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(DIC) Disseminated Intravascular Coagulation
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(Blood Coagulation)
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(Anticoagulant Mechanism)
(AT ) CPC
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(Fibrinolysis)XIIatPAuPAFDP EC
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//-DIC
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9-139+38 36.820/88/150/100mmHg128/130/1200ml90/60mmHgRBC1.501012/L,(Hb)50g/L,(WBC)11.0109/L,,(PLT) 45109/L+++RBC+WBC++PT2514TT2112Fg0.98g/L3P+++6%D-++B
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1.DIC2.DIC3.DIC4.DIC
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DIC(Concept of DIC)
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DIC (Etiology of DIC)1.(Infectious Diseases)(infection of bacteria)(septicemia)(severe infective hepatitis)
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2.Malignant Tumors)
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3.(Obstetric accidents)
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4.(Severe trauma)
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9-1
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Pathogenesis)!!!
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((Severe tissue injury)
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(Extensive damage of vascular endothelial cells)
EC
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ADP
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(Excessive destruction of the circulating blood cells and platelet activated)ADPTXA2
ADP
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(Other thromboplastic material entering the blood)
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9-1 TF
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Predisposing Factors to DIC)
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Block of reticuloendothelial system)TFAg-Ab FDP Shwartzman
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Severe hepatic disease)Ag-AbTF
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Hypercoagulable state ATPC EC()
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Disorder of microcirculation)()ECDIC
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Decrease of fibrinolysis function
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Stages of DIC
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(Consequences of DIC)
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(bleeding)DIC
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(Dysfunction of multiple organs) DIC
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(shock)
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(Microangiopathic hemolytic anemia,MHA)microangiopathic hemolytic anemiaschistocyte
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RBC20005200
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9-1 1. 3P+++D-++ 2. 1 2+++RBC(+)WBC(+)+ 328/ 4130/ 3. ABP 90/60mmHg 4. Hb 50g/LRBC6%
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(Principles of Management of DIC)1.2.3.4.