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ݩ[email protected] 㛫⏕≀Ꮫ Vol. 26, No. 1 (2020) 51 ੜি ఢ প৾ প৾৶৾௺ଢ଼ఐ েఐ৾௧వ ಟኈ 2 ࡀ⚾ࠊᡤᒓ῝⏣◊✲ᐊ Duke-NUS Medical School David M Virshup ᩍᤵ ඹ◊✲ᡴデ ࠋࡓࡗ࠶ࡀసᡂࡓࡋኚ␗⾜ࡢゎᯒ࠸ࡋࡇ࠺࠸ ⚾ࠋ࠸ࡋᡭᣲࡓࡆ⏣῝ࠊᩍᤵ⚾㐺௵ ࠊࡋᐇ㝿ᡭࡇࡃ࠸ ࠋࡓࡗ࡞ඹ◊ ✲㛤ጞࡓ࠶ࡢࡑࠊࡑࠊ 2 㛫⛬ᗘᮇ㛫ࡗࡓVirshup ◊✲ ᐊゼ✲◊ࠊィ⏬ᐇ㦂ᡭἲ ࠸ࡘሗ⾜ࡇ࠺ ࠋࡓࡗ࡞Ώ⯟ᅜእ㐍ฟࡇ࠺࠸ᐇ㝿᪥ ᖖⓗⱥㄒᡭ⥆ࢺࡢ➼ࡁぢ⯙ ࠸࡞ࡓࡗ࠸ᚰ㓄ከᑡ ࠊࡀࡓࡗ࠶࠾ࠊࡋᅵ⏘ᦠ ࠊ࠼ពỴ ✵ࢠ ࠋࡓࡗ❧ࡧ㉥㐨┤ୗ⨨ᖖኟฟ❧๓ࡗࡍࡣ ࠊࡀࡓ࠸ ࠋ࠸㞳㝣 ࡕࡣࡓࡗ╔ࠊࡀࡔࡢ࠺ࡢࡘ࠸㛫⿇ࡗ࡞╔ࠊࡓ࠸ධᅜᑂᰝฟ㐜 ࠋࡓࡗ ✵ࢠᕷ⾤ᆅMRT ࠺࠸㟁㌴ ࠋ࠺᪥ᮏᬑ㏻ษ➢࡞␗ࡣMRT ษ➢ࡇࡍ ࠺࠸࠸࡞ࡉవィᩱ㔠ᡶࡇ࠺ಀဨࡀࡓ࠸ࡣࡅࡔ࠺ᡭ㛫ࡢࡓࡗ๓༑ศㄪ⾜ࡇࡃࡢࡌ᪉ከࢩࠊࡀ࠺せ⾪ࡓࡓࡗ࠶࡞ࠎWikipedia Ẹ᪘ᵓᡂ⳹ࡣ ࠋ࠸㌴ෆᵓᡂࡢࡑ࡞࠺༳㇟ ࡓࡅ ࠊࡀほගᆅேẼ ࠊࡃࡋࢫ࡞ࡁࡓࡗほගᐈከ⾤ࠋࡓࡗᅪẖ 㞺ᅖẼࡢࡘ࠸ࡀࡀ⚾ࠋࡓࡋࢳࡣࢱࢼ ୰⳹ᩱ⌮ᗑ ࠸࠾ࡍࡀ࠺࠸⤒࠸ࡋ ࠋࡓࡋ᪥ᮏ᪥ᮏㄒࡇ࠸࡞࠸↓ࡎࢩࠊఫẸⱥㄒ ࠊࡀࡔࡢࡓ࠸ࡢࡃ୰⳹ ⌮ᗑⱥㄒࡇ࠸࡞ࡌ ࠋࡓࡗ࠶Virshup ◊✲ᐊⱥㄒࠊࡀࡓ࠸ ᢡ▱࠸࡞ゝㄒ⪺࠼ࡇ ࠋࡓࡁඹ◊✲┤ ࡢࢡࢻࢫRajesh Narasimamurthy ༤ኈฟ㌟ⱥㄒࡇ࠸࡞ ࠊࡀࡓࡗ࠶ࡋࡤࡋ᰿Ẽᐇ㦂ᡭἲㄝ㆟ㄽ࠾ࡓヰ⬟ຊࡓࡗࡀ ࠋ࠺ᐇ㦂ᐊ✲◊ࡣᐊẖศࡇ࠸࡞࠸ 㣗⥴⾜◊✲ᐊẖศ ࠸࡞ࡣ ࠋࡓࡗࡔ࠺ࡗࡔࡢࡃ㣗⾜ ࡀࡓ࠸㸦⚾ఱᗘࡏࡉ ࡓࡗRajesh ࢱࢪ࠺ࡑࡔᐙᘚ ᙜᣢ ࠋࡓ࠸᪥ᮏẚࢱࢪ ࡞࠺ࡑࡍࡀࢩࠊࡀ ࢱࢪẼ㍍㣗⾜ࢺࢫ ࡞ࡣࡃࠋ࠸ࡋᅾ୰ᗘ Rajesh ࢱࢪࢺࢫ㐃⾜ ࠋࡓࡗᑠ㯏㇋ീ௨㣗ᛂ⚾ࠋࡓࡗ࠶ࡀ࠼ࢱࢪࡢࠋ࠸࡞㸲㐌㛫 ࠸▷࠺࠸ᮇ㛫ࢩࡀࡓࡗࡔ ࡞␗ࠊ⫼ᬒᣢࡓࡗࡀࠎ⮬ࠊศ␗ ⌮ゎ࠶ࡀᅵᆅ ࠋࡓࡌ࡞ࡕඹ◊✲PER2 Ⅼኚ␗ゎᯒࠋࡓࡋPER2 ࢭ࡞ࠎṧᇶᏳᐃᛶไᚚ▱ࡀࡢࡇࠊࡀኚ␗ࡢࡕ࠺ࡢࡑࡣࢫ 478 ࢭࡢ┠␒ࡓࡋ ࡢࡇࠋṧᇶ ș-TrCP ㄆ㆑PER2 ৾৬ୡ੶ ३থफ़এ شঝ௰बथ

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  •  [email protected]   Vol. 26, No. 1 (2020) 

    51 

        

          

    2Duke-NUS Medical School David M Virshup

    2Virshup

     

     MRT

    MRT

     

    Wikipedia

     Virshup

    Rajesh Narasimamurthy

     

    Rajesh

    Rajesh

     

    PER2 PER2

    478

    -TrCP PER2

       

     

  •    Vol. 26, No. 1 (2020) 

    52 

    --TrCPVirshup PER2

    FASP-TrCP PER2

    Zhou et al., Mol. Cell, 2015 FASP -TrCP

    (CK1)

    CK1 FASP -TrCP-

    PER2

    -TrCP PER2Virshup

    PER2 

    Virshup

      

     

      

    David M Virshup Rajesh Narasimamurthy David M Virshup