> fun for you
DESCRIPTION
The evolution of beverages and chocolate. > good for you. > better for you. > fun for you. Sugar is the fuel for the brain and the nerves the basis for cognitive performance. Sugar protects cells from Apoptosis - PowerPoint PPT PresentationTRANSCRIPT
![Page 1: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/1.jpg)
08-2005
> fun for you
The evolution of beverages
and chocolate
> better for you
> good for you
![Page 2: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/2.jpg)
08-2005
Sugar is
• the fuel for the brain and the nerves
• the basis for cognitive performance
![Page 3: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/3.jpg)
08-2005
Sugar protects cells from
•Apoptosis
•Radicals (reactive oxygen species / ROS)
![Page 4: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/4.jpg)
08-2005
Sugar protects healthy cells, but also cancer cells from apoptosis and radicals!
![Page 5: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/5.jpg)
08-2005
Aerobic glycolysis by proliferating cells: a protective strategy against reactive oxygen species
Brand and Hermfisse, 1997; The FASEB Journal
Sugar metabolism protects from radicals!
![Page 6: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/6.jpg)
08-2005
Sugar metabolism inhibits aging cancer cells, but also slows down aging of humans !Absence of TKTL1 sugar metabolism shortens life span of humans!
![Page 7: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/7.jpg)
08-2005
Inhibition of apoptosis in nerve cells by sugar metabolism
Inhibition of radical / ROS production
Sugar protects nerve cells from apoptosis even when the amyloid beta plaques are already present
Sugar metabolism protect nerve cells from Alzheimer‘s disease !
![Page 8: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/8.jpg)
08-2005
s
The newly discovered sugar metabolism not yet present in text books explains the protective role of sugar
![Page 9: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/9.jpg)
08-2005
Janus-faced character of sugar
Role in healthy cells:
prevents and neutralizes radicals
fast glucose degradation
protection from glucose- associated cell-damages / advanced glycation end products (AGEs) in endothelial cellsnerves retina
Role in cancer cells:
energy realease without oxygen degradation of
surrounding matrix
invasion and metastasis
resistence towards radio and
chemotherapy
![Page 10: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/10.jpg)
08-2005
Sugar is the fuel for the evolution of the human brain
> from Neandertals to Homo sapiens
![Page 11: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/11.jpg)
08-2005
Science Mai 2010
![Page 12: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/12.jpg)
08-2005
![Page 13: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/13.jpg)
08-2005
Dig Dis Sci. 2013 Jul;58(7):2061-7. doi: 10.1007/s10620-013-2591-3. Epub 2013 Feb 20.
Prediabetes is associated with a high-risk colorectal adenoma.Cha JM, Lee JI, Joo KR, Shin HP, Jeun JW, Lim JU.
prediabetes and pre-cancer
![Page 14: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/14.jpg)
08-2005
Diabetologia. 2010 Sep;53(9):1867-76. doi: 10.1007/s00125-010-1796-7.
Diabetes, prediabetes and cancer mortality
Zhou XH, Qiao Q, Zethelius B, Pyörälä K, Söderberg S, Pajak A, Stehouwer CD, Heine RJ, Jousilahti P, Ruotolo G, Nilsson PM, Calori G, Tuomilehto J; DECODE Study Group.
Diabetes and prediabetes were associated with an increased risk of cancer death.
Mortality from cancers rose linearly with increasing glucose concentrations.
prediabetes / diabetes and cancer
![Page 15: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/15.jpg)
08-2005
s
glycemic load and colon cancer
![Page 16: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/16.jpg)
08-2005
s
glycemic index and breast cancer
![Page 17: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/17.jpg)
08-2005
N Engl J Med. 2013 Aug 8;369(6):540-8. doi: 10.1056/NEJMoa1215740.
Glucose levels and risk of dementia.Crane PK, Walker R, Hubbard RA, Li G, Nathan DM, Zheng H, Haneuse S, Craft S, Montine TJ, Kahn SE, McCormick W, McCurry SM, Bowen JD, Larson EB.SourceDepartment of Medicine, University of Washington, Seattle, WA, USA. [email protected]
higher glucose levels are a risk factor for dementia, even among persons without diabetes.
blood glucose level and dementia / Alzheimer
![Page 18: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/18.jpg)
08-2005
![Page 19: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/19.jpg)
08-2005
![Page 20: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/20.jpg)
08-2005
Am J Clin Nutr. 2011 Feb;93(2):374-81.
Galactose promotes fat mobilization in obese lactating and nonlactating women
Mohammad MA, Sunehag AL, Rodriguez LA, Haymond MW.Department of Pediatrics, Children's Nutrition Research Center, US Department of Agriculture/Agricultural Research Service, Baylor College of Medicine, Houston, TX 77030-2600, USA.
healthy sugars and fat burning
![Page 21: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/21.jpg)
08-2005
Neuropharmacology. 2014 Feb;77:68-80. Long-term oral galactose treatment prevents cognitive deficits in male Wistar rats treated intracerebroventricularly with streptozotocin.Salkovic-Petrisic M1, Osmanovic-Barilar J2, Knezovic A2, Hoyer S3, Mosetter K4, Reutter W5.AbstractBasic and clinical research has demonstrated that dementia of sporadic Alzheimer's disease (sAD) type is associated with dysfunction of the insulin-receptor (IR) system followed by decreased glucose transport via glucose transporter GLUT4 and decreased glucose metabolism in brain cells. An alternative source of energy is d-galactose (the C-4-epimer of d-glucose) which is transported into the brain by insulin-independent GLUT3 transporter where it might be metabolized to glucose via the Leloir pathway. …Beneficial effect of oral galactose was independent of the rat age and of the galactose dose ranging from 100 to 300 mg/kg/day. …Oral galactose exposure might have beneficial effects on learning and memory ability and could be worth investigating for improvement of cognitive deficits associated with glucose hypometabolism in AD.
![Page 22: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/22.jpg)
08-2005
Z Stomatol. 1989 Jun;86(4):179-89.
Anticaries effectiveness of D(+)-galactose
Lembke A, Pause B.
1.5% galactose prevents caries significantly and strongly reduces the amount of film
The effect is based on the property of galactose to occupy the receptors of the pellicle (layer of glycoprotein on the tooth enamel)
healthy sugars and tooth protection
![Page 23: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/23.jpg)
08-2005
Int J Cosmet Sci. 2002 Aug;24(4):225-34. doi: 10.1046/j.1467-2494.2002.00141.x.
Removal and prevention of dental plaque with d-tagatose.Lu Y, Levin GV.
SourceSpherix Incorporated (formerly Biospherics Inc.), 12051 Indian Creek Court, Beltsville, Maryland 20705, USA.
Thus, d-tagatose has the potential for preventing and removing plaque development and for altering the subgingival microbiota. These effective qualities offer conservative control of gingival and periodontal disease.
healthy sugars and tooth protection
![Page 24: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/24.jpg)
08-2005
Nutr Res. 2010 Dec;30(12):801-6. doi: 10.1016/j.nutres.2010.09.007.Dietary supplementation with d-tagatose in subjects with type 2 diabetes leads to weight loss and raises high-density lipoprotein cholesterol.Donner TW1, Magder LS, Zarbalian K.
AbstractOral d-tagatose (d-tag) attenuates the rise in plasma glucose during an oral glucose tolerance test in subjects with type 2 diabetes mellitus (DM) and reduces food intake in healthy human subjects. A reduction in food consumption and less weight gain occur in rats fed tagatose. This pilot study explored the metabolic effects of d-tag given daily to 8 human subjects with type 2 DM for 1 year. We hypothesized that this treatment period would lead to weight loss and improvements in glycated hemoglobin and the lipid profile. A 2-month run-in period was followed by a 12-month treatment period when 15 g of oral d-tag was taken 3 times daily with food. No serious adverse effects were seen during the 12-month treatment period. Ten of the initially 12 recruited subjects experienced gastrointestinal side effects that tended to be mild and transient. When 3 subjects were excluded who had oral diabetes, medications added and/or dosages increased during the study and mean (SD) body weight declined from 108.4 (9.0) to 103.3 (7.3) kg (P = .001). Glycated hemoglobin fell nonsignificantly from 10.6% ± 1.9% to 9.6% ± 2.3% (P = .08). High-density lipoprotein cholesterol progressively rose from a baseline level of 30.5 ± 15.8 to 41.7 ± 12.1 mg/dL at month 12 in the 6 subjects who did not have lipid-modifying medications added during the study (P < .001). Significant improvements in body weight and high-density lipoprotein cholesterol in this pilot study suggest that d-tag may be a potentially useful adjunct in the management of patients with type 2 DM.
![Page 25: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/25.jpg)
08-2005
s
healthy sugars increase muscular performance
![Page 26: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/26.jpg)
08-2005
Use of healthy sugars
galactose, isomaltulose, tagatose, trehalose
for beverages and chocolate
![Page 27: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/27.jpg)
08-2005
Natural and digestible
Fuel for constant energy
Low glycemic index
Tooth friendly
Inducing fat burning
![Page 28: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/28.jpg)
08-2005
Healthy sugars for the prevention of:
Diabetes
Alzheimer
Cancer
Metabolic syndrome
Overweight
![Page 29: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/29.jpg)
08-2005
Patent Refreshing beverage
![Page 30: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/30.jpg)
08-2005
Summary
![Page 31: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/31.jpg)
08-2005
![Page 32: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/32.jpg)
08-2005
Patent chocolate mass
![Page 33: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/33.jpg)
08-2005
Summary
![Page 34: > fun for you](https://reader036.vdocuments.net/reader036/viewer/2022062517/56813859550346895da001e7/html5/thumbnails/34.jpg)
08-2005
Coca-Cola : vitaminwater
3% sugar (Fruktose, Saccharose)
Stevia
Citric acid--------------------------------------Claims:
Calorie restricted
Coy beverages
2.5% sugar (Galactose, Isomaltulose, Trehalose,Tagatose)
Stevia
Gluconic acid---------------------------------------Claims:
Calorie restricted Low sugarTooth friendlyLow glycemic indexInducing fat burning Protection of neurons / brain