ziprasidone - pubmed health · ziprasidone - pubmed health 6/19/2012 8:59:11 am] tell your doctor...

Ziprasidone - PubMed Health

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AHFS Consumer Medication Information.

Ziprasidone (zi pray' si done)Last Revision: May 16, 2011.

Why is this medication prescribed?Ziprasidone is used to treat the symptoms of schizophrenia (a mental illness that causesdisturbed or unusual thinking, loss of interest in life, and strong or inappropriateemotions). It is also used to treat episodes of mania (frenzied, abnormally excited orirritated mood) or mixed episodes (symptoms of mania and depression that happentogether) in patients with bipolar disorder (manic depressive disorder; a disease thatcauses episodes of depression, episodes of mania, and other abnormal moods).Ziprasidone is in a class of medications called atypical antipsychotics. It works bychanging the activity of certain natural substances in the brain.

How should this medicine be used?Ziprasidone comes as a capsule to take by mouth. It is usually taken twice a day withfood. Take ziprasidone at around the same times every day. Follow the directions onyour prescription label carefully, and ask your doctor or pharmacist to explain any partyou do not understand. Take ziprasidone exactly as directed. Do not take more or lessof it or take it more often than prescribed by your doctor.

Your doctor may start you on a low dose of ziprasidone and gradually increase yourdose.

Ziprasidone may help control your symptoms but will not cure your condition. Continueto take ziprasidone even if you feel well. Do not stop taking ziprasidone without talking toyour doctor.

Other uses for this medicineThis medication may be prescribed for other uses; ask your doctor or pharmacist formore information.

What special precautions should I follow?Before taking ziprasidone,

Warning

Studies have shown that older adults with dementia (a brain disorder thataffects the ability to remember, think clearly, communicate, and performdaily activities and that may cause changes in mood and personality) whotake antipsychotics (medications for mental illness) such as ziprasidonehave an increased risk of death during treatment. Older adults withdementia may also have a greater chance of having a stroke or mini-stroke

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Ziprasidone versus other atypicalantipsychotics for schizophreniaZiprasidone is one of a group of new'atypical' antipsychotics used fortreating schizophrenia. This reviewwanted to find out if there wasevidence to support that there is anydifference between ziprasidone and

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SchizophreniaBipolar disorderObsessive-compulsive disorderDementiaDelirium

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tell your doctor and pharmacist if you are allergic to ziprasidone or any othermedications.

tell your doctor if you are taking amiodarone (Cordarone, Pacerone),chlorpromazine (Thorazine), cisapride (Propulsid) (no longer available in theU.S.), disopyramide (Norpace), dofetilide (Tikosyn), dolasetron (Anzemet),droperidol (Inapsine), erythromycin (E.E.S., E-Mycin, Erythrocin), gatifloxacin(Tequin)(no longer available in the U.S.), halofantrine (Halfan)(no longeravailable in the U.S.), levomethadyl (ORLAAM) (no longer available in the U.S.),mefloquine (Lariam), mesoridazine (Serentil; no longer available in the U.S.),moxifloxacin (Avelox), pentamidine (NebuPent, Pentam 300), pimozide (Orap),procainamide (Procanbid, Promine, Pronestyl), quinidine (Quinidex), sotalol(Betapace), sparfloxacin (Zagam), tacrolimus (Prograf), or thioridazine (Mellaril).Your doctor may tell you not to take ziprasidone if you are taking one or more ofthese medications.

tell your doctor and pharmacist what other prescription and nonprescriptionmedications, vitamins, nutritional supplements, and herbal products you aretaking or plan to take. Be sure to mention any of the following: antidepressants;certain antifungals such as fluconazole (Diflucan), itraconazole (Sporanox),ketoconazole (Nizoral), and voriconazole (Vfend); aprepitant (Emend);carbamazepine (Tegretol); clarithromycin (Biaxin, in Prevpac); cyclosporine(Neoral, Sandimmune); delavirdine (Rescriptor); diltiazem (Cardizem, Dilacor,Tiazac, others); diuretics ('water pills');dopamine agonists such as bromocriptine(Parlodel), cabergoline (Dostinex), levodopa (Dopar, Larodopa), pergolide(Permax), and ropinirole (Requip); efavirenz (Sustiva); fluoxetine (Prozac,Sarafem); fluvoxamine (Luvox); HIV protease inhibitors including atazanavir(Reyataz), indinavir (Crixivan), lopinavir (in Kaletra), nelfinavir (Viracept),ritonavir (Norvir, in Kaletra), and saquinavir (Fortovase, Invirase); hormonalcontraceptives (birth control pills, rings, patches, implants, and injections);lovastatin (Mevacor, in Advicor); medications for anxiety, high blood pressure orseizures; nefazodone; sertraline (Zoloft); sleeping pills; tranquilizers;troleandomycin (TAO; no longer available in the U.S.); verapamil (Calan,Covera, Isoptin, Verelan); and zafirlukast (Accolate). Your doctor may need tochange the doses of your medications or monitor you carefully for side effects.

tell your doctor if you use or have ever used street drugs or have overusedprescription medications or if you have recently had a heart attack or havetrouble swallowing. Also tell your doctor if you have or have ever had heart orliver disease, breast cancer, heart failure, an irregular heartbeat, a stroke ormini-stroke, or seizures, or if you or anyone in your family has or has ever haddiabetes. Also tell your doctor if you have ever had to stop taking a medicationfor mental illness because of severe side effects.

tell your doctor if you are pregnant, especially if you are in the last few monthsof your pregnancy, or if you plan to become pregnant or are breast-feeding. Ifyou become pregnant while taking ziprasidone, call your doctor. Ziprasidonemay cause problems in newborns following delivery if it is taken during the lastmonths of pregnancy.

you should know that ziprasidone may make you drowsy. Do not drive a car oroperate machinery until you know how this medication affects you.

you should know that alcohol can add to the drowsiness caused by thismedication. Do not drink alcohol while taking ziprasidone.

you should know that you may experience hyperglycemia (increases in yourblood sugar) while you are taking this medication, even if you do not alreadyhave diabetes. If you have schizophrenia , you are more likely to developdiabetes than people who do not have schizophrenia, and taking ziprasidone orsimilar medications may increase this risk. Tell your doctor immediately if youhave any of the following symptoms while you are taking ziprasidone: extremethirst, frequent urination, extreme hunger, blurred vision, or weakness. It is very

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important to call your doctor as soon as you have any of these symptoms,because high blood sugar that is not treated can cause a serious conditioncalled ketoacidosis. Ketoacidosis may become life-threatening if it is not treatedat an early stage. Symptoms of ketoacidosis include: dry mouth,nausea andvomiting, shortness of breath, breath that smells fruity, and decreasedconsciousness.

you should know that ziprasidone may cause dizziness, lightheadedness, andfainting when you get up too quickly from a lying position. This is more commonwhen you first start taking ziprasidone. To avoid this problem, get out of bedslowly, resting your feet on the floor for a few minutes before standing up.

you should know that ziprasidone may make it harder for your body to cooldown when it gets very hot. Tell your doctor if you plan to do vigorous exerciseor be exposed to extreme heat.

What special dietary instructions should I follow?Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking thismedicine.

Be sure to drink plenty of water every day while you are taking this medication.

What should I do if I forget a dose?Take the missed dose as soon as you remember it. However, if it is almost time for thenext dose, skip the missed dose and continue your regular dosing schedule. Do not takea double dose to make up for a missed one.

What side effects can this medication cause?Ziprasidone may cause side effects. Tell your doctor if any of these symptoms aresevere or do not go away:

drowsiness

headache

restlessness

anxiety

constipation

diarrhea

loss of appetite

muscle pain

runny nose, sneezing

cough

weight gain

Some side effects can be serious. If you experience any of the following symptoms orthose listed in the IMPORTANT WARNING section or the SPECIAL PRECAUTIONSsection, call your doctor immediately:

unusual movements of your face or body that you cannot control

fast, irregular, or pounding heartbeat

rash or hives

fever

muscle stiffness

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confusion

sweating

painful erection of the penis that lasts for hours

Ziprasidone may cause other side effects. Call your doctor if you have any unusualproblems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to theFood and Drug Administration's (FDA) MedWatch Adverse Event Reporting programonline [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].

What storage conditions are needed for this medicine?Keep this medication in the container it came in, tightly closed, and out of reach ofchildren. Store it at room temperature and away from excess heat and moisture (not inthe bathroom). Throw away any medication that is outdated or no longer needed. Talk toyour pharmacist about the proper disposal of your medication.

In case of emergency/overdoseIn case of overdose, call your local poison control center at 1-800-222-1222. If thevictim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

drowsiness

slurred speech

sudden movements that you cannot control

uncontrollable shaking of a part of the body

anxiety

What other information should I know?Keep all appointments with your doctor and the laboratory. Your doctor may ordercertain lab tests to check your body's response to ziprasidone.

Do not let anyone else take your medication. Ask your pharmacist any questions youhave about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription(over-the-counter) medicines you are taking, as well as any products such as vitamins,minerals, or other dietary supplements. You should bring this list with you each time youvisit a doctor or if you are admitted to a hospital. It is also important information to carrywith you in case of emergencies.

American Society of Health-System Pharmacists, Disclaimer

AHFS Consumer Medication Information. Copyright, 2011. The American Society ofHealth-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. AllRights Reserved. Duplication for commercial use must be authorized by ASHP.

The following brand names are from RxNorm, a standardizednomenclature for clinical drugs produced by the National Library ofMedicine:

Brand names

06/19/12

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