zeneca vol ii 06-27-1995 part 2 - united states environmental … · 2014-12-02 · pac900-05/02...

----

PAC900-05/02

PERCHLOROETHYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL ANJMAL DATA SUPPLEMENT

APPENDJX l2B PATHOLCX;Y - FO ANJMAL GENERATION

NO: 145 SEX: M toSE: 1000 Pf111 ON STUDY: 129 days (19 >.ks l TERMINAL

MACROPATilOLCX;Y

Killed by Fluothane

THE FOlLOWING TISSUES WERE SUEMITI'ED

EPIDIDYMIS ; KIDNEY ; LIVER ; PITUITARY GLIIND ; PROSTATE GLIIND ; SEMINAL VESICLE ; TESTIS

NO ABNORMALITIES wERE SEEN IN THE ANJMAL

MICROPATilOLCX;Y

...... '""' r -o .., 0 ....,"" TISSUE CHECK: TOTAL EXAMINED NOT EXAM MISSING NAD

PROTOCOL REQUIRED 2 2 0 0 1 NOT PROTOCOL (SUEMITI'ED) 5 0 5 0 0

(NOT SUEMITI'ED) 0 0 0 0 00>

"w

THE FOlLOWING TISSUES ~~ MARKED NAD

LIVER

THE FOLLO\o/ING MICROSCOPIC OBSERVATIONS v/ERE MADE

KIDNEY Chronic progressive glarerulonephropathy : (llliniJMll Increase :in nuclear plearorphlsm : (Illi.n.lnal l

-------------------------------------------------------END OF ANJMAL---------------------------------------------------------------

PAC900-05/02

PERC!ILOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL ANlliAL DATA SUPPLEMENT

APPENDIX l2B PATHOLOGY - FO GENERATION

AliD1AL NO: 146 SEX: M OOSE: 1000 Pfll1 ON STUDY: 129 days (19 <k:s) TERMINAL

MACROPATHOLOGY

Killed by Fluothane ; No live pups recorded on day 1 following any mating.

THE FDWJ\.JING TISSUES 'WERE SUEMITTED

EPIDIDYMIS ; lG1JNEY ; LIVER ; PITUITARY GLANO ; PROSTATE GLANO ; SEMINAL VESICLE : TESTIS

NO ABNOllM!\LITIES 'WERE SEEN IN THE AliD1AL

MICROPATHOLOGY

n -j

......., r

...... ... 0 -------------.0

" TISSUE CHECK: TOTAL EXAMINED NOT EXAM MISSING NAD

PROTCCOL REQUIRED 2 2 0 0 0 NOT PROTCCOL (SUEMITTED)

(NOT SUEMITTED) 5 0

4 0

1 0

0 0

40"" "...

THE FDWJ\.JING TISSUES 'WERE MARKED NAD

EPIDIDYMIS ; PROSTATE GLANO ; SEMINAL VESICLE ; TESTIS

THE FDWJ\oJING MICROSCOPIC OBSERVATIONS 'WERE MADE

lG1JNEY Chronic progressive glCIJErulooephropathy : (minimal)Increase :in nuclear plearorphism : (minimal)

LIVER Hepatitis ' (slight ; nultifocal)

-------------------------------------------------------END OF A!ID!AL---------------------------------------------------------------

~

PAC900-05/ 02

PERCHLOROETHYLENE: MIJLTIGENERATION lliHALATION STUDY IN THE RAT

INDIVIDUi\L ANIMAL DATA SUPPLEMENT

APPENDIX 12B

PATHOLOGY - FO GENERATION ANIMAL NO: 147 SEX: M IXJSE: 1000 ppn ON STUDY: 129 days (19 wks l TERMINAL

MACRoPATHQu:x:;y

Killed by Fluothane ; No live pups recorded on day 1 following any oot:ing.

THE FOLLO\IDIG TISSUES WERE SUPMITI'ED

EPIDIDYMIS ; KIDNEY ; LIVER : PITUITARY GUND ; PROSTATE GUND ; SEMrnAL VESICLE ; TESTIS

NO ABNORMALITIES Jo/ERE SEEN IN THE ANIMAL

MICROPATHOLOGY

n ....; r-... -..." 0 ""' 'D.._,

TISSUE CHECK: TOTAL EXAMINED NOT EXPM MISSING NAD

PROTOOOL REQUIRED NOT PROTOOOL (SUPMITI'EDl

(NOT SUPMITI'ED)

z 5 0

2 4 0

0 1 0

0 0 0

1 40 0"\..._,

CJ1

THE FOLLO\IDIG TISSUES WERE MARKED NAD

EPIDIDYMIS ; LIVER ; PROSTATE GUND ; SEMrnAL VESICLE ; TESTIS

THE FOLLO\IDIG MICROSCOPIC OBSERVATIONS Jo/ERE MADE

KIDNEY Unilateral hydronephrosis : (slight) Increase in nuclear pleaoorphism : (minimall

-------------------------------------------------------END OF ANIMAL---------------------------------------------------------------

PAC900-05/02


INDIVIDUAL ANIMAL DATA SUPPLEMENT

APPENDIX 12B

PATHOLOGY - FO GENERATION ANIMAL NO: 148 SEX: M lXJSE: 1000 Jl!lll ON STUDY: 129 days (19 M<:s) TERMINAL

MACROPATHOLcm'

Killed by Fluothane

THE FOLLOWING TISSUES WERE SUEMITTED

EPIDIDYMIS ; KIDNEY ; LIVER ; PITUITARY GLAND ; PROSTATE GLAND ; SEMINAL VESICLE : TESTIS

NO ABNORMALITIES WERE SEEN IN THE ANIMAL

MICROPATHOLOGY

n -< r.._ -o.._.., 0

"'....., TISSUE CHECK: TOTAL EXAMINED NOT EXAM MISSING NAD

PROTOCOL REQUIRED NOT PROTOCOL CSUEMITTED)

(NOT SUEMITTED)

2 5 0

2 0 0

0 5 0

0 0 0

1 0 0

0'> ....., 0'>

THE FOLLffiilllG TISSUES vlERE MARKED NAD

LIVER

THE FOLLOWING MICROSCOPIC OBSERVATIONS WERE MADE

KIDNEY Chronic progressive glcnerulone.l?hropathy : (minimal ; unilateral) Unilateral liydranephr9sis : {slight)Increase in nuclear plearorphism : {minimal)

-------------------------------------------------------EI<D OF ANIMAL---------------------------------------------------------------

~~

PAC900-05/02

PERCHLORDETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL ANlMAL DATA SUPPLEMENT

APPENDIX 12B

PATHOLOGY - FO GENERATION ANlMAL NO: 149 SEX: M rosE: 1000 Pfill ON STUDY: 129 days (19 wks l TERMINAL

MACROPATHOLCGY

Killed by Fluothane

THE FOLLOWING TISSUES \o/ERE SUEMITI'EO

EPIDIDYMIS ; KIDNEY ; LIVER ; PITUITARY GLAND ; PROSTATE GLAND ; SEMI.Nl\L VESICLE ; TESTIS

THE FOLLOOING MACROSCOPIC OBSERVATIONS wERE MADE

KIDNEY Pelvic dilatation : (right ; mxlerate)

NO ABNORMALITIES \o/ERE SEEN IN THE REMAINING TISSUES

MICROPATHOLOGY

"--l, ., ....._ ....._

0 """ '-0..._,

0) ...... ...... TISSUE CHECK: TCTAL EXP.MINED NOT EXAM MISSING NAD

PROTOCOL REQUIRED 2 2 0 0 1 NOT PROTOCOL (SUEMITI'EO)

(NOT SUEMITI'EO) 5 0

0 0

5 0

0 0

0 0

THE FOLLO\o/ING TISSUES \o/ERE MARKED NAD

LIVER

THE FOLLO\f.ING MICROSCOPIC OBSERVATIONS \o/ERE MADE

KIDNEY Chronic progressive glCIIErulan€jlhropathy : (IIlir.imlllUnilateral liydranephi:osis : (nrilerate) Increase in nuclear plearorphisrn : (IIlir.imll)

-------------------------------------------------------END OF ANJMAL---------------------------------------------------------------

------

·-·----· ···-- ·- ·-·

PAC900-05 I02

PERCHLOROETHYLENE: MIJLTIGENERATION INHAI.ATION STUDY IN THE RAT

INDIVIDUAL ANll1AL DATA SUPPLEMENT

APPENDIX l2B

PATHOLOGY - FO GENERATIONANll1AL NO: 150 SEX: M rxJSE: 1000 ppn ON STUDY: 129 days (19 wks) TERMINAL

MACROPATHOLOGY

Killed by Fluothane

THE FOLLOWING TISSUES WERE SUEMITTEO

EPIDIDYMIS ; KIDNEY ; LIVER ; PITUITARY GLAND ; PROSTATE GLAND ; SEMINAL VESICLE TESTIS

NO ABNORMALITIES WERE SEEN IN THE ANll1AL

MICROPATHOLOGY

n -I,-o .., 0 <0 .....,

TISSUE CHECK: TOTAL EX~'MINED NOT EXAM MISSING NAD

PROTOCOL REQUIRED NOT PROTOCOL CSUEMITTEO)

(NOT SUEMITTEO)

2 5 0

2 0 0

0 5 0

0 0 0

1 0 0

0\ ....., OJ

THE FOU.OHING TISSUES WERE MARKED NAD

LIVER

THE FOU.OV1ING MICROSCOPIC OBSERVATIONS WERE !-fADE

KIDNEY Chronic progressive glCIIErulonephropathy : <minimal)Increase in nuclear plearorphism : (minimal)

-------------------------------------------------------EI<D OF ANTI1AL---------------------------------------------------------------

,-,

PAC900-05/02

PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL AN]}lAL DATA SUPPLEMENT

APPENDIX 12.B

PATHOLCGY - FO GENERATION AN]}lAL NO: 151 SEX: M I:OSE: 1000 ppn ON STUDY: 130 days {19 wksJ TERMINAL

MACROPATHOLCGY

Killed by Fluothane

THE FOWJWING TISSUES \.JERE SUPMITI'ED

EPIDID!MIS ; KIDNEY ; LIVER ; PITUITARY GI..!IND ; PROSTATE GI..!IND ; SEMINAL VESICLE ; TESTIS

NO ABNORMALITIES wERE SEEN IN THE AN]}lAL

MICROPATHOLCGY

n --i r ......., ...... 0""' " '"" TISSUE CHECK: TOTAL EX!>MINED NOT EXAM MISSING NAD

PROTOCOL REQUIRED 2 2 0 0 1 NOT PROTOCOL {SUPMITI'ED) 5 4 1 0 3

{NOT SUPMITI'ED) 0 0 0 0 0 "' " '"" No live pups following any mating.

THE FOWJWING TISSUES \.JERE MARKED NAD

EPIDID!MIS ; LIVER ; SEMINAL VESICLE ; TESTIS

THE FOWJWING MICROSCOPIC OBSERVATIONS WERE MADE

KIDNEY Increase in nuclear plearorphlsm : {rnin:imal)

PROSTATE GI..!IND Prostatitis : {minimall

-------------------------------------------------------~ OF AN]}!AL---------------------------------------------------------------

---

PAC900-05/02



APPENDIX 12B

PATHOLCGY - FO GENERATION ANlMAL NO: 152 SEX: M IXJSE: 1000 ppn ON STUDY: 130 days (19 wks) TEl1MINAL

MACROPATHOLCGY

Killed by Fluothane

THE FOLLOWING TISSUES WERE SUIMITTED

EPIDIDYMIS ; KIDNEY ; LIVER ; PITUITARY GLAND ; PROSTATE GLAND ; SEMINAL VESICLE ; TESTIS

THE FOLLOWING MACROSCOPIC OBSERVATIONS WERE MADE

ORAL CAVITY Teeth broken : upper incisors.

NO ABNORMALITIES WERE SEEN IN THE REMAINING TISSUES

MICROPATHOLCGY

n -< r ....... "'0 ....... ""' 0

......""

():)"' 0 TISSUE CHECK: TOTAL EXAMINED NOT EXAM MISSING NAD

PROTOCOL REQUIRED 2 2 0 0 1 NOT PROTOCOL (SUIMITTED) 5 0 5 0 0

(NOT SUIMITTED) 1 0 1 0 0

THE FOlLOWING TISSUES WERE MARKED NAD

LIVER


KIDNEY Chronic progressive glarerulcn:ephropat;llY, : cm:in:inal ; unilateral)Increase :in nuclear plearorpbiSlll : (minlmal)

-------------------------------------------------------END OF ANJMAL---------------------------------------------------------------

PP..C900-05/02


INDIVIDUAL ANl11AL DATA SUPPLEMENT

APPENDIX 12B

PATHOLOGY - FO GENERATION ANl11AL NO: 153 SEX: M IXJSE: 1000 PJlll ON STUDY: 130 days (19 wks) TERMINAL

MACROPATHOLOGY

Killed by Fluothane

THE FOLLOWING TISSUES WERE SUEMITI'ED

EPIDID'!MIS ; KIDNEY : LIVER : PITUITARY GLAND ; PROSTATE GLAND : SEMINAL VESICLE : TESTIS

NO ABNORMALITIES WERE SEEN IN THE AN.IMAL

MICROPATHOLOGY

n ..... r --o -..,. 0

"' ...... TISSUE CHECK: TOTAL EXAMINED NOT EXAM MISSING NAD


(NOT SUEMITI'EDl 0 0 0 0 0 "' co-THE FOWJHING TISSUES \o/ERE MARiiED NAD

LIVER

THE FOLLOHING MICROSCOPIC OBSERVATIONS WERE MADE

KIDNEY Unilateral hydronephrosis : (slight) Increase in nuclear plearorphism : (minimall

-------------------------------------------------------END OF ANJ11AL---------------------------------------------------------------

--

PAC900-05/02


=IVIDUAL ANIMAL DATA SUPPLEMENT

APPENDIX 12B

PATHOLOGY - FO GENERATION ANIMAL NO: 154 SEX: M COSE: 1000 ppn ON STUDY: 130 days (19 wks) TERMINAL

MACROPATHOLOGY

Killed by Fluothane ; No live pups recordad on day 1 follCMing any rmting.

THE FOLLOWING TISSUES WERE SUEMITTEO



MICROPATHOLOGY

n ..... r -.., -<> 0 lD....,

TISSUE CHECK: TOTAL EXliMINEO NOT EXAM MISSING NAD

PROTOCOL REQUIBED NOT PROTOCOL (SUEMITTEO)

(NOT SUEMITTEO)

2 5 0

2 4 0

0 1 0

0 0 0

1 3 0CD "'

N

THE FOLLOWING TISSUES WERE MARKED NAD

EPIDIDYMIS ; LIVER ; SEMINAL VESICLE ; TESTIS


KIDNEY Increase in nuclear ple(lllJrphism : (mlnim9.l)

PROSTATE GLAND Prostatitis : (mlnim9.l)

-------------------------------------------------------EI<D OF ANIMAL---------------------------------------------------------------

~'

PliC900-05/ 02



APPENDIX l2B PATHOLOGY - FO ANJMAL GENERATION

NO: 155 SEX: M lXlSE: 1000 ppn ON STUDY: 131 days (19 wks I TERMINAL

MACROPATHOLOGY

Killed by Fluothane

THE FOlLOWING TISSUES \>JERE SUOOTTED

EPIDIDYMIS ; KIDNEY : LIVER : PITUITARY C.J..AND : PROSTATE GLAND : SEMINAL VESICLE : TESTIS

NO ABNOFMALITIES \>JERE SEEN IN THE ANJMAL

MICROPATHOLOGY

n -i r..._ -o..._ -"" 0 <.0 ___,

TISSUE CHECK: TCTAL EXAMINED NOT EXJIM MISSING NAD

PROTCCCL REQUIRED 2 2 0 0 1 NOT PROTCX::OL (SUOOTTEDl 5 0 5 0 0

(NOT SUOOTTEDl 0 0 0 0 0 a-, CD w

THE FOI.LO\o/ING TISSUES HERE MARKED NAD

LIVER

THE FOlLOWING MICROSCOPIC OBSERVATIONS HERE MADE

KIDNEY Increase in nuclear pleCIIDrphism : (m.lnimal. l

-------------------------------------------------------END OF ANJMAL---------------------------------------------------------------

PAC900-05/02


INDIVIDUAL ANIM'\1 DATA SUPPLEMENT

APPENDIX 12B

PATHOLCGY - FO GENERATION ANIMAL NO: 156 SEX: M IXJSE: 1000 ppn ON STUDY: 131 days (19 wks) TERMINAL

MACROPATHOLCGY

Killed by Fluothane

THE FOWJWJNG TISSUES WERE SUEMITTED

EPIDIDYMIS ; KillNEY ; LIVER ; PITUITARY GLAND ; PROSTATE GLAND ; SEMINAL VESICLE ; TESTIS

THE FOWJWJNG MACROSCOPIC OBSERVATIONS WERE MADE

KillNEYPelvic dilatation : £right ; mxlerate)

NO ABNOBMALITIES WERE SEEN IN THE REMAINING TISSUES

MICROPATilOLCGY

("") ...... r .._.., .._.,. 0 ....,""

0> co..,. TISSUE CHECK: TOTAL EXAMINED NOT EXAM MISSJNG NAD

PROTOCOL llEQUIBED 2 2 0 0 1 NOT PROTOCOL CSUEMITTED)

(NOT SUEMITTED) 5 0

0 0

5 0

0 0

0 0

THE FOWJWJNG TISSUES WERE MARI<ED NAD

LIVER

THE FOWJWJNG MICROSCOPIC OBSERVATIONS WERE MADE

KillNEY Chronic progressive glaneruloneQh.ropathy : (rnln.imli ; tmilateral) Unilateral liydronephrosis : (mxlerate) Transitional epithelial hyperplasia : (slight ; nultifocal ; tmilateral)

~

PAC900-05/02

PERCHLORDETHYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT


APPENDIX 12B

ANJMAL PATHOLOGY - FO GENERATIONNO: 156 SEX: M IXJSE: 1000 ppn ON STUDY: 131 days (19 wksl TERMINAL

MICROPATHOLOGY

OONTINUATION - THE FOLLOWING MICROSOOPIC OBSERVATIONS WERE MADE

KIDNEY Increase :in nuclear plearorphism : (m:in.imal)

-------------------------------------------------------END OF ANJMAL----------------------------------------------------------------I n r...._ -c...._ -"' 0 >D

"

(X) "' U1

PAC900-05/02

PERCHLORDETHYLENE: MULTIGENERATION IN!!Al.ATION STUDY IN THE RAT


APPEND]]( 12B

PATHOLCGY - FO GENERATION ANlMAL NO: 157 SEX: M OOSE: 1000 Pfill ON STUDY: 131 days (19 t-.>ks) TERMINAL

MACROPATHOLCGY

Killed by Fluothane

THE FOLLOOING TISSUES 'WERE SUEMITTED


THE FOLLOWING MACROSCOPIC OBSERVATIONS 'WERE MADE

KIDNEY Pelvic dilatation : tright ; mxlerate)

NO ABNORMALITIES 'WERE SEEN IN THE REMAINING TISSUES

MICROPATHOLOGY

--!'"' , , ..._ ..._ 0""' <.0

"

0> ():) 0> TISSUE CHECK: TOTAL EXAMINED NOT EX.AM MISSING NAD

PROTOCOL REQUIRED 2 2 0 0 1 NOT PROTOCOL (SU!MITTED) 5 0 5 0 0

(NOT SUEMITTED) 0 0 0 0 0

THE FOLLOIVING TISSUES WERE MARKED NAD

LIVER

THE FOLLOIVING MICROSCOPIC OBSERVATIONS 'WERE MADE

KIDNEY Bilateral hydronephrosis : tslight)Tubular basOph.ilii>. : {mlnimal ; llllltliocal)Increase in nuclear pleamrphism : (mlnimal)

-------------------------------------------------------E!<D OF ANJMAL---------------------------------------------------------------~.

--

PAC900-05/02

PERCHLORDETHYLENE: MULTIGENERATION INHAlATION STUDY IN THE RAT


APPENDIX 12B

PATHOLOGY - FO ANJMAL GENERATIONNO: 158 SEX: M !XlSE: 1000 PJlll ON STUDY: 131 days (19 wks) TERMINAL

M.J\CROPATHOLOGY

Killed by Fluothane

THE FOWJHING TISSUES HERE SUEMITTED

EPIDIDYMIS : KIDNEY ; LIVER ; PITUITARY GLAND ; PROSTATE GLAND ; SEMINAL VESICLE : TESTIS

NO ABNORMALITIES wERE SEEN IN THE ANJMAL

M.ICROPATHOLOGY

-< '""' r -" -"" 0 <0....,

TISSUE CHECK: TOTAL EXl\t1lliED NOT EXAM M.ISSING NAD

PROTOCOL REQUIRED 2 2 0 0 1 NOT PROTOCOL (SUEMITTED)

(NOT SUEMITTEDl 5 0

0 0

5 0

0 0

00

0"> co .__,

THE FOLLO\.JING TISSUES HERE l'l\RKED NAD

LIVER

THE FOLLOHING M.ICROSCOPIC OBSERVATIONS WERE MADE

KIDNEY Unilateral hydronephrosis : (slight) Interstitial nephritis : (slight ; focal ; unilateral) area of inflB!!IMtion and tubular dilatation. Increase in nuclear pleamrphisrn : (minimall

-------------------------------------------------------END OF ANJMAL---------------------------------------------------------------

PAC900-05/02

PERCHLORDETHYLENE: MllLTIGENERATION INHALATION STUDY IN THE RAT


APPENDIX 12B

ANJMAL PATHOLCGY - FO GENERATIONNO: 159 SEX: M I:OSE: 1000 ppn ON STUDY: 131 days (19 M<s) TERMINAL

MACRDPATHOLCGY

Killed by Fluothane

THE FOLLOWING TISSUES WERE SUR1ITI'ED

EPIDIDYMIS ; IGDNEY ; LIVER ; PITUITARY GLAND ; PROSTA'IE GLAND ; SEMINAL VESICLE ; '!ESTIS

NO ABNORMALITIES WERE SEEN IN THE ANJMAL

MICBDPATHOLCGY

-1 '"' ..._ ..._., r

""'0 <D .....,

TISSUE CHECK: TOTAL EXAMINED NOT EXAM MISSING NAD

PROTOCOL BEQUIRED 2 2 a 0 1 NOT PROTOCOL (SUR1ITI'ED)

(NOT SUR1ITI'ED) 5 0

0 0

5 0

0 0

00 0"> co

co


LIVER

THE FOLLOWING MICBDSCOPIC OBSERVATIONS WERE MADE

KIDNEY Chronic progressive glarerulonephropathy : <mirumal)Increase Jn nuclear plearorphism : (minimal)

-------------------------------------------------------EiiD OF ANJMAL---------------------------------------------------------------

~ .~

PAC900-05/02


INDIVIJJUAL ANIMAL DATA SUPPLEMENT

APPENDIX l2B

PATHOLCX;Y - FO GENERATION ANIMAL NO: 160 SEX: M DJSE: 1000 pj:IIl ON STUDY: 131 days ( 19 wi<:s I TERMINAL

MACROPATHOLCX;Y

Killed by Fluothane

THE FOlLOWING TISSUES l>IERE SUEMITTED

EPIDIDYMIS ; KIDNEY : LIVER : PITUITARY GLANO ; PROSTATE GLANO : SEMINAL VESICLE : TESTIS


MICROPATHOLOGY

('"") --i r.._ .._..," 0 .__, "' TISSUE CHECK: TOTAL EXllMINEil NOT EXAM MISSING NAD

PROTOCOL REQUIRED 2 2 0 0 1 NOT PROTOCOL (SUEMITTE!Jl

(NOT SUEMITTE!Jl 5 0

0 0

5 0

0 0

00"' O:J

"' THE FOLLOHING TISSUES WERE MARKED NAD

LIVER

THE FO!LOHING MICROSCOPIC OBSERVATIONS lo/ERE MADE

KIDNEY Chronic progressive glarerulonephropathy : (rnin.inal : unilateral)Increase in nuclear pleamrphism : (rnin.inal)

-------------------------------------------------------END OF ANIMAL---------------------------------------------------------------

PAC900-05/02

PERCHLOROETHYLENE: MilLTIGENERATION INHALATION STUDY IN THE RAT


APPENDIX 12B

PATHOLOGY - FO GENERATION ANJMtU.. NO: 161 SEX: M roSE: 1000 ppn ON STUDY: 131 days (19 wks) TERMINAL

MACROPATHOLOGY

Killed by Fluothane

THE FOlLOWING TISSUES "WERE SUPMITTED


NO ABNORMALITIES "WERE SEEN IN THE ANIMAL

MICROPATHOLOGY

n --i, ........, ...... 0""' lO..._,

TISSUE CHECK: TOTAL EXAMINED NOT EXAM MISSID; MAD

PROTOCOL BEQUIBED 2 2 0 0 0 NOT PROTOCOL (SUPMITTED) 5 0 5 0 0

(NOT SUPMITTED) 0 0 0 0 0lO "" 0

THE FOlLOWING MICROSCOPIC OBSERVATIONS viERE MADE

KIDNEY Chronic progressive glarerulonephropathy : (nrinimal)Increase in nuclear pleamrphism : {minimal)

LIVER Hepatitis : (nrinimal ; focal)

-------------------------------------------------------END OF ANIMAL---------------------------------------------------------------

~ ~'

PAC900-05/02


INDIVIDlTAL ANIMAL DATA SUPPLEMENT APPENDIX 12B

PATHOLOGY - FO ANIMAL

GENERATIONNO: 162 SEX: M DJSE: 1000 ppn ON STUDY: 131 days (19 wks) TERMINAL

M.t,CROPATHOLOGY

Killed by Fluothane

THE FOLLOWING TISSUES \>/ERE SUEMITTED

EPIDIDYMIS : KIDNEY ; LIVER ; PITUITARY GLAND : PROSTATE GLAND ; SEMINAL VESICLE ; TESTIS : URINARY BLADDER

THE FOLLOWING MACROSCOPIC OBSERVATIONS V1ERE MADE

URINARY BLADDERDiscoloured urine : red.

NO ABNORMALITIES wERE SEEN IN THE REMAINING TISSUES

MICROPATHOLOGY

n -i r -... -o -....., 0

...... ""

~

....."" TISSUE CHECK: TOTAL EXt'MINED NOT EXEIM MISSING NAD

PROTOCOL REQUIRED NOT PROTOCOL (SUEMITTEDl

(NOT SUEMITTED)

2 6 0

2 0 0

0 6 0

0 0 0

1 0 0

THE FOLLOWING TISSUES 1-/ERE MARKED NAD

LIVER

THE FOLLOWING MICROSCOPIC OBSERVATIONS V1ERE MADE

KIDNEY Unilateral hydronephrosis : (sligntJ Increase in =lear plearorphism : (minimall

-------------------------------------------------------END OF ANIMAL---------------------------------------------------------------

PAC900-05/02

PERCHLOROETHYLENE: MDLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL ANIM.'\L DATA SUPPLEMENT

APPENDIX 12B

PATHOLOGY - FO GENERATIONANlM!\1.. NO: 163 SEX: M OOSE: 1000 pjlll ON STUDY: 131 days (19 wks) TERMlNAL

MACROPATHOLOGY

Killed by Fluothane ; No live pups recorded on day 1 following any mat:ing.


EPIDIDYMIS ; EYE ; KIDNEY ; LIVER ; PITIJITARY GLAND ; PROSTATE GLAND ; SEMINAL VESIClE ; TESTIS

THE FOlLOWING MACROSCOPIC OBSERVATIONS WERE MADE

EYEEyelid/s sta:ined : (right)


MICROPATHOLOGY

('"')__, ,...._., .._ 0 ""' "" "

en N TISSUE CHECK: TOTAL EXAMINED NOT EXAM MISSING NAD

PROTOCOL REQUIREJ)NOT PROTOCOL (SUEMITTED)

(NOT SUEMITTED)

2 6 0

2 4 0

0 2 0

0 0 0

0 4 0

""


EPIDIDYMIS ; PROSTATE GLAND ; SEMINAL VESIClE ; TESTIS

THE FOlLOWING MICROSCOPIC OBSERVATIONS WERE MADE

KIDNEY Chronic progressive glCllErulonephropathy : cnrlnimal ; unilateral)Increase :in nuclear pleCI!Drphism : (minimal)

~ ~

PAC900-05/02


INDIVIDUAL J\NIMI\L DATA SUPPLEl1ENT

APPENDIX 12B

J\NIMI\L PATHOLOGY - FO GENERATION NO: 163 SEX: M OOSE: 1000 ppn ON STUDY: 131 days (19 wi<:s J TERMINAL

MICROPATHOLOGY

CONTINUATION - THE FOLLOWING MICROSCOPIC OBSERVATIONS WERE MADE

LIVER Mononuclear cell infiltration : (m.in.imll ; focal)

-------------------------------------------------------END OF J\NIMI\L---------------------------------------------------------------n -< r ....... "' .......

""' 0 <.0....,

"' <.0 w

PAC900-05/02

PERCHLOROE'I'HYLENE: MULTIGENERATION INHAlATION STUDY IN THE RAT

INOIVIDUAL ANlMAL DATA SUPPLEMENT

APPENDIX 12B PATHOLOGY - FO GENERATION

ANlMAL NO: 164 SEX: M DJSE: 1000 ppn ON STUDY: 131 days (19 M<:s) TERMINAL

MACROPATHOLOGY

Killed by Fluothane ; No live pups recorded on day 1 following any mating.

THE FOlLOWING TISSUES WERE SUEMJ:TTED

EAR/ ZYMBALS GLIIND ; EPIDIDYMIS ; KIDNEY ; LIVER ; PITUITARY GLIIND ; PROSTATE GLIIND ; SEMINAL VESICLE ; TESTIS


EAR/ZYMBALS GLIINDPinna/ e traumatised : (left) ear tom.


MICROPATHOLOGY

"--< r -"0 -.,. 0

"" "

"' "".,. TISSUE CHECK: TOTAL EX.A.MINEO NOT EX!>M MISSING NAD

PROTOCOL REQUIRED NOT PROTOCOL (SUEMJ:TTED)

(NOT SUEMJ:TTED)

2 6 0

2 4 0

0 2 0

0 0 0

1 4 0

THE FOlLOWING TISSUES WERE MARKEO NAD

EPIDIDYMIS ; LIVER ; PROSTATE GLIIND ; SEMINAL VESICLE ; TESTIS


KIDNEY Chronic progressive g).amrulonephropathy : (mirumal ; unilateral)Increase in nuclear pleamrphism : Cmirumal)

-------------------------------------------------------END OF ANJMAL---------------------------------------------------------------

-

PAC900-05/02


INDIVIDtll\L ANlMAL D.'>.TA SUPPLEMENT

APPENDIX 12B PATHOLOGY - FO GENERATION

ANlMAL NO: 165 SEX: M IXJSE: 1000 ppn ON STUDY: 131 days (19 wks J TERMINAL

MACROPATHOLOGY

Killed by Fluothane

THE FOLLOWTh'G TISSUES WERE SOl'MITI'ED

EPIDIDl:MIS ; KIDNEY ; LIVER ; PITUITARY GLAND ; PROSTATE GLAND ; SEMINAL VESICLE ; TESTIS

NO ABNORMALITIES VIERE SEEN IN THE ANlMAL

MICROPATHOLOGY

n --l,.... ....... -o ....... 0""' ....., "" TISSUE CHECK: TOTAL EX!>MINED NOT EX!>M MISSING NAD

PRDTOCOL REQUIRED 2 2 0 0 1 NOT PROTOCOL (SOl'MITI'ED) 5 0 5 0 0

(NOT SOl'MITI'EDl 0 0 0 0 0 "' ()1 "" THE FOLLO\IDIG TISSUES WERE MARKED NAD

LIVER

THE FOLLO\IDIG MICROSOOPIC OBSERYATIONS WERE MADE

KIDNEY Increase in nuclear plearorphism : (m.inimal)

-------------------------------------------------------END OF ANJMAL---------------------------------------------------------------

PAC900-05/02



APPENDIX 12B

PATHOLOOY - FO GENERATIONANIMAL NO: 166 SEX: M IXlSE: 1000 ppn ON STUDY: 131 days {19 wks) TERMINAL

MACROPATHOLOOY

Killed by Fluothane ; No live pups recorded an day 1 follow:ing any mat:lng.

THE FOLLOWING TISSUES WERE SU!'MITI'ED


THE FOLLO\VING MACROSCOPIC OBSERVATIONS \.JERE MADE

KIDNEY Pelvic dilatation : <right ; nnderate)


MICROPATHOLOOY

"-< r ....... -o ....... 0""' <.0 ......

0> <.0 0> TISSUE CHECK: TOTAL EXliMINED NOT EXAM MISSING NAD

PROTOCOL BEQUIRED 2 2 0 0 1 NOT PROTOCOL (SU!'MITI'ED) 5 4 1 0 4

<NOT SU!'MITI'ED) 0 0 0 0 0

THE FOLLO\VING TISSUES WERE MARKED NAD

EPIDIDYMIS ; LIVER ; PROSTATE GLAND ; SEMINAL VESICLE ; TESTIS

THE FOLLO\VING MICROSCOPIC OBSERVATIONS WERE MADE

KIDNEY Chronic progressive glaneruloneiJ]lropathy : (minimal)Unilateral liydronephi'osis : (ncilerate) Increase :in nuclear plemorphism : (m:lnimal)

-------------------------------------------------------El!D OF ANIMAL---------------------------------------------------------------

~

PAC900-05/02

PERCHLORDETHYLENE: MIJLTIGENERATION INHALATION STUDY IN TilE RAT


APPENDIX l2B PATHOLOGY - FO GENERATION

ANI!1'\L NO: 167 SEX: M D::JSE: 1000 ppn ON STUDY: 131 days (19 14:s) TERMINAL

MACROPATHOLOGY

Killed by Fluothane

TilE FOLLO\iiNG TISSUES WERE SUBMITTED

EPIDIDYMIS ; KIDNEY ; LIVER ; PITUITARY GLAND : PRDSTATE GLAND ; SEMINAL VESICLE ; TESTIS

TilE FOLLO\iiNG MACROSCOPIC OBSERVATIONS WERE MADE

KIDNEYDepressed area/s : cranial aspect, linear, 10mn in length.

NO ABNOBMALITIES WERE SEEN IN TilE REMAINING TISSUES

MICRDPATHOLOGY

r> ...... r--"' ..,.-0 co.._,

CT\ co.._, TISSUE CHECK: TOTAL EXliMINED NOT EXAM MISSING NAD

PROTOCOL REQUIRED: 2 2 0 0 1 NOT PROTOCOL (SUBMITTED): 5 0 5 0 0

(NOT SUBMITTED) : 0 0 0 0 0

TilE FOLLO\iiNG TISSUES WERE MARKED NAD

LIVER

TilE FOLLO\iiNG MICRDSCOPIC OBSERVATIONS WERE MADE

KIDNEY Increase in nuclear plearorphism : (m.in.imal)

-------------------------------------------------------END OF ANlli\1---------------------------------------------------------------

PAC900-05/02

PERCHLOROETHYLENE: MULTIGENERATION INHAlATION STUDY IN THE RAT

INDIVIIJUAL ANIMAL DATA SUPPLEMENT APPENDIX 12B

ANIMAL PATHOLCGY - FO GENERATION NO: 168 SEX: M !XlSE: 1000 ppn ON STUDY: 131 days (19 wks) TERMINAL

MACROPATHOLCGY

Killed by Fluothane


EPIDIDYMIS ; lGJJNEY ; LIVER ; PITUITARY GLAND ; PROSTATE GLAND ; SEMINAL VESICLE ; TESTIS

THE FOLLO\ID!G MACROSCOPIC OBSERVATIONS WERE MADE

lGJJNEYPelvic dilatation : (right ; IIDderate)


MICROPATHOLCGY

("'")

..... ..._ ""0 ..._.., 0 '-0 ......

'-0"" CXl TISSUE CHECK: TOTAL EXAMINEO NOT EX.AM MISSING !lAD


INOT SUEMITI'ED) 0 0 0 0 0

THE FOLLO\ID!G TISSUES WERE MARKED !lAD

LIVER

THE FOLLO\ID!G MICROSCOPIC OBSERVATIONS WERE MADE

lGJJNEY Chronic pr.ogressive glcmm!laneJ!h:ropathy : (mlltimal ; tmilateral)Unilateral. liydronephfosis : ! slight) Increase :in nuclear pleDIIDrphism : (mlltimal)

-------------------------------------------------------END OF ANIMAL---------------------------------------------------------------

PAC900-05/02



APPENDIX l2B

PATHOLOGY - FO GENERATION ANlMAL NO: 169 SEX: F DOSE: 1000 ppn ON STUDY: 135 days (20 wks) TERMINAL

MACROPATHOLOGY

Killed by Fluothane

THE FOLLOWING TISSUES wERE SU!!MITTED

CERVIX : KIJ)NEY ; LIVER ; M/>M1ARY GLAND : OVAPC£ : PITUITARY GLAND : UTERUS ; VAGINA


UTERUSImplantation site/s present : left 4, right 11.


MICROPATHOLOGY

n -I,...... u ........,. 0

..... '""

0">

'"" TISSUE CHECK: TOTAL EXAMINED NOT EXAM MISSING NAD

PRD'ID:XlL REQUIRED 2 2 0 0 1 NOT PRD'ID:XlL (SU!!MITTED l 6 0 6 0 0

(NOT SUl!MITTElll 0 0 0 0 0

'""

THE FOLLOHING TISSUES WERE MARRED NAD

LIVER


KIJ)NEY Unilateral hydronephrosis ; (slight)Pelvic urolithiasis : (minimal ; unilateral)Intratubular microlithiasis : (minimall

---

PAC900-05/ 02

PERCHLOROETHYLENE: MULTIGENERATION INHAI.ATION STUDY IN THE RAT

INDIVIDUAL ANIMAL DATA SUPPLEMENT i\PPENOIX l2B

ANIMAL NO: PATHOLOGY - FO GENERATION 169 SEX: F LOSE: 1000 PJlll ON STUDY: 135 days (20 wks) TEBMINAL

MICROPATHOLOGY

CONTINUATION - THE FOLLOWING MICROSCOPIC OBSERVATIONS WERE MADE

KIDNEY Increase :in nuclear plecnnrphlsm : (nrlnimal)

-------------------------------------------------------ENO OF ANIMAL---------------------------------------------------------------~ 1""" -.,-""' 0 t.D....,

...., 0 0

PAG900-05/02



APPENDIX 12B

PATHOLOGY - FO GENERATION ANlMAL NO: 170 SEX: F !XJSE: 1000 P!IU ON STUDY: 155 days (23 wks) TERMINAL

MACROPATHOLOGY

Killed by Fluothane

THE FOILOHING TISSUES HERE SUI?MITIED

CERVIX : KIDNEY ; LIVER : MllM1ARY G!liND ; OVAPC£ ; PITUITARY G!liND ; tiTERUS ; VAGINA

THE FOLLOHING MACROSCOPIC OBSERVATIONS HERE MADE

UTERUS Implantation site/s present : left 8, right 7 .

NO ABNORMALITIES HERE SEEN IN THE REMAINlNG TISSUES

MICROPATHOLOGY

n -1 r--..,--. ""' 0 co "

"0 ..... TISSUE CHECK: TOTAL EXAMINED NOT EXAM MISSING NAD

PROTOOOL REQUIRED 2 2 0 0 1 NOT PROTOOOL (SUI?MITIEDl 6 0 6 0 0

(NOT SUI?MITIEDl 0 0 0 0 0

THE FOLLOHING TISSUES HERE MARKED NAD

LIVER

THE FOLLOWING MICROSCOPIC OBSERVATIONS HERE MADE

KIIlNEY Intratubular microlithiasis : (Illininal)Increase in nuclear pleCllDrphism : (Illininal l

-------------------------------------------------------END OF ANJMAL---------------------------------------------------------------

--------

PAC900-05/02


INDIVIDUAL liNIMAL DATA SUPPLEMENT

APPENDIX 12B

PATHOLCGY - FO GENERATION liNIMAL NO: 171 SEX: F !XlSE: 1000 PJlll ON STUDY: 151 days (22 <.f.<:s) TERMINAL

MACROPATHOLCGY

Killed by Fluothane

THE FOlLOWING TISSUES 'WERE SUEMITTED

CERVIX ; KIDNEY ; LIVER ; M!\!41ARY GLAND ; OVARY ; PITUITARY GLAND ; UTERUS ; VAGINA

THE FOlLOWING MACROSCOPIC OBSERVATIONS 'WERE MADE

UTERUS Implantation site/s present : left 4, right 9.

NO ABNORMALITIES 'WERE SEEN IN THE REMAINING TISSUES

MICROPATHOLCGY

n__, r.._ .._ -"'

"0

0

...... '"'

...... 0 N TISSUE CHECK: TOTAL EXt\MINED NOT EXJIM MISSING NAD

PROTOCOL REQUIRED: 2 2 0 0 1 NOT PROTOCOL (SUEMITTED) : 6 0 6 0 0

(NOT SUEMITTED) : 0 0 0 0 0

THE FOlLOWING TISSUES 'WERE MARKED NAD

LIVER

THE FOlLOWING MICROSCOPIC OBSERVATIONS 'WERE MADE

KIDNEY Increase .in nuclear pleCillJrphism : un.inimal)

-------------------------------------------------------END OF IINIMAL---------------------------------------------------------------

PAC900-05/ 02



APPENDIX l2B

PATHOLCGY - FO ANIMAL GENERATIONNO: 172 SEX: F DOSE: 1000 ppn ON STUDY: 136 days (20 wks) TERMll'W..

MACROPATHOLCGY Killed by Fluothane

THE FOLLOWING TISSUES \JERE SUPMITI'ED

CERVIX ; KIIJNI!:Y ; LIVER ; M/>}MARY GLAND ; OVAP::l ; PITOITARY GLAND ; UTERlJS : VAGINA THE FOLLOWING MACROSOOPIC OBSERVATIONS 1-iERE MADE

KIIJNI!:Y Pelvic dilatation : (right : slight>

UTERlJSImplantation site/s present : left 1, right 3.

NO ABNORMALITIES wERE SEEN IN THE REWIINlNG TISSUES

MICROPATHOLCGY

".....--...r "C --... ..,.0

.._,"'

.._,0w

TISSUE CHECK: TOTAL EXAMINED NOT EXAM MISSING NliD PROTOOOL REQUIBED 2 2 0 0 1NOT PROTOOOL (stllMLTI'ED) 6 0 6 0 0(NOT SUPMITI'EDl 0 0 0 0 0

THE FOLLOWING TISSUES 1-iERE MARKED NliD

LIVER

THE FOWJIIDI'G MICROSOOPIC OBSERVATIONS 1-iERE ------------------------------------------------

MADE

KIIJNI!:YUnilateral hydronephrosis : (slightl

PAC900-05/02


INDIVIDUAL ANJM<\1 DATA SUPPLEMENT

APPENDIX 12B

PATHOLOGY - FO GENERATION ANIMAL NO: 172 SEX: F OOSE: 1000 ppn ON STUDY: 136 days (20 wks) TERMINAL

MICROPATHOLOGY

OONTINUATION - THE FOWJ\1ING MICROSOOPIC OBSERVATIONS WERE MADE

KIDNEY Intratubular microlithiasis : tmininE.l)Increase m nuclear plearorphism : (mininE.l)

-------------------------------------------------------END OF 1\NIMAL---------------------------------------------------------------n -I r..._ -o..._ ""'0 lD .....

...., 0

""'

-~

PAC900-05/02

PERCHLOROETHYLENE: MULTIGENERATION IDHALATION STODY IN THE RAT


APPENDIX 12B

PATHOLOGY - FO GENERATION ANIMAL NO: 173 SEX: F DOSE: 1000 ppn ON STODY: 134 days (20 wksJ 'I'ERMINAL

MACROPATHOLOGY

Killed by Fluothane

THE FOWJ\ill!G TISSUES WERE SUl'MITTED

CERVIX ; KIDNEY : LIVER ; MIIM1ARY GLAND : OVARY ; PITOITARY GLAND ; TAIL ; UTERUS ; VAGINA

THE FOLLOWING MACROSOOPIC OBSERVATIONS WERE 111\DE

TAIL Kinked

UTEROS Implantation site/s present : left 4, right 8.


MICROPATHOLOGY

n -I r

--" -"'---0

....,"'

...., 0 <n


PRDTOOOL REQUIRED NOT PRDTOOOL (SUl'MITTED)

(NOT SUl'MITTEDl

2 7 0

2 0 0

0 7 0

0 0 0

1 0 0

THE FOWJ\ill!G TISSUES WERE MARKED NAD

LIVER

THE FOWJ\ill!G MICRDSOOPIC OBSERVATIONS WERE 111\DE

KIDNEY Intratubular microlithiasis : (rrrinimal)

PAC900-05/02

PERCHLOROETHYLENE: MULTIGENERATION INl!AI.ATION STUDY IN THE RAT


APPENDIX 12B

PATHOLOGY - FO GENERATION ANIMAL NO: 173 SEX: F IDSE: 1000 ppn ON STUDY: 134 days (20 >ks) TERMINAL

MICROPATHOLOGY

CONTINUATION - THE FOLLOWING MICROSCOPIC OBSERVATIONS 'WERE MADE

KIDNEY Increase in nuclear plearorphism : (minimal)

-------------------------------------------------------00 OF A1Dl1~----------------------------------------------------------------~ r ' "'0 ' -"" 0 <0.....,

....., 0

"'

~'

PAC900-05/02

PERCHLOROETHYLENE: MI.ILTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL .ANlMAL DATA SUPPLEMENT

APPENDIX 12B

PATHOLOGY - FO GENERATION.ANlMAL NO: 174 SEX: F IXlSE: 1000 pp:n ON STUDY: 100 days (15 wksl INTERCURRENT

MACROPATHOLOGY

Killed by Fluothane : Failed to produce FlA litter.

THE FOWJ\.;m; TISSUES WERE SUEMITIED

CERVIX : KIDNEY : LIVER ; LUNG ; M.AM1ARY GLi\ND ; OVAP:I ; PITUITARY GLi\ND ; UI'EJJJJS ; VAGINA

THE FOWJl.;m; MACROSOOPIC OBSERVATIONS WERE MADE

KillNEYPale

LIVER Pale

LUNGPale area/s : all lobes and surfaces. Red area{s : all lobes and surfaces.

OVARY Pale

PITUITARY GLi\ND Pale

UI'ElJJJS Foetus Ies present : left hom, 4 foetuses, 2 towards 0\Tarian eod dead, remainder alive. Right hom, 7 alive.

VAGINA Blood in lUl!Eil Discharge : red.


n -i r -.., -. 0""' "' "

"0

"

PAC900-05/02


INDIVIDUAL ANlMAL DATA SUPP!..EMENT APPENDIX l2B

PATHOLOGY - FO ANlMAL GENERATIONNO: 174 SEX: F OOSE: 1000 ppn ON STUDY: 100 days 115 wks) INTERCURRENT

MICROPATHOLOGY


PROTOCOL REQUIRED: NOT PRDTOCCL (SlJPMITTED):

(NOT SllPMITTED) :

2 7 0

2 5 0

0 2 0

0 0 0

0 40

....,_, r THE FOLLOWING TISSUES 1oiERE MARKED NAD

CERVIX ; MIIM-1/ffiY GLAND ; OVAFY ; VAGINA

THE FOLLOWING MICROSCOPIC OBSERVATIONS 1oiERE MADE

KIDNEY Intratubular microlithiasis : (slight)

LIVER Hepatocyte necrosis : (slight) centrilobular.

1ITERIJS Dystocia [diagnosis based on macroscopic observations)

FACTOR CONTRIBUTORY TO DEATH

1ITERIJS : Dystocia [diagnosis based on macroscopic observations)

-------------------------------------------------------Elnl OF ANlMAL---------------------------------------------------------------

....... "0 ........., 0 1.0 ..._,

..._, 0 co

~' -

PAC900-05 I02

PERCHLOROETI!YLENE: MDLTIGENERATION INHAlATION STUDY IN THE RAT

INDIVIIJUAL ANIMAL DATA SUPPLEMENT

APPENDIX 12B

PATHOLOGY - FO GENERATIONANIMAL NO: 175 SEX: F DJSE: 1000 pj:Ill ON STUDY: 102 days (15 ~s) INTERCURRENT

MACROPATHOLOGY

Killed by Fluothane : Failed to produce FlA litter.

THE FOLLOWING TISSUES WERE SUI'MITTED

CERVIX ; KIDNEY : LIVER ; MI\!11ARY GLAND ; OVPJlY : PITUITARY GLAND ; UTERUS ; VAGINA

THE FOLLOWING MACROSOOPIC OBSERVATIONS WERE MADE

KIDNEYPale

LIVER Accentuated lobular pattern : (slight)PaleSpeckled : (minimal) red. in parts.

OVPJlYPale

PITUITARY GLANDPale

UTERUS : Pups closest to uterine opening in both horns appear at opening sinultaneously and therefore are blocking exit.Foetus/es present : left hom; 6 present, 2 dead, 4 alive along with scar fran born pup. Right hom: 6 present, all dead.VAGINABlood in lmenDischarge : red.


n r-i ..._-c ......._,. 0 '-0

"

"0 '-0

PAC900-05/02



APPENDIX l2B

PATHOLOGY - FO GENERATIONANIMAL NO: 175 SEX: F IDSE: 1000 ppn ON STUDY: 102 days (15 -wks) INTERCURRENT

MICROPATHOLOGY

TISSUE CHECK: TOTAL EXliMINED NOT EXAM MISSING NAD

PROTOCOL REQUIRED NOT PROTOCOL (SUFMITTEO)

(NOT SUFMITTEO)

2 6 0

2 4 0

0 2 0

0 0 0

0 30

" --l THE FOLLOWING TISSUES WERE MARKED NAD

l1<\111ARY GLAND ; OVAFY ; VAGINA


KIDNEY Intratubular microlithiasis : {nrlnimal ; unilateral)

LIVER Hepatocyte necrosis : (moderate) centrilobular.

UTERUS Dystocia (diagnosis based on lll'!croscopic observations)


UTERUS : Dystocia (diagnosis based on lll'!Croscopic observations)

-------------------------------------------------------END OF ANIMAL---------------------------------------------------------------

-..' -o-.. .., 0 <D ......

...... 0

....,

<~

PAC900-05/02

PERCHLDRDETIIYLENE: MULTIGENERATION INHALATION STUDY lN THE RAT

INDIVIDUAL ANIMAL DATA SUPPLEMENT APPENDIX 12B

PATHOLCGY - FO ANIMAL

GENERATIONNO: 176 SEX: F DOSE: 1000 ppn ON STUDY: 151 days (22 ,-k;s I TERMINAL

MACRDPATHOLCGY

Killed by Fluothane

THE FOlLOWING TISSUES WERE SUPMITI'ED

CERVIX ; KIDNEY ; LIVER ; MAMMARY GLAND ; OVAP..Y ; PITUITARY GLAND ; UTERUS ; VAGINA

THE FO!LOVIING M.'<CROSCCPIC OBSERVATIONS WERE MADE

UTERUSImplantation site/s present : left 5, rignt 5 .

NO .ABNORMALITIES WERE SEEN IN THE REMAINING TISSUES

MICRDPATHOLcx:;y

n ..... r -...., -....,. ...... 0

"'

...... ..... ..... TISSUE CHECK: TOTAL EXAMINED NOT EXliM MISSING NAD

PRDTOCCL REQUIRED 2 2 0 0 1 NOT PRDTOCCL (SUPMITI'EDl 6 0 6 0 0

(NOT SUPMITI'ED) 0 0 0 0 0

THE FOlLOWING TISSUES WERE MiiRKED NAD

LIVER

THE FOlLOWING MICRDSCCPIC OBSERVATIONS ViERE MADE

KIDNEY Intratubular microlithiasis : (m:irUJral l

-------------------------------------------------------END OF ANIMAL---------------------------------------------------------------

PAC900-05/ 02



APPENDIX 12B

PATHOLCX;Y - FO GENERATION ANlMAL NO: 177 SEX: F J:XJSE: 1000 ppn ON STUDY: 135 days (20 wks) TERMINAL

MACRDPATHOLCX;Y

Killed by Fluothane

THE FOLLOWING TISSUES WERE SUBMITTED

CERVIX ; KIDNEY ; LIVER ; MA!11ARY GLAND ; OVN!..Y ; PITUITARY GLAND ; UTERUS ; VAGINA


UTERUSJinplantatian site/s present : left 7, right 6.


MICRDPATHOLCX;Y

r. -i r ---o ..,.--0 .._,""

.._,

..... TISSUE CHECK: TOTAL EXAMINED NOT EXAM MISSING NAD

PROTOCOL REQUIRED 2 2 0 0 1 NOT PROTOCOL (SUJlMITTED) 6 0 6 0 0

(NOT SUBMITTED) 0 0 0 0 0

"'


LIVER


KIDNEY Chronic progressive glCIIErulonephropathy : (minimal ; unilateral)Intratublllar microlithiasis : tinin:iin3.1)

-------------------------------------------------------END OF ANJMAL---------------------------------------------------------------

~ ~

PAC900-05/02

PEllCHLORDETHYLENE: MULTIGENERATION INHt\IATION STUDY IN THE RAT

INDIVIDUAL AN1MAL DATA SUPPLEMENT

APPENDIX l2B

PATHOLCGY AN1MAL -NO: FO GENERATION178 SEX: F IXJSE: 1000 Pfl!l ON STUDY: 155 days (23 wksl TERMINAL


THE FOLLOWING TISSUES WERE SOEMI:TTED

CERVIX : KIDNEY : LIVER : MAM1ARY GLliND : OVARY : PITUITARY GLi'.ND ; UTERUS : VAGINATHE FOLLO\illlG MACROSCOPIC OBSERVATIONS WERE MADE


NO ABNOJJMIILITIES WERE SEEN IN THE REMAINING TISSOES

MICROPATHOLCGY

n.....r-._ -o-.__,.0 \0......

......,.... TISSUE CHECK: TOTAL EXAMINED li'OT EXAM MISSING NAD

PROTOCOL REQUIRED 2 2 0 0 1NOT PROTOCOL (SOEMI:TTEDl 6 0 6 0 0(NOT SOEMI:TTEDl 0 0 0 0 0

w

THE FOLLO\IDlG TISSUES WERE MIIRl.<ED NAD

LIVER

THE FOLLO\IDlG MICROSCOPIC OBSERVATIONS WERE MADE

KIDNEYIntratubular microlithiasis : (minimal)Increase in nuclear pleCIIXJrphism : (minimall

-------------------------------------------------------ENO OF ANJMAL---------------------------------------------------------------

PAG900-05/02

PERCHLOROETHYLENE: MIJLTIGENERATION lNHAI.ATION STUDY IN THE RAT


APPENDIX l2B

PATHOLOGY - FO GENERATION ANIMAL NO: 179 SEX: F DOSE: 1000 ppn ON STUDY: 134 days (20 >Jks) TERMINAL

MACROPATHOLOGY

Killed by Fluothane

THE FOLLOWING TISSUES WERE Slll'MITTEO

A1llXl1INAL CAVITY ; CERVIX ; KIDNEY ; LIVER ; M.AM1ARY GLIINO ; OVARY ; PITUITARY GL11N0 ; UTERUS ; VAGINA

THE FOLLOIVING MACROSCOPIC OBSERVATIONS WERE MADE

A1llXl1INAL CAVITY Mass 1 : l2mn d.iam=ter, spherical, dark red, attached to cardia of stanach and ventral papillary lobe of liver.

KIDNEYPelvic dilatation : (right ; slight)


NO ABNORMALITIES 1-lERE SEEN IN THE REMAINING TISSUES

MICROPATHOLOGY

"--< r ' -o ' ..,. 0 ~ .....

..... .......,.


PROTOCOL REQUIRED 2 2 0 0 1 NOT PROTOCOL (Slll'MITTEO) 7 0 7 0 0

(NOT Slll'MITTEO) 0 0 0 0 0


LIVER


~.

PAC900-05/02

PERCHLOROETiiYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT


PATHOLOGY - FO ANIMAL NO:

GENERATION179 SEX: F lXJSE: 1000 ppn ON STUDY: 134 days (20 wks l TERMINAL

MICROPATHOLOGY

!G])NEY Chronic progressive glarerulonei;Jill:apathy : (minimal ; unilateral)Unilateral hydronephrosis : (slight) Intratubular microlithiasis : (Illl11inBll

-------------------------------------------------------END OF ANIMAL---------------------------------------------------------------n --! r ....... -o ....... 0 """ <0 ......

...... ,_. U1

--

Pl>£900-05/02


INDIVIDUAL ANM\L DATA SUPPLEMENT

APPENDIX l2B PATHOLOGY - FO ANM\L GENERATION

NO: 180 SEX: F lXJSE: 1000 Jlll1l ON STUDY: 134 days (20 wks) TERMINAL

MACROPATHOLOGY

Killed by Fluothane


CERVIX ; KIDNEY ; LIVER ; MIIM1ARY GLAND ; OVARY ; PITUITARY GLAND ; UTERlJS ; VAGINA




MICROPATHOLOGY

n -j r...._ -o ...._ _,. 0 <0

"

"..... 01 TISSUE CHECK: TOTAL EXAMINED NOT EXAM MISSING NAD

PROTOCOL REQUIRED NOT PROTOCOL (SUEMITI'ED)

!NOT SUEMITI'ED)

2 6 0

2 0 0

0 6 0

0 0 0

00 0

THE FOLLOHING MICROSCOPIC OBSERVATIONS \>JERE MADE

KIDNEY Intratubular microlithiasis : crni.nimal)Increase in nuclear pleCIJDrphism : (rni.nimal)

LIVER Subcapsular fibrosis and inflarrrnation : !Slight ; focal) with increased pi@lEntation.

-------------------------------------------------------END OF ANM\L---------------------------------------------------------------

PAC900-05/02

PERCHLOROETHYLENE: MULTIGENERATION JNHALATION STUDY IN THE RAT


APPENDIX 12B

PATHOLOGY - FO GENERATIONANIMAL NO: 181 SEX: F IXJSE: 1000 Jlllll ON STUDY: 134 days (20 wks l TERMINAL

MACROPATHOLOGY

Killed by Fluothane

THE FOLLOWING TISSUES wERE SUFMITTED

CERVIX ; KIDNEY ; LIVER ; MI'M1ARY GLAND ; OVAP:i ; PITUITARY GLAND : UTERUS ; VAGINA



NO ABNORMALITIES WERE SEEN IN THE BEMAINING TISSUES

MICROPATHOLOGY

n -; r..._ "0 ..._ ""' 0 __,'"'

__, ......__, TISSUE CHECK: TOTAL EXt\MINElJ NOT EXAM MISSING NAD

PROTOCOL REQUIRED NOT PROTOCOL (SlJFMITTED)

(NOT SUFMITTEDl

2 6 0

2 0 0

0 6 0

0 0 0

200

THE FOLLOI-IING TISSUES WERE MARKED NAD

KIDNEY : LIVER -------------------------------------------------------END OF ANIMAL---------------------------------------------------------------

PAC900-05/ 02



ANIMAL PATHOLOGY - FO GENERATIONNO: 182 SEX: F DJSE: 1000 ppn ON STUDY: 134 days (20 wks) TERMINAL

MACROPATHOLOGY

Killed by Fluothane

THE FOLLOWING TISSUES WERE SUl'MI'l'l'ED

CERVIX ; IGDNEY ; LIVER ; MAM1ARY GLAND ; OVAFY ; PITUITARY GLAND ; UTERUS ; VAGINA


UTERUSImplantation site/s present : ri~t 5, left 6 .

NO ABNORMALITIES WERE SEEN IN THE REM<\INING TISSUES

MICRDPATHOLOGY

n ..... r -...., -... .p. 0

"' "

"..... CP TISSUE CHECK: TOTAL EXAMINED NOT EXAM MISSING NAO

PROTOCOL REQUIRED 2 2 0 0 1 NOT PROTOCOL (SllJMJ:TJ'ED)

(NOT SU!'MITI'ED) 6 0

0 0

6 0

0 0

0 0

THE FOLLOWING TISSUES WERE MARKED NAO

LIVER


lGDNEY Intratubular microlithiasis : (sli~t) Increase :in nuclear plearorphism : cmin:irnal)

-------------------------------------------------------~ OF ANIMAL---------------------------------------------------------------

"~

PAC900-05/02


I!IDIVIDUAL ANJMAL DATA SUPPLEMENT

APPENDIX l2B

PATHOLOGY - FO GENERATIONANJMAL NO: 183 SEX: F COSE: 1000 P!lll ON STUDY: 134 days (20 wks) TEJlMINAL

MACROPATHOLOGY

Killed by Fluothane


CERVIX : KIDNEY ; LIVER ; !1.AM1ARY GLt\ND : OVPEf ; PITUITARY GLt\ND : UTERUS ; VAGINA


UTERUSImplantation site/s present : left 4, rignt 4.


MICROPATilOLOGY

n -1 r -----o

-"' 0 <0 ......

...... ...... <0 TISSUE CHECK: TOTAL EXl\MINED NOT ElQlM MISSTh'G NtiD

PROTOCOL REQUIRED NOT PROTOCOL (SU!'M1TTEDl

(NOT SUEMITTEDl

2 6 0

2 0 0

0 6 0

0 0 0

1 0 0

THE FOLLOWING TISSUES WERE MIIRKED NtiD

LIVER


KIDNEY Intratubular microlithiasis : (minimall

-------------------------------------------------------END OF ANJMAL---------------------------------------------------------------

PAC900-05/02


INDIVIDUAL ANIMAL DATA SUPPLEMENT .APPENDIX 12B

ANIMAL PATHOLOGY - FO GENERATION NO: 184 SEX: F OOSE: 1000 ppn ON STUDY: 134 days (20 wks) TERMINi\L

MACROPATHOLOGY

Killed by Fluothane

THE FOLLOWING TISSUES WERE SUEMITIED

CERVIX ; KIDNEY ; LIVER ; MAM1i\RY GLi\ND ; OVARY ; PITUITARY GLi\ND ; UTERUS ; VAGINA

THE FOlLOWING MACRDSOOPIC OBSERVATIONS vlERE MI\DE



MICROPATHOLOGY

n .... ' ....... '"0 ....... ""' 0 lO....,

...., 0 TISSUE CHECK: TOTAl EXI\MINElJ NOT EXAM MISSING NIID

PROTOCOL REQUIRED 2 2 0 0 1 NOT PROTOCOL (SUEMITIED) 6 0 6 0 0

(NOT SUEMITIED) 0 0 0 0 0

THE FOLLOWING TISSUES WERE Mi\RKED NIID

LIVER

THE FOLLOWING MICROSOOPIC OBSERVATIONS WERE MADE

KIDNEY Intratubular microlithiasis : (mlnJmal)Increase in nuclear plecnnrphl5m : (min.iJnal)

-------------------------------------------------------~ OF ANIMAL---------------------------------------------------------------

"'

~

PAC900-05/02



ANIMAL PATHOLCGY - FO GENERATIONNO: 185 SEX: F IXlSE: 1000 Jllill ON STUDY: 134 days (20 wks) TERMINAL

MACROPATHOLCGY

Killed by Fluothane

THE FOWJHING TISSUES WERE SUOOTTED

CERVIX ; KIDNEY ; LIVER ; MM11ARY GLAND ; OVPJIT ; PITUITPJIT GLAND ; UTERUS ; VAGINA

THE FOWJ\-IING MACROSCOPIC OBSERVATIONS WERE MADE

UTERUS Implantation site/s present ' left 4, rigrrt 3 •


MICROPATHOLCGY

n -l r ......., ...... ""' 0

"'....,

...., N .... TISSUE CHECK: TOTl\L EXAMINED NOT EXAM MISSING NliD

PROTCCOL REQUIRED: 2 2 0 0 1 NOT PROTCCOL (SUOOTTEDl: 6 0 6 0 0

(NOT SUOOTTEDl : 0 0 0 0 0

THE FOWJHING TISSUES WERE MARKED NliD

LIVER


KIDNEY Tubular basophilia : (minimal ; nultifocal)Intratubular microlithiasis ' (sligrrtJIncrease in nuclear p1earorphism : (rninimall

-------------------------------------------------------END OF ANIMAL---------------------------------------------------------------

PAC900-05/02

PERCHLORDETHYLENE: MULTIGENERATION INHALATION STUDY JN THE RAT

JNDIVIDUAL AN1MAL DATA SUPPLEMENT

APPENDIX 12B

PATHOLOGY - FO GENERATION AN1MAL NO: 186 SEX: F D:lSE: 1000 ppn ON STUDY: 134 days (20 wks) TERMINAL

MACROPATHOLOGY

Killed by Fluothane

THE FOlLOWJ}K; TISSUES WERE SUEMITJ'ED

CERVIX ; KIDNEY ; LIVER ; W.M1ARY GLAND ; OVARY ; PITUITARY GLAND ; UTERUS ; VAGINA

THE FOlLOWJ}K; MACROSCOPIC OBSERVATIONS WERE MADE

UTERUS , Implantation site/s present : right 1, left 1.

NO ABNORMALITIES WERE SEEN JN THE REMAINING TISSUES

MICROPATHOLOGY

n -< r-" -""'0

"" .....,

....., N N TISSUE CHECK: TOTAL EXPMINED NOT EXAM MISSJNG NAD


(NOT SUEMITJ'ED) 0 0 0 0 0

THE FOlLOWJ}K; TISSUES WERE MARKED NAD

LIVER

THE FQlLQ\IDK; MICROSCOPIC OBSERVATIONS WERE MADE

KIDNEY Tubular basophilia : (rrrin.imal ; focal ; unilateral)Intratubular microlithiasis : {slight)

-------------------------------------------------------E!<D OF ANJMAL---------------------------------------------------------------

~

PJ\C900-05/02


INDIVIDUJ\1 AN1MAL DATA SUPPLEMENT

APPENDIX 12B

PATHOLCGY - FO GENERATION AN1MAL NO: 187 SEX: F !XJSE: 1000 ppn ON STUDY: 151 days (22 wks) TERMINAL

MACROPATHOLCGY

Killed by Fluothane


CERVIX ; KIDNEY ; LIVER ; Ml\!11\RY GLAND : OVAP::f ; PITUITARY GLAND : UTERUS : VIIGINA

THE FOLLOliiNG MACROSOOPIC OBSERVATIONS WERE MADE


NO ABNORMALITIES \;"ERE SEEN IN THE REMAINING TISSUES

MICRDPATHOLCGY

n --< r.._ -c .........,. 0 <.0 ......

...... N w TISSUE CHECK: TOTAL EXllM.JNED NOT EXAM MISSING Ni\D

PRDTOOOL REQUIRED: 2 2 0 0 1 NOT PRDTOOOL (SUEMITI'EDl: 6 0 6 0 0

(NOT SUEMITI'ED) : 0 0 0 0 0

THE FOLLOWING TISSUES WERE MARKED Ni\D

LIVER

THE FOLLOliiNG MICRDSOOPIC OBSERVATIONS WERE MADE

KIDNEY Intratubular microlithiasis : (minimal)

-------------------------------------------------------END OF ANlMAL---------------------------------------------------------------

PAC900-05/02



APPENDIX l2B

PATHOLOGY - FO GENERATIONANIMAL NO: 188 SEX: F lXlSE: 1000 PJlll ON STUDY: 155 days (23 wks) TEEIMlNAL

MACROPATHOLOGY

Killed by Fluothane

THE FDLLOlVING TISSUES WERE SUEMITTED

CERVIX ; KIDNEY ; LIVER ; MliM1ARY GLAND ; OVARY ; PITUITARY GLAND ; UTERUS ; VAGINA


KIDNEY Pale area/s : cright) several, up to 2rnm diameter, capsular surface.


NO ABNOllMIILITIES WERE SEEN IN THE REMAINING TISSUES

MICROPATHOLOGY

..... " r..._ ""0 ..._ 0 -!'>

<.0..._,

..._, N -!'>

TISSUE CHECK: TOTAL EXt\MINED NOT EXAM MISSING NAD

PROTOCOL REQUJRED NOT PROTOCOL (SUEMITTED)

(NOT SUEMITTED)

2 6 0

2 0 0

0 6 0

0 0 0

1 0 0

THE FDLLOIVING TISSUES WERE MARKED NAD

LIVER

THE FDLLOIVING MICROSCOPIC OBSERVATIONS WERE MADE

KIDNEY Tubular basophilia : (minimal ; nultifocal ; unilateral)

~

PAC900-05/02

PERCHLOROETHYLENE: MULTIGENERATION lNHALATION STUDY IN THE RAT

INDIVIDUAL liNlMAL DATA SUPPI..l'MENT

APPENDIX 12B

PATHOL(X;Y - FO GENERATION liNlMAL NO: 188 SEX: F D:JSE: 1000 ppn ON STUDY: 155 days (23 wks) TERMINAL

MICROPATHOLOGY

OONTINUATION - THE FOlLOWING MICROSOOPIC OBSERVATIONS WERE MADE

~ Intratubular microlithiasis : (minimall

-------------------------------------------------------E!{D OF liNIMAL---------------------------------------------------------------n -i r ...... '"0 ........, 0

"" "

"N U1

------

PAC900-05/02



APPENDIX 12B PATHOLCGY - FO GENERATION

ANlMAL NO: 189 SEX: F OOSE: 1000 ppn ON STUDY: 134 days (20 ""'s) TERMINAL

!1J\CROPATHOLCGY

Killed by Fluothane

THE FOlLOWING TISSUES WERE SUIMITI'ED

CERVIX ; KIDNEY ; LIVER ; l1AI4!ARY GLAND ; OVAKf ; PITUITAKf GLIIND ; UTERUS ; VAGINA


UTERUS Implantation site/s present : right 8, left 5.


MICROPATHOLOGY

n -l r--o .,. 0 ....,"'

...., N 0\ TISSUE CHECK: TOTAL EXAMINED NOT EXAM MISSING NAD

PROTOCOL REQUIRED 2 2 0 0 1 NOT PROTOCOL (SUPMITI'ED) 6 0 6 0 0

(NOT SUIMITI'ED) 0 0 0 0 0


LIVER


KIDNEY Unilateral hydronePhrosis : (slight) Intratubular microlithiasis : (IIllilinal) Increase :in nuclear plecm:n:phism : (minimal)

-------------------------------------------------------END OF ANJMAL---------------------------------------------------------------

~'

PAC900-05/0Z



APPENDIX 12B

PATHOLOGY - FO GENERATION ANlMAL NO: 190 SEX: F DOSE: 1000 ppn ON STUDY: 134 days (20 wks I TERMINAL

MACROPATHOLOGY

Killed by Fluothane ; Failed to produce an F1A litter.

THE FOLLOWING TISSUES WERE SUEMI'ITED

CERVIX ; KIDNEY ; LIVER ; Mi\M1ARY GLAND ; OVNJY ; PITUITARY GLAND ; Ul'ERUS ; VAGINA


Ul'ERUS Foetus/es present : left 6, all alive, right 0.


MICROPATHOLOGY

-; " ....... ........," 0 <0 .....

..... N ..... TISSUE CHECK: TOTAL EXAMINED NOT EXAM MISSING NAD

PROTOCOL REQUIRED NOT PROTOCOL (SUEMI'ITED)

(NOT SUEMI'ITED)

z 6 0

z 3 0

0 1 0

0 z 0

1 z 0

THE FOLLOWING TISSUES WERE MISSING

CERVIX : (inadequate l VAGINA ' (inadequate)


LIVER ; Mi\M1ARY GLAND ; OVNJY

PAC900-05/02



APPENDIX 12B

PATHOLOGY - FO GENERATIONANlMAL NO: 190 SEX: F I:OSE: 1000 ppn ON STUDY: 134 days 120 wks) TERMINAL

MICROPATHOLOGY

THE FOLLOWING MICROSCOPIC OBSERVATIONS VlERE MADE

KIDNEY Intratubular microlithiasis : <minimal)UTERUS . Placental tissue in llliiEil. Foetuses in llliiEil. (I113.croscopic observatioo)

-------------------------------------------------------E!<D OF ANlMAL---------------------------------------------------------------

r'")

--< r ...... -o ......... 0 ....., "'

....., S5

,_

------------------------------------------------

PAC900-05/02

PERCHLOROE'l'HYLENE: MULTIGENERATION INHAI.ATION STUDY IN THE RAT

INDIVIllUAL ANlMAL DATA SUPPLEMENT

APPENDIX 12B

PATHOLOGY - FO GENERATION ANlMAL NO: 191 SEX: F IXJSE: 1000 ppn ON STUDY: 134 days (20 M<:s l TEBMINi\L

MACROPATHOLOGY

Killed by Fluothane

THE FOLLOWING TISSUES WERE SUJ:MITTED

CERVIX : KIDNEY : LIVER : LUNG ; l11#1ARY GLAND ; ORAL CAVITY ; OVAP:f ; PITUITARY GLAND ; UTERUS : VAGINA


LUNGRed spot/s : all lobes and surfaces. Pale spot/s : all lobes and surfaces.

ORAL CAVITYTeeth maloccluded

NO ABNOllMALITIES WERE SEEN IN THE REMAINING TISSUES

MICROPATHOLOGY

(") ...... r-... "'0 -... .,. 0

.__. "'

.__. N

"' TISSUE CHECK: TOTAL EXi\MINED NOT EXAM MISSING NAD

PROTOCOL BEQUIRED NOT PROTOCOL (SUJ:MITTEDl

(NOT SUJ:MITTED)

2 8 0

2 0 0

0 8 0

0 0 0

1 0 0

THE FOLLOWING TISSUES WERE MABBED NAD

LIVER


PAC900-05/02



APPENDIX 12B

PATHOLOGY - FO AN1MAL NO: GENERATION

191 SEX: F OOSE: 1000 ppn ON STUDY: 134 days (20 Wks) TEFMINAL

MICROPATHOLOGY KIDNEY

Intratubular microlithiasis : cm:in:imal)Increase mnuclear pleamrphism : (m:in:imal)

-------------------------------------------------------END OF ANlMAL---------------------------------------------------------------n_, ........,,

.........,.0co......

......w0

~

PAC900-05/02


INDIVIDUAL ANIMIIL DATA SUPPLEMENT APPENDIX 12B

ANIMIIL PATHOLCGY - FO GENERATIONNO: 192 SEX: F IXJSE: 1000 PJn1 ON STUDY: 134 days ( 20 ~s) TERMINAL

MACROPATHOLCGY

Killed by Fluothane

THE FOLLOWING TISSUES vlEBE SUEMI'ITED

CERVIX ; KIDNEY ; LIVER ; Mll!11ARY GLAND : OVARY : PITUITARY GLANO : UTERUS : VAGINA

THE FOLLOWING MACROSCOPIC OBSERVATIONS l-IERE MADE


NO ABNORMALITIES 1-lERE SEEN IN THE REMAINING TISSUES

MICROPATHOLCGY

n -l r ...... -o ...... ""' 0 .._, "'

...... w ..... TISSUE CHECK: TOTAL EXI\MINEJ) NOT EXAM MISSING NAD

PROTOCOL REQUIRED 2 2 0 0 1 NOT PROTOCOL (SUEMI'ITED) 6 0 6 0 0

(NOT SUEMI'ITEDJ 0 0 0 0 0

THE FOLLOWING TISSUES 1-lERE MARKED NAD

LIVER

THE FOLLOWING MICROSCOPIC OBSERVATIONS 1-lERE MADE

KIDNEY Intratubular microlithiasis : (mlnimal)

-------------------------------------------------------END OF ANIMIIL---------------------------------------------------------------



APPENDIX 13

PATHOLOGY - FIA PUPS

Key:

M = male F = female PM = post mortem NAD =no abnormalities detected A8N = abnormal lAD = individual animal data sheet INT = intercurrent EVC = evisceration WT = weight CLIN 08S =clinical observations ID = identification * = lAD present EXAM = examined Pup 281 - record 'DELETED' - should have been GROSS PM but recorded as DISCARDED in error. Pups 43A, 183D, 1918 - record 'DELETED' - recorded as LOST but subsequently found. Pups 48A and 488- record 'DELETED' - recorded as FULL PM in error.

CTL/P/4097 - 732

PAC905-01/11

PERC!IT..ORDETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT


APPENDIX 13

PATHOLOOY - F1A PUPS GROUP: 1 rosE: 0 Jlllll

LITI'ER: 25

LITTER SUMMARY

n__, r....._ -o....._ ..,. 0

"' ......

...... w w

PUP ID

SEX BODY wr

CLIN OBS

FATE DATE P.M. DATE IAO

A B c D E F G H I J K L M

M F F F F M M M F F F F F

77.6 72.4 62.1 71.2 73.0 70.7

NAD NAD NAD NAD NAD NAD

LOST LOST LOST LOST LOST LOST SELECTED SELECTED SELECTED FULL 1M GROSS 1M GROSS 1M DISCARDED

17/08/9217/08/9217/08/9217/08/9217/08/9223/08/9210/09/9210/09/9210/09/92 10/09/92 10/09/92 10/09/92 10/09/92

NAD NAD NAD

10/09/9210/09/9210/09/92

*

PAC905-0l/ll

PERCHLOROETHYLENE: MIJLTIGENERATION INHliLIITION STUDY IN THE RAT


APPENDIX 13

PATHOLOGY - F1A PUPS GROUP: 1 OOSE: 0 Jlll11

PUP ID: 25/J SEX: F ON STUDY: 29 days { 5 wks) FULL R1

MACROPATHOLOGY

Killed by Fluothane

THE FOLLOWING TISSUES WERE SUEMI'ITED

CERVIX ; KIDNEY ; LIVER ; OVNIT ; PITUITARY GLAND ; liTERUS ; VAGINA

NO ABNORMALITIES WERE SEEN IN THE ANlMAL

MICROPATHOLOGY

n -I r ...... "0 ...... ""' 0 ~ ....,


PROTOCOL REQUIRED 2 2 0 0 2 NOT PROTOCOL {SUEMI'ITED) 5 0 5 0 0

{NOT SUEMI'ITED) 0 0 0 0 0

...., w ""'

THE FOLLOVITNG TISSUES WERE MARKED NAD

KIDNEY ; LIVER


FCD NOT RECORDED

-------------------------------------------------------END OF PUP------------------------------------------------------------------

-,

PAC905-01/ll

PERCHLOROETHYLENE: MULTIGENERATION INHt\IATION STUDY IN THE RAT


APPENDIX 13

PATHOLCGY - F1A PUPS GROUP: 1 !XlSE: 0 ppn

LITI'ER: 26

LITTER SUMMARY

n -1....... "0 ........, 0 1.0....,

PUP SEX BODY CLIN FATE DATE P.M. DATE IAD ID wr OBS

A B c D E F G H I J

M M F M M F F M M F

86.3 76.1 87.6 87.7 84.9 85.1


LOST SELECTED SELECTED GROSS PM GROSS PM GROSS PM GROSS PM DISCIIRDED DISCIIRDED DISCIIRDED

20/08/9213/09/9213/09/9214/09/92 14/09/92 14/09/92 14/09/92 14/09/9214/09/9214/09/92

NAD NAD NAD NAD

14/09/9214/09/9214/09/9214/09/92

...., w <.n

-----· ·····-- ---·---·---.

PAC905-01/ll

PERCHLOBDET!IYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT


APPENDIX 13

PATHOLOGY - F1A PUPS GROUP: 1 IDSE: 0 Jlllll LITTER: 28

LITTER SUMMARY

....,

..... r -.., -... 0 lD ......

PUP ID

SEX BODY wr

CLIN OBS

FATE DATE P.M. DATE IAD

A B c D E F G H I J

M F F M M F F F F F

77.7 74.2 81.2 95.1 83.1 83.2

79.3


NAD

SELECTED SELECTED FlJIL H1 GROSS H1 GROSS H1 GROSS H1 DISCARDED DISCARDED DISCARDED GROSS H1

12/09/9212/09/9214/09/92 14/09/92 14/09/92 14/09/92 14/09/9214/09/9214/09/9214/09/92

NAD ABN NAD NAD

NAD

14/09/9214/09/9214/09/9214/09/92

14/09/92

* *

DELETED

...., w 0'1

PAC905-0l/ll

PERCHLORDETHYLENE: MIJLTIGENERATION INHALATION STUDY lli THE RAT

INDIVIlJUAL ANIMAL DATA SUPPID!ENT

APPENDIX 13

PATHOLCGY - FlA PUPS PUP ID: GROUP: 1 28/C IDSE: SEX: 0 F PflTl

ON STUDY: 31 days (5 wks) FULL R1

WICRDPATHOLCGY

Killed by Fluothane

THE FOLLOWING TISSOES WERE SUEMITI'ED

CERVIX : KIDNEY ; LIVER ; OVARY : PITUITARY GLAND ; UTERUS : VAGlliA

NO ABNOJJMALITIES WERE SEEN lli THE ANIMAL

MICRDPATHOLCGY

" --; r ..._ -c..._.., 0

....., "' TISSOE CHECK: TOTAL EX.AMINED NOT EXAM MISSING NAD

PROTOCOL REQUIRED 2 2 0 0 2 NOT PROTOCOL (SUEMITI'EDl 5 0 5 0 0

(NOT SUEMITI'EDl 0 0 0 0 0

....., w .....,

THE FOLLOWING TISSOES WERE MI\RKElJ NAD

KIDNEY ; LIVER


FCJJ NOT RECORDED

-------------------------------------------------------END OF PUP---------------------------------------------------------~---------

-·-- -- --· ··-·-----

PAC905-01/ll


INDIVIDUAL ANllifU.. DATA SUPPLEMENT

APPENDIX 13

PATHOLOGY - F1A PUPS GROUP: 1 lXJSE: 0 Jlllll

PUP ID: 28/D SEX: M ON STUDY: 31 days (5 ""'s) GROSS l'M

MACROPATHOLOGY

Killed by Fluothane

THE FDWJWING TISSUES WERE SUFMITTED

KlJJNEY

THE FDILO\i!NG MACROSCOPIC OBSERVATIONS WERE MADE

KlJJNEY Pelvic dilatation : {right ; slight)

-------------------------------------------------------END OF PUP------------------------------------------------------------------

(")

-< ;-... -o -... .,. 0 1.0....,

...., '-" ():)

-, -------

PAC905-01/ll

PERCHLOROETHYLENE: Ml.JLTIGENERATION INHAlATION STUDY IN THE RAT

INDIVIDUliL ANIM'\L DATA SUPPLEMENT

APPENDIX 13

PATI!OL(X;Y - F1A PUPS GROUP: 1 IXJSE: 0 PJlll LITTER: 30

LITTER SUMMARY

PUP SEX BODY CLIN FATE DATE P.M. DATE lAD ID wr OBS

A B c

M F M

105.0 101.0 107.5

NAD NAD NAD

SELECTED SELECTED GROSS EM

16/09/92 16/09)92 16/09/92 NAD 16/09/92

n_, r..._ -o..._.., 0 <D .....

..... w <D

PAC905-01/ll

PERCHLORDETHYLENE: MULTIGENERATION INHALATION STUDY lli THE RAT


APPENDIX 13

PATHOLOGY - FlA POPS GROUP: 1 lXlSE: a ppn

LITI'ER: 32

LITTER SUMMARY

n ..... ........, r

....... 0 "" ....., ""

....., ""0

POP SEX BODY CLlli FATE DATE P.M. DATE IAD ID wr OBS

A B c D E F G H I J

M F F F M M F F M F

76.4 74.2 78.6 74.5 78.1 77.8 78.9 71.1

NAD NAD NAD NAD NAD NAD NAD NAD

SELECTED SELECTED SELECTED FULL R1 GROSS R1 GROSS R1 GROSS R1 GROSS R1 DISCARDED DISCARDED

09/09/9209/09/9209/09/9209/09/92 09/09/92 09/09/92 09/09/92 09/09/92 09/09/9209/09/92

NAD NAD NAD NAD NAD

09/09/92 09/09/9209/09/9209/09/9209/09/92

*

PAC905-01/ll

PERCHLOROETHYLENE: MDLTIGENERATION INHAlATION STUDY IN THE RAT

INDIVIDUAL ANJMAL DATA SUPE'Ll'MENT

APPENDIX 13 PATHOLOGY - F1A PUPS

PUP GROUP: 1 !XJSE: 0 ppnID: 32/D SEX: F ON STUDY: 29 days (5 wks) FULL I'M

MACROPATHOLOGY

Killed by Fluothane

THE FOI.LOWING TISSUES lo/ERE SUEMITTED

CERVIX ; lGDNEY : LIVER ; OVN?:f : PITUITN?:f GLI\NIJ : UTERUS : VAGINA

NO ABNOBMALITIES WERE SEEN IN THE ANJMAL

MICROPATHOLOGY

r>--! ,...........'"0.......""'0 .....,"'

NAD TISSUE CHECK: TOTAL EXAMINED NOT EXAM MISSING

PROTOCOL REQUIRED 2 2 0 0 1NOT PROTOCOL (Slll'MITTEDl 5 0 5 0 0

(NOT Slll'MITTEDl 0 0 0 0 0

....., ...... ""'

THE FOI.LOWING TISSUES WERE MARKED NAD

LIVER

THE FOI.LOWING MICROSOOPIC OBSERVATIONS WERE MADE

lGDNEYInterstitial nephritis : (minimall

FACTOR OONTRIBUTORY TO DEATH

FCD NOT REOORDED

-------------------------------------------------------END OF PUP------------------------------------------------------------------

PAC905-01/ll

PERCHLORDETHYLENE: MlJLTIGENERATION INHALATION STUDY IN THE RAT


APPENDIX 13

PATHOLOGY - FlA PUPSGROUP: 1 L'OSE: 0 PJlll LITTER: 33

LITTER SUMMARY

n --! r...... "0 ......... 0.., " '

PUP ID

SEX BODY wr

CLIN OBS

FATE DATE P.M. DATE lAD

A B c D E F G H I J K L

M F M M M F F F F M M F

78.6 65.7 71.8 69.1 72.7 71.7 63.6

NAD NAD NAD NAD NAD NAD NAD

SELECTED SELECTED FULL B1 GROSS B1 GROSS B1 GROSS B1 GROSS B1 DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

10/09/9210/09/9210/09/92 10/09/92 10/09/92 10/09/92 10/09/92 10/09/9210/09/9210/09/9210/09/9210/09/92

NAD NAD NAD NAD NAD

10/09/9210/09/9210/09/9210/09/9210/09/92

..

"... N

PAC905-0l/ll

PERCHLOROET!!YLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDllAL ANIMAL DATA SUPPLENENT

APPENDIX 13

PATHOLOGY - FlA PUPS GROUP: 1 DJSE: 0 P!l1l

PUP ID: 33/C SEX: M ON STUDY: 29 days (5 wks l FULL IM

MACROPATHOLOGY

Killed by Fluothane

THE FOllOWING TISSUES \.JERE SUPMITI'ED

EPIDIDYMIS ; KIDNEY : LIVER ; PITUITARY GLAND ; PROSTATE GLAND ; SEMINAL VESICLE ; TESTIS

NO ABNORMALITIES \o/ERE SEEN IN THE ANIMAL

MICROPATHOLOGY

n -1 r--. -o--._,. 0

"" " TISSUE CHECK: TOTAL EXAMINED NOT EXAM MISSING NAil

PROTOCOL REQUIRED: 2 2 0 0 2 NOT PROTOCOL (SUPMITI'EDl: 5 0 5 0 0

(NOT SUPMITI'EDl : 0 0 0 0 0

....., _,. w

THE FOLJ..OWING TISSUES \o/ERE MARKED NAil

KIDNEY ; LIVER


FCD NOT RECORDED

-------------------------------------------------------END OF PUP------------------------------------------------------------------

PAC905-01/ll



APPENDIX 13

PATHOLCGY - F1A PUPS GROUP: 1 !XJSE: 0 ppn

LITTER: 34

LITTER SUMMARY

r. -1 r...... "" ...... ""' 0

"' .....,

PUP ID

SEX BODY wr

CLIN OBS


A B c D E F G H I J

F M M F F F F F F F

91.0 88.5 79.8 79.1 80.5 80.7


LOST SELECTED SELECTED SELECTED FULL FM GROSS FM GROSS FM DISCARDED DISCARDED DISCARDED

17/08/9210/09/9210/09/9210/09/9210/09/92 10/09/92 10/09/92 10/09/9210/09/9210/09/92

NAD NAD NAD

10/09/9210/09/9210/09/92

*

....., ""' ""'

,-<

PAC905-0l/ll

PERCHLOROETHYLENE: M!JLTIGENERATION INHALATION STUDY IN THE RAT

INOIVIDUAL ANJMAL DATA SUPPLEMENT


PUP ID: GROUP: 1 34/E DJSE: SEX: 0 F PfillON STUDY: 29 days (5 wks I FULL R1

MACROPATHOLOGY

Killed by Fluothane

THE FOLLOWING TISSUES WERE SUPMITI'ED

CERVIX ; KIDNEY ; LIVER ; OVAPCI ; PITUITARY GLAND ; UTERUS ; VAGINA


MICROPATHOLOGY

n .-I ..._.,..._ 0 """ <.0.._,


PROTOCOL REQUIRED: NOT PROTOCOL (SUPMITI'ED):

2 5

2 0

0 5

0 0

20

(NOT SUPMITI'ED) : 0 0 0 0 0

.._, U1 """


KIDNEY ; LIVER

FACTOR OONTRIBUTORY TO DFATH

FCD NOT REOORDED

-------------------------------------------------------END OF PUP------------------------------------------------------------------

PAC905-01/ll

PERCHLOROETHYLENE: MIJLTIGENERATION INHAlATION STUDY IN THE RAT


APPENDIX 13

PATHOLOGY - FlA PUPS GROUP: 1 lXlSE: 0 Jlll1l LITTER: 35

LITTER SUMMARY

r. --l r..._ "C..._ ""' 0

""....,

I

...., ""' 0\

PUP ID

SEX BODY wr

CLIN OBS



M M F M F F F F F F F F

78.0 78.9 78.0 81.0 73.7 76.9


SELECTED SELECTED SELECTED GROSS R1 GROSS R1 GROSS R1 DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

01/10/9201/10/9201/10/9201/10/92 01/10/92 01/10/92 01/10/9201/10/9201/10/9201/10/9201/10/92Ol/10/92

NAD NAD NAD

01/10/9201/10/9201/10/92

~

PAC905-01/ll


INDIVIDUAL ANTI1AL DATA SUPPLEMENT

APPENDIX 13

PATHOLOGY - FlA PUPS GROUP: 1 OOSE: 0 ppn

LITTER: 36

LITTER SUMMARY



M F M M M F F M M M F F F

65.0 64.6 83.2 81.5 84.1 72.5 70.7


SELECTED SELECTED FUlL B1 GROSS B1 GROSS B1 GROSS B1 GROSS B1 DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

12/09/9212/09/9214/09/9214/09/9214/09/9214/09/9214/09/9214/09/9214/09/9214/09/9214/09/9214109/9214)09/92

NAD NAD NAD NAD NAD

14/09/9214/09/9214/09/9214/09/9214/09/92

* '"' -1 r ......., ........,. 0

"'.....,

.....,..,.

.....,

---------·----· -·- --·

PAC905-01/ll



APPENDIX 13

PATHOLOGY - F1A PUPS GROUP: 1 rosE: o ppn

PUP ID: 36/C SEX: M ON STUDY: 31 days ( 5 wks) FOLL FM

MACROPATHOLOGY Killed by Fluot.bane

THE FOLLOWING TISSUES VlERE SUEMITTED

EPIDIDYMIS ; KIDNEY ; LIVER ; PITUITARY GLAND ; PROSTATE GLAND ; SEMINAL VESICLE : TESTIS

NC ABNORMALITIES VlERE SEEN IN THE ANIMAL

MICROPATHOLOGY

"..... ,....... -o ....... """ 0 1.0....,

TISSUE CHECK: TOTAL EXAMINED NCT EXAM MISSING NAD

PROTOCOL REQUIRED NCT PROTOCOL (SUEMITTED)

2 5

2 0

0 5

0 0

2 0

(NOT SUEMITTED) 0 0 0 0 0

...., co """

THE FOLLOWING TISSUES VlERE MARKED NAD

KIDNEY ; LIVER

FACTOR CCNTRIBUTORY TO DEATH

FCD NCT JJECORDED

-------------------------------------------------------END OF PUP------------------------------------------------------------------

PAC905-01/ll

PERCHLOROETHYLENE: l1IJLTIGENERATION INHALATION STUDY IN THE RAT


APPENDIX 13

PATHOLOGY - FlA PUPSGROUP: 1 IXJSE: 0 ppn

LITTER: 37

LITTER SUMMARY

n --; r ........, ....... ""' 0

"" .....

..... ""' ""

PUP ID

SEX BODY wr

CLIN OBS



M F M M F F M M M F F F F

75.7 72.8 67.3 74.2 72.0 73.1


SELECTED SELECTED GROSS R1 GROSS R1 GROSS R1 GROSS R1 DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

02/10/9202/10/9202/10/92 02/10/92 02/10/92 02/10192 02/1019202/10)9202/10/9202/10/9202/10/9202/10/9202/10/92

NAD NAD NAD NAD

02/10/9202/10/9202/10/9202/10/92

PAC905-0l/11

PERCHLORDETHYLENE: MULTIGENERATION INHALATION STUDY lli THE RAT


APPENDIX 13

PATHOLOGY - FlA PUPS GROUP: 1 !XlSE: 0 ppn

LITTER: 38

LITTER SUMMARY

n ...... r ....... "' .........,. 0 \0.....,

I

PUP ID

SEX BODY wr

CLlli OBS


A B c D E F G H I J K

M F M M M F F M M F F

72.3 62.9 78.0 69.8 76.3 64.9 69.2


SELECTED SELECTED FULL EM GROSS EM GROSS EM GROSS EM GROSS EM DISCARDED DISCARDED DISCARDED DISCARDED

11/09/9211/09/9211/09/92 11/09/92 11/09/92 11/09/92 11/09/92 11/09/9211/09/9211/09/9211/09/92

ABN NAD NAD A8N NAD

11/09/9211/09/9211/09/9211/09/9211/09/92

*

*

....., U1 0

__.-,

PP.£905-01/11

PERCHLORDETHYLENE: MULTIGENERATION TIIlHAIATION STUDY IN THE RAT

INDIVIDUAL ANJMI\1 DATA SUPPLEMENT

APPENDIX D

PATHOLOGY - F1A PUPS GROUP: 1 IXlSE: 0 ppn

PUP ID: 38/C SEX: M ON STUDY: 29 days (5 wksl FULL PM

MACROPATHOLOGY

Killed by Fluothane

THE FOLLOHING TISSUES 1~ SUPMlTTED

EPIDIDYMIS ; KIDNEY ; LIVER ; PITUITARY GLAND : PROSTATE GLAND ; SEMINAL VESICLE ; TESTIS

THE FOLLOHING MACROSCOPIC OBSERVATIONS HERE MADE

KIJ:NEY Pelvic dilatation : (right ; slightl

NO ABNORMALITIES HERE SEEN IN THE REMAINING TISSUES

MICROPATHOLOGY

"-I ....... -o ........,. 0 <0

"

U1" ..... TISSUE CHECK: TOTAL EXFM!NED NOT EXFM MISSING N!ID

PROTOCOL REQUIRED 2 2 0 0 1 NOT PROTOCOL (SUPMlTTEDl 5 0 5 0 0

(NOT SUPMlTTEDl 0 0 0 0 0

THE FOLLOHING TISSUES HERE MARKED N!ID

LIVER

THE FOLLOHING MICROSCOPIC OBSERVATIONS HERE MADE

KmrniT Unilateral hydronephrosis : (slighti

·--~-----·-·- --···-. . .. ~ ·-. ·-·-· --·-·-··

PAC905-0l/ll

PERCHLORDETHYLENE: MULTIGENERATION INHAI.liTION STUDY IN THE RAT


APPENDIX 13

PATHO!.,(X;Y - FlA PUPS GROUP: 1 IXJSE: 0 ppn

PUP ID: 38/C SEX: M ON STUDY: 29 days (5 t-.ks) FOLL FM

MICRDPATHO!.,(X;Y


FCD NOT RECORDED

-------------------------------------------------------END OF PUP------------------------------------------------------------------~ r

" -o "~ C) co ~

~ t.n N

~.

PAC905-01/ll

PERCHLOROETHYLENE: Ml.JLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIlJUAL ANJMliL DATA SUPPLEMENT

APPENDIX 13

PATHOLOGY - F1A PUPS GROUP: 1 lXJSE: 0 ppn

PUP ID: 38/F SEX: F ON STUDY: 29 days (5 M<s J GROSS lM

MACRDPATHOLOGY

Killed by Fluothane

THE FOLLOWING TISSUES WERE SUEMITIED

KIDNEY

THE FOLLOHING MACROSOOPIC OBSERVATIONS WERE MADE

KIDNEY Pelvic dilatation : (right : IJDdarate l

-------------------------------------------------------END OF PUP------------------------------------------------------------------

--< '"' -...., r

-... 0""' .._,""

...., w "'

PAC905-01 I11

PERCHLORDETilYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT


APPENDIX 13

PATHOLOGY - FlA POPS GROUP: 1 IXlSE: 0 PJlll LIITER: 39

LITTER SUMMARY

".....,... ....... ""0 ........,. 0 1.0 .....,

I

POP ID

SEX BODY wr

CLIN OBS



F M F F F F F F F F F F

71.5 69.9 66.2

NAD NAD NAD

LOST GROSS B1 GROSS B1 GROSS B1 DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

07/09/92 01/10/92 01/10/92 01/10/92 01/10/92 01/10/9201/10/92 01/10/9201/10/92 01/10/9201/10/92 01/10/92

NAD NAD NAD

01/10/9201/10/9201/10/92

..... (J"1.,.

'~

PAC905-01/ll


INDIVIDUAL AN1M'\L DATA SUPPLEMENT

APPENDIX 13

PATIJOLOGY - FlA PUPS GROUP: 1 DJSE: 0 ppn

LIT'IER: 40

LITTER SUMMARY

PUP SEX BODY CLIN FATE DATE P.M. DATE IAD ID l-IT OBS

A B c

F F F

94.3 85.1 96.1

NAD NAD NAD

SELECTED E1JLL FM GROSS FM

15/09/92 15/09/9215/09/92

NAD NAD

15/09/92 15/09/92 *

n ..... r ....... ".........,. 0

""' .....,

....., U1 U1

PAC905-0l/11

PERCIJLORDETHYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT


APPENDIX 13

PATHOLOGY - FlA PUPS GROUP: 1 DJSE: 0 PJl1l

PUP ID: 40/B SEX: F ON STUDY: 29 days ( 5 ""'s) FOLL EM

MACROPATHOLOGY

Killed by Fluoth.ane

THE FOlLOWING TISSUES WERE SU!!MITTED

CERVIX ; lCIDNEY ; LIVER ; OVARY ; PITUITARY GLAND ; U'IERIJS ; VAGINA


MICROPATHOLOGY

n --l r "1::> ........., 0 co ......

TISSUE CHECK: TOTAL EXAMINED NOT EXI\M MISSING NAD

PROTOCOL REQUIRED NOT PROTOCOL (SU!!MITTED)

(NOT SU!!MITTED)

2 5 0

2 0 0

0 5 0

0 0 0

200

...... 01

"'

THE FOlLOWING TISSUES WERE MARKED NAD

lCIDNEY ; LIVER


FCD NOT RECORDED

-------------------------------------------------------END OF PUP------------------------------------------------------------------

~

I

PAC905-0l/ll

PERCHLORDETHYLENE: MDLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL ANlli\L DATA SUPPLEMENT

APPENDIX 13

PATHOLOGY - FlA PUPS GROUP: 1 IXJSE: 0 P!ID

LITTER: 41

LITTER SUMMARY

n -! r--o -""' 0 'D ......

PUP ID

SEX BODY wr

CLJN OBS



M F M M F F F F F F F

79.9 77.6 75.3 76.5 75.3 78.1


SELECTED SELECTED GROSS R1 GROSS R1 GROSS R1 GROSS R1 OISCl\RDED DISCl\RDED DISCl\RDED DISCl\RDED DISCl\RDED

02/10/9202/10/9202/10/92 02/10/92 02/10/92 02/10/92 02/10/9202/10)9202/10/9202/10/9202/10/92

NAD NAD NAD NAD

02/10/9202/10/9202/10/9202/10/92

...... tn ......

--~--- ··~- '--· --~

PAC905-01/ll



APPENDIX 13

PATHOLCGY - FlA PUPS GROUP: 1 IXJSE: 0 ppn

LITTER: 42

LITTER SUMMARY

(") -i r...... -o ......... 0 1.0

"

.._, U1 co

PUP SEX BODY CLIN FATH DATE P.M. DATE IAD ID wr OBS


F M M F M M F F M M M F F

5.5 73.8 74.5 67.9 79.3 86.4 76.5 74.3

ABN NAD NAD NAD NAD NAD NAD NAD

INT EVC SELECTED SELECTED SELECTED GROSS PM GROSS PM GROSS PM GROSS PM DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

22/08/92 19/09/9219/09/9219/09/9221/09/92 21/09/92 21/09/92 21/09/92 21/09/9221/09/9221/09/9221/09/9221/09/92

ABN

NAD NAD NAD NAD

22/08/92

21/09/9221/09/9221/09/9221/09/92

PAC905-01/ll

PERCHLOROETHYLENE: MIJLTIGENERATION INHALATION STODY IN THE RAT

INDIVIDUAL 1\N.ll<fliL DATA SUPPLEMENT

APPENDIX 13

PATHOLOGY - l'1A PUPS GROUP: 1 lXlSE: 0 ppn

LITIER: 43

LITTER SUMMARY

n -i r-.... -o-.....,. 0 0.0 ......

...... U1 0.0

PUP ID

SEX BODY wr

CLIN OBS

FATE DATE P.M. D.A.TE IAD


M M M M F M M M M M M M M

9.2

79.5 71.0 80.9 73.8

ABN

NAD NAD NAD NAD

LOST INT EVC LOST SELECTED SELECTED GROSS EM GROSS EM DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

2J./08/922J./08/92 27/08/9214/09/9214/09/9214/09/92 14/09/92 14/09/9214/09/9214/09/9214/09/92 14/09/9214/09/92

ABN

NAD NAD

21/08/92

14/09/9214/09/92

DELETED

PAC905-0l/ll

PERC!ITJ)ROETHYLENE: M!JLTIGENERATION INHAlATION STUDY IN THE RAT


APPENDIX 13

PATHOLCGY - F1A POPS GROUP: 1 IXJSE: 0 ppn

LI1TER: 44

LITTER SUMMARY

n -1 r ...... -o ......... 0 0.0

"

POP ID

SEX BODY wr

CLIN OBS



M M F M F F M M F F F F

94.0 83.5 81.7 94.0 96.6 84.3 79.4


LOST LOST LOST SELECTED SELECTED SELECTED GROSS FM GROSS FM GROSS FM GROSS FM DISCARDED DISCARDED

28/08/9228/08/9228/08/9221/09/9221/09/9221/09/9221/09/92 21/09/92 21/09/92 21/09/92 21/09/9221/09/92

NAD NAD NAD NAD

21/09/9221/09/9221/09/9221/09/92

" "' 0

PAC905-01/ll

PERCHLOllDETHYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT

INOlVIIJUAL ANIMAL DATA SUPPLEMENT

APPENDIX 13

PATHOLOGY - F1A PUPS GROUP: 1 IXJSE: 0 ppn

LITTER: 45

LITTER SUMMARY

" -; r ...... -o ........,. 0 <0 .....,

I



F M M F F M M M M M F F

83.2 79.2 74.0 71.9

NllD NllD NllD NllD

LOST GROSS EM GROSS EM GROSS EM GROSS EN DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

14/09/92 08/10/92 08/10/92 08/10/92 08/10/92 08/10/92 08/10/92 08/10/92 08/10/92 08/10/92 08/10/92 08/10/92

NllD ABN NllD NllD

08/10/9208/10/92 08/10/9208/10/92

*

....., O"l .....

PAC905-01/11

PERCHLOROEI'HYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT


APPENDIX 13

PATHOLOGY - F1A PUPS GROUP: 1 IXJSE: 0 PJlll

PUP ID: 45/C SEX: M ON STUDY: 29 days ( 5 wks) GROSS R1

MACROPATHOLOGY

Killed by Fluothane

THE FOLLOI-IING TISSUES \<ERE SUBMITTED

KIDNEY

THE FOlLOWING MACRDSIXJPIC OBSERVATIONS \<ERE MADE

KIDNEY Pelvic dilatation : (left ; rroderate)

-------------------------------------------------------END OF PUP------------------------------------------------------------------

,...., -l r...._.,...._ ..,. 0 lO ......

...... 0"\ N

PAC905-0l/ll

PERCHLORDETHYLENE: MIJLTIGENERATION lliH!ILATION STUDY IN THE RAT


APPENDIX 13

PATHOLOGY - F1A PUPS GROUP: 1 OOSE: 0 ppn

LITTER: 46

LITTER SUMMARY

"-< r ........, ...... ""' 0

'"' "



F M F M M F F M M M F F

75.5 72.4 73.0 67.2 71.5 59.3


LOST SELECTED SELECTED GROSS EM GROSS EM GROSS EM GROSS EM DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

23/08/9216/09/9216/09/9216/09/92 16/09/92 16/09/92 16/09/92 16/09/9216/09/9216/09/9216/09/9216/09/92

NAD NAD NAD NAD

16/09/9216/09/9216/09/9216/09/92

"0\ w

PAC905-01/11

PERCHLORDETHYLENE: M!JLTIGENERATION INHAlATION STUDY IN THE RAT


APPENDIX 13

PATHOLOGY - F1A PUPS GROUP: 1 IDSE: 0 Jliiil LIITER: 47

LITTER SUMMARY

" -; r...... "0 ......... 0

""....,

...., ""...

PUP ID

SEX BODY wr

CLIN OBS


A B c D E F G H I J

M F F M M M F F M M

88.0 81.5 74.7 87.8 78.1 81.2 79.3 63.5


SELECTED SELECTED SELECTED FULL FM GROSS FM GROSS FM GROSS FM GROSS FM DISCARDED DISCARDED

11/09/9211/09/9211/09/9211/09/92 11/09/92 11/09/92 11/09/92 11/09/92 11/09/9211/09/92

NAD NAD NAD NAD NAD

11/09/9211/09/9211/09/9211/09/9211/09/92

*

PAC905-0l/ll

PERCHLOROETHYLENE: M!JLTIGENERATION INH.<\11\TION STUDY IN THE RAT

INDIVIDUAL ANlMAL D.'\TA SUPPLlliENT

APPENDIX 13 PATHOLOGY - FlA PUPS

GROUP: 1 DJSE: 0 PUP

PfillID: 47/D SEX: M ON STUDY: 29 days (5 wksl FULL EM

MACROPATHOLOGY

Killed by Fluothane

THE FOU.OHING TISSUES \o/ERE SUPMITTED

EPIDIDYMIS ; KIDNEY ; LIVER ; PITUITARY GLAND ; PROSTATE GLI\NO : SEMINAL VESICLE ; TESTIS

NO ABNORMALITIES \>/ERE SEEN IN THE ANlMAL

MICROPATHOLOGY

n ...... -...., r

-....., 0 ....., "'

TISSUE CHECK: TOTAL EXt\MINED NOT EXAM MISSING NAD

PROTOCOL REQUIRED 2 2 0 0 2NOT PROTOCOL (SUPMITTEDl 5 0 5 0 0

(NOT SUPMITTEDl 0 0 0 0 0

....., 0"\ (J1

THE FOLLOV/ING TISSUES \>/ERE MARKED NAD

KIDNEY ; LIVER


FCD NOT RECORDED

-------------------------------------------------------END OF PUP------------------------------------------------------------------

PAC905-01/ll

PERCHLORDET!IYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT


APPENDIX 13

PATHOLOGY - FlA PUPS GROUP: 1 IXJSE: 0 ppn

LITl'ER: 48

LITTER SUMMARY

n -1 r ...... "" ...... ""0

"".....,

PUP ID

SEX BODY wr

CLIN OBS


A B c D E F G H I J

M F M F M M M F F F

75.6 75.1 75.6 75.1 82.2 75.5 75.3 73.2 72.9

NAD NAD NAD NAD NAD NAD ABN NAD NAD

FULL R1 FULL R1 SELECTED SELECTED FULL R1 GROSS R1 GROSS R1 GROSS R1 GROSS R1 DISCABDED

09/09/9209/09/9209/09/9209/09/9209/09/92 09/09/92 09/09/92 09/09/92 09/09/92 09/09/92

NAD NAD NAD NAD NAD

09/09/9209/09/9209/09/9209/09/9209/09/92

* *

DELETED DELETED

•

....., "' "'

PP..C905-0l/ll

PERCHLOROETHYLENE: M!JLTIGENERATION INHAlATION STUDY IN THE RAT


APPENDIX 13

PATHOLOOY - FlA PUPS GROUP: 1 OOSE: 0 ppn

PUP ID: 48/E SEX: M ON STUDY: 29 days (5 wks J FULL EM

MACROPATHOLOOY

Killed by Fluothane

THE FOWJ\IDlG TISSUES viERE SUEMITTEO

EPIDIDYMIS ; KIDNEY ; LIVER ; PITUITARY GLAND ; PROSTATE GLAND : SE!ill!AL VESICLE ; TESTIS

i\'0 ABNORMALITIES viERE SEEN IN THE ANIMAL

MICROPATHOLOOY

"--! ' ....... -o .........,. 0 0.0....,

TISSUE CHECK: TOTAL EXi'.MINEIJ NOT EXAM MISSING NAD

PROTCCOL REQUIRED 2 2 0 0 2 i\'OT PROTCCOL (SUEMITTEO) 5 0 5 0 0

(NOT SUEMITTEOl 0 0 0 0 0

...., 0"1....,

THE FOWJ\IDlG TISSUES V1ERE MARKED NAD

IGDNEY ; LIVER


FCD NOT RECORDED

-------------------------------------------------------END OF PUP------------------------------------------------------------------

PAC905-0l/ll



APPENDIX 13

PATHOLOGY - F1A PUPS PUP ID:

GROUP: 1 48/G

rosE, SEX:

a M

IJll11ON STUDY: 29 days ( 5 wks) GROSS EM

MACROPATHOLOGY

Killed by Fluothane


EYE : Clinical observation of left eye lid stained, not apparent at necropsy.

-------------------------------------------------------END OF PUP------------------------------------------------------------------~ " " ~ " C) uo

'"

'"en (X)

?~,

PAC905-01/ll

PERC!ll..ORDETHYLENE: MULTIGENERATION lliHALATION STIIDY IN THE RAT


APPENDIX 13

PATHOLCGY - FlA PUPS GROUP: 2 OOSE: 100 ppn

LITIER: 74

LITTER SUMMARY

PUP SEX BODY CLIN FATE DATE P.M. D.'\.TE IAD ID wr OBS

A B c D E F G H I J K L M N

M M F M M F F M M M F F F F

69.5 71.7 73.5 68.1 70.3 68.2 68.8


SELECTED SELECTED SELECTED GROSS R1 GROSS R1 GROSS R1 GROSS R1 DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

24/09/9224/09/9224/09/9224/09/9224/09/9224/09/9224/09/9224/09/9224/09/9224/09/9224/09/9224/09/9224/09/9224/09/92

NAD NAD NAD NAD

24/09/9224/09/9224/09/9224/09/92

("'>

-l.-...._ "0...._

"" 0

"' .....,

....., 0'1

"'

PAC905-01/ll

PERCHLORDETilYLENE: MIJLTIGENERATION INHAlATION STUDY IN THE RAT


APPENDIX 13


LITTER: 76

LITTER SUMMARY

n -1 r-... "0-... "" 0

'"' .....,

I

PUP ID

SEX BODY wr

CLIN OBS



M F F F M M F F F F F

74.8 62.6 66.2 71.7 70.9 74.7 71.0 73.1


SELECTED SELECTED SELECTED FULL PM GROSS PM GROSS PM GROSS PM GROSS PM DISCARDED DISCARDED DISCARDED

10/09/9210/09/9210/09/9210/09/92 10/09/92 10/09/92 10/09/92 10/09/92 10/09/9210/09/9210/09/92

NAD NAD NAD NAD NAD

10/09/9210/09/9210/09/9210/09/9210/09/92

*

.....,

....., 0

~ ·~

--

. ---- --···-- - -------· ----PAC905-0l/ll



APPENDIX 13

PATHOLCGY - F1A PUPS GROUP: 2 IXJSE: 100 ppn

PUP ID: 76/D SEX: F ON STUDY: 29 days (5 wks) F1lLL R1

MACROPATHOLOGY

Killed by Fluothane

THE FOLLOWING TISSUES WERE SUJM[TTED

CERVIX ; KIDNEY ; LIVER : OVPJJY ; PITUITPJJY GLAND ; 1.iTERUS ; VAGINA

NO ABNOllMALITIES WERE SEEN IN THE ANIMAL

-------------------------------------------------------ENO OF PUP------------------------------------------------------------------

" -i r

--., -o

0 <.0

"

.._,.._,

.....

--- ---

------

PAC905-01/ll

PERCHLOROETHYLENE: MULTIGENERATION INHAlATION STUDY lN THE RAT


APPENDIX 13


LITTER: 77

LITTER SUMMARY

PUP ID

SEX BODY wr

CLJN CBS


A B c D E

M F M MM

99.1 93.6

105.6 97.6

NAD NAD NAD NAD

SELECTED SELECTED GROSS B1 GROSS B1 DISCARDED

15/09/9215/09/9215/09/92 15/09/92 15/09/92

NAD ABN

15/09/9215/09/92 * ,..,

..... r "0 ..,. 0

"' "

" "N

---~·-~--~-- ~-------

.-.~·

PAC905-0l/ll



APPENDIX 13 PATHOLOOY - F1A PUPS

PUP ID: GROUP; 2

77/D OOSE:

SEX: 100

M ppnON STUDY: 29 days (5 M<s l GROSS PM

MACROPATHOLOOY

Killed by Fluothane

THE FOlLOWING TISSUES VIERE SUEMI.TTED

KillNEY

THE FOI.LCJVIING MACROSOOPIC OBSERVATIONS VIERE MADE

KillNEYPelvic dilatation : (left ; slight : right : !!Dderate)

-------------------------------------------------------END OF PUP------------------------------------------------------------------

r> -I r.._ .._" .., 0 '-0 ....

" "w

~----·---------- --

PAC905-01/11

PERCHLORDETHYLENE: MULTIGENERATION JM!ALATION STUDY IN THE RAT


APPENDIX 13

PATHOLCGY - F1A PUPS GROUP: 2 IXJSE: 100 Jlllil LI'I'I'ER: 78

LITTER SUMMARY

n -{ r ...... -o ........, 0

"' " . " "..,

PUP ID

SEX BODY wr

CLIN OBS

FATE DATE P.M. DATE L\D


M M M F M M F F M M F F

84.3 78.9 82.4 82.9 79.1 73.2.


LOST LOST SELECTED SELECTED GROSS PM GROSS PM GROSS PM GROSS PM DISCAlllJED DISCAlllJED DISCAlllJED DISCAlllJED

06/09/9206/09/9230/09/9230/09/9230/09/92 30/09/92 30/09/92 30/09/92 30/09/9230/09/9230/09/9230/09/92

NAD NAD NAD NAD

30/09/9230/09/9230/09/92 30/09/92

~. -

PAC905-01/ll


INDIVIDT.!AL ANlMI\L DATA SUPPLEMENT

APPENDIX 13

PATHOLOGY - FlA PUPS GROUP: 2 rosE: 100 Jl!IIl LITTER: 79

LITTER SUMMARY

n -I r..._..,..._., 0

"' ...._,

...._,

...._, U1

PUP ID

SEX BODY wr

CLIN OBS



M F M M F F M M M M M M M M

53.8 54.5 58.2 58.7 55.7 58.6


SELECTED SELECTED GROSS PM GROSS PM GROSS PM GROSS PM DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

12/09/9212/09/9214/09/92 14/09/92 14/09/92 14/09/92 14/09/9214/09/9214/09/9214/09/9214/09/9214/09/9214/09/9214/09/92

NAD NAD NAD NAD

14/09/9214/09/9214/09/9214/09/92

.J

PAC905-01/ll



APPENDIX 13

PATHOLCGY - F1A PUPS GROUP: 2 lXJSE: 100 ppn

LITTER: 81

LITTER SUMMARY

n -i r._ "'0._ ""' 0 1.0....,

....,...., 0\

PUP ID

SEX BODY wr

CLIN OBS

FATE DATE P.M. DATE TAD


M M M F M M M F F M M F F

67.5 75.6 65.7 74.4 70.7 73.4 66.3 68.6


LOST SELECTED SELECTED SELECTED FULL R1 GROSS R1 GROSS R1 GROSS R1 GROSS R1 DISCARDED DISCARDED DISCARDED DISCARDED

16/08/92 09/09/9209/09/9209/09/9209/09/92 09/09/92 09/09/92 09/09/92 09/09/92 09/09/9209/09/9209/09/9209/09/92

NAD NAD NAD NAD NAD

09/09/92 09/09/9209/09/9209/09/9209/09/92

*

-··--·-------- ··----- ... - -·

PAC905-01/11

PERCHLOROETHYLENE: MIJLTIGENERATION INHEILIITION STUDY IN THE RAT


APPENDIX 13 PATHOI..OOY - FJA PUPS

GROUP: 2 !XlSE: 100PUP ID: 81/E SEX: M

ptm ON STUDY: 29 days (5 wksJ FOLL PM

MACROPATHOI..OOY

Killed by Fluothane

THE FOWJWTh'G TISSOES WEllE SUEMITIED

EPIDIDYMIS : KIDNEY ; LIVER ; PITUITARY GLAND ; PROSTATE GLAND ; SEMINAL VESICLE ; TESTIS

NO ABNORMALITIES WEllE SEEN IN THE ANJM.'L

-------------------------------------------------------END OF PUP------------------------------------------------------------------

n --! r-., -.!:> 0 '-0....,

....,....,....,

.. - -··----· ·--~·-·--

PAC905-01/ll

PERCHLOROETHYLENE: M!JLTIGENERATION INliAI.ATION STUDY IN THE RAT

OOIVIDUAL ANJMAL DATA SUPPLEMENT

APPENDIX 13

PATHOLCGY - F1A PUPS GROUP: 2 OOSE: 100 ppn

LITTER: 82

LITTER SUMMARY

n -< r ....... " ........., 0 \0....,

...,..., ():)



F F M F F M M F F M M M M F

6.5

78.7 77.2 79.2 86.8 86.9 81.3 79.9

ABN


INT EVC LOST SELECTED SELECTED FULL PM GROSS PM GROSS PM GROSS PM GROSS PM DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

16/08/92 19/08/9212/09/9212/09/9214/09/92 14/09/92 14/09/92 14/09/92 14/09/92 14/09/9214/09/9214/09/92 14/09/92 14/09/92

ABN

NAD NAD NAD NAD NAD

16/08/92

14/09/9214/09/9214/09/9214/09/9214/09/92

*

~~

PAC905-0l/ll

PERCHLOROETHYLENE: MDLTIGENERATION INHAlATION STUDY IN THE RAT


APPENDIX 13


PUP ID: 82/E SEX: F ON STUDY: 31 days (5 wks) FOLL R1

MACROPATHOLOGY

Killed by Fluothane

THE FOLLOWING TISSUES WERE SUPMITIED

CERVIX : KIDNEY : LIVER : OVAF::l ; PITUITAF::l GLAND : UTERUS : VAGINA


-------------------------------------------------------END OF PUP------------------------------------------------------------------

n ..... r...._ -c...._..,. 0 ..._,"'

..._, ..._,

"'

PAC905-01/11

PERCHLOROETHYLENE: MULTIGENERATION INHAL!\.TION STUDY IN THE RAT

INDIVIDUAL ANJMAL DATA SUPPLEl1ENT

APPENDIX 13

PATHOLOGY - F1A PUPSGROUP: 2 DOSE: 100 ppn

LITTER: 83

LITTER SUMMARY

"-l r..._ -o..._ ""'0

"' .....,

PUP ID

SEX BODY wr

CLIN OBS

FATE DATE P.M. DA'IE IAD

A B c D E F G H I

M M M M M M M M M

82.9 83.8 79.6 74.0

NAD NAD NAD NAD

SELECTED RJLL FM GROSS FM GROSS FM DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

09/09/9209/09/92 09/09/92 09/09/92 09/09/9209/09/9209/09/9209/09/9209/09/92

NAD NAD NAD

09/09/9209/09/9209/09/92

*

....., co 0

PAC905-0l/ll

PERCHLOROETHYLENE: MDLTIGENERATION INHALATION STUDY IN THE RAT


APPENDIX 13

PATHOLCGY - F1A PUPSGROUP: 2 IDSE: 100 ppn

PUP ID: 83/B SEX: M ON STUDY: 29 days (5 wks) FULL PM

MACROPATHOLOGY

Killed by Fluothane

THE FOILO\VING TISSUES HERE SUBMITI'ED

EPIDIDYMIS ; KIDNEY ; LIVER ; PITUITARY GLAND : PROSTATE GLAND ; SEMINAL VESICLE ; TESTIS

THE FOILO\illlG MACROSCOPIC OBSERVATIONS HERE MADE

KIDNEY Pelvic dilatation : (right ; ooderate)

NO ABNOBMALITIES HERE SEEN IN THE REMAINING TISSUES

-------------------------------------------------------END OF PUP------------------------------------------------------------------

n --; ,......... -o ........,. 0 lD

"

"CX> ......

PAC905-0l/11

PERCHLORDETHYLENE: MDLTIGENERATION INHALATION STUDY IN THE RAT

INOI\IIDUAL ANJMAL DATA SUPPLEMENT

APPEND1X 13

PATHOLOGY - FlA PUPSGROUP: 2 OOSE: 100 ppn

LITTER: 84

LITTER SUMMARY

" -; r ........, ....... ""'0 <.0 ......

...... 00 N

PUP ID

SEX BODY wr

CLIN OBS



M M F F M M M F F M M M F

66.1 70.9 68.4 70.5 70.6 67.5 74.7 71.4


LOST SELECTED SELECTED SELECTED RlLL R1 GROSS R1 GROSS R1 GROSS R1 GROSS R1 DISCARDED DISCARDED DISCARDED DISCARDED

16/08/9209/09/9209/09/9209/09/9209/09/92 09/09/92 09/09/92 09/09/92 09/09/92 09/09/9209/09/9209/09/9209/09/92

NAD NAD NAD NADNAD

09/09/9209/09/9209/09/9209/09/9209/09/92

*

PAC905-01/ll



APPENDIX 13 PATHOL03Y - F1A PUPS

GROUP: 2 DJSE: 100 ppnPUP ID: 84/E SEX: M ON STUDY: 29 days (5 wks l FDLL R1

MACROPATHOL03Y

Killed by Fluothane

THE FDLLOHING TISSUES IIERE SU!!MITI'ED

EPIDIDYMIS ; KIDNEY ; LIVER ; PITUITARY GLAND ; PROSTATE GLAND : SEMINAL VESICLE : TESTIS

NO IIBNORMALITIES I1ERE SEEN IN THE AN1MAL

-------------------------------------------------------END OF PUP------------------------------------------------------------------

n -i r -.... -o-.... ""' 0

....., "'

....., co w

PAC905-01/ll

PERCHLORDETHYLENE: MULTIGENERATIDN INHALIITIDN STUDY IN THE RAT


APPENDIX 13


LITTER: 85

LITTER SUMMARY

" -;,.... ........, ........, 0

""....,

...., co..,

PUP ID

SEX BODY wr

CLIN OBS



M M M F F M M F F M M F

84.6 79.6 70.8 71.9 80.4 83.1 73.3 75.4


LOST SELECTED SELECTED SELECTED SELECTED GROSS PM GROSS PM GROSS PM GROSS PM DISCARDED DISCARDED DISCARDED

08/09/9202/10/9202/10/9202/10/9202/10/9202/10/92 02/10/92 02/10/92 02/10/92 02/10/9202/10/9202/10/92

NAD NAD NADNAD

02/10/9202/10/9202/10/9202/10/92

I

PAC905-01/11


INDIVIDUI\L ANlMI\L DATA SUPPLEMENT

APPEND]]( 13


LITIER: 86

LITTER SUMMARY

"-i r...._ -o...._.., 0 <0 ......

PUP ID

SEX BODY \-IT

CLIN OBS



M F F F M M F F M F F

72.0 68.3 75.8 67.5 68.9 77.9 62.4 70.9


SELECTED SELECTED SELECTED FULL PM GROSS PM GROSS PM GROSS PM GROSS PM DISCAROEO DISCARDED DISCARDED

11/09/9211/09/9211/09/92 11/09/92 11/09/92 11/09/92 11/09/92 11/09/92 11/09/9211/09/9211/09/92

NAD NAD NAD NAD NAD

11/09/9211/09/9211/09/9211/09/9211/09/92

*

...... OJ IJ1

PAC905-0l/ll

PERCHLORDETHYLENE: MJ.JLTIGENERATION INHAlATION STUDY IN THE RAT

OOIVIDUAL liNIMAL DATA SUPPLEMENT

APPENDlX 13

PATHOLOGY - FlA POPS GROUP: 2 !XlSE: 100 ppn

POP ID: 86/D SEX: F ON STUDY: 29 days (5 wks) FULL 1M

!-~.ACROPATHOLOGY

Killed by Fluothane


CERVIX ; KIDNEY ; LIVER ; OVAFY ; PITOITARY GLAND ; Ul'ERlJS ; VAGINA

NO ABNORMALITIES WERE SEEN IN THE liNIMAL

-------------------------------------------------------END OF POP------------------------------------------------------------------

n__,

-r-.., -.., 0 ..,.._,

.._, (l:J CT\

PAC905-01/ll



APPENDIX 13

PATHOL(X;Y - FlA PUPS GROUP: 2 IXJSE: 100 Jlllll LITTER: 87

LITTER SUMMARY

n -1 r........, ........,. 0 <0....,

...., ():J....,

PUP ID

SEX BODY wr

CLIN OBS


A B c D E F G H I J K L M N 0 p

F M F F F M F F M M M M M M F F

4.1 66.0 60.5

55.5 61.9 68.3 50.5 66.4

ABN NAC NAC

NAC NAC NAC NAC NAC

INT EVC SELECTED SELECTED DISCABDED FULL FM GROSS FM GROSS FM GROSS FM GROSS FM DISCABDED DISCABDED DISCABDED DISCABDED DISCABDED DISCABDED DISCABDED

18/08/92 14/09/9214)09/9214/09/92 14)09/92 14/09/92 14/09/92 14/09/92 14/09/92 14/09/9214/09/9214/09/9214/09/9214/09/9214/09/9214/09/92

A8N

NAC NAC NAC NAC NAC

18/08/92

14/09/9214/09/9214/09/9214/09/9214/09/92

*

~ '~

PAC905-01/ll

PERCHLOROETHYLENE: MULTIGENERATION lliHALATION STUDY IN THE RAT

INDIVIDUAL ANlli\1 DATA SUPPLEMENT


PUP ID: GROUP: 2

87/E lXJSE:

SEX: 100

F ppn

ON STUDY: 29 days (5 wks) FUlL R1

MACROPATHOLOGY

Killed by Fluothane

THE FOLLOWING TISSUES WERE SUJMITTEO

CERVIX ; KIDNEY ; LIVER ; OVNIT ; PITUITARY GLAND ; UTERUS ; VAGINA

NO ABNORM.<\LITIES WERE SEEN IN THE ANlli\1

-------------------------------------------------------END OF PUP------------------------------------------------------------------

n --! ......-..... "'0-..... ""' 0 <0 .....,

....., OJ OJ

~~

PAC905-01/ll

PERCHLOROETHYLENE: MDLTIGENERATION INHALATION STUDY lli THE RAT

INDIVIDtiAL ANIMAL Di\.TA SUPPLEMENT

APPENDIX 13

PATHOLOGY - FlA PUPSGROUP: 2 !XJSE: 100 PJlll LITTER: 88

LITTER SUMMARY

"--< r -., -""' 0 <0 '-J

'

PUP ID

SEX BODY wr

CLlli OBS



M F F M M F F M M F F

76.7 75.6 77.7 80.8 81.3 73.8 74.7


SELECTED SELECTED FULL PM GROSS PM GROSS PM GROSS PM GROSS PM DISCAROED DISCAROED DISCAROED DISCAROED

09/09/9209/09/9209/09/92 09/09/92 09/09/92 09/09/92 09/09/92 09/09/9209/09/9209/09/9209/09/92

NAD NAD NAD NAD NAD

09/09/9209/09/9209/09/9209/09/9209/09/92

*

'-J OJ <0

PAC905-0l/ll



APPENDIX 13

PATHOu:x:;¥ - FJA PUPS GROUP: 2 IXJSE: 100 ppn

PUP ID: 88/C SEX: F ON STUDY: 29 days (5 Wks) FULL FM

MACRDPATHOu:x:;¥

Killed by Fluothane

THE FOILOliDlG TISSUES WERE SUEMITTED

CERVIX ; KIDNEY ; LIVER ; OVARY ; PITUITARY GLAND ; UTERUS ; VAGINA


-------------------------------------------------------END OF PUP------------------------------------------------------------------

-; '""' r ...... -o ........,. 0 ....,""

...., "" 0

~

PAC905-01/ll

PERCHLOROETHYLENE: MULTIGENERATION 1NHALATION STUDY IN THE RAT


APPENDIX 13

PATHOLOGY - F1A PUPSGROUP: 2 IXJSE: 100 ppn

LITTER: 89

LITTER SUMMARY

n -l r....._ .,....._

"" 0 <.0....,

' ...., <.0 ~

PUP ID

SEX BODY wr

CLIN OBS



M F M M F F M M M M F F

73.3 68.1 71.5 74.8 65.0 70.9


SELECTED SELECTED GROSS R1 GROSS R1 GROSS R1 GROSS R1 DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

01/10/9201/10/9201/10/92 01/10/92 01/10/92 01110/92 01/10/9201/10/9201/10)9201/10/9201/10/9201/10/92

NAD NAD NAD NAD

01/10/9201/10/9201/10/9201/10/92

.L

PAC905-01/11



APPENDIX 13

PATHOLCGY - FlA PUPSGROUP: 2 OOSE: 100 Jl!l1lLITTER: 91

LITTER SUMMARY

PUP SEX BODY CLIN FATE DATE P.M. DATE IADID wr OBS

A F LOST 07/09/92B M 73.7 NAD SELECTED 01/10/92c F 70.6 NAD SELECTED 01/10/92D M 74.5 NAD GROSS PM 01/10/92 NAD 01/10/92E M 67.6 NAD GROSS PM 01/10/92 NAD 01/10/92F F 65.4 NAD GROSS PM 01/10/92 NAD 01/10/92G F 69.0 NAD GROSS PM 01/10/92 NAD 01/10/92H M 60.5 ABN GROSS PM 01/10/92 ABN 01/10/92I *M DISCARDED 01/10/92 J F DISCARDED 01/10/92K F DISCARDED 01/10/92L F DISCARDED 01/10/92

,....,....r

0<.0

----"""'....,

'....,<.0N

-~

PAC905-01/11


INDIVIDUt\L ANIMAL D.<\.TA SUPPLEMENT

APPENDIX 13 PATHOLOGY - FJA PUPS

GROUP: 2 lXJSE: 100 Pfill PUP ID: 91/H SEX: M ON STUDY: 29 days (5 wksJ GROSS PM

MACROPATHOLCGY

Killed by Fluothane

THE FOLLO\-IING TISSUES WERE SUEMITTED

TAIL

THE FOlLO\-IING MACROSCOPIC OBSERVATIONS WERE MI\DE

TAIL Traumatised : cannibalised. Swollen

-------------------------------------------------------END OF PUP------------------------------------------------------------------

n --< r -.., ..,. -0 ....., ""

....., w ""

. ]_ -.

PAC905-01/ll

PERCHLORDET!lYLEN& MULTIGENERATION INHALATION STUDY IN TilE RAT

INDIVTIJUAL AN1MI\L DATA SUPPLEMENT

APPENDIX 13

PATHOLOGY - FlA PUPS GROUP: 2 DJSE: 100 ppn

LITTER: 92

LITTER SUMMARY

r. -1 ..... ....... "0 .........,. 0

"" "

PUP ID

SEX BODY wr

CLIN OBS


A B c D E F G H I J

M M F F M M M M F M

5.7 6.1 5.9 6.2

107.1 104.0 91.9

ABN ABN ABN ABN

NAD NAD NAD

INT EIJC INT EIJC INT EIJC INT EIJC LOST LOST GROSS B1 GROSS B1 GROSS B1 DISCARDED

05/09/92 05/09/92 05/09/92 05/09/92 09/09/9209/09/9205/10/92 05/10/92 05/10/92 05/10/92

ABN ABN NAD NAD

NAD NAD NAD

05/09/9205/09/9205/09/9205/09/92

05/10/9205/10/9205/10/92

" ""..,.

~~.~ ~

PAC905-01/ll

PERCHI.JJROETHYLENE: M!JLTIGENERATION INHALATION STUDY lli THE RAT INDIVIIlUAL Atm<AL DATA SUPPLEMENT

APPENDIX 13

GROUP: PATIJOLCGY - PlA 2 PUPSIXJSE: 100 LITTER: 93 PJl1l

LITTER SUMMARYPUP SEX BODY CLlli FATE DATE P.M.ID WI' DATE OBS IAD

A F LOST 18/08/92B M 70.4 NAD SELECTED ll/09/92c M 76.7 NAD SELECTED ll/09/92D F 69.2 NAD SELECTED ll/09/92E M 72.8 NAD FUlL FM ll/09/92 NAD F M ll/09/9270.3 NAD GROSS FM ll/09/92 NAD *G M ll/09/92 73.6 NAD GROSS FM ll/09/92 NADH F ll/09/9270.6 NAD GROSS FM ll/09/92 NAD I F ll/09/9270.9 NAD GROSS FM ll/09/92 NAD J ll/09/92M DISCARDED ll/09/92K M DISCARDED ll/09/92L M DISCARDED ll/09/92

--i "r-...... "'tl ...... .., 0 ....., "" .

....., <.n""

PAC905-01/ll

PERCHLOROET!IYLENE: MULTIGENERATION INHALATION STUDY IN TilE RAT


APPENDIX 13

PAT!IOL(X;Y - F1A PUPS PUP GROUP: 2 OOSE: 100 ppn

ID: 93/E SEX: M ON STUDY: 29 days (5 wks) FULL IM

MACRDPATHOL(X;Y Killed by Fluothane

TilE FOLLOWING TISSUES WERE SUEMITTED


NO ABNOBMALITIES WERE SEEN IN TilE ANlMAL

-------------------------------------------------------END OF PUP------------------------------------------------------------------

n -<........., ...... ""' 0 1.0 ......

...... 1.0

"'

~. ~.

PAC905-01/ll

PERCHLOROETHYLENE: MIJLTIGENERATION INHALPJ:ION STUDY IN THE RAT


APPEND]]( 13

PATHOLOGY - F1A PUPSGROUP: 2 !XlSE: 100 PJlilLITI'ER: 94

LITTER SUMMARY


A M 60.1 NAD SELECTED 10/09/92B F 67.3 NAD SELECTED 10/09/92c M 80.9 NAD GROSS EM 10/09/92 NAD 10/09/92 D M 73.2 NAD GROSS EM 10/09/92 NAD 10/09/92 E F 67.7 NAD GROSS EM 10/09/92 NAD 10/09/92F F 69.6 ·NAJ) GROSS EM 10/09/92 NAD 10/09/92G M DISCARDED 10/09/92H M DISCARDED 10/09/92I M DISCARDED 10/09/92J M DISCARDED 10/09/92K M DISCARDED 10/09/92 L F DISCARDED 10/09/92

n r.....

---.., ---" 0 '-0 ..._,

I

..._, '-0..._,

PAC905-0l/11

PERCHLORDETHYLENE: MIJLTIGENERATION INHAlATION STUDY IN THE RAT

INDIVIDUAL ANll1AL DATA SUPPLEMENT

APPENDIX 13

PATHOLOGY - F1A PUPSGROUP: 2. IXlSE: 100 P!lll LITTER: 95

LITTER SUMMARY

n -< r'-o '..,. 0

'"" .....,

I

PUP ID

SEX BODY wr

CLIN OBS



M F M M M F F M M M F

69.8 62.6 67.5 72.5 66.2 71.8 62.0


SELECTED SELECTED FULL EM GROSS EM GROSS EM GROSS EM GROSS EM DISCARDED DISCARDED DISCARDED DISCARDED

11/09/9211/09/9211/09/92 11/09/92 11/09/92 11/09/92 11/09/92 11/09/9211/09/9211/09/9211/09/92

NAD NAD NAD NAD NAD

11/09/9211/09/9211/09/9211/09/9211/09/92

*

.....,

'"" CD

~

--

PAC905-0l/11


OOIVIIJUl\L ANIMI\L DATA SUPPLEMENT

APPENDIX 13

PATHOLCGY - FlA PUPS PUP

GROUP: 2 D:JSE: 100 JlllllID: 95/C SEX: M ON STUDY: 29 days (5 wks J FULL FM



EPIDIDYMIS : KIDNEY ; LIVER : PITUITARY GLAND ; PROSTATE GLAND ; SEMINAL VESICLE ; TESTIS

NO ABNO!IMALITIES WERE SEEN IN THE ANIMI\L

-------------------------------------------------------END OF PUP------------------------------------------------------------------

n -1,... -o --0""' 1.0 ......

..... 1.0 1.0

PAC905-01/ll

PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY lN THE RAT

JNDIVIDUAL ANJMAL DATA SUPPLEMENT

APPENDIX 13

PAT!!OLCX;Y - F1A PUPS GROUP: 2 IXJSE: 100 ppn

LITTER: 96

LITTER SUMMARY

PUP ID

SEX BODY wr

CLJN OBS


A B c D

M F F M

75.2 78.5 79.4 84.6

NAD NAD NAD NAD

SELECTED SELECTED SELECTED GROSS PM

15/09/9215/09/9215/09/9215/09/92 NAD 15/09/92 '"' ....;

r...... '"0 ...... ""'0 <0..._,

I

"" 0 0

PAC905-01/ll



APPEND1X 13

PATHOLOGY - F1A PUPS GROUP: 3 !XJSE: 300 ppn

LITTER: 122

LITTER SUMMARY



M M F M M F F F F F F F M M

63.5 60.0 63.7 57.9 65.6 55.9 56.6


SELECTED SELECTED SELECTED GROSS FM GROSS FM GROSS FM GROSS FM DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED LOST LOST

02/10/9202/10/9202/10/9202/10/9202/10/9202/10/9202/10/9202/10/9202/10/9202/10/9202/10/9202/10/9208/09/9208/09/92

NAD NAD NAD NAD

02/10/9202/10/9202/10/9202/10/92

"-< r -., -.., 0 '-0.._,

CX> 0....

PAC905-01/ll

PERCHLORDETHYLENE: MIJLTIGENERATION INHAlATION STUDY IN THE RAT


APPENDIX 13

PATHOLCGY - F1A PUPSGROUP: 3 lXJSE: 300 PJlllLITTER: 123

LITTER SUMMARY


A M LOST 23/08/92B F LOST 23/08/92c M 69.2 NAIJ SELECTED 16/09/92D F 63.0 NAIJ SELECTED 16/09/92E F 64.2 NAIJ SELECTED 16/09/92F M 68.5 NAIJ GROSS PM 16/09/92 NAIJ 16/09/92G M 63.1 NAIJ GROSS PM 16/09/92 NAIJ 16/09/92H F 66.1 NAIJ GROSS PM 16/09/92 NAIJ 16/09/92I M DISCARDED 16/09/92J M DISCARDED 16/09/92K M DISCARDED 16/09/92L M DISCARDED 16/09/92M M DISCARDED 16/09/92 N M DISCARDED 16/09/92

r...... ' ..._ -c ..._.., 0 '-0....,

():) 0N

PAC905-01/ll


INDIVIDUAL AN1Mt\L DATA SUPPLEMENT

APPENDIX 13

PATHOLOGY - F1A PUPS GROUP: 3 !XJSE: 300 pj:Ill

LITI'ER: 124

LITTER SUMMARY

PUP ID

SEX BODY wr

CLIN OBS


A B c D E F G H I J

M M M M F F M M F F

74.5 75.3 75.6 73.3 69.5 71.3


SELECTED SELECTED GROSS PM GROSS PM GROSS PM GROSS PM DISCi\RilED DISCi\RilED DISCARDED DISCARDED

02/10/9202/10/9202/10/92 02/10/92 02/10/92 02/10/92 02/10/9202/10/92 02/10/92 02/10/92

NAD NAD NAD ABN

02/10/9202/10/9202/10/9202/10/92 *

n --1 r ....... "'0 ........., 0 ~ ....,

' co 0

""'

PAC905-0l/11



APPENDIX 13

PATHOLOGY - FlA PUPS

PUP ID: GROUP: 3 124/F IXJSE: SEX: 300 F pp;nON STUDY: 29 days ( 5 wks) GROSS EM

MACROPATHOLOGY

Killed by Fluothane

THE FOWJWING TISSUES WERE SUEMI:TTED

KIDNEY

THE FOWJWING MACROSCOPIC OBSERVATIONS WERE MADE

KIDNEYPelvic dilatation : (right ; slight)

-------------------------------------------------------END OF PUP------------------------------------------------------------------

n --j r

--" ..,. --0 ....,""

co 0..,.

PAC905-01/ll


INDIVIDU!IL ANIMAL DATA SUPPLEMENT

APPENDIX 13

PATHOLOGY - F1A PUPS GROUP: 3 roSE: 300 Jllill

LITTER: 125

LITTER SUMMARY


A B c D E F G H I

M M M F M M F F F

6.2 78.8 87.5 82.0 89.6 84.6 81.5 82.5

ABN Ni\l) Ni\l) Ni\l) Ni\l) Ni\l) Ni\l) Ni\l)

INT EVC SELECTED SELECTED SELECTED FULL R1 GROSS R1 GROSS R1 GROSS R1 DISCARDED

17/08/9214/09/9214/09/9214/09/9214/09/9214/09/9214/09/9214/09/9214/09/92

ABN

Ni\l) Ni\l) Ni\l) Ni\l)

17/08/92

14/09/9214/09/9214/09/9214/09/92

* n -i r..._.,..._..,. 0 '0

" '

co 0 U"1

PAC905-0l/ll



APPENDIX 13 PATHOLCGY - FJA PUPS

GROUP: 3 IXJSE: 300 ppnPUP ID: 125/E SEX: M ON STUDY: 29 days (5 'Wks) FULL FM

MACROPATHOLCGY

Killed by Fluothane

THE FOlLOWING TISSUES WERE SUEMITl'ED


NO ABNORMALITIES WERE SEEN IN THE ANlMAL

-------------------------------------------------------END OF PUP------------------------------------------------------------------

.-n -I

-.., -0""" 1.0 ......

00 0 01

-,

PAC905-01/11

PERCHLOROETHYLENE: MDLTIGENERATION INHAI..ATION STUDY lli THE RAT

INDIVIDUAL ANJMI\1 DATA SUPPLEMENT

APPENDIX 13


LITTER: 126

LITTER SUMMARY

PUP SEX BODY CLlli FATE DATE P.M. DATE IAD ID wr OBS

A B c D

M M M M

94.7 90.2 89.9 90.8

NAD NAD NAD NAD

SELECTED SELECTED GROSS R1 GROSS R1

11/09/9211/09/9211/09/9211/09/92

NAD NAD

11/09/92 11/09/92

n -! r-""C --"' 0 <.0....,

CD 0....,

PAC905-0l/ll



APPENDIX 13

PATHQr..cx:;y - FlA PUPS GROUP: 3 roSE: 300 P!Ifl LITTER: 129

LITTER SUMMARY

PUP ID

SEX BODY wr

CLIN OBS


A B c D E

M M F F F

67.7 53.9 69.6 78.0 68.4

NAD NAD NAD NAD NAD

SELECTED SELECTED SELECTED SELECTED FULL fM

09/09/9209/09/9209/09/9209/09/9209/09/92 NAD 09/09/92 n

-l r- * ....... "0 ....... "" 0 co .....,

I

co 0 co

-,

PAC905-0l/ll

PERCHLOBDETHYLENE: MIJLTIGENERATION INHAlATION STUDY lN THE RAT

INDIVIDUAL ANIM.'\1 DATA SUPPLEMENT

APPENDlX 13

PATHOLOGY - FlA PUPS GROUP: 3 lXJSE: 300 ppn

PUP ID: 129/E SEX: F ON STUDY: 29 days (5 wks l FOLL EM

MACROPATHOLOGY

Killed by Fluothane

THE FOILCIWING TISSUES WERE SUEMITI'ED

CERVIX ; KIDNEY ; LIVER ; OVAP.Y ; PITUITAP.Y GLAND ; UTERUS ; VAGINA

NO ABNORMALITIES WERE SEEN lN THE ANIMAL

-------------------------------------------------------END OF PUP------------------------------------------------------------------

-< ",......._ ..._" 0 _.,. <.0 .....

co 0 <.0

P.A.C905-01/ll

PERCHLORDETIIYLENE: MIJLTIGENERATION INHALATION STUDY Til THE RAT

TIIDIVIDUAL ANn1AL DATA SUPPLEMENT

APPENDIX 13


LITTER: 131

LITTER SUMMARY

PUP ID

SEX BODY wr

CLTII OBS


A B c D E F G

M M F M M F M

76.0 73.4 69.3 70.8 63.8 62.5


SELECTED SELECTED SELECTED GROSS PM GROSS PM GROSS PM DISCARDED

15/09/9215/09/9215/09/9215/09/9215/09/9215/09/9215/09/92

NAD NAD NAD

15/09/9215/09/9215/09/92

n ..... r..._ "0..._.,. 0 <.0....,

I

CX> .... 0

~

PAC905-01/ll



APPENDIX 13

PATHOLOGY - FJA PUPS GROUP: 3 IXlSE: 300 P!Dl

LITI'ER: 133

LITTER SUMMARY


A B c D E F G H I J

M F M M F F M F F F

83.3 78.4 80.9 69.6 77.2 79.0


SELECTED SELECTED GROSS PM GROSS PM GROSS PM GROSS PM DISCARDED DISCARDED DISCARDED DISCARDED

02/10/9202/10/92 02/10/92 02/10/92 02/10/92 02/10/92 02/10/92 02/10/9202/10/9202/10/92

NAD NAD NAD NAD

02/10/9202/10/9202/10/92 02/10/92

n --i r ---o -"' --0

"' " 1

co ...... ......

PAC905-01/ll

PERCHLORDETilYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDU!IL ANIMAL DATA SUPPLEMENT

APPENDIX 13

PATHOLOGY - FJA PUPS GROUP: 3 OOSE: 300 ppn

LITTER: 134

LITTER SUMMARY

PUP ID

SEX BODY wr

CLIN OBS

FATE DATE P.M. DATE IAC

A B c D E F G H I

M F F MM MFFM

76.5 65.2 76.7 62.9 72.5 80.3 70.1 63.0

N!'.D NAD NAD NAD NAD NAD NAD NAD

SELECTED SELECTED SELECTED Ff.li.L fM GROSS fM GROSS fM GROSS fM GROSS fM DISCARDED

09/09/92 09/09/92 09/09/92 09/09/92 09/09/92 09/09/92 09/09/92 09/09/92 09/09/92

NAD NAD NAD NAD NAD

09/09/9209/09/92 09/09/9209/09/9209/09/92

* n -1 r -..., -.. .., 0 ....,"'

00 ..... N

~

PAC905-0l/ll



APPENDIX 13

PATHOLOGY - F1A PUPS GROUP: 3 DJSE: 300 ppn

PUP ID: 134/D SEX: M ON STUDY: 29 days (5 wksl ruLL R1

M.A.CROPATHOLOGY

Killed by Fluothane

THE FOLLOWING TISSUES WERE SUPMITIED

EPIDIDYMIS ; KIDNEY ; LIVER ; PITUITARY GL.A.ND ; PROSTATE GLAND ; SEMIN.A.L VESICLE ; TESTIS

NO .A.BNORMALITIES WERE SEEN IN THE ANIMAL

-------------------------------------------------------END OF PUP------------------------------------------------------------------

n --<,.._ "0.._ ""' 0 <.0.._,

CD ...... w

----

P.t\C905-01/ll

PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE BAT


APPENDIX 13

PATHOLOGY - F1A PUPSGROUP: 3 rosE: 300 ppn

LITI'ER: 135

LITTER SUMMARY

PUP ID

SEX BODY wr

CLIN OBS


A B c D E F G H

M M F M M M M M

70.8 72.0 65.4 71.0 72.9 71.1


SELECTED SELECTED SELECTED F1JLL EM GROSS EM GROSS EM DISCARDED DISCARDED

09/09/9209/09/9209/09/9209/09/92 09/09/92 09/09/92 09/09/92 09/09/92

ABN NAD NAD

09/09/9209/09/92 09/09/92

* n -I r--o ., 0 1.0.._,

I

ex> .......,

~ ~

PAC905-0l/ll


INDIVIDl.TAL AN1MIIL DATA SUPPLEMENT

APPENDIX D

PATHOLOGY - F1A PUPS GROUP: 3 IXlSE: 300 P!lll

PUP ID: DS/D SEX: M ON STUDY: 29 days ( 5 wks l FULL FM

MACROPATrlOLOGY

Killed by Fluothane

THE FOlLOHING TISSUES HERE StJIM[TI'ED

EPIDID'MIS ; KIDNEY ; LIVER ; PITUITARY GLAND ; PROSTATE GLAND : SEMINAL VESICLE : TESTIS

THE FOWJHING MACROSCOPIC OBSERVATIONS HERE MADE

KIDNEY Pelvic dilatation : (right ; slight)

NO ABNORMALITIES HERE SEEN IN THE REMAINING TISSUES

-------------------------------------------------------END OF PUP------------------------------------------------------------------

n -! r -.., -0""" <.0 .....,

OJ ~

tJ1

PAC905-01/ll

PERCHLORDETHYLENE: MULTIGENERATION INHALATION STllDY IN THE RAT

INDIVIDUAL ANlMAL DATA SllPPLEMENT

APPENDIX 13

PATHOLOGY - FlA PUPS

GROUP: 3 !XlSE: 300 ppn LITTER: 136

LITTER SUMMARY IADP. DATE DATE CLIN FATE PUP SEX BODY

OBS ID wr N!\1) 09/09/92

M 65.1 SELECTED A SELECTED 09/09/92F 63.2 NAD B 09/09/9267.3 NAD SELECTED c F NAD 09/09/92 *NAD FULL PM 09/09/92 67.4 D F NAD 09/09/92

NAD GROSS PM 09/09/92 66.6 E M NAD 09/09/92GROSS PM 09/09/92

F M 73.1 NAD NAD 09/09/92 GROSS PM 09/09/92 *

G M 70.7 ABN NAD 09/09/9209/09/92 61.6 NAD GROSS PM H F NAD 09/09/92

NAD GROSS PM 09/09/92 I F 65.0 ABN 09/09/92

GROSS PM 09/09/92 *ABN J F 65.7 DISCARDED 09/09/92

K F DISCARDED 09/09/92L F

M.

n --< .-....... ., ....... 0 ""' >.0 .....

co....."'

~-

.~~

PAC905-0l/ll

PERCHLOROETHYLENE: MULTIGENERATION INHALATION STIJDY IN THE RAT


APPENDIX 13 PATHOLCGY - F1A PUPS

GROUP: 3 OOSE: 300 PUP ID: 136/D

ppnSEX: F ON STUDY: 29 days (5 wks l FOLL R1

MACROPATHOLCGY

Killed by Fluothane

THE FOLLOHING TISSUES WERE SUEMITI'ED

CERVIX ; KIDNEY ; LIVER ; OVAPCI ; PITUITAPCI GLAND ; UI'ERUS ; VAGINA

NO ABNORMALITIES HERE SEEN IN THE ANIMAL

-------------------------------------------------------END OF PUP------------------------------------------------------------------

"..... r ....... "'0 ........., 0 ....,""

():)........,

_J L--····

PAC905-0l/ll

PERCHLOROETHYLENE: MIJLTIGENERATION INHALATION STUDY IN TilE RAT


APPENDIX 13

PATHOLOGY - FlA PUPSGROUP: 3 IXJSE: 300 ppn

PUP ID: 136/G SEX: M ON STUDY: 29 days (5 Wks) GROSS PM

MACROPATHOLOGY Killed by Fluothane

TilE FOLLOWING MACROSCOPIC OBSERVATIONS WERE MADE

EYE : Clinical observation of eye lida stabled not apparent at necropsy.

-------------------------------------------------------El<D OF PUP------------------------------------------------------------------

n

~ -1

--....,. 0 ....,""

():) ..... ():)

~

~ '

PAC905-0l/ll

PERC!IT.DRDETHYLENE: MULTIGENERATION INHAlATION STUDY IN THE RAT

INDIVIDUAL ANlMIIL !lATA SUPPLEMENT

APPENDIX 13 PATHOLOGY - F1A POPS

GROUP: 3 136/J !XlSE: 300 PJ:nl POP ID: SEX: F ON STUDY: 29 days ( 5 wks) GROSS EM

!:'ACROPATHOLOGY

Killed by Fluothane


EYE


EYE Eyelid/s stained

-------------------------------------------------------END OF POP------------------------------------------------------------------

n ..... r---o ....... 0""' ~ .....,

CX> ...... ~

.!.

n.....,...........,........,.0\J:)

"'

O:JN0

~'

-•-~-

PAC905-0l/11

PERCHLORDETHYLENE: M!JLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL ANlM'\1 D.>\TA SUPPLEMENT

APPENDIX 13

PATHQr..cx;y - F1A PUPSGROUP: 3 IDSE: 300 ppn

LITTER: 137

LITTER SUMMARY PUP SEX BODY CLIN FATE DATE P.M. DATE IADID wr OBS

A F LOST 18/08/92B M 64.0 NAD SELECTED 11/09/92c F 57.9 NAD SELECTED 11/09/92D F 56.5 NAD SELECTED 11/09/92E F 61.9 NAD FULL PM 11/09/92 NAD 11/09/92F M 61.9 NAD GROSS PM 11/09/92 *NAD 11/09/92 G M 64.4 NAD GROSS PM 11/09/92 NAD 11/09/92H F 61.7 NAD GROSS PM 11/09/92 NAD 11/09/92I F 60.4 NAD GROSS PM 11/09/92 NAD 11/09/92J F DISCARDED 11/09/92K F DISCARDED 11/09/92L F DISCARDED 11/09/92M F DISCARDED 11/09/92N F DISCARDED 11/09/92

_j,- ----·' ·

PAC905-0l/ll

PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY 1N THE RAT


APPENDIX 13 PATHOLOGY - FJA PUPS

PUP ID: GROUP: 3

137/E OOSE:

SEX: 300

F ppn

ON STUDY: 29 days (5 wks l FOLL H1

MACROPATHOLCJGY

Killed by Fluothane

THE FOLLCJWING TISSUES WERE SUEMITTED

CERVIX ; KIDNEY ; LIVER ; OVARY ; PITUITARY GLIINO ; UTERUS : VAGINA

NO ABNORMALITIES WERE SEEN 1N THE ANIMAL

-------------------------------------------------------END OF PUP------------------------------------------------------------------

n .-! --...,--...,. 0

"' "

OJ N,...

' -·-~ J.-- . ···-··

PAC905-0l/ll

PERCHLOROETHYLENE: MULTIGENERATION lNlli\LATION STUDY IN THE RAT


APPENDIX 13

PATHOLOGY - FJA PUPSGROUP: 3 !XlSE: 300 ppnLITTER: 138

LITTER SUMMARY

PUP SEX BODY CLIN FATE DATE P.M. DATE IADID wr CBS

A M LOST 06/09/92B M 79.4 NAD SELECTED 30/09/92c F 66.0 NAD SELECTED 30/09/92 D M 75.5 NAD GROSS fM 30/09/92 NAD 30/09/92E M 71.1 NAD GROSS fM 30/09/92 NAD 30/09/92F F 67.4 NAD GROSS fM 30/09/92 NAD 30/09/92G F 66.6 NAD GROSS fM 30/09/92 NAD 30/09/92H M DISCARDED 30/09/92I M DISCARDED 30/09/92J M DISCARDED 30/09/92K M DISCARDED 30/09/92

(")

,.... -i

......

...... ..,"'" 0

""' '

Nco N

~

·~·~

PAC905-01/ll


INDIVIlll'.lJ\L ANIMAL DATA SUPPLEMENT

APPENDIX 13

PATHOLOGY - FlA PUPS GROUP: 3 DOSE: 300 ppn

LITTER: 139

LITTER SUMMARY

PUP SEX BODY CLIN FATE D.f\TE P.M. DATE IAD ID l-IT OBS


M F F F M M M M M F F F F

67.5 61.6 60.0 59.3 63.5 62.4 60.1 65.2 61.1 63.8 60.2

NAD NAD NAD NAD NAD NAD ABN ABN ABN NAD NAD

ABN

SELECTED SELECTED SELECTED FULL PM GROSS PM GROSS PM GROSS PM GROSS PM GROSS PM GROSS PM GROSS PM DISCARDED GROSS PM

09/09/9209/09/92 09/09/9209/09/92 09/09/92 09/09/92 09/09/92 09/09/92 09/09/92 09/09/92 09/09/92 09/09/9209/09/92

NAD NAD NADABN ABN ABN NAD NAD

ABN

09/09/9209/09/92 09/09/92 09/09/9209/09/9209/09/92 09/09/9209/09/92

09/09/92

*

* * *

*

n r--! ..._ -o ..._ ..,. 0

...., ""

co N w

_ _! ••l_.___ _

PAC905-0l/ll


JNDIVIDUAL ANn1AL DATA SUPPLEMENT

APPENDIX 13

PATHOLOOY - FlA PUPS GROUP: 3 DJSE: 300 ppn

PUP ID: 139/D SEX: F ON STUDY: 29 days (5 'Wks) POLL :EM

MACROPATHOLOOY

Killed by Fluothane

THE FOWJWING TISSUES WERE SUEMITTED

CERVIX ; KIDNEY ; LIVER ; OVPJIT ; PITUITPJIT GLAND ; UlERUS ; VAGINA

NO ABNORMALITIES WERE SEEN IN THE ANn1AL

-------------------------------------------------------END OF PUP------------------------------------------------------------------

""' ...., r ...... "'0 ...... ""'0 <.0

"

CXl N

""'

----r

PAC905-0l/ll

PERCHLOROETHYLENE: MIJLTIGENERATION INHAlATION STUDY lli THE RAT

INDIVIDUAL ANJWIL DATA SUPPLEMENT

APPENDIX 13 PATHOLCX;Y - FlA PUPS

PUP ID: GROUP: 3 139/G IXJSE: SEX: 300 M PJlilON STUDY: 29 days ( 5 wics) GROSS PM

!'.ACROPATHOLOGY

Killed by Fluothane

THE FOLLOiiiNG TISSUES WERE SUPMITIED

EYE

THE FOLLO\iiNG MACROSCOPIC OBSERVAIIONS WERE MADE

EYE Eyelid/s stained : (left : slight)

-------------------------------------------------------END OF PUP------------------------------------------------------------------

"-< r ---c --""'0 'D

"

OJ N U1

.J ________ "

PAC905-0l/ll



APPENDIX 13

PATHOLCGY - FlA PUPS GROUP: 3 OOSE: 300 ppn

PUP ID: 139/H SEX: M ON STUDY: 29 days (5 wks) GROSS FM

MACROPATHOLCGY

Killed by Fluothane

THE FDLLOWING MACROSCOPIC OBSERVATIONS 'WERE MADE

EYE Eyelid/s stamed : (noderate)

-------------------------------------------------------END OF PUP------------------------------------------------------------------

n -i

........, r

.........,. 0 'D

"

OJ N

"'

-, '

--

-~-

""" PAC905-0l/ll

PERCHLORDE'TIM.ENE: MIJLTIGENERATION INHAlATION STUDY IN THE RAT


APPENDIX 13

PATHOu:x;¥ - FJA PUPS GROUP: 3 DJSE: 300 P!Ill

PUP ID: 139/I SEX: M ON STUDY: 29 days (5 wksl GROSS B1

MACROPATHOu:x;¥

Killed by Fluothane


EYE Eyelid/s stained : (right ; slight)

-------------------------------------------------------END OF PUP------------------------------------------------------------------

n__,

-o ' --.., 0 <.0....,

CD N....,

,_j __ . .! ----·-··-·- --·

PAC905-0l/11

PERC![J)ROETHYLENE: MllLTIGENERATION INHALATION STUDY IN THE RAT



PUP ID: GROUP: 3 139/M lXlSE:

SEX: 300

F ppnON STUDY: 29 days (5 wks) GROSS FM

MACROPATHOLOGY

Killed by Fluothane


EYE Eyelid/s stained : (left ; slight)

-------------------------------------------------------END OF PUP------------------------------------------------------------------

r"l-1r......"'0...... ""'0

""'

coNco

~ 1.- --- -..........,-- _.

Pl\C905-01/ll

PERCHLOROEI'HYLENE: MULTIGENERATION INIIAI.ATION STUDY IN THE RAT


APPENDIX 13

PATHOLOGY - F1A PUPS GROUP: 3 IXlSE: 300 PlD1

LITI'ER: 141

LITTER SUMMARY


A B c D E F G H I

M M F F F F F F F

27.4 80.0 77.1 80.8

ABN NAD NAD NAD

INT EVC GROSS R1 GROSS R1 GROSS R1 DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

26/09/92 07/10/92 07/10/92 07/10/92 07/10/92 07/10/9207/10/9207/10/92 07/10/92

ABN NAD NAD NAD

26/09/9208/10/9208/10/92 08/10/92n

-l r--.. "0 -.. 0""' ...., "'

co N

"'

PAC905-01/11

PERCHLORDETHYLENE: MULTIGENERATION :INHAlATION STUDY IN THE RAT


APPENDIX 13

PATHOLCGY - Fl.A PUPSGROUP: 3 DJSE: 300 ppn

LITI'ER: 143

LITTER SUMMARY PUP SEX BODY CLIN FATE DA'IE P.M. DATE lADID wr OBS

A M 58.9 NAD SELECTED 11/09/92B F 59.1 NAD SELECTED 11/09/92c F 54.4 NAD SELECTED 11/09/92D M 59.9 NAD FtlLL FM 11/09/92 NAD 11/09/92E F 51.8 NAD FtlLL FM 11/09/92 NAD 11/09/92 **F M 57.0 NAD GROSS FM 11/09/92 NAD 11/09/92G M 58.9 NAD GROSS FM 11/09/92 NAD 11/09/92H F 56.6 NAD GROSS FM 11/09/92 NAD 11/09/92I F 58.9 NAD GROSS FM 11/09/92 NAD 11/09/92J M DISCARDED 11/09/92K M DISCARDED 11/09/92L M DISCARDED 11/09/92M M DISCARDED 11/09/92 N M DISCARDED 11/09/92

"_, ' ....... "0 .......... 0 1.0 .....

CX> w0

PAC905-01/11



APPENDIX 13

PATHOLOGY - F.lA PUPS PUP

GROUP: 3 !XJSE: 300 ppnID: 143/D SEX: M ON STUDY: 29 days (5 wksl FOLL FM



EPIDIDYMIS ; IaruEY ; LIVER ; PITUITARY GLAND ; PROSTATE GLAND ; SEMINAL VESICLE ; TESTIS

00 ABNOJJMALITIES WERE SEEN IN THE ANJMAL

-------------------------------------------------------END OF PUP------------------------------------------------------------------

("") ..... r ....... -o ........,. 0 .._,""

co w I-'

• J.._ .. __ J -- ·

PAC905-0l/11

PERC!!LORDETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL ANJMi\L DATA SUPPLEMENT

APPENDIX 13

PATHOLOGY - FJA POPS GROUP: 3 OOSE: 300 ppn

POP ID: 143/E SEX: F ON STUDY: 29 days (5 wks) FOLL EM

MACROPATHOLOGY

Killed by Fluothane

THE FOlLOWING TISSUES w'ERE SUEMITI'ED

CERVIX ; KIDNEY ; LIVER ; OVMrl ; PITUITARY GLAND ; UTERilS ; VAGlliA

NO ABNORMALITIES WERE SEEN IN THE ANJMi\L

-------------------------------------------------------END OF POP------------------------------------------------------------------

n -i r ....... ....... " .., 0

..... '""

co w N

~.

PAC905-01/ll


INDIVIDUAL ANIMAL D.A.TA SUPPLEMENT

APPENDIX 13

PATHOLCGY - FlA PUPS GROUP: 3 !XlSE: 300 ppn

LITTER: 144

LITTER SUMMARY



F M F M F F M M M F F M M

4.8

74.0 71.7 70.6 81.4 67.6 78.0 71.7 72.1

ABN


INT EVC LOST LOST SELECTED SELECTED SELECTED FULL PM GROSS PM GROSS PM GROSS PM GROSS PM DISCARDED DISCARDED

12/08/9216/08/9222/08/9209/09/9209/09/9209/09/9209/09/9209/09/9209/09/9209/09/9209/09/9209/09/9209/09/92

ABN

NAD NAD NAD NAD NAD

12/08/92

09/09/9209/09/9209/09/9209/09/9209/09/92

* "-i r --o -..,. 0 <.0 ......

():) w w

-'·

PAC905-0l/ll

PERCHLORDETHYLENE: M!JLTIGENERATION INHAlATION STUDY IN THE RAT


APPENDIX 13 PATHOLOGY - FlA PUPS

PUP ID: GROUP: 3 144/G OOSE: 300 ppn

SEK: M ON STUDY: 29 days (5 >iks) FOLL EM

MACROPATHOLOGY

Killed by Fluothane

THE FOLLOWING TISSUES WERE SUEMITJ.'ED

EPIDIDYMIS ; KIDNEY ; LIVER ; PITUITARY GLAND ; PROSTATE GLAND ; SEMJNAL VESICLE ; TESTIS


-------------------------------------------------------END OF PUP------------------------------------------------------------------

(") -I....... "'0 ...... 0""' ..... ""

co w

""'

~ ~~--

P.I<.C905-01/ll

PERCHLOROETHYLENE: MJ.JLTIGENERATION INHAlATION STUDY IN THE RAT


APPENDIX 13


LITIER: 169

LITTER SUMMARY

PUP ID

SEX BODY wr

CLIN OBS



F F F M F F F F F F F F F

4.6 4.4 6.8

67.4 64.4 68.1 60.4

ABN ABN ABN NAD NAD NAD NAD

INT EVC INT EVC INT EVC SELECTED SELECTED GROSS EM GROSS EM DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED DISCARDED

16/08/92 16/08/92 20/08/92 13/09/9213/09/92 14/09/92 14/09/92 14/09/92 14/09/9214/09/9214/09/9214/09/9214/09)92

ABN ABN ABN

NAD NAD

16/08/9216/08/9220/08/92

14/09/92 14/09/92

n r -i

....... -o ....... 0 ""' <.0 .....,

00 w U1

.~

I.

.-(")--1

......"0........,.0\0.....,

cowOl

~

PAC905-01/ll


OOIVIIJUAL ANIMAL DATA SUPPLEMENT

APPENDIX 13

PATHOLOGY - FlA PUPSGROUP: 4 rosE: 1000 ppn

LI'ITER: 170

LITTER SUMMARY

PUP SEX BODY CLIN FATE DATE P.M. DATE lADID wr OBS

A F LOST 11/09/92B M 16.1 ABN INT FUU. 26/09/92 ABN 27/09/92c M 64.3 NAD SELECTED *05/10/92 D F 55.4 NAD SELECTED 05/10/92E M 58.2 NAD GROSS .EM 05/10/92 NAD 05/10/92F M 57.2 NAD GROSS .EM 05/10/92 NAD 05/10/92G F 52.8 NAD GROSS .EM 05/10/92 NAD 05/10/92H F 45.6 NAD GROSS .EM 05/10/92 NAD 05/10/92I M DISCARDED 05/10/92J M DISCARDED 05/10/92K M DISCARDED 05/10/92L M DISCARDED 05/10/92M F DISCARDED 05/10/92N F DISCARDED 05/10/920 F DISCARDED 05/10/92

~

..:...- ---- .i -·

PAC905-01/ll

PERCHLORDETHYLENE: MDLTIGENERATION INHAlATION STUDY IN THE RAT

INOIVIDUAL ANlMAL DATA SUPPLEMENT

APPENDIX 13


PUP ID: 170/B SEX: M ON STUDY: 21 days (3 wksl INT FULL

MACROPATHOLOGY

Killed by F1uothane

THE FOLLOWING TISSUES WERE SUJ:MITTEO

BRAIN : EPIDIDYMIS ; KIDNEY ; LIVER : PIWITARY GLAND ; PROSTATE GLAND ; SEMINAL VESICLE : STERNlM ; TESTIS : URINARY lli.JillDER


BRAIN Enlarged cerebral hemispheres Soft

SEMINAL VESICLEReduced : by 75%.

SKfJIL Craniun dared

STERNlM Inverted

URINARY BLADDER Distended : x2.5.

NO ABNORMALITIES WERE SEEN IN THE REMiiiNING TISSUES

MICRDPATI!OLOGY

"-< r ...... -c ...... 0""' <.0 .....,

co w.....,


PRDTOOOL REQUIRED 2 2 0 0 1 NOT PRDTOOOL (SUJ:MITTEO) 8 0 8 0 0

(NOT SUJ:MITTEO) 1 0 1 0 0

.! --

PAC905-01/ll

PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN 'lliE RAT

INDIVIIJUAL ANlMAL DATA SUPPLEMENT

APPENDIX 13

PATHOLOGY - FlA PUPS GROUP: 4 JXJSE: 1000 PJI11

PUP ID: 170/B SEX: M ON STUDY: 21 days (3 wks) INT FULL

MICROPATHOLOGY

THE FOlLOWING TISSUES WERE MARl<ED NAD

LIVER


KIDNEY Vacuolar degeneration of proximal convoluted tubules : (marked)


FCD UNKNOWN

-------------------------------------------------------END OF PUP------------------------------------------------------------------

n -i r-'"0 --0 ""' <.0.....,

o:> w o:>

.~.

. I ··

PAC905-01/11

PERCHLCROETHYLENE: MDLTIGENERATION INHM.ATION STUDY IN THE RAT

INDIVIDUAL ANIMAL !lATA SUPPLEMENT

APPENDIX 13

PATilOLOGY - F1A PUPS GROUP: 4 !XlSE: 1000 Pfill LITTER: 171

LITTER SUMMARY

("")

-< /"""--o -""' 0 \0....,

I

PUP ID

SEX BODY wr

CLIN OBS



M F M M F F M F F F F F

67.1 63.7 64.3 64.6 61.8 64.2 44.4 47.0

NAD NAD NAD NAD NAD NAD ABN ABN

SELECTED SELECTED GROSS PM GROSS PM GROSS PM GROSS PM GROSS PM GROSS PM DISCAROED DISCAROED DISCAROED DISCAROED

01/10/9201/10/9201/10/92 01/10/92 01/10/92 01/10/92 01/10/92 01/10/92 01/10/9201/10/9201/10/9201/10/92

NAD NAD NAD NAD ABN NAD

01/10/9201/10/9201/10/9201/10/9201/10/9209/11/93 *

*

00 w \0

- .!. __·'

PAC905-01/ll



APPENDIX 13

PATHOLOGY - FlA PUPS GROUP: 4 IXlSE: 1000 ppn

PUP ID: 171/G SEX: M ON STUDY: 29 days (5 Wks) GROSS R1


THE FOlLOWING TISSUES WERE SUEMI:TTEO

HEART

THE FOlLOWING MACROSOOPIC OBSERVATIONS WERE WIDE

EYE : Clinical observation of discharge not apparent at necropsy.HEART

Enlarged : xl.S.

-------------------------------------------------------END OF PUP------------------------------------------------------------------

--l '"' ,........ "'0 ...... ..,. 0 ...., '""

o:>..,. 0

~.

'

PAC905-01/ll

PERCHLOROETHYLENE: MULTIGENERATION JNHALATION STUDY IN THE RAT


APPENDIX 13

PATHOLCGY - FlA PUPS

PUP ID: GROUP: 4 OOSE: 1000 ppn

171/H SEX: F ON STUDY: 433 days (52 wksl GROSS R1

MACROPATHOLCGY

Killed by Fluothane : No macroscopic findings were detected to account for clinical abnonnality.

NO ABNORMALITIES 1-IERE SEEN IN THE AN1MAL

-------------------------------------------------------El<D OF PUP------------------------------------------------------------------~ ...... ' "'0 ........,. 0

....,"'

..,."' ,....

-I __. !..

PAC905-01/ll

PERCBLOROETHYLENE: Mill.TIGENERATION INHALATION STUDY IN THE RAT


APPENDIX 13

PATHOLOOY - FlA PUPSGROUP: 4 lXJSE: 1000 ppn

LI'ITER: 172

LITTER SUMMARY

PUP ID

SEX BODY wr

CLIN OBS


A B c D

F F F F

9.9 76.6 67.1 63.4

ABN NAD NAD NAD

INT EVC SELECTED SELECTED FULL PM

17/08/92 09/09/9209/09/9209/09/92

ABN

NAD

17/08/92

09/09/92 * n_, ;....... "t) ........,. 0 lL)...., I

co.,. N

~'

zeneca vol ii 06-27-1995 part 2 - united states environmental … · 2014-12-02 · pac900-05/02...

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