yuli lestari 10505002
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Ubiquitin- Protein Ligase Tambahan pembahasan Artikel : Getting into position : the catalytic mechanisms of protein ubiquitylation. Yuli Lestari 10505002. Agenda Presentasi. Overview Ubiquitin, Ubiquitin Ligase Artikel Pendahuluan Pengaruh Modifikasi Ubiquitin - PowerPoint PPT PresentationTRANSCRIPT
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Ubiquitin- Protein LigaseTambahan pembahasan Artikel :Getting into position : the catalytic mechanisms of protein ubiquitylation
Yuli Lestari 10505002
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Agenda Presentasi
Overview Ubiquitin, Ubiquitin Ligase
Artikel Pendahuluan Pengaruh Modifikasi Ubiquitin The Ubiquitin-Proteosom Pathway Mekanisme Katalitik
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Overview…
Sejarah 1975 pertama kali diidentifikasi Ditemukan berat molekul Belum diketahui fungsi secara umum
Perkembangan Penelitian Isolasi Pemurnian Karakterisasi
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Overview…(2)
Definisi Ubiquitin Ubiquitin Ligase (6.3.2.19)
Struktur
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Overview…(3)
Peran Ubiquitin Ligase Ubiquitilation system
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Overview…(4) Peran Ubiquitin Ligase
Proses Antigen Apoptosis Biogenesis organel Siklus sel Transkipsi DNA Diferensiasi Respon immun dan imflamasi Infeksi virus Biogenesis ribosom, dan lain-lain.
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Overview…(4)
Domain Ubiquitin Ligase
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Artikel…
Judul:Getting into position : the catalytic
mechanisms of protein ubiquitylation
*Lori A Passmore dan David Barford*Section of structural Biology, The Insitut of Cancer
Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK
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Artikel…(2)
Pendahuluan Latar Belakang Tujuan
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Artikel…(3)
Pengaruh Modifikasi Ubiquitin
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Artikel…(4)
The Ubiquitin-Proteosom Pathway
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Artikel…(5)
Mekanisme Katalitik E1, enzim ubiquitin pengaktifasi
Reaksi yang terjadi:ATP+ubiquitin+lysine ↔AMP
+diphosphate+protein N-ubiquityllysine E2, enzim ubiquitin terkonjugasi
Pada tahap ini, terjadi proses transfer ubiquitin.
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Artikel…(6) Mekanisme Katalitik
Proses Transfer:
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Artikel…(7)
Mekanisme Katalitik E3, Ubiquitin Ligase
E3 HECT Ubiquitin Ligase E3 RING Ubiquitin Ligase
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Artikel…(8)
E3 HECT Ubiquitin Ligase
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Artikel…(9)
E3 RING Ubiquitin Ligase
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Artikel…(10) Reaksi Katalisa Ubiquitin dan Asetilasi
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Sekian…
Wassalamualaikum…