1. Viral reproductive disorders in sows
an update 2011
H. Nauwynck
Laboratory of Virology
Faculty of Veterinary Medicine
Ghent University, Belgium

2. 1. CL (progesterone)
Normalgestation in the sow
2. Cytokine/growth factor
cross talk
?
3. Immune suppression
3. How do viruses cause reproductive problems?
General disease (fever)
~ pro-inflammatory cytokines causing distortion of cytokine balance
-> swine influenza virus,
2. Replication of pathogens in reproductive tract/embryo/fetus
~ damaging the placenta and/or cytokine balance
~ direct negative impact on embryo/fetus
-> DNA viruses: Aujeszkys disease virus, parvovirus, porcine circovirus 2
-> RNA viruses: porcine reproductive and respiratory syndrome virus, porcine enteroviruses, encephalomyocarditis virus, classical swine fever virus
4. How do virusesreachembryos/fetuses?
1. Contaminatedsperm
5. 2. Viremia + transplacental spread
How do virusesreachembryos/fetuses?
6. 1. Via contaminatedsperm
Virus excretion in sperm
~ viremia
DNA-viruses
ADV (