0830 - falcinelli - miami 6th kpro study group meeting may ... · iridodialisis, air into the bulb...
TRANSCRIPT
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
OSTEO-ODONTOKERATOPROSTHESISFOUNDATIONROME - ITALY
HONORARY PRESIDENT PRESIDENT
Rosario Brancato Luciano Cerulli
SCIENTIFIC DIRECTOR
Giancarlo Falcinelli
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
MODIFIED OSTEO-ODONTO-KERATOPROSTHESIS
(MOOKP)
OVER 30 YEARS OF EXPERIENCE
FALCINELLI G.C. – COLLIARDO P. – FALCINELLI G. – TALONI M.
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
FOR PERSONAL FUNDAMENTAL MODIFICATIONS TO THE ORIGINAL STRAMPELLI’S TECHNIQUE, OUR OOKP IS NAMED
FALCINELLI’S MODIFIEDOSTEO-ODONTO-KERATOPROSTHESIS
Surgical technique in two Stages separated by
3 months interval
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
MODIFIED OOKP: BIOLOGICAL KProsPERFORMED FROM 1973 WITH STRAMPELLI’SOSTEO-ODONTO LAMINA WHICH IS THE FIRST (1964) AND WELL ESTABLISHED BIOLOGICAL HAPTIC FOR KPros MADE OF LIVING HUMAN TISSUE
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
FIRST STAGE OF MODIFIED OOKPA) PREPARATION ACRYLIC OSTEO-ODONTO LAMINA (OOL)OSTEO-ODONTO ACRYLIC LAMINA IS PREPARED FROM MONO ROOTED TOOTH AND BURIED IN PALPEBRAL –ZYGOMATIC SUBCUTANEOUS POCKET FOR THREE MONTHS
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
B) PREPARATION OF THE OCULAR SURFACE
AFTER A SUPERFICIAL KERATECTOMY AND CONJUNCTIVA DETACHED OCULR SURFACE IS COVERED WITH BUCCAL CHEEK MUCOSA
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
2nd STAGE OF MODIFIED OOKP AFTER 3 MONTHS
1) REMOVAL OF BURIED LAMINA 2) DETACHMENT OF BUCCAL MUCOSA3) TREPHINING OF OPAQUE CORNEA AND 3
RADIAL CUTS
4) TOTAL REMOVAL OF THE IRIS
1
2
1
3 4
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
5) CRYOEXTRACTION OF THE LENS EVEN IF TRANSPARENT
6) ANTERIOR VITRECTOMY ABOUT 1,5 cc
7) IMPLANT OF PROSTHESIS
8) RECOVERING WITH BUCCAL MUCOSA
5
6 7 8
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
1 2
1) THE EYE AFTER OPERATION
(TEN DAYS)
2) AFTER ONE MONTH
3) WITH COSMETIC SHIELD
1
2 3
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
FALCINELLI’S INNOVATIONS TO STRAMPELLI’S TECHNIQUE
1) Lamellar keratectomy includingBowman’s membrane
2) Use of thicker cheek mucosa
3) Increase in diameter of opticalcylinder pondered and careful
4) Obligatory total iridoablation
5) Cryoextraction of the lenswhether transparent or not
6) Obligatory anterior vitrectomy
7) Use of biological glue to reattachthe periosteum
8) Biometric assessment ofoptical cylinder power
9) Joining of 2 osteo-odontolaminae
10) Use of impacted teeth11) Use of blood relation’s teeth in
toothless patients12) Use of Eckardt’s prothesis in
retinal detachment
13) Double thread cyclodiastasis with a single sclerotomy
14) Posterior drainage tube inrefractory glaucoma
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
FURTHER MODIFICATIONS TO
FALCINELLI’S TECHNIQUELamina shorter………New optical design cylinders……….Cyclocryotherapy…….. on allpatients as a preventive forglaucoma.
An. Inst. Barraquer (Barc.) 30-59-63 (2001)
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
NO SHORTER LAMINA TO AVOID MUCOSA DAMAGE
When the lamina is shortened, even by a few millimeters, the haptic loses a large part of the alveolar bone necessaryfor the survival of the dentine on which the optical cylinderis fixed
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
NO INCREASED DIAMETER OF OPTICAL CYLINDER TO ENLARGE THE VISUAL FIELD
Our optical cylinder’s diameters have beenincreased much more than Strampelli’s. A further increase requires an excessivetrephining both of the dentine with demageto the lamina and of the cornea with possibleretroprosthetic membrane, vitreous retinalcomplications or expulsion of the prosthesis.
FALCINELLI
STRAMPELLI
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
No CYCLOTHERAPY PERFORMED AT STAGE 1 EVEN IN NOT GLAUCOMATOUS PATIENTS AS A
PREVENTIVE MEASURE FOR GLAUCOMA :
Every ophthalmologist knows that cyclocriotherapy isnot the ideal treatment for glaucoma. Moreover in patients not suffering from this disease can create some problems to the acqueous veins which maycontribute to the onset of glaucoma.
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
NO EXTRACAPSULAR EXTRACTION
With the technique performed in England open-skywith posterior capsulectomy, anterior vitrectomy, total iridodialisis, air into the bulb and patient supine in bed
fo some days.The capsular residuals, pushed against the trabeculum, may increase the risk of glaucoma.Moreover possible cortical residuals may cause cyclitic or uveitic inflammations as happened in Strampelli’s original technique.
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
EXTRACAPSULAR LENSEXTRACTION
Apparently easier and safer, alreadyused in OOKP by Strampelli,Barraquer, Casey, Dal Fiume,Iannetti, Marchi, Tempranogives results not so good as ours
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
The results of British innovationscompared with those of Falcinelli’s modified OOKP
17,40%45,65%3PL-NPL
NOT IMPROVED OR BLINDNESS
34,78%
17,38%4NOT IMPROVED OR BLINDNESS
5,65%
0,00%0CF-HM
IPOVISION26,10%
26,10%6IPOVISION13,20%
13,20%76/36-6/60-1/60
4,35%13,76%26/18-6/24
30,45%739,62%216/6-6/12 USEFUL
V.A.39,15%
4,35%1USEFUL
V.A.81,12%
37,74%206/5
Cumulative%EyesCumulative%Eyes
LIU’S CONSECUTIVE CASES N° 23 presented at IOSS
INTERNATIONAL MEETING –Grosseto - ITALY 2002Follow-up 4,05 months
(range 0,05 - 5)
FALCINELLI’S CASES N° 56 published by Liu in “Indipendent
Survey of long-term results of Falcinelli’s OOKP”
Follow-up 5,11 years (range 0,2 - 16)
V.A.
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
MODIFIED OSTEO-ODONTOKERATO PROSTHESIS (MOOKP)
257 OPERATED EYES FROM 1973 TO 2005
FOLLOW-UP: 4 MONTHS < < 31 yrs(10.15 yrs + 6.08 yrs)
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
257 EYES - 232 CONSECUTIVEPATIENTS DURING 32 YEARS
58 PATIENTS DIED2 IMPLANTED IN BOTH EYES
39 PATIENTS LOST TO FOLLOW - UP1 IMPLANTED IN BOTH EYES
OOKP 1973-2005 257 EYES
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
OOKP 1973-2005 257 EYES
232 PATIENTS
139 MALES 93 FEMALES
207 MONOCULARS 25 BINOCULARS
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
OOKP 1973-2005 257 EYES
NUMBER OF YEARS OF BLINDNESSBEFORE IMPLANT
0 yr < < 59 yrs(6.97 yrs + 8.61 yrs)
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
OOKP 1973-2005 257 EYES
AVERAGE AGE AT TIME OFIMPLANTATION
17 yrs < < 83 yrs(53.23 yrs + 15.87 yrs)
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
7.0018FAILED KP, PATHOLOGY NOT INCLUDED IN THIS TABLE
7.0018CORNEAL SEQUELAE OF ANTI GLAUCOMA SURGERY
8.1721SEQUELAE OF INFECTIVE KERATITIS
35.8192BURNS (ALCALI, ACIDS, PHYSICAL INJURIES
42.02108DRY EYE SYNDROME (58 pemfigoid, 13 Sjogren, 10 trachoma, 10 Lyell,12 Stevens Johnson, 3 GVH, 2 others)
%N°BASIC PATHOLOGYOOKP 1973-2005 257 EYES
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
DRY EYE + BURNS
77,83% OF OUR CASES
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
OOKP 1973-2005 257 EYES
- 83 EYES (32,29%) OF OUR CASESHAVE HAD ONE OR MORE
PENETRATING KERATOPLASTY- 8 EYES (3,11%) WITH EPITHELIAL
STEM CELLS
FAILED BEFORE MOOKP
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
COMPLICATIONS DURING SURGERY(1st + 2nd stage) 22: ALL CURED
3 oro-nasal fistula3 mandibular fracture7 damaged tooth4 corneal perforation2 haemovitreous2 scleral rupture1 choroidal detachment
OOKP 1973-2005 257 EYES
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
OOKP 1973-2005 257 EYES
COMPLICATIONS AFTER 1st STAGEBEFORE IMPLANT 16: ALL CURED
001CHOROID DETACHMENT
1
003RETINAL DETACHMENT3
5011TOTAL16 (6.83%)
005MUCOSA ALTERATION5
300LAMINA REABSORPTION
3
202LAMINA INFECTION4
NEW LAMINANOT CUREDCURED
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
COMPLICATIONS AFTER IMPLANT FOR THE PROSTHESIS: 28 CURED: 26
226TOTAL28 (10.89%)
01RETROPROSTHETIC FISTULA1
11PROSTHESIS EXPULSION2
12OPTIC CYLINDER EXPULSION3
02OPTIC CYLINDER INSTABILITY2
020BUCCAL MUCOSA ALTERATION
20
NOT CUREDCURED
OOKP 1973-2005 257 EYES
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
COMPLICATIONS AFTER IMPLANT FOR THE EYE: 40CURED: 24
1624TOTAL40 (15.56%)
02CHOROIDAL DETACHMENT2
14UVEITIS, RETROPROSTHETIC MEMBRANE
5
111HAEMOVITREOUS12
92ENDOPHTHALMITIS11
55RETINAL DETACHMENT10
NOT CUREDCURED
OOKP 1973-2005 257 EYES
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
OOKP 1973-2005 257 EYES
GLAUCOMAIS THE MOST FREQUENT COMPLICATION
OF OOKP BUTWE ARE NOT SURE IF MODIFIED OOKP
MUST BE CONSIDERED THE DIRECT CAUSE OF GLAUCOMA
CERTAINLY AN INACCURATE SURGICAL PROCEDURE CAN FACILITATE THE
ONSET OF GLAUCOMA AFTER OOKP
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
GLAUCOMA
BEFORE OOKP 97 (37.74 %)
RE-APPEARANCE OF GLAUCOMA 53 (54.64 % of 97 eyes) EX NOVO GLAUCOMA 16
TOTAL GLAUCOMA AFTER IMPLANT 69 (26,85%)
OOKP 1973-2005 257 EYES
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
OOKP 1973-2005 257 EYES
SURGICAL TREATMENT OF GLAUCOMAAFTER OOKP
25 CASES, 28 OPERATIONS(3 eyes operated twice)
12 retroequatorial drainage (1 double int.) 8 STAB. - 2 Sl.W.12 double thread cyclodiastasis (2 double int.) 7 STAB. - 3 Sl.W.3 transcleral cyclophotocoagulation 1 STAB.-1 W.-1 AG1 diathermy of long ciliaries a. 1 W. 3 endo ciclo photocoagulation 1 STAB. - 1 W.
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
OOKP 1973-2005 257 EYES
RESULTS OF MEDICAL, SURGICAL andLASER TREATMENTS OF GLAUCOMA
69 CASES POST-IMPLANT GLAUCOMA(53 RELAPSED + 16 EX NOVO)
27 (39.12 %) STABILIZED - (Stab.)16 (23.18 %) SLIGHTLY WORSE - (Sl. W.) 23 (33.33 %) WORSENED - (W.)3 ( 4.37 %) ABSOLUTE GLAUCOMA - (A.G.)
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
PERCENTAGE %N. EYEVISUAL ACUITY
0.00 %0no L. P.
0.39 %1L. P.
3.50 %9H. M.
2.33 %62/50 - 1/50
4.67 %121/10 - 3/50
11.67 %304/10 - 2/10
10.51 %277/10 - 5/10
66.93 %17210/10-8/10
3.89 %3.89 %3.50 %
7.00 %
4.67 %
89.11 %
77.44 %
66.93 %
CUMULATIVE %
NOT IMPROVEDOR BLINDNESS
3.89 %
IPOVISION
7.00 %
USEFUL V.A.
89.11 %
OOKP 1973-2005 257 EYES
BEST VISUAL ACUITY
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
PERCENTAGE %N. EYEVISUAL ACUITY
2.72 %7no L. P.7.78 %20L. P.4.28 %11H. M.
3.50 %92/50 - 1/50
5.45 %141/10 - 3/50
10.51 %274/10 - 2/10
9.34 %247/10 - 5/10
56.42 %14510/10-8/10
14.78 %12.06 %4.28 %
8.95 %
5.45 %
76.27 %
65.76 %
56.42%
CUMULATIVE %
NOT IMPROVEDOR BLINDNESS
14.78%
IPOVISION
8.95%
USEFUL V.A.
76.27%
OOKP 1973-2005 257 EYES
FINAL VISUAL ACUITY
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
ANATOMICAL FAILURE11 (4.7%)
LAMINA REMOVED 10ENUCLEATED EYE 1
OOKP 1973-2005 257 EYES
ANATOMICAL SUCCESS
223 (95.3%)
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
F.M.: AGE 80 - 41 YEARS GOOD V.A. THANKS TO OOKP 1966 STRAMPELLI OPERATED BOTH EYES: 20/20LEFT EYE RE-OPERATED BY US IN 1993 FOR INSTABILITY OF OPTIC CYLINDER: V.A. 20/20 AT PRESENTRIGHT EYE: BLIND FOR ABSOLUTE GLAUCOMA BUT STILL AFTER 36
YEARS HAS AN ANATOMICALLY PERFECT PROSTHESIS,STUDIED BY SPIRAL VOLUMETRIC TAC (GRABNER’STECHNIQUE)
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
I conclude that the biological properties of Strampelli’s OOKP with the surgical innovations
introduced by us make MOOKP, if correctly performed, a surgical approach less prone to
complications and with a very good functional outcome, compared to the original OOKP technique or to the other keratoprostheses.
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Bascom Palmer Eye Institute 6th KPRO STUDY GROUP MEETINGSaturday, 6th May 2006
University of Miami - Florida
Thank-you for honouringwith your qualifiedattendance my great teacher, Porf. Benedetto Strampelli