lisa Brandes 122 HGS 432-2583 (McDougal Fellows, Orientation, Commencement, etc.) http://www.yale.edu/graduateschool/mcdougal/

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BIOLOGICAL AND BIOMEDICAL SCIENCES http://info.med.yale.edu/bbs/main.htmlDirector Lynn Cooley I363 SHM 785-5067 FAX 785-3734 Administrative Director John Alvaro L200 SHM 785-3735 FAX 785-3734 MEDICAL SCIENTIST TRAINING PROGRAM http://www.med.yale.edu/mdphd/ Director James Jamieson 317 ESH 785-4403 FAX 785-7446 Program Coordinator Cheryl DeFilippo 312 ESH 785-2103 FAX 785-6936 SPECIAL UNIVERSITY OFFICES Security: http://www.yalesecurity.yale.edu/services.html Campus Police 785-5555 http://www.yale.edu/police/ Yale Shuttle Services http://www.yale.edu/parkingandtransit/shuttle/dayshuttles.htm Student Life: http://www.yale.edu/graduateschool/studentLife/indexhb.html University Housing Department http://www.yale.edu/hronline/gho/ Off-campus listings 155 Whitney Ave 432-9756 Graduate Apartments Manager 432-8270 Graduate Dormitories Manager 432-2167 Helen Hadley Hall 432-2140 Yale Health Service (Information & Emergencies) 432-0123 17 Hillhouse Avenue http://www.yale.edu/uhs/

Member Services 432-0246 Pharmacy 432-0033 Mental Hygiene 432-0290 Infirmary 432-0001 International Center 442 Temple Street 432-6460 Office of International Students & Scholars 421 Temple Street 432-2305 http://www.oiss.yale.edu/ Office for Women in Medicine L202 SHM 785-4860 http://info.med.yale.edu/owm/ Cushing Medical Library SHM 785-5354 http://www.med.yale.edu/library/ Kline Science Library C8 KBT 432-3439

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http://www.library.yale.edu/science/library/kline.html Media Services http://www.yale.edu/mediaservices/ ITS Helpdesk http://www.yale.edu/its/ 785-3200 Or 432-9000 Academic Computing (School of Medicine) 785-5181 Yale Bookstore 77 Broadway 777-8440 http://yale1.bkstore.com/bkstore/content Yale Telephone Directory http://scripts.its.yale.edu/cgi-bin/ph Yale Yellow Pages http://www.yale.edu/awd/# NEW HAVEN INFORMATION AND NUMBERS Guide to the City of New Haven http://www.cityofnewhaven.com/Guide/index.asp New Haven Public Library 946-8130 http://www.cityofnewhaven.com/library/ Tweed-New Haven Airport 466-8833 http://www.flytweed.com/ Connecticut Limousine 1-800-472-5466 or 878-2222 http://www.ctlimo.com/ OTHER Cold Spring Harbor Laboratory Cold Spring Harbor, NY 11724 (516) 367-8346 http://www.cshl.org/ Marine Biological Laboratory Woods Hole, MA 02543 (508) 548-3705 http://www.mbl.edu/ Society for Neuroscience 1121 14th Street, NW Suite 1010 Washington, DC 20005 (202) 962-4000 http://www.sfn.org/

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THE GRADUATE PROGRAM IN NEUROSCIENCE Policy and Personnel The Neuroscience Track is composed of the faculty and graduate programs of the Interdepartmental Neuroscience Program (INP) and the Department of Neurobiology. The Interdepartmental Neuroscience Program is overseen by two co-directors who represent the Biomedical Sciences from each end of the Yale campus. Haig Keshishian is located at 640 Kline Biology Tower and can be reached at 432-3478. Charles Greer is located at FMB 412 and can be reached at 785-4034. The Neurobiology graduate program is overseen by their DGS, Amy Arnsten, who is located in B428 in the Sterling Hall of Medicine and can be reached at 785-4431. The day-to-day functioning of the Neuroscience Track and the Interdepartmental Neuroscience Program is handled by Carol Russo, who is located at L200 Sterling Hall of Medicine. The Neurobiology office assistant is located in C303 SHM and can be reached at 785-4323. Educational policy for the Neuroscience Track and affiliated programs is decided upon and reviewed by the INP Executive Committee, the Neurobiology DGS, and the Graduate Student Affairs and Curriculum subcommittees of the respective programs (committee members are listed in the appendices). Neuroscience Track Student Committees Advisory Committee Each entering student is assigned an advisory committee. This committee will be responsible for establishing the student’s course of study and for monitoring his or her progress in the first 1-2 years. This committee will meet with the student in January and in June and at those times this committee will provide each first year student with written evaluation summarizing their lab rotation and their academic standing. The advisory committee may be subsequently modified to include faculty with expertise in the student’s emerging area of interest. Interdepartmental Neuroscience Program Student Committees Qualifying Examination Committee The qualifying exam committee will be comprised of 4 faculty members from 4 different areas of specialization from at least 2 different departments. Dr. Charles Greer, or his representative, will sit as a fifth, non-examining member of the committee (when not included in the original four faculty members), chairing each examination. This committee should be formed during the second year of study; the examination must be completed by the end of May of the second year. Thesis Prospectus Committee For students who have completed their Qualifying Exam and are engaged in full-time research, a thesis prospectus committee will be formed which will consist of the student’s thesis advisor and a minimum of 3 other ladder faculty members. At least two formal meetings shall occur with the student and the thesis committee. The prospectus committee will be selected by the student, but each committee must be approved by the Directors of the Program.

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M.D./Ph.D. Students Questions related to the M.D./Ph.D. Program should be addressed to the Director of the Medical Scientist Training Program (MSTP), James Jamieson (C317 ESH; 785-4403). However, all INP M.D./Ph.D. students will also be assigned committees made up of INP faculty to assist them directly with their program of study. Responsible Conduct in Science All First Year Neuroscience Track students are required to take our Bioethics in Neuroscience course, currently offered in the Spring semester. The INP will provide them with copies of the required texts which are theirs to keep. Yale University believes that all individual research and research training should be conducted in a scientifically responsible and ethical manner. Yale’s Guidelines for the Responsible Conduct of Research set forth the responsibilities of the faculty together with specific comments relating to the management, date, authorship and the evaluation of the scholarly efforts and research. This guideline builds upon information provided in the Faculty Handbook and various University policy statements: Policy on Collaborative Research; Patient Policy; University Policy on Academic Misconduct; and The University Policy on Conflict of Interest. It is Yale policy to encourage research and scholarly activities essential to the training of students, to the advancement of knowledge, and essential to the intellectual growth of the faculty. Yale expects that scholarly activities will be conducted with the highest ethical and professional standards. While professional standards may vary across fields, the University has developed a set of guiding principles and policies that are applicable to all research and scholarly activity at Yale. http://www.yale.edu/provost/handbook/handbook_x__university_policies_concerni.html#T4 Additional specific policy and procedure govern the use of animals in research, the involvement of human subjects and experimentation with radioisotopes and other hazardous materials. All students are expected to complete required training in the areas that affect their research. CURRICULUM Outline The first 3 to 4 semesters of graduate study are spent in formal course work, independent reading and laboratory rotations. Each student’s program of study is designed in consultation with an advisory committee of the Neuroscience Track. This program should both satisfy the INP and Neurobiology requirements and serve as a good background for the thesis research. Formal Courses Each student is expected to gain a broad base of knowledge in selected areas through elective courses in Neuroscience and other disciplines. A list of Neuroscience core and elective courses is given in the course listing at the back of this book. A complete list of courses available can be found in the Graduate School Program and Policy Handbook, which may be obtained from the Registrar’s office (246 Church Street) or is available in the Program office. Students are expected to take four core courses and three elective and reading courses to be agreed upon by their advisory committee.

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REQUIREMENTS FOR THE Ph.D. DEGREE Courses The Neuroscience Track requires that students complete the following four Neuroscience courses: Principles of Neuroscience (NSCI 501a) Structural and Functional Organization of the Human Nervous System (NSCI 510) Neurobiology (NSCI 720) Bioethics in Neuroscience (NSCI 580b) Students must complete three additional courses from the following list, or from other Graduate level course listings in related departments: Seminar in Brain Development and Plasticity (NSCI 504) Cellular and Molecular Mechanisms of Neurological Disease (NSCI 507) Regulation of Cell Fate in CNS Development (NSCI 514) Neuroimaging in Neuropsychiatry (NSCI 521) History of Modern Neuroscience (NSCI 535b)

Synaptic Organization of the Nervous System (NSCI 539) Neurophysiology (NSCI 571) Experimental Methods in Neuroscience (NSCI 600) Neurophysiology: Theory and Practice (NSCI 610) Neurobiology of Learning and Memory (NSCI 614) Foundations of Behavioral Neuroscience (NSCI 645) Descriptions for these courses can be found on the INP website http://info.med.yale.edu/neurosci/ and all current BBS courses can be found on the BBS website: http://info.med.yale.edu/bbs/main.html Grades At the completion of a course, students are normally assigned a grade of Honors, High Pass, Pass or Fail. The Graduate School requires that Ph.D. students obtain a minimum of two grades of Honors in regular term courses by the end of the second year of study (See Graduate School Programs and Policies Handbook). It is expected that students will receive grades of no less than HP in any course taken for graduate credit. Tutorials, informal seminars, research courses and term courses having fewer than 3 credit hours cannot be used to fulfill the Honors requirement. Laboratory Rotations Laboratory rotations are considered an essential component to interdisciplinary training and each student is required to complete a minimum of two rotations by the end of second semester. The rotations should be in different laboratories and, preferably, in different areas of Neuroscience from at least two departments. At least one of these must be in the lab of an INP faculty member. The minimum duration of a rotation is one semester or a full summer. Each rotation should be long enough to allow the student to gain technical expertise and an appreciation of the practical aspects of an area of

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Neuroscience. The laboratory rotations can serve the dual functions of broadening a student’s background and helping in the choice of a future thesis advisor. Should a particular laboratory not meet the needs of a student, he/she is encouraged to consider moving to another lab. At the end of the rotation, the P.I. will complete the Rotation Evaluation form evaluating the participation of that student in the laboratory and they will submit this to the Neuroscience office. The Qualifying Examination A primary objective of an interdisciplinary program is training well-rounded students. The qualifying examination is viewed as one means of obtaining that goal. The Graduate School requires that “A general oral or written qualifying examination, separate from course examinations must be passed by the student in the major subject offered and such subordinate subjects as may be required by the department concerned”. The INP and Neurobiology qualifying examinations involve directed reading with faculty and a written and an oral component and should be completed before the end of May of the second year. Thesis Prospectus The Graduate School requires that all students submit a brief outline of proposed thesis work before beginning the seventh semester. This should be completed by the end of May in the third year. Students will not be allowed to register for the fourth year of study without an approved prospectus. The prospectus should consist of a written summary of research accomplished and planned, together with a tentative title for the thesis. This must be approved by the student's Thesis Prospectus Committee and accepted by the Director of Graduate Studies. The prospectus should be submitted at least 6 months before submitting the final dissertation. Admission to Candidacy Students who have satisfied their Program’s course requirements, laboratory rotations, the Graduate School Honors requirement, have successfully completed the qualifying exam, and have an approved prospectus will be formally admitted to Candidacy for the Ph.D. degree. The Graduate School requires that this be completed before the beginning of the seventh semester. Thesis Defense All INP students are required to present a public seminar of their thesis research. This seminar is to be immediately followed by a closed oral defense of the student’s thesis research. All Neurobiology students are required to have a closed oral defense with the student's thesis research committee. If the committee finds the dissertation acceptable, the student then must present a public seminar of their thesis research within one week of the committee meeting. Masters Degrees Although the Neuroscience Track does not admit students for a terminal master's degree, the rules of the Graduate School provide for the optional awarding of a Master of Philosophy degree. The minimum general requirements for this degree are that a

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student shall have completed all requirements for the Ph.D. except the prospectus and dissertation. A Master of Science degree is awarded only to students who are not continuing for the Ph.D but have successfully completed one year of the doctoral program. The minimum requirement for this is a passing grade in at least four courses, including two Honors grades, and completion of two successful laboratory rotations. Students are not admitted for this degree. Students should petition for these degrees at the Office of the Registrar (246 Church St.) by October 1 for a December award and March 15 for a May award. Publications The Graduate School requires that publications based upon the dissertation results should include a statement to that effect. For example, the author should state that the paper is based upon: “a dissertation submitted to fulfill in part the requirements for the Degree of Doctor of Philosophy at Yale University”. National funding agencies also require the following statement to be included: “This investigation was supported by National Research Service Award #______, from the National Institute of _________ __________”. Other funding which the student has received (i.e. Howard Hughes, NSF, etc.) should be similarly acknowledged. Residence Requirement The minimal residence requirement for the graduate school is three years; the maximum period of enrollment for the Ph.D. degree is normally six years. Students who have formally transferred credit for graduate work completed at another institution may reduce the minimum residence requirement by special petition. The maximum time may also be extended by special petition, but only if all requirements for the Ph.D. except for the completion of research and submission of the dissertation have been fulfilled. If you must petition for Extended Registration, please do so in a timely fashion. Teaching Requirement Neuroscience students have a two semester TA requirement. This policy will address how and when these requirements will best be met. First-year students may not TA without written permission from the DGS. One semester of teaching must be completed by the end of the third year. It is strongly recommended that both requirements be completed by the end of the third year as students are increasingly focused on full-time laboratory work and find it difficult to fit in TA responsibilities at this point. If this requirement is not met by the end of the third year, a written petition must be made to the Director of the Program and must include information on how and when the requirement will be met. Specifically, the first requirement must be met by teaching in either Principles of Neuroscience (NSCI 501a), Neurobiology (NSCI 720a), Brain & Thought (CogSci 201a) or in Structural and Functional Analysis of the Human Nervous System (NSCI 510b). The second course may be chosen from the list of neuroscience courses listed in the

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Graduate School of Arts and Sciences Programs & Policies Handbook, or from the INP Ethics course. If not from that list of courses, the course must have approval of the DGS. Students selected for a TA position in the Ethics course should note that two years of teaching in this course is required for it to be counted as fulfilling one TA requirement. Evaluation As each requirement is fulfilled, the student will receive formal evaluation of progress. First year students will receive summaries of rotation and academic standing evaluations, second year students will receive a written summary of the Qualifying Examination performance, which will include their current academic standing. Third year students and beyond will receive a written summary of the prospectus and subsequent thesis committee meetings, to be written by the PI or the committee chair, with copies to the committee members and the INP or Neurobiology office. Each student’s file will be reviewed annually by the appropriate program committee.

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INP DEPARTMENTAL REQUIREMENTS FOR MD-PhD STUDENTS Course Requirements: 5 courses are required, and students must obtain a grade of Honors in two of these courses and this must be achieved in the first two years of the combined program. Required courses are Principles of Neuroscience (Neuroscience 501a) and Structural and Functional Analysis of the Human Nervous System (Neurobiology 500b). Three more elective graduate level courses are required. The following courses taken during the first two years of medical school will count towards the student's elective requirements in the INP, provided the student has registered to receive a graduate grade in the course: CBIO 502a, CBIO 601, GENE 500b, IBIO 530a, MB&B 800a. In the case of students accepted into the MD-PhD Program during their first year of medical school, a letter from the faculty member in charge of the first-year course indicating the grade achieved in the course is required and an official transcript from the Medical School must be submitted to the Graduate School. Laboratory Rotations: 2 rotations are required; rotations in another department/program will count towards this requirement upon approval of the INP Director of Graduate Studies. Teaching Requirements: MD/PhD students are required to TA one term, two terms are preferred. Previous teaching (as TA) in the histology labs or courses in MCDB does count toward this requirement as long as the student has taught while enrolled at Yale as an MD/PhD student. Qualifying Exam: MD/PhD students must complete their qualifying exam before the end of their first year as an affiliated graduate student. Thus, if the student affiliates at the customary point of year 3.5 (beginning of the Spring semester of the third year of matriculation at Yale), they must complete the examination before registering for the Spring semester of the fourth year at Yale. Prospectus: MD/PhD students must complete and submit their thesis prospectus by the end of the second year as an affiliated graduate student. Thus, if the student affiliates at the customary point of year 3.5, they must submit the approved prospectus before registering for the Spring semester of the fifth year (at the beginning of year 3 as an affiliated graduate student). Please note that every thesis prospectus MUST be approved by the thesis committee. Admission to Candidacy: MD/PhD students are required to have been admitted to candidacy by the end of the second year as an affiliated graduate student. Generally, the submission of the thesis

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prospectus is the final requirement for admission to candidacy and paperwork for both is submitted to the Graduate School at the same time. Other requirements: All graduate students who are admitted to candidacy are required to have an annual thesis committee meeting. All graduate students are required to give a student research presentation annually and are expected to attend rotation/student research talks as well as INP-sponsored journal clubs. Affiliation requirement: A copy of the student’s application to the MD/PhD program, a copy of the student’s current transcript and notation of rotations completed must be submitted to the INP office. The DGS must have this information in hand before the official MD/PhD student affiliation form can be approved. Timeline: Year One: MD/PhD students complete courses in the Medical School and register for selected courses in the Graduate School. Most who identify Neuroscience as their probable PhD field will take the required course, Principles of Neuroscience, in the fall semester. This is the recommended timing. MD/PhD students should take Neurobiology 500b in the spring for graduate school credit/grade. Other electives as listed above may be taken for graduate school credit to fulfill our requirements and indeed, it is recommended that this be done. Two laboratory rotations should be completed in the summer. The DGS and the Neuroscience Office may be of assistance in identifying appropriate laboratories based in the student’s interests. Year Two: Courses in the Medical School are typically taken. Part 1 of the Boards is taken. Year Three: By January of the third year, a thesis lab should be identified and all paperwork should be completed (affiliation form completed and copy of student’s academic record including application transferred to Neuroscience Office). Student’s stipend is supplemented by PI/PI’s primary department at time of affiliation. Year Four: Qualifying Examination must be completed within one year of laboratory/program affiliation. This is a graduate school rule and graduate school registration for the following semester may be held up if this requirement is not fulfilled in a timely manner. Typically this will be fulfilled before the Spring Semester of the Fourth year. Year Five: The Thesis Prospectus must be approved and submitted to the Graduate School by the end of the second year of laboratory/PI affiliation. Typically, this is by the end of the Fall Semester of Year Five. Registration for the following semester may be held up if this requirement is not fulfilled in a timely manner. The Thesis Committee approves the prospectus and required paperwork is then delivered to the INP office by the student. The INP office will then complete the Admission to Candidacy paperwork and submit it to the Graduate School. The Prospectus must be submitted to the Graduate School at least six months before the dissertation is submitted.

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Year Six: Typically an MD/PhD student will complete and defend their dissertation at the end of the Fall semester or the beginning of the Spring semester. We require that MD/PhD students defend their dissertations before returning to fulfill the remaining Medical School requirements. Year Seven: Student completes all remaining requirements and graduates in May. While this is considered a guideline for a typical MD/PhD student, we recognize that not every student will follow this path. Any digression from this timeline must be discussed and approved by the DGS, with appropriate notes to the student’s file and copies to the MD/PhD office. Continued participation in the INP is subject to the satisfactory completion of requirements in a timely fashion and if any question arises about the satisfactory progress of a student and the qualifying examination committee or the thesis committee cannot agree on an appropriate resolution, then the INP Executive Committee will have the authority of the INP faculty to determine a course of action.

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PROCEDURES FOR THE QUALIFYING EXAMINATION, THESIS PROSPECTUS AND DISSERTATION

Qualifying Examination INP During the second year, each student will choose a qualifying examination committee, which is to be comprised of four faculty members from at least two different departments representing four different areas of specialization. Dr. Charles Greer or his representative will chair each committee. He may also act as both a fourth examining member and chair. Each of the four faculty members, in discussion with the student, will select ten -fifteen important papers from their field of specialization that the student will read, study and discuss with the faculty member. It is recommended that the student meet on a regular basis with each faculty member to discuss the assigned papers over a six week period. A typical scenario would involve a minimum of four to six sessions with each faculty advisor. No later than three months after receiving the papers, each committee member will prepare two essay questions based upon the readings. These eight questions will be presented to the student, who will select three questions representing three different areas of specialization. After the list of eight questions has been presented to the student, the student will have forty-eight hours to answer the questions. Library and literature resources will be available and the student may complete the exam in the location of their choice. Any one of the answers should not exceed the equivalent of three type-written pages single-spaced; references may be included at the discretion of the student. No later than one week after the written exam is completed, an oral examination will be held with the student and the members of the committee. An oral examination focusing on the readings will be held with the student and the members of the committee. As described above, the Qualifying Examination has three parts, all of which are evaluated. The student’s performance in meetings and discussions with faculty committee members, the written examination, and the oral examination are assessed when the committee members are all present for the oral examination. The qualifying examination must be completed by the end of the second year. The exam should be completed by the end of May of the second year. Exemption from this deadline requires the approval of the INP Executive Committee. If a student fails the Qualifying Exam they can be terminated from the Program upon agreement of the Qualifying Committee. At the discretion of the committee, the student may be offered a second attempt at the Exam. If so, then a new committee will be formed by the Director of the Program.

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Neurobiology Students in Neurobiology are expected to take their Qualifying Examination by the end of the second year. The student chooses 4 faculty members - 2 related to molecular/cellular neuroscience and 2 related to systems/integrative neuroscience - to perform directed readings. The student and faculty member should choose 15-25 papers on a defined research topic. Ideally, the student should meet weekly for 4 - 8 weeks with the faculty member to discuss the papers in detail. Research advisors should be aware of the great commitment expected during the qualifying examination and permit students to greatly reduce their time in the laboratory during the preparation process. The qualifying Examination has 2 parts: a written and oral exam. The written exam is carried out over 2 days. The student is given 2-3 questions on each research topic; the student chooses one question per topic and has 3 hours to respond to each questions. The written exam is open book. The written responses are distributed to the faculty members and read prior to the oral exam, which occurs within 1 week of the written exam. The student is asked to choose 1-4 additional faculty members to attend the oral exam as "readers"; they will read the answers and participate in the oral exam. The Director of Graduate Studies for Neurobiology is also in attendance at the oral exam. The oral exam usually lasts about 2 hours, and is used to fortify or elaborate on the written exam. Students who perform exceptionally well on the Qualifying Exam can pass "with Distinction". Students who fail the exam are allowed to take it over one more time; if this performance is not satisfactory students are required to leave the program with an M.S. degree. Thesis Prospectus - INP and Neurobiology Prior to the writing of the thesis, the student will attend at least 2 formal meetings with the thesis advisor and a committee of a minimum of 3 additional ladder faculty members. Typically, the thesis advisor will chair the meeting, although the committee can select another member to act as chair at this time. Two weeks prior to the first meeting the student will distribute a short document of no more than 10 pages which includes a brief introduction to the problem(s) being studied, the techniques being employed and a short discussion of potential outcomes and/or pitfalls. This document should be modeled on the NIH NRSA Predoctoral fellowship guidelines and students are encouraged to submit the final document for consideration by NIH. The first meeting of the thesis committee must occur prior to the end of the third year. It is strongly recommended that this meeting occur early in the third year as to gain the maximum benefit from the committee members in the design of the thesis project. The student will make a concise presentation to the committee and then this meeting should address the strengths and weaknesses of the proposed research. The thesis prospectus must be approved by the committee and the Program Director and submitted to the Graduate School by May 30 in partial completion of the requirements for admission to candidacy for the Ph.D. degree. The student must be admitted to candidacy to be eligible to register for the seventh semester. The second and all subsequent committee meetings will take the form of an interim progress report in which the student makes a presentation of progress to date and the committee discusses the progress and/or problems relevant to the thesis. The PI or chair of the committee will write a summary of the meeting using the form available from the INP website which will be copied to the committee members, including the student. A copy must also go to the

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INP or Neurobiology office. We expect each student's thesis committee to meet at least once a year, more often if necessary. It is expected that the thesis prospectus committee will also serve as the final thesis defense committee. Changes in a student’s thesis committee require approval of the Directors of Graduate Studies. It is expected that the student will be in continual communication with the thesis committee during completion of the research and preparation of the written document and, again, at minimum, formal committee meetings must take place annually, with documentation of completion to be forwarded to the Neuroscience or Neurobiology offices. Dissertation and Defense INP During the final stages of thesis research, the student should maintain especially close communication with the thesis advisor and committee in order to most effectively establish the content and composition of the dissertation. As the dissertation nears completion to the satisfaction of the thesis committee, a date for the defense should be scheduled by the student and the committee in consultation with the Directors. No later than two weeks before the defense is to take place, the “final” draft of the dissertation shall be distributed to the committee members. The thesis committee will consist of 4 members, including the thesis advisor and 3 additional faculty members from at least two different departments. An outside reader (outside the University) is optional and is not required by the Graduate School or the INP. A committee chair other than the thesis advisor will be appointed by the committee members if this has not already occurred. However, the thesis advisor may be an active participant during the defense and may ask questions or reformulate questions asked by other members of the committee or may act as an advocate on behalf of the student. The thesis advisor will remain present during the committee deliberations at the conclusion of the thesis defense. The thesis defense consists of two parts: 1) An open seminar to which all members of the academic community will be invited; and 2) An oral defense of the thesis, which will include only the student and the thesis committee. The oral defense should not exceed two hours. When the defense has been completed, the student will leave the room and the committee will discuss acceptance of the thesis (with or without revisions) or remand it to the student for further work. Once all changes have been made to the satisfaction of the committee, each committee member will submit a written report and recommendations to the Graduate School and the Directors, who will approve the award of the Ph.D. Neurobiology The Dissertation and Defense in Neurobiology are similar to that in the INP, with the exception that the oral defense of the thesis with the thesis committee occurs prior to the open seminar. The public seminar is only given if the thesis committee has approved the dissertation, and should occur within one week of the committee's approval.

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Dissertation Submission The student must inform the Graduate School of his/her intent to petition for the Ph.D. degree (by March 15 for a May award; October 1 for a December award) after the thesis has been successfully defended. This petition includes 1) an unbound copy of the final draft of the thesis (due at the beginning of October for December degrees, March 16 for May degrees); 2) soft-bound copies of the final draft of the thesis which the Graduate School will send to the committee members, along with the formal evaluation forms which the committee members will complete and return; and 3) The INP office will complete and submit the Notification of Readers form - the list of names and addresses of the committee members.

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REGISTRATION General Information All students in residence or in absentia are required to register with the Graduate School. Failure to do so will result in ineligibility to use University facilities, including the Libraries and the Health Services. Students are normally given the first week of classes to register (see the Calendar for dates http://www.yale.edu/bulletin/html/grad/introduction.html#Calendar). Online Course Selections are due September 20. Some changes can be made after this (consult the Graduate School Registrar for details), but a $25.00 fee will be charged for each change. Formal registration takes place in the Neuroscience Program Office, L200 SHM. Continuing students (those who have completed the 4 year full-tuition requirement) must also complete the Online Course Selection to ensure their Continuous Registration for the next academic year. Online Course Selection and Instructions for same are found here: http://www.yale.edu/sfas/registrar/ Students who wish to maintain the option to use University facilities and all students supported on Yale-administered funds during the summer months must also register with the Graduate School. This applies whether or not the student will actually reside in New Haven. There is no fee for summer registration if a student has been registered during the preceding academic year. Summer registration must be completed at the Registrar’s Office (HGS or 246 Church) in June. Foreign Student Registration Foreign students must register at the Office of International Students and Scholars (421 Temple St.) before registering with the Graduate School. Foreign students are strongly encouraged to use this office as a resource for any problems related to their foreign-student status. In Absentia Registration Students whose circumstances require full-time study at another institution, or dissertation research on a full-time basis outside the New Haven area can register in absentia provided he/she receives prior written approval of the Program Directors and the Dean of the Graduate School. Students who register in absentia do not qualify for Yale Health Plan services unless they are paying full tuition, but may enroll themselves and their dependents at full cost. Leave of Absence A student in good standing who wishes to interrupt his/her study temporarily for personal reasons (i.e. maternity leave, financial necessity, health problems or other extenuating personal circumstances) may, with approval of the Directors and the Dean, be granted a leave of absence of up to one year for students who have successfully completed one year of study and two years for students who have been admitted to candidacy for the Ph.D. degree. Students on leave may not engage in full-time degree-related activities during the period of leave. However, students may participate in full-time teaching or other full-time employment or pursue training for a special skill while on

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leave of absence. Students on leave of absence need not apply for readmission before returning to Yale. However, to be considered for financial aid in the year following a leave of absence, students must submit a formal application to the Program by February 1 of the year preceding return. Students on leave will not be enrolled in the Yale Health Plan but may continue membership by paying full fees. Tuition Full tuition is charged to all Ph.D. students for 8 semesters, except in the case of students who have completed all degree requirements (including submission of the dissertation) in less than four continuous years from the date of entry into the Ph.D. program. After eight semesters, the student must continue registering until the dissertation is submitted or the terminal date is passed. The fee for continuous registration is currently $ 293 per term. Tuition charges for students who are considering leaves of absence or registration in absentia should be arranged in consultation with the Graduate School.

FINANCIAL AID Sources of Support For the 2006-2007 year, all students will receive tuition plus a stipend of $27,000 (12 months). The most common sources of support are: 1. U.S.P.H.S. National Research Service Awards: Each year, the National Institute of Health (NIH) provides Yale with funds for graduate student tuition and a stipend ($20,772 for the ‘06-‘07 year). The Graduate School and/or the Medical School provides students with a stipend supplement. These awards are available for a maximum of 4 years. There is no "Payback" obligation for pre-doctoral support. 2. External Fellowships: Several external fellowships which are administered by federal or private sources are also available to graduate students in Biomedical Sciences. A list of these awards is available on the INP website or with the Assistant Dean of Biomedical Sciences (HGS, 432-2744). Students are encouraged to refer to this list regularly to determine required qualifications and application deadlines. The INP and Neurobiology programs strongly encourage students to apply for any outside fellowships, and in particular those awarded by the National Science Foundation, the Department of Defense and the Homeland Security Office. More senior students are encouraged to submit Predoctoral NRSA applications. Information for these awards are available in the Program offices. Most applications are now completely online and links are available on the INP website. 3. University Fellowships: These fellowships are awarded by the Graduate School and/or the Medical School.

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4. Research Assistantships: Research grants and contracts awarded by outside agencies to support the research projects of individual faculty members may provide funds for Research Assistantships for graduate students. These appointments are decided by faculty negotiation. In most cases, these appointments are given to senior students who are engaged in full-time dissertation research in the laboratory of the P.I. granting the funds. Pay Periods The Graduate and Professional student payroll runs on a semi-monthly schedule of payments (the 15th and last business day of each month). Checks can be deposited directly into any bank account at the request of the student. See Carol in the INP office for Direct Deposit set-up or change of address. Loans For information on the various types of graduate student loans, consult the Financial Aid Office (125 HGS; 432-2739). Travel Money First-year and unaffiliated second-year students are provided with $800 in travel funds for use towards one scientific meeting per year. See the INP Office to make arrangements for this. Students are encouraged to attend the Society for Neuroscience annual meeting in the fall.

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LECTURES, SEMINARS AND JOURNAL CLUBS

Yale graduate students in the Biomedical Sciences have access to a large number of relevant research seminars, journal clubs, retreats and symposia. The programs of the Neuroscience Track sponsor the following events, which students are expected to attend: Seminar Series The INP seminar series provides an opportunity for students and post-docs in the neuroscience community at Yale to interact on a one-to-one basis with visiting neuroscientists in an informal setting. The seminars are held monthly, on the second Tuesday of the month, September through June in the Medical School. Neuro students select the speakers, drawing from the fields of cellular and molecular neurobiology, neurophysiology, developmental neurobiology, and systems/computational neuroscience, and make the invitations themselves. A student host coordinates lunch with interested graduate students and the speaker. Following each seminar, graduate students and post-docs are invited to have dinner with the speaker. Contact the INP office for additional information. Announcements are sent each month. The Neurobiology series is usually held monthly on Thursdays at noon in SHM I304. Neurobiology students and postdocs invite speakers from a variety of disciplines. Students and postdocs are invited to have lunch with the speaker after the seminar. Each speaker is assigned a student or postdoc host, who may also join the speaker for dinner. Journal Clubs The INP student-directed journal club brings together graduate students and post doctoral fellows in the neurosciences to discuss current papers in the field. Members meet on a biweekly basis and take turns in leading the discussions. The Journal Club is an excellent opportunity to practice presenting papers in a congenial and collegial atmosphere, to keep apprised of neuroscience research and to maintain contact with fellow students, events and research within the expansive Yale neuroscience community. Anyone with an interest in neuroscience is invited, but members are encouraged to attend regularly. Announcements are sent for each scheduled date. The paper to be presented is always available on the INP website prior to the Journal Club. The Neurobiology Journal Club coordinates with the Neurobiology Seminar Series. Students meet monthly prior to a Seminar to discuss several papers from the speaker's lab. Students discuss the papers over lunch in an informal atmosphere. These discussions can be particularly helpful in learning about research outside one's field. Club Neurobiology is sponsored by the Section of Neurobiology and is intended to serve as an informal forum for members of the Neurobiology community to interact. In particular, seminars are presented by post-doctoral fellows from Neurobiology labs. Club Neurobiology is scheduled the third Tuesday of each month, throughout the

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academic year. This seminar series is held in SHM B145, dinner and drinks are available at 5:00 pm, with the seminar beginning at 5:30 pm. Spike Club (http://jacknife.med.yale.edu/spikeclub/) is a student organized journal club that reviews recent papers in systems neuroscience. Meetings are held every other week at noon in the Dome Room (SHM C-500). A delectable lunch from one of New Haven's finest dining establishments is served. We wish to thank the Yale Interdepartmental Neuroscience Program and the Swartz Initiative for Theoretical Neuroscience at Yale for their generous support. Future meetings will be supported by the Swartz Initiative, and the journal club will reflect such interests. Synaptic Transmission Journal Club meets Fridays at noon, alternating with Spike Club. Developmental Biology Journal Club meets on occasional Thursdays in the Child Study Center.

Graduate Student Seminar Series

To maintain regular interactions among the student body, INP students participate in a regular “In Progress” seminar series. At these seminars, students make short presentations of research-in-progress to Neuroscience students and faculty. This gives graduate students a unique opportunity to have their work evaluated by their peers and faculty. Second year students coordinate the scheduling of this series and are in charge of providing lunch for everyone. Guidelines for these presentations are as follows: • Talks should consist of a clear and well organized presentation of the background

and rationale for the research, and the recent findings. Plan a ten or twenty minute talk and allow a further five or ten minutes for discussion, which may occur at any time during the talk or after.

• Begin your talk by introducing yourself and announce in whose lab you are working.

For clarity, you should make sure that the first few overheads or slides give adequate background for your presentation. Your audience is quite diverse. After giving the background, then go through your data, presenting it in as clear a fashion as possible. Pay attention to the order in which you present your information and to the manner in which your data slides or overheads are set up. Make sure you arrange the data in a fashion that is logical and easy to interpret. This will avoid confusion and save time. End by clearly stating your conclusions. Practicing your talk in front of a mentor, members of your lab, and/or a few friends is a good idea.

• First and second year students are often nervous about giving these seminars

because they feel they do not have sufficient data. This should not be a concern.

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Use the opportunity to practice presenting. These talks should be no more than 10 minutes.

• More senior students should focus on the more recent experiments. Do not try to

gloss over problem areas. Remember that a primary function of these seminars is to get feedback from your colleagues. Someone in the audience may have an idea which could help, and you should encourage such ideas to come out. These talks should be twenty minutes.

Other opportunities to present Neurobiology students have the chance to present their thesis research as an informal seminar to the other students and faculty. Seminars usually occur monthly in the mornings over coffee and pastry. The seminar series is an excellent opportunity to learn about public speaking in a friendly environment. Annual Interdepartmental Neuroscience Program Retreat This annual weekend meeting is open to all members of the Yale Neuroscience community. It features seminars by faculty and an afternoon poster session. There is also ample time for informal discussion to enable conferees to become acquainted with current Neuroscience research on the Yale campus as well as opportunities to interact with students, postdoctoral fellows and faculty from all areas of neuroscience at Yale. Other Seminar Series of Interest Department Day Time Location Molecular Psychiatry (BSTP) Monday 3:45 pm 133 CMHC John B. Pierce Seminar Monday 4:00 pm JBPierce Lib. Child Study Center Grand Rounds Tuesday 1:00 pm Cohen Aud Clinical Neuroscience Grand Rounds Wednesday 8:00 am Brady Aud Biology Department Seminar Wednesday 4:30 202 OML Cell Biology Seminar Wednesday 12:30 C429 SHM Current Work in Behavioral Neuroscience Thursday 3:30 pm 100 AKW Cellular & Molecular Physiology Seminar Thursday 4:00 B147 SHM Molecular Biophysics and Biochem. Seminar Wednesday 4:00 OML/BASS/Hope Neurobiology Thursday 12:00 I304 SHM Pharmacology Seminar Thursday 12:30 Giarman Room Psychiatry Grand Rounds Friday 10:15 am CMHC Aud. OFF-CAMPUS NEUROSCIENCE COURSES Neuroscience students are encouraged to take advantage of the several Neuroscience Summer and Short Courses which are offered in various regions. First and second year students must have permission from a Neuroscience Program Director to apply for these courses. Although many summer courses are offered internationally, those

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offered by the Marine Biological Laboratory (Woods Hole, MA) and Cold Spring Harbor Laboratory (Cold Spring Harbor, NY) are among the very best. Course listings can be found on the home pages of these institutions. Marine Biological Laboratory, Woods Hole, MA (508) 289-7401, admissions@mbl.edu, http://www.mbl.edu Cold Spring Harbor, Cold Spring Harbor, NY (516) 367-8345, meetings@cshl.org, http://www.cshl.org/

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CAMPUS FACILITIES, MISCELLANEOUS INFORMATION Libraries The main Yale campus libraries of interest to Biomedical students are: 1) The Medical Library (SHM) Hours: M-Th 8:00 am-midnight; F 8:00 am-10:00 pm; Sat 10:00 am-7:00 pm; Sun 11:00 am-midnight. 2) The Kline Science Library (C level, Kline Biology Tower) Hours: M-Th 8:30 am-midnight; F 8:30 am-9:00 pm; Sat10:00 am-7:00 pm; Sun1:00 pm-midnight. Both of these libraries have access to Interlibrary Loans, and can obtain periodicals and papers from other libraries across the United States. Rare books from Yale Libraries are stored in the Seeley Mudd Library (38 Mansfield St.; 432-3203). Books can be delivered by courier to other libraries on request. Photocopying New Neuro students will be given information regarding photocopying privileges at the orientation meeting. These privileges are extended until you have settled into a thesis lab. All campus libraries have photocopying machines for use on either a cash or charge basis. The libraries will also copy documents on request, but this can become both costly and time consuming. Be sure to inquire about the time and cost requirements before submitting a request for photocopying to any of the Yale libraries. Bulk copy, if arranged for easy management, can also be done by the Copy Center, which is located at 127 College Street (785-4675). Outside commercial copiers are also available in many locations adjacent to the campus. The McDougal Graduate Student Center McDougal Center- Hall of Graduate Studies (HGS), 320 York Street (432-8273, mcdougal.center@yale.edu, www.yale.edu/mcdougal). At Yale, there is no general campus center, student union, or student center for the entire University community. For graduate students, much of student life is based in their respective departments and schools, and dormitories or apartment complexes. The McDougal Center is a place where graduate students from across the campus regularly meet and share interests. Mission- A generous gift from Mr. Alfred McDougal, a Yale alumnus, and his wife, Ms. Nancy Lauter, enabled Yale in 1997 to create the McDougal Graduate Student Center. The McDougal Center provides space and program funding for building intellectual, cultural, and social life, and for facilitating professional development activities across the departments of the Graduate School of Arts and Sciences. The McDougal Center warmly welcomes the participation of students from other Yale Graduate and Professional Schools, postdoctoral fellows, faculty, staff, alumni/ae of the Graduate School, and members of the larger Yale community. Its web site (http://www.yale.edu/mcdougal) provides all kinds of information relating to graduate student life. The Center provides members of the graduate student community with a place of their own on campus.

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Facilities-The facilities of the McDougal Center enhance student life in many ways. The magnificently restored Common Room has been transformed into a lounge with comfortable furnishings, internet ports, newspapers and magazines, and a student-run cafe serving coffee and light food throughout the day. In an adjacent wing on the first floor of HGS the Center has a large multi-purpose Program Room (HGS 119) with a stage, seating for up to 100, and advanced video and sound projection equipment. The Program Room provides space for lectures, conferences, performances, film series, workshops and other events by and for students. The Center also has smaller conference and meeting rooms. Graduate student groups and departments may request to reserve space by contacting the center office at 432-8273, stopping by HGS 123, or filling out a request on line at www.yale.edu/mcdougal/mcdougal/roomform.htm. There is a public computer cluster supported by ACS, a public copy machine, a public phone, bulletin boards and information kiosks as well. The lower floor also offers offices for the Assembly of Graduate Students, graduate student organizations, rooms for Teaching Fellows to meet with students, lockers for graduate student use and vending machines. The McDougal Center is open days, evenings, and weekends. Student Life Programs - Lisa Brandes, Director, 123 HGS, 432-8273. The Center offers a variety of activities open to the G&P community. These include weekly movies on the Really Big Screen, coffeehouse musical evenings, happy hours, poetry readings, student research presentations, health and wellness workshops, teas with campus and community figures, and service opportunities such as blood drives. It hosts activities organized by student groups and departments, including cultural festivals, movies, lectures, receptions, and conferences. Activities are publicized in campus publications, in McDougal Notes calendar, on the web site, and via email lists. Graduate Career Services (GCS) -123 HGS, 432-8896, www.yale.edu/gcs. Graduate Career Services was established to guide and educate graduate students about academic and non-academic career opportunities and job search strategies. The office offers programs such as professional career development workshops, seminars, resume/CV reviews, individual counseling, on campus interviews, dossier service and current job listings. The Office of Teacher Preparation -123 HGS, 432-8896. This office directs the teacher preparation program within the McDougal Graduate Student Center, and also works with faculty and graduate students to enhance teacher preparation programs in departments. They advise the Working at Teaching program. The mission of Working at Teaching (www.yale.edu/wat) is to help improve the teaching skills of Yale graduate students and to contribute to their professional development as teachers. WAT offers excellent peer-led training workshops for teaching assistants each semester, promotes dialogue in the Yale community about all aspects of pedagogy through forums and lectures, and supports teaching assistants by publishing a handbook, maintaining a resource office, and conducting classroom visitations. WAT is sponsored by the Graduate School and is housed in the McDougal Center. While most of the students who participate in WAT programs come from the Graduate School, other G&P students who teach take part in its activities.

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Resource Library for Fellowships, Careers, and Teaching (formerly the Fellowship Library)- B44 HGS, McDougal Center, www.yale.edu/mcdougal/resource This is a self-service reference library intended to assist Yale graduate students, postdocs, and faculty in finding fellowships, pre-dissertation, dissertation, travel and research funding. (Teacher training and career services books are being added). It contains a physical site (Room B44) of grant and funding books, announcements, and files on programs and topics, and a virtual site of links, announcements and searchable databases. For room access, check out the key from the Center office, Room 123 HGS, or ask the night program attendant on duty to let you in. Handouts and the web can explain to you how to use the materials, but the actual research is up to you. Graduate Student Organizations The Graduate Student Assembly (http://www.yale.edu/assembly/) The Graduate Student Assembly (GSA) is the elected body of Yale students in the Graduate School of Arts and Sciences. The Assembly's goals are to:

• identify the needs and concerns of graduate students, consider possible solutions, and present these to the Dean and other administrators.

• discuss and advise on changes to Graduate School policy proposed by the administration.

• provide a means for communication and deliberation both among graduate students and between grad students and other members of the university community.

Meetings The Graduate Student Assembly meets every other Wednesday in the Hall of Graduate Studies (HGS) room 119 at 7pm. Meetings are open to all Graduate Students. Conference Travel Fund The Conference Travel Fund aims to support the professional development of graduate students by providing financial assistance to present papers and posters at conferences on a competitive basis. Conference funds are disbursed three times per year with application deadlines on October 15th, February 15th and May 1st. Applications for the February 15th, 2007 cycle will be accepted from January 15 - February 15, 2007. The Graduate-Professional Student Senate (GPSS) is a university-wide organization representing the interests of all graduate and professional students and provides a means of voicing concerns to the University administration as well as to the various departments and schools. http://www.yale.edu/gpss/Senate/aboutus.html The Graduate Employees and Students Organization (GESO) was founded in 1990 with the purpose of achieving negotiated agreements with the University Administration, including conditions of graduate student employment and life.

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The Graduate and Professional Student Center at Yale (GPSCY) provides a central meeting place for graduate and professional students, faculty and alumni. Open only to members and their guests, the GPSCY operates a full service bar with reduced prices, sponsors receptions, dances and parties and hosts conferences, rehearsals and exhibitions. http://www.yale.edu/gpss/GPSCY_Bar/gryphons.html There are many other formal student organizations at Yale, covering a broad spectrum of interests and activities including an active graduate-professional intramural sports league. Grievance Procedures For students who feel they have been treated unfairly in some capacity by an individual or group within the University, several courses of action are available. First, the advice of the thesis advisor, the Graduate Student Affairs Committee or either of the Program Co-Directors may be sought. Alternatively, if the matter is one which is not appropriate to raise within the Program administrative structure, other University agencies may be contacted, which include: 1) The Dean of the Graduate School (Jon Butler -112 HGS; 432-2733); or 2) The Deputy Provost (Stephanie Spangler - 137 HGS; 432-4446), whose office is especially concerned with matters relating to equal rights for minorities and for women. The Office for Women in Medicine can also be contacted. It is located in L202 SHM; 785-4680. In addition, the Dean of Graduate Studies has appointed a standing Grievance Committee to receive and review student complaints of sexual harassment. This Committee is comprised of six members (2 faculty; one member of the Graduate School Administration; two students; and one counselor). Students may bring questions about procedure, seek informal advice, or present a complaint to any member of the board, either orally or in writing. Yale Health Plan The Yale Health Plan (YHP) is a comprehensive health care program, located at the University Health Care Services Center (17 Hillhouse Avenue) which is available to all faculty, students and staff. All Yale students who are enrolled in graduate study at least half-time are automatically members of the YHP and are eligible for ambulatory care services and the use of the infirmary at no additional cost. Yale requires that students have hospitalization coverage as well. For all graduate students who do not have hospitalization from another source, this coverage will be provided at no cost to the student. There is also supplemental coverage for prescriptions, eye care and other services. This coverage must be paid for by the student, the program does not cover this. If NOT WANTED, each student must sign a completed waiver form every year and forward it to the YHP by September 15. Students may also enroll their spouses and dependents by filing an application with the YHP. The Graduate School will pay for half of this fee. The rest of the fee is applied through the Bursar’s office. Only those spouses and dependents specifically enrolled are eligible to receive YHP benefits and services. In addition to primary and emergency care, a full range of specialty services are available, including Allergy, Dermatology, Otolaryngology, General Surgery, Mental Hygiene, Neurology, Obstetrics and

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Gynecology, Ophthalmology, Orthopedic Surgery, Optometry, Contact Lenses and Urology. For first-year students, YHP membership begins on the first day of registration. Prior to registration, a complete medical examination form and health report must be submitted to the YHP. If these forms are not available, YHP will provide the necessary examinations, and will bill the student a $25 charge. Additional information can be obtained by contacting the Member Services Office at 432-0246. Dining Facilities Several University dining facilities are maintained for the convenience of students, faculty and staff. In the Medical School and Science Hill areas, these include: 1. Marigold’s (367 Cedar St., adjacent to SHM). 2. Yale-New Haven Hospital Cafeteria (Main – 1st floor of the Hospital) 3. Yale-New Haven Hospital Cafeteria (2nd floor of the Clinic Building, 330 Cedar St). 4. Kline Biology Tower Cafeteria (12th floor, KBT) 5. School of Organization and Management Cafeteria (135 Prospect St.) 6. Hall of Graduate Studies Cafeteria (York Street) Shuttle Buses Schedules and routes can be found here: http://www.yale.edu/parkingandtransit/shuttle/ The Yale Shuttle Bus is a campus-wide service operated by the University. The Shuttle runs every 20 minutes during peak hours, and every 40 minutes for the remaining time, starting at 7:20 a.m. until 6:00 p.m. The Shuttle is free with a valid Yale identification card, or $.65 without. Schedule information is also available in SHM CE 1 or at the Parking Service Office, Hendrie Hall, 165 Elm St. Evening Transportation Medical School Shuttle Service 203 785-5555: Between the hours of 5:00 p.m. and 6:00 a.m., Monday - Friday, the service provides scheduled and unscheduled pick-up of Yale University students and staff within the boundaries of the Medical School. Yale Minibus (Nighttime) 203 432-6330: Buses run from 6:00 p.m. to 7:30 a.m. Monday through Sunday (seven nights a week). This service runs on a scheduled route around the campus and also takes dispatched calls for off-route pickups. From 1:00 a.m. to 7:30 a.m., service is available on call-in basis only. Dial 2-6330 from any campus phone for service. In addition to these services, the University Police provide transportation 24 hours a day for medical emergencies to the University Health Services. Call 432-4400 for this service. Parking Parking is available in various locations around campus on both a regular and a special service basis. Inquiries and applications for permits should be directed to the Medical School Parking Office, Basement of SHM (785-4201) for the Medical School Area or

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the Office of Parking and Transit Services, 155 Whitney Ave (432-9790) for the Science Hill district. Security Yale Security emphasizes that the campus is not immune to crime, property loss or personal injury. Individuals are urged to walk in groups, or request to be escorted by the Student Patrol Service which has been set up by the University Police to provide for safety on the streets and in the parking lots. Night-time transportation is available for students working late in the evenings. Identification Card During registration, incoming students will receive an identification card for access to campus facilities. In case of a lost or stolen ID card a new ID can be issued for a fee at the Medical School Support Center (CE 1 SHM) 9:00 a.m.-12:00 p.m., Tuesdays. Email Addresses All neuroscience students can be reached by email. Use the generic Yale address format of firstname.lastname@yale.edu. Faculty - All neuroscience faculty can be reached by email. Use the generic Yale address format of firstname.lastname@yale.edu. Computer Accounts Each incoming graduate student is set up with a free computer account, including email access. Username and PIN number are sent to incoming students in the summer. This account gives you access to the Internet, MedLine, ORBIS, etc. Keys Most areas on campus are now accessible by swipe-access with your current ID. Departmental keys (for labs, etc.) should be obtained through the specific department’s business office. Mail New students may have their mail sent to of the INP office, where it will be held for pick up, or forwarded to the department in which the student is currently working. Neurobiology students have mailboxes across from C303 SHM ATM In the Medical School area, there is an ATM and Bank of America branch at 330 Cedar Street, between the Clinic Building and FMB on the first floor (go to the Information Desk and turn left). There is another ATM located on the the main floor of the hospital.

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RECREATIONAL OPPORTUNITIES 1. University Athletic Facilities are available for standard fees. They include: a. Payne Whitney Gymnasium (70 Tower Parkway; 432-1444), for sports, dance, exercise and swimming. b. Ingalls Skating Rink (73 Sachem Street; 432-4771) for ice skating sessions between mid-October and April. c. The Yale Golf Course (Ray Road; 432-0895). d. Cullman Tennis Courts (for indoor tennis, late October through late April) and outdoor courts (Derby Avenue; 432-0693).

e. The Yale Sailing Center (Short Beach, Branford; 488-9330), which has equipment available for rent and offers sailing lessons.

f. Outdoor Education Center (East Lyme, Ct.) Call 432-2492 for info. 2. Musical Opportunities/Activities include: a. The Yale Symphony Orchestra, which is comprised of students from all levels within the University. b. A variety of choral groups, encompassing several musical styles. For more information, contact the Music Department at 432-2986. c. The Yale School of Music sponsors frequent recitals, which are listed in the Weekly Bulletin & Calendar. d. The New Haven Symphony Orchestra and the Woolsey Hall Concert Series. Tickets are available at the New Haven Symphony Office, 33 Whitney Avenue. 3. Theatrical Productions a. The Yale Repertory Theatre (Chapel and York; 432-1234) b. The Long Wharf Theatre Company (222 Sargent Drive; 787-4282) c. The Yale Cabaret (217 Park Street; 432-1566) d. The Shubert Theatre and The Palace Theatre (College Street) 4. University Museums

a. The Peabody Museum of Natural History (Sachem & Whitney; 432-5050), Exhibits of the natural history of the New England area, with extensive collections in geology, anthropology and ornithology. Displays include minerals; birds of Connecticut; fossil plants, fish, birds, reptiles and mammals; and, of course, dinosaurs. b. The Yale Art Gallery (Chapel & York Street; 432-2600) includes extensive collections of 17th, 18th and 19th century paintings and furnishings. c. The British Art Center (Chapel & High Street; 432-2858) contains a collection of British paintings, drawings, prints, rare books and sculpture assembled over the past 35 years by Paul Mellon.

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NEUROSCIENCE TRACK FACULTY RESEARCH INTERESTS Meenakshi Alreja, In vitro electrophysiological studies on the neurobiology of the septohippocampal pathway, a brain pathway that is involved in cognitive functions and degenerates in Alzheimer’s disease and other neurodegenerative disorders Amy Arnsten, Examination of the catecholamine and second messenger mechanisms influencing the cognitive functioning of the prefrontal and entorhinal cortices, brain regions commonly dysfunctional in mental illness Thomas Biederer, Molecular analysis of synapse formation in the developing central nervous system of vertebrates. Hal Blumenfeld, Neuroimaging and electrophysiology studies of corticothalamic mechanisms causing impaired consciousness in epilepsy. Angelique Bordey, Glial influence on postnatal neurogenesis in the subventricular zone and cerebellum. Charles Bruce, Neurophysiology of information processing in cerebral cortex. Benjamin Bunney, Neurobiology of schizophrenia and movement disorders, especially as related to central dopaminergic systems. John Carlson, Function and development of the Drosophila olfactory system. Wei Chen, Functional organization of olfactory neuronal circuits. Marvin Chun, Functional MRI studies of visual perception, memory, and executive control. Lawrence Cohen, Imaging the input and output of the olfactory bulb R. Todd Constable, Technical aspects of functional MRI with particular emphasis in fMRI for neurosurgical planning, and the application of fMRI and ERP to better understand language and memory systems in the human brain and the response to injury. Pietro De Camilli, Membrane traffic at the neuronal synapse; phosphoinositide metabolism and neuronal function. Sabrina Diano, Role of thyroid hormones, steroid hormones, neuropeptides and UCPs in the homeostatic mechanisms of CNS in physio-pathological conditions. Ronald Duman, Molecular, cellular, and anatomical sites which mediate the adaptive responses of mammalian neurotransmitter signal transduction pathways to psychotropic drugs, hormones, and environmental stimuli.

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Barbara Ehrlich, Regulation of intracellular calcium signaling using electrophysiological, biochemical and molecular techniques. Paul Forscher, Molecular mechanisms of neuronal growth and guidance. Karyn Frick, Neurobiology of learning and memory. Jeremy Gray, fMRI studies of human emotion-cognition interactions. Charles Greer, Mechanisms that influence axonal and dendritic growth and specificity of targeting in sensory systems. Lise Heginbotham, Structure-function studies of ion channel proteins. Tamas Horvath, Determine the signaling flow and regulatory relationship within and between neuronal circuits that underlie the maintenance of physiological and pathological homeostatic conditions. James Howe, Glutamate receptors. Marcia Johnson, Cognitive neuroscience studies of human cognition and memory and of the relation between emotion and cognition. Sven-Eric Jordt, Molecular neurobiology of sensory transduction and pain. Len Kaczmarek, Long-lasting changes in neuronal activity. Haig Keshishian, Factors governing the formation of synaptic connections during development. Ken Kidd, Molecular and genetic mapping of genes of neuropsychiatric relevance; searching for genetic causes of neuropsychiatric diseases. Jeffery Kocsis, Pathophysiology of axons and neurons. Michael Koelle, Mechanism of signaling by G protein-coupled neurotransmitter receptors using a combination of C. elegans genetics and biochemical experiments. Anthony Koleske, Regulation of neuronal differentiation and morphogenesis by nonreceptor tyrosine kinases. Hür Köser, Creation of miniature microfluidic chambers to study cellular chemotaxis in real-time. Robert LaMotte, Neurobiology of pain and tactile sensations.

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Mark Laubach, Neurophysiological studies of associative learning, sensorimotor integration, and the effects of aging using chronic neuronal ensemble recording in frontal cortex, basal ganglia, and other brain areas in rodents. David LaVan, Micro- and nano-fabrication. Development of polymer based electrodes. Development of novel materials for biomedical applications. Erin Lavik, Developing new therapeutic approaches for the treatment of spinal cord injury and retinal degeneration. Daeyeol Lee, Neural basis of decision making and sequence learning. Michael Levene, Nonlinear optical techniques and micro-optics for in vivo microscopy; single molecule spectroscopy. James Mazer, Neurophysiological basis of natural vision. Gregory McCarthy, Functional anatomy of the human brain. David McCormick, Cellular basis for cortical and thalamic function. Gero Miesenböck, Neuronal circuits and behavior. Mark Mooseker, Molecular and functional analysis of the cytoskeleton, with current emphasis on myosin superfamily of actin-based molecular motors. Angus Nairn, Dopaminergic signal transduction in the central nervous system. Dhasakumar Navaratnam, Molecular aspects of inner ear function. Michael Nitabach, Behavioral and physiological genetics in the fly, with goal of dissecting neural circuit function. Marina Picciotto, Use of mouse genetics and molecular biological approaches to study the role of neuromodulatory systems in behavior. Vincent Pieribone, Information encoding in somatosensory cortex and optical probes of membrane potential. Maria Mercedes Piñango, Language-brain relations: cortical dissociations in language localization, time-course of language processing during real-time sentence comprehension. Pasko Rakic, Developmental neurobiology, genetic and epigenetic regulation of neural interactions. George Richerson, Sensitivity to changes in pH of CNS respiratory neurons; Electrophysiological effects of nonvesicular GABA release.

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Robert Roth, Biochemistry, pharmacology, and function of midbrain dopamine systems. Gary Rudnick, Structure and function of biogenic amine transporters, which are targets for antidepressants and psychostimulants. W. Mark Saltzman, Biomaterials for drug delivery in the central nervous system, particularly in the development of controlled release systems for treating brain tumors. Laurie Santos, Social and physical cognition in non-human primates. Joseph Santos-Sacchi, Auditory biophysics, hair cell physiology, role of outer hair cells in cochlear amplification. Glenn Schafe, Neural organization of the brain’s fear system; emotional learning & memory. Michael Schwartz, Development and organization of connectivity in the mammalian cerebral cortex. Nenad Sestan, Molecular control of neuronal identity and connectivity in the cerebral cortex. Gordon Shepherd, Experimental and computational studies of sensory transduction, synapses, dendrites, and microcircuits using the olfactory pathway as a model system. Fred Sigworth, Ion channel structure and gating mechanisms. Dana Small, Affective sensory neuroscience with an emphasis in multisensory integration of taste and smell and in brain representation of feeding and food reward in health and in addiction. Behavioral and neuroimaging approaches are used in humans. Matthew State, Gene discovery and characterization in childhood neuropsychiatric and developmental disorders. Elke Stein, Axon guidance in the developing nervous system. Stephen Strittmatter, Molecular determinants of axonal guidance during development and regeneration. Jane Taylor, Neurobiology of addiction, depression and other neuropsychiatric disorders involving motivation, learning and cognition. Behavior and molecular approaches in mice, rats and monkeys. Ning Tian, The development of synaptic pathways and the activity-dependent synaptic plasticity in mammalian retina. Susumu Tomita, Revealing molecular mechanisms for synaptic strength regulation

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Vinzenz Unger, Structure and function of metal transporters; Structure of scaffolding complexes in the postsynaptic density; Structure of membrane associated proteins. Flora Vaccarino, Regulation of progenitor cell differentiation in normal development and after injury. Xiao-Jing Wang, Dynamical aspects of neural computation and memory in cortex. Stephen Waxman, Molecular neurobiology of disease, with emphasis on ion channel function and dysfunction in spinal cord injury, multiple sclerosis, and stroke. David Wells, Molecular mechanisms of synaptic plasticity; role of local protein synthesis. Robert Wyman, Molecular biology and neurophysiology of gap junctions; genetic control of neural circuit development. Tian Xu, Mechanisms underlying neurodegeneration in Drosophila model. Mark Yeckel, Cellular and systems characterization of cortical neurons involved in learning and memory. David Zenisek, Presynaptic mechanisms of retinal neurons. Weimin Zhong, Asymmetric cell division and the development of the mammalian neocortex. Yufeng Zhou, Structure and function of ion channels. Steven Zucker, Computational neuroscience. Affiliated faculty – these faculty do not have an appointment in a Basic Science Department Patrick Allen, Molecular mechanisms of synaptic communication Robert Beech, Roles of transcription factors and adult neurogenesis in the neurobiology of psychiatric disorders. Hilary Blumberg, Understanding the neural systems that underlie emotional processing. Nicholas T. Carnevale, Development of a theoretical framework for understanding the functional consequences of the mechanisms that underlie the origin, propagation, and interaction of electrical and chemical signals in neurons. Ralph DiLeone, Understanding the molecular and neuronal circuits that are responsible for controlling reward-related behavior.

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Albert Lo, Pathobiology of demyelinating disease, neuronal injury and repair, neuroprotection, MS epidemiology, robotic neurorehabilitation, clinical trial design and methodology Laura Manuelidis, Experimental models of Creutzfeldt Jakob Disease and variants; mechanisms of dementia & infectious agents. Rory McCrimmon, Glucose-sensing mechanisms used by specific brain regions; metabolic adaptations in brain following recurrent exposure to low glucose. Sam Sathyanesan, Regulation of angiogenesis in adult rodent brain and contribution to cellular and behavioral effects. Robert Sherwin, How the brain senses changes in blood glucose and the effect of decrements in blood glucose on brain function. James Swain, Combining psychological assessments and functional magnetic resonance brain imaging to study thoughts and behaviors of parents in the early postpartum. Michael Westerveld, Memory disorders associated with epilepsy and development of cognitive function across the lifespan. Anne Williamson, Physiological changes seen in the chronically epileptic brain.

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NEUROSCIENCE TRACK COMMITTEES Admissions Committee Charles Greer (Chair) Mark Yeckel Amy Arnsten Marina Picciotto Haig Keshishian Barbara Ehrlich Marvin Chun David Zenisek Interdepartmental Neuroscience Program Committees Executive Committee Charles Greer Co-Director Haig Keshishian Co-Director Amy Arnsten Neurobiology Barbara Ehrlich Pharmacology Marvin Chun Psychology Lawrence B. Cohen C & M Physiology Tony Koleske Molecular Biophysics and Biochemistry Marina Picciotto Psychiatry Mark Yeckel Neurobiology Jeffery Kocsis Neurology Christian von Hehn Student Representative Graduate Student Affairs Committee Charles Greer (Chair) Haig Keshishian (Student Representative to be announced) Curriculum Committee , Chair Michael Nitabach Angelique Bordey Graduate students: Nicole Horst, The composition of these committees is subject to rotation or change on an annual basis.

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Neuroscience Courses 2006-2007 FALL 2006 *NSCI 501a, Principles of Neuroscience. Marina Picciotto, Mark Yeckel. WF 3.15–4.45, TAC N203, first class meets Wednesday September 6. General neuroscience seminar: Lectures, readings and discussion of selected topics in neuroscience. Emphasis will be on how approaches at the molecular, cellular, physiological and organismal levels can lead to understanding of neuronal and brain function. Also NBIO 500a. NSCI 519a/b, Tutorial By arrangement with faculty and approval of DGS. NSCI 585a, Stem and Progenitor Cells in the Adult Nervous System. Eleni Markakis, Angelique Bordey. T TH 1:30 – 3:00 Hope 211 This seminar course will examine through original papers in the literature, our current knowledge of adult neurogenesis and neural stem/progenitor cells. We will study the advantages and disadvantages of transplantation techniques vs. recruitment of endogenous progenitors for repair of the damaged nervous system, in a variety of animal models. The focus will be on consensus work, but we will also delve into the controversies of neural stem cell research. The strengths and limitations of various techniques will be examined. The semester will end with a survey of progenitor cells used in clinical trials. *NSCI 720a, Neurobiology. Haig Keshishian, Paul Forscher. MWF 11:30 – 12:20 102 KBT Examination of the excitability of the nerve cell membrane provides a starting point for the study of molecular, cellular and intracellular mechanisms underlying the generation and control of behavior. Also MCDB 720au, NBIO 720a. The following course is also of particular value to students in Neuroscience: MCDB 721Lau, Laboratory for Neurobiology. Haig Keshishian, Robert Wyman.

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SPRING 2007 *NSCI 580b, Bioethics in Neuroscience. Charles Greer. TH 4–5.30 This course is an introduction to ethics and ethical decision-making in the Neurosciences. Format for the course is an informal discussion. Each week, we will be joined by members of the Yale faculty and community who can share their experiences and expertise as it relates to the topic of the week. This course is mandatory for first year graduate students in the Interdepartmental Neuroscience Program (INP). Grading is pass/fail and is determined based on attendance/participation, weekly reaction papers and a final term paper. NSCI 535b History of Modern Neuroscience. Gordon Shepherd. First class meets Monday, January 22 In this course we focus on the original breakthroughs that led to major lines of research being pursued today. Subjects include classic papers in the discoveries of DNA, action potential, synaptic transmission, growth factors, second messengers, neurotransmitters, Hebb synapse, dendrites, hippocampus and memory, cortical columns, REM sleep, neuroendocrine system, instrumental conditioning, reticular activating system, psychoactive drugs, computer modeling, and artificial intelligence. Also NBIO 535b. NSCI 504b/MCDB 735b, Seminar in Brain Development & Plasticity. Elke Stein, Weimin Zhong. MW 2.30-3.45 Weekly seminars (Monday) and discussion sessions (Wednesday) to explore recent advances in our understanding of brain development and plasticity, including neuronal determination, axon guidance, synaptogenesis and developmental plasticity. Also MCDB 735bu. *NSCI 510b, Structural and Functional Organization of the Human Nervous System. Michael Schwartz, Pasko Rakic. An integrative overview of the structure and function of the human brain pertaining to major neurological and psychiatric disorders. Also NBIO 500b. NSCI 514b, Neurodevelopment and Neuropsychiatric Disorders. Flora Vaccarino. This course is intended to discuss the development of the central nervous system as it applies to neuropsychiatric disorders. We will focus on the mechanisms that regulate progenitor cell proliferation, the acquisition of regional and cellular identity, neuronal migration and cell death. Information drawn from these basic developmental mechanisms will be used to discuss the newest emerging ideas about the pathogenesis of disorders such as autism, Tourette’s syndrome, depression and other affective disorders. NSCI 502b, Cell Biology of the Neuron, Elke Stein MW 4:30 – 6 pm *Required courses

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