(DIC) Disseminated Intravascular Coagulation

(Blood Coagulation)

(Anticoagulant Mechanism)

(AT ) CPC

(Fibrinolysis)XIIatPAuPAFDP EC

//-DIC

9-139+38 36.820/88/150/100mmHg128/130/1200ml90/60mmHgRBC1.501012/L,(Hb)50g/L,(WBC)11.0109/L,,(PLT) 45109/L+++RBC+WBC++PT2514TT2112Fg0.98g/L3P+++6%D-++B

1.DIC2.DIC3.DIC4.DIC

DIC(Concept of DIC)

DIC (Etiology of DIC)1.(Infectious Diseases)(infection of bacteria)(septicemia)(severe infective hepatitis)

2.Malignant Tumors)

3.(Obstetric accidents)

4.(Severe trauma)

9-1

Pathogenesis)!!!

((Severe tissue injury)

(Extensive damage of vascular endothelial cells)

EC

ADP

(Excessive destruction of the circulating blood cells and platelet activated)ADPTXA2

ADP

(Other thromboplastic material entering the blood)

9-1 TF

Predisposing Factors to DIC)

Block of reticuloendothelial system)TFAg-Ab FDP Shwartzman

Severe hepatic disease)Ag-AbTF

Hypercoagulable state ATPC EC()

Disorder of microcirculation)()ECDIC

Decrease of fibrinolysis function

Stages of DIC

(Consequences of DIC)

(bleeding)DIC

(Dysfunction of multiple organs) DIC

(shock)

(Microangiopathic hemolytic anemia,MHA)microangiopathic hemolytic anemiaschistocyte

RBC20005200

9-1 1. 3P+++D-++ 2. 1 2+++RBC(+)WBC(+)+ 328/ 4130/ 3. ABP 90/60mmHg 4. Hb 50g/LRBC6%

(Principles of Management of DIC)1.2.3.4.