1 impact of bioinformatics in our life and bme engineer responsibility dr fadhl alakwaa...
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Impact of Bioinformatics in our life and BME engineer
responsibility
Dr Fadhl Alakwaafadhl-alakwa.weebly.com
OUTCOMES
Why human Look different than Chimpanzee?
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OUTCOMES
Why do we look different ?
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OUTCOMESWhy our body is very complicated?
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OUTCOMESHow much we know about our biological system?
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http://www.pbs.org/wgbh/pages/frontline/shows/teenbrain/work/how.html10/12/2013
OUTCOMESWhat is our role in solving life big mystery? BME
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DNA
Our cell is the basic unit of our body
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DNA is composed of nucleotides
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Phosphate
Sugar
Nitrogenous base
A
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There are 4 nucleotide A G C T
DNA is composed of nucleotide
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Phosphate
Sugar
Nitrogenous base
A
A
T
G
C
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A T G C
5 P’ 3OH’
A T G C A T G C
5 3
4 DNA is composed of millions of nucleotides
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A C G T A C G T
ACG
TACG
T
No of base pairs= Genome SizeHG= 3200 Mbp (Mb)
5 DNA is double strand connected with hydrogen bounds
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6 DNA size= Genome size
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SEQ 1: AAAATTTTTTGGGGGGGGCCCCCCCCCCCCCCCCCC
7 How many different sequences we get?
SEQ 2: AAAATTTTTTGGGGGGGGCCCCCCCCCCCACCCCCC
SEQ N: AAAATTTTTTGGGGGGGGCCCCCCCCCCCCCCCCCA
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SEQ 1: AAAATTTTTTGGGGGGGGCCCCCCCCCCCCCCCCCC
7 How many different sequence we get?
SEQ 2: AAAATTTTTTGGGGGGGGCCCCCCCCCCCACCCCCC
SEQ N: AAAATTTTTTGGGGGGGGCCCCCCCCCCCCCCCCCA
4^ 3200 X10^6
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OUTCOMES• Yes we are different because we
came from different sequence.
• Twins has the same DNA sequence
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SEQ 1: AAAATTTTTTGGGGGGGGCCCCCCCCCCCCCCCCCC
8 Data bases for all organism
SEQ 2: AAAATTTTTTGGGGGGGGCCCCCCCCCCCACCCCCC
SEQ N: AAAATTTTTTGGGGGGGGCCCCCCCCCCCCCCCCCA
4^ 3200 X10^6
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• Start on• End on
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9 The Human genome project
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10 Data bases for all organism
The data bases sizes, logos
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OUTCOMESWhat is our role in solving life big mystery? BME
• Search and storage • Sequence alignment• 3D structure predication• Computational biology• System biology• Bioinformatics• Gene function ontology• Drug discovery
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OUTCOMES
Why human Look different than Chimpanzee?
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OUTCOMESWhat is our role in solving life big mystery? BME
• DNA sequencer• M-RNA analysis• PCR• Electrophoresis
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Cell function = proteins
Protein is composed of amino acids
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1Amino acid
A
A
F
N
G
G
ST
S
D
K
COO-NH3+ C
R
HAmino group Carboxylic
acid group
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Protein is synthesized from genes
Protein is synthesized from genes
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2Genes located on DNA
A
A
F
N
G
G
ST
S
D
K
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