biotransporters. · bioengineering biotransporters. boost your pk/pd studies to new...
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bioengineering
Biotransporters.Boost your PK/PD studies
to new levels. Introducing
the ADME Knockout Rat
collection from SAGE™Labs.
For more information or to order
a knockout rat model, visit
wherebiobegins.com/bioengineering
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Sig
Four ADMEresearch partnersyou need to know.Meet our ADME Knockout Rats. With greater
predictability than chemical inhibitor assays,
they’re better by design.
SAGE is a trademark of Sigma-Aldrich Co. and its a�liate Sigma-Aldrich Biotechnology, LP.
For more information or to order a knockout rat model, visit
wherebiobegins.com/bioengineering
Screen xenobiotic compounds in research
applications such as:
• Drug transport across the blood/brain barrier,
liver, intestine and placenta
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Observe in�ammatory stimulus response and
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Advance the study of anti-cancer compounds
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E�ectively screen for P-gp drug interactions
as they relate to:
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and intestine
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Knockout of Bcrp Gene Knockout of Mrp2 Gene
Knockout of Mrp1 Gene Knockout of Mdr1a Gene
0422Product_FOCVR3 385 4/23/11, 10:34:56 AM
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Moving science forward
©2011Therm
oFisherScientificInc.Allrightsreserved.
NowSoldas
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GE,im
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OneTaq™ DNA Polymerase
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Congratulations to Dr. Christopher Gregg on winning the 2010 Eppendorf
& Science Prize for his studies on genes that alter their expression in the
brains of offspring according to whether they were inherited from the
father versus the mother. His findings suggest new pathways that may
help to understand brain diseases such as autism, schizophrenia and
eating disorders.
The annual international US$ 25,000 Eppendorf & Science Prize for
Neurobiology honors young scientists for their outstanding contributions
to neurobiological research based on methods of molecular and cell bio-
logy. The winner and finalists are selected by a committee of independent
scientists, chaired by Science’s Senior Editor, Dr. Peter Stern.
To be eligible, you must be 35 years of age or younger. If you’re selected
as this year’s winner, you will receive US$ 25,000, have your work
published in Science and be invited to visit Eppendorf in Hamburg,
Germany. Past winners and finalists have come from as far a field as
China, Chile, India and New Zealand. Yes, it can happen to you!
Deadline for entries
June 15, 2011
2010 WinnerChristopher Gregg, Ph.D.Postdoctoral FellowHarvard University
It´s easy to apply! Learn more at
www.eppendorf.com/prize
Ku
rstin
Ro
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Be the
10th
winner!
Get recognized!
US$ 25,000 Prize
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Dr. Carl Alving
on his inspiration
for inventing
the vaccine patch.
“A dreamtoldme todo it.”
MemberCentral is the new website that looks at science through the eyes of AAAS members. It
celebrates their achievements—like Dr. Alving’s vaccine patch—and their shared belief in the
transformative power of science. Use MemberCentral to connect with other members, learn
about work being done in other fields, and get fresh perspectives on issues ranging from
speciation to STEM education.
VisitMemberCentral today and get to know the
AAAS member community in a whole new way.
Blogs I Videos I Webinars I Discounts I Downloads | Community
MemberCentral.aaas.org
Dr. Carl Alving
on his inspiration
for inventing
the vaccine patch.
“A dreamtoldme todo it.”
Carl R. Alving, M.D.
Chief of the Department of Adjuvant & Antigen Research,
Division of Retrovirology
at the Walter Reed Army Institute of Research
AAASmember
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Submission
deadline
August 1
imagination at work
* For the purpose of this prize, molecular biology isdefined as “that part of biology which attempts tointerpret biological events in terms of the physico-chemical properties of molecules in a cell”.
(McGraw-Hill Dictionary of Scientific andTechnical Terms, 4th Edition).
GE Healthcare Bio-Sciences AB,Björkgatan 30, 751 84 Uppsala, Sweden.© 2011 General Electric Company– All rights reserved.
28-9402-06AB
Imagine standing on the podium at the Grand Hotel in Stockholm, making your
acceptance speech for the GE & Science Prize for Young Life Scientists. Imagine
having your essay read by your peers around the world. Imagine discussing your
work in a seminar with other prize winners and Nobel Laureates. Imagine what you
could do with the $25,000 prize money. Now stop imagining. If you were awarded your
Ph.D. in molecular biology in 2010, then submit your 1000-word essay by August 1,
and you can make it reality.
Want to build a better reality? Go to www.gescienceprize.org
The GE & Science Prize for Young Life Scientists.Because brilliant ideas build better realities.
Yournamehere.
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Leonard Zon, M.D.HHMI/Children’s Hospital
and Harvard Medical School
Boston, MA
Hakim Djaballah, Ph.D.Memorial Sloan-Kettering
Cancer Center
New York, NY
Gregory Verdine, Ph.D.Harvard University
Cambridge, MA
PARTICIPATING EXPERTS
During normal growth and differentiation,maintaining the appropriate homeostatic balance ina cell is paramount. This fundamental level of controlis achieved through the interaction of small moleculechemical modulators with those proteins involved incellular signaling. Researchers can take advantageof these regulatory interactions to study signalingpathways, for instance by designing chemicals thatreverse the hyper-proliferation phenotype seen inmany cancers. These small molecules can be usedboth as tools to interrogate a particular pathway andas precursors for drug development. This webinarwill provide an overview of how chemical biologycan be used in various model systems to bothadvance our understanding of basic cell signalingmechanisms as well as aid in the discovery of novelsmall molecule therapeutics for cancer.
During this webinar, the panelists will:• Provide an overview of how chemical biology can
impact cancer research
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May 3, 201112 noon ET, 9 am PT,4 pm GMT, 5 UK
WEBINAR
Probing Cancer PathwaysHow Chemical Biology Can Inform
Oncology Research
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489www.sciencemag.org/products SCIENCE VOL 332 22 APRIL 2011
Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are
featured in this space. Emphasis is given to purpose, chief characteristics, and availability of products and materials. Endorsement by Science or AAAS of any products or
materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.
Electronically submit your new product description or product literature information! Go to www.sciencemag.org/products/newproducts.dtl for more information.
LIFE SCIENCE TECHNOLOGIES
NEW PRODUCTS
AAAS/Science Business Office Feature LIFE SCIENCE TECHNOLOGIES
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AAAS/Science Business Office Feature
CELL COUNTER Designed for laboratories that routinely work with cells tagged with a large
variety of fl uorescent labels, the new Cellometer Vision allows users to easily
change out either of the two fl uorescence optics modules in the instrument
and replace it with another one. This enables scientists to perform experiments
using their choice of fl uorescent labels, with a broad spectrum of excitation and
emission wavelengths from ultraviolet to red. Using proprietary patent-pending
image processing and data analysis algorithms, Cellometer Vision combines
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cells that are loaded into a disposable chamber. A wide variety of fl uorescent
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generate reliable viability results.
Nexcelom Bioscience
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LIVER MICROSOMES A comprehensive range of liver microsome products from over 12
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able. Researchers can select from pure microsomes or S9 fractions,
or animal liver cytosol. In order to facilitate requirements recom-
mended by REACH, bespoke microsome products from other spe-
cies or strains can also be supplied. Microsomes are a valuable tool
for investigating drug metabolism and examining in vitro drug-drug
interactions. They are produced by mechanically homogenizing cells
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Sera Lab
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CLOUD COMPUTING FieldAlign V3.0 is the latest in Cresset’s new generation of cloud-en-
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servers. FieldAlign is a powerful molecular design and 3D structure-
activity relationship (SAR) tool that generates biologically relevant
molecular comparisons, which can be used to fi nd the root causes of
activity or inactivity. FieldAlign helps chemists to gain detailed under-
standing of the SAR of their lead molecules and to use this to design
the best next synthesis. FieldAlign V3.0 introduces a range of user
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line interface supports scripting and workfl ow systems, and is now
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using imported data or standard physical properties such as wcLogP,
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Cresset Group
For info: +44-(0)-1707-356120 www.cresset-group.com
RNA, DNA, AND PROTEIN ISOLATIONTri-Xtract is a convenient, ready-to-use reagent designed for the iso-
lation of total RNA, DNA, and protein. Tri-Xtract is suitable for the
isolation of total RNA from small quantities of tissues and cells from
human, animal, plant, yeast, bacterial, and viral origin. Tri-Xtract is
a monophasic solution of phenol and guanidine thiocyanate that
maintains the integrity of the RNA during cell disruption and homog-
enization. The isolation procedure takes less than an hour and the
isolated RNA is suitable for Northern blots, dot blot hybridization, in
vitro translation, RNase protection assays, and poly (A+) selection.
G-Biosciences
For info: 314-991-6034 www.gbiosciences.com
FULL-LENGTH HUMAN PROTEINSThe new range of over 4,000 full-length, affi nity-purifi ed human
proteins, which are expressed in HEK293 cells and derived using
an extensive collection of human cDNA clones, is currently the
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been prepared to ensure optimal preservation of protein structure,
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come affi nity purifi ed and are guaranteed to be greater than 80%
pure, making them ideal for use as native antigens for optimized
antibody production, positive controls in antibody assays, enzyme-
linked immunosorbent assay standards, protein-protein interaction
experiments, in vitro biochemical assays, cell-based functional as-
says, and SRM/MRM standards. All the human proteins in the new
range are available in small trial-size quantities, which can be quickly
developed into larger (milligram) quantities.
AMS Biotechnology
For info: +44-(0)-1235-828200 www.amsbio.com
FREEZE-DRYER AND LYOPHILIZATION SYSTEMThe latest freeze-drying and lyophilization innovation for improving
process control and minimizing issues of scale-up, the LyoStar 3, is
confi gured with the most innovative controls and instrumentation,
including Smart Freeze-Dryer Technology and Praxair’s ControLyo On
Demand Nucleation Technology. The LyoStar 3 is the ultimate lab-
scale system for formulations studies, process optimization, and
scale-up work. The system is a freeze-dryer that provides unmatched
process accuracy, reliability, and unique ease-of-use features. Until
now, the freezing step of lyophilization was uncontrolled due to the
random nature of the nucleation or crystal-forming process. Using
ControLyo technology on the LyoStar 3 now makes nucleation con-
trol a reality by regulating the nucleation temperature to within 1°C
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quality, and yield.
SP Scientifi c
For info: 845-255-5000 www.spscientifi c.com
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Congratulations to the
AAAS Student Poster Competition Winners
The 2011 Student Poster Competition took place at the AAAS Annual Meeting in Washington, DC, 17-21 February. The students’
work in a variety of fields displayed originality and understanding that set them apart from their peers. First-place winners receive
cash prizes thanks to the generous support of Subaru of America, Inc.
BRAIN AND BEHAVIORWinner:Maria R. Torres, University of
California, Irvine
Investigating the Role of Down Syndrome
Astrocytes in Dendritic SpineMorphology
Honorable Mention: Nicholas D. Olivas,University of California, Irvine
Cell-Type Specific Excitatory Connectivity
of Hippocampal CA1 Interneurons Revealed
by Laser Scanning Photostimulation
CELLULAR AND MOLECULAR BIOLOGYWinner (tie): Kimberly Rebecca Kukurba,
Arizona State University
Genome-Wide Discovery of Human T
ranslation Enhancing Elements
Winner (tie): Aida Mohammadreza, Ari-
zona State University
Measuring Oxygen Consumption Rates
of Esophageal Cancer Cells at the Single
Cell Level
Honorable Mention: Nathan Gamarra,
University of California, Irvine
Antibiotic Resistance in Aquatic Stentro-
phomonas maltophilia
DEVELOPMENTAL BIOLOGY,PHYSIOLOGY, AND IMMUNOLOGYWinner: Dayan Li, Harvard University
The Role of PRDM8 in Sonic Hedgehog-
Dependent Neural Tube Development
Honorable Mention: Cristian Aguilar,
University of California, Irvine
Epigenetic Modifications During
Dedifferentiation in the Axolotl
Regenerating Limb
ENVIRONMENT AND ECOLOGYWinner: Nathaniel Mueller, University of
Minnesota
Are Changes in Agricultural Management
More Crucial to Food Security than
Climate Change?
Honorable Mention: Erica Warkus,
Arizona State University; Martine
Wagstaff and Scott Morello, University of
Massachusetts, Boston
Do Macroalgae Use Allelochemicals To
Outcompete Invertebrates for Space in
the Gulf of Maine?
MATH, TECHNOLOGY, AND ENGINEERINGWinner: Yakov Kronrod, Chang Hu,
Olivia Buzek, and Alex Quinn,
University of Maryland
Using Monolingual Crowds To Improve
Translation
Honorable Mention: Charles A. Forman,
Virginia Polytechnic Institute and
State University
Superconducting RF Accelerator Cavity:
Examination of the Interior Surface
MEDICINE AND PUBLIC HEALTHWinner: Allen Clayton, RachelM. Serafin,
Chau C. Quach, SethW. Brittle, Stephanie
Cabey, and Christine Gurdon,Marist College
Emerging Contaminants: Silver Nanopar-
ticles Bioaccumulation and Genotoxicity
in Aquatic Organisms
HonorableMention:Hansa Thompson and
Susan Holechek, Arizona State University
Independent Expression and Analysis
of the Two Domains of Vaccinia Virus’s
E3L Gene
PHYSICAL SCIENCESWinner:Matthew R. Edwards and Clayton
E. Myers, Princeton University
Temperature Effects on Electrical Proper-
ties of Superconducting Flux Conservers
Honorable Mention:Makrete Krikorian
and Jeffrey Meisner, Columbia University
Single-Molecule Conductance of
Disubstituted Stilbenes
SOCIAL SCIENCESWinner: Eric Michael Johnson, University
of British Columbia
Demographics, Inequality, and Entitle-
ments in the Russian Famine of 1891
Honorable Mention: Trent James Bowen,
Arizona State University
Educational Barriers to Preventative
Medicine in Accra, Ghana
Full abstracts can be viewed atwww.aaas.org/meetings.
The 2012 Poster Submission site opens on 12 July 2011. The Student Poster
Competition recognizes the individual research efforts of undergraduate-
and graduate-level students who are enrolled in a degree program. Posters
are judged at the meeting. Winners in each category receive a cash award
and framed certificate. Individuals holding doctoral degrees are not eligible
and are invited to submit for the General Poster session.
Sign up atwww.aaas.org/meetings to receive announcements about the 2012 AAAS Annual Meeting 16-20 February in Vancouver, BC.
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go to www.invitrogen.com/benchpro2100download the free mobile app at http://gettag.mobi
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