1 © 2012 AB SCIEX

The New TripleQuad™ 6500 & QTRAP® 6500 Systemswith IonDrive™ Technology

The new AB SCIEX 6500 Series with multi-component IonDrive™ Technology AB SCIEX’s most sensitive triple quad

• up to 10X increase in sensitivity

• Up to 20X increase in detector dynamic range

- all with no compromise in mass range.

New Products in 2012

2 © 2012 AB SCIEX

IonDrive™ Technology Key Innovations

Higher sensitivity

Extended mass range m/z 5 – 2,000 with advanced dual RF electronics

Extended dynamic range

SelexION™ technology compatible

Faster MRM3

IonDrive™ Turbo V Source IonDrive™ QJet Guide IonDrive™ HE Detector

Driving Performance by Driving More Ions While Maintaining Ruggedness

3 © 2012 AB SCIEX

IonDrive™ Turbo V Source – Produce More Ions

Original Turbo V™ New IonDrive Turbo V

4 © 2012 AB SCIEX

IonDrive™ QJet Ion Guide – A Dual Stage RF Ion Guide

Computed gas flow model showing flow through the ion guide

Larger diameter of first stage Better ion capture

Smaller diameter of second stage Better focusing into Q0

End Result: More ions transmitted, fewer neutrals reaching Q0

5 © 2012 AB SCIEX

Two Software Selectable Mass Ranges

6 © 2012 AB SCIEX

SelexION™ Technology - A higher level of Selectivity

New Products in 2012

S/N = 3

Salmeterol without SelexION Salmeterol with SelexION

S/N = 252

7 © 2012 AB SCIEX

ekspert™ microLC 200

The world’s only dedicated micro-UHPLC designed to deliver up to fivefold faster separations and up to fourfold improved sensitivity

• Reduction in mobile phase costs up to 95%

• Designed specifically for high throughput mass spectrometry laboratories

• Ideal for pharmaceutical applications – small molecules and biologics

New Products in 2012