z a cd alan chan mp2 'but i don't want to go among mad people,' said alice. 'oh,...
TRANSCRIPT
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Alan Chan
MP2
'But I don't want to go among mad people,' said Alice. 'Oh, you can't help that,' said the cat. 'We're all mad here.'Lewis Carroll
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HPI: you are on cardiology call on a quiet night. You are called about a 54 yo WF s/p orthotopic heart txp doing fairly well post op. He is on immunosuppressant therapy. He has had nausea dry heaving x2 d, currently mild fever to 100.8, and malaise x2 d.
Chief Complaint: Nausea
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Medications• NovoLog and Lantus insulin • CaCO3 1250 mg b.i.d.• Epogen 10,000 units MWF• Vitamin D 50,000 units MTh• CellCept 1000 mg b.i.d.• Protonix 40 mg b.i.d.• Paxil 10 mg daily.• Pravastatin 20 mg daily.• Tacrolimus 2 mg b.i.d.• Prednisone 10 mg qday• Valcyte 450 mg daily.• Cipro 250 mg q12
Allergies NKDA
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PMH: POD 22 OHT for nonischemic cardiomyopathy with relatively no post op complications, HTN, DM
PSurgH: no others
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VS: Temp 100.8, Resp 16, BP 134/68, Pulse 68
Significant findings….
General: NAD obese male
Skin: 2+ pitting edema – not new; stage II wound on his coccyx, no drainage, mild TTP
HEENT: wnl
Neck: large neck
Chest: CTA bilat
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CVS: rrr
Abd: lg pannus, BS present, benign
Ext: full ROM, but slow due to some stiffness
Neuro: wnl
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Differential Diagnosis
CC: FeverHPI: 54 yo s/p OHT, with
some mild nausea, fever, arthralgia
PMH: DM, HTN
PE Findings
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Laboratory Data
CBCBMPUrinalysisCardiac EnzymesLiver Function Tests CoagulationEndocrinologySerology Immunologic StudiesOther SerologyBody Fluid AnalysisCytologyPathology
MicrobiologyCXREKGUltrasoundCT ScanMRI2-D EchoOther Studies Other Imaging
Clinical CourseDifferential DiagnosisDiscussion
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Urine Analysis
color clear yellow
sp gr 1.020
pH 5
Hgb sm
ketone neg
glu neg
prot 30
LE pos
nitrite neg
urobil neg
bili neg
Microscopic
21-40 wbc
1-5 rbc
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Liver Function Tests -wnl
AST XX (15-41)
ALT XX (7-35)
Alk Phos XXX (32-91)
Albumin X.X (3.5-4.8)
T Bilirubin X.X (0.3-1.2)
D Bilirubin X.X (0.1-0.5)
I Bilirubin X.X (0-0.7)
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CXR
• IMPRESSION: • 1. Increasing left lower lobe airspace disease.
Stable right basilar• subsegmental atelectasis.• 2. Stable bilateral pleural effusions.• 3. Stable marked cardiomegaly.
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Clinical Course
• You find out that he had mild fever the other day and was pan cultured. He was started on avelox and then changed to cipro after sensitivities of organisms.
• You suspect AIN and started him on higher dose steroids with continued taper
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Acute Interstitial Nephritis
• Immune mediated tubulo-interstitial injury
• Usu abrupt • Infection – bacteria (Corynebacterium diphtheria,
legionella, staph/strep, yersinia), viral (CMV, EBV, HSV, hep C, HIV), other (leptospira)
• Immune – acute rejection of kidney, GNs, vasculitis, SLE
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Discussion
• Drug induced, but not necessarily dose related
• Abx – cephalosporins, cipro and other quinolones, PCNs, rifampin, sulfonamidees
• Most NSAIDs• Diuretics – lasix, thiazides, triamterene• Misc – allopurinol, cocaine
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Presentation
• Nonspecific s/s• Fever (27%)• Skin rash – nonspecific diffuse (15%)• Arthralgia • Above triad present 5-10% in practice, but 80% on
the boards• Malaise• Nausea +/- vomiting• Eosinophilia (23%)• Flank pain
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PP
• Inflammatory cells in interstitium – edema, but vessels and glomeruli ok
• Fibrosis later – either diffuse or patchy, from cortex out to medullocorticol jxn
• Mononuclear and T lymphocytes, with plasma cells and eosinophils
• NSAIDs – a/w minimal change disease• Antigen driven – T cell mediated hypersensitivity and
cytotoxic T cell injury
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Dx
• Gold std bx – but not typically done
• Urine eos – in mid 80s, thought Hansel stain more sensitive than Wright’s stain. Recent studies show not very good test
• PPV 38%, sens 40%
• Imaging – U/S – no specific findings; Gallium 67 – may only be useful to tell ATN from AIN
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Labs
• Older individuals may have mild proteinuria (usu < 1 g/day)
• Signs of tubulointerstitial damage – like RTA
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Tx
• Stop offending agent or treat the infection• Typically quick recovery, NSAIDs may take up to
18months• Steroids – no trials support use. Small studies have
shown faster diuresis and improvement in Cr; others have had conflicting data (IC evidence)
• Can try Cytoxan if steroids don’t work in 2-3 wk• Use slow steroid taper of your choice if seems to
work.
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Other syndromes that mimic
• Analgesic induced, toxin induced, sarcoidosis, chronic IN, tubulointerstitial nephritis uveitis
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MKSAP – nephro #44
• A 44 yo man with a history of nephrolithiasis requests nonpharmaceutical interventions for stone prevention. His last symptomatic kidney stone was 2 years ago. He does not recall the exact type of stone that he formed but believes that it contained calcium. Previous laboratory studies have showed normal renal function and normal levels of calcium, phosphorus, and uric acid. A plain abdominal radiograph performed 1 year ago revealed no genitourinary calcifications. He does not have a family history of nephrolithiasis wishes to reduce his chances of developing further kidney stones.
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Discussion
• In addition to increasing fluid intake to >2 L/d, which of the following is the best initial therapy for this patient?
• A Increase dietary calcium intake• B Decrease dietary sources of citrate• C Increase dietary animal protein intake• D Increase dietary sodium intake
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A – more calcium
• Increasing calcium intake decreases the risk for calcium oxalate stones because calcium binds to gastrointestinal sources of oxalate and therefore prevents absorption.
• Dietary modifications such as decreasing animal protein intake, decreasing sodium intake, and increasing citrate can reduce the risk for recurrent kidney stones without additional medical therapy.