What is your position: ❒ Physician ❒ Nurse ❒ Other (Specify): __________________________________________________________

Name: (Last, First, Middle): ____________________________________________ ❒ Grantee ❒ Seminar Faculty ❒ Registrant

Affiliation/Institution: _________________________________ Specialty: ___________________________________ Degree: ____________________

Mailing Address: _______________________________________________ City, State: _______________ Zip: ___________________________________

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Type of Practice: ❒ Private ❒ Academic ❒ Hospital ❒ Government ❒ Other (Specify): _________________________________

In Training: ❒ Medical Student ❒ Resident ❒ Fellow ❒ Other (Specify): _________________________________________________

How did you hear of this program? ❒ Brochure ❒ Journal ❒ Ad ❒ Colleague ❒ Email ❒ Website

Other (Specify): _______________________________________________________________________________________________________________

Self Description (for statistical purposes only): Birthplace: ________________________ Gender: ❒ Male ❒ Female

Ethnicity: Do you consider yourself to be Hispanic/Latino? ❒ Yes ❒ No

In addition, select one or more of the following racial categories to describe yourself:

❒ American Indian or Alaska Native ❒ Asian ❒ Black or African American ❒ Native Hawaiian or Other Pacific Islander ❒ White

Payment:

❒ Check enclosed, payable to: UM Pediatric Nephrology Seminars

❒ Charge registration fee $__________________, to my ❒ VISA ❒ Master Card

Card Number:________________________________________________________ Expiration Date: __________________________________________

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Since meeting room temperature and personal comfort zones may vary a light jacket or sweater is suggested.

Flanked by the roaring Atlantic Ocean and rippling Intracoastal Waterway, the Alexander All Suite Ocean Front Resort is located in the heart of Miami Beach. Attendees will enjoy late-winter in South Florida which is unlike that in any other part of the U.S. thanks to a subtropical climate and strong Caribbean/Latin American influences. It’s just the right place for recharging your personal and professional perspectives in the company of friends and colleagues. You won’t need your coat, boots, or umbrella, but a light jacket may feel good in Miami’s moonlit evening breezes and super-air conditioned restaurants.

Room Rates: $289 + $11.00 Resort Fee and 13% tax-Single/Double Occupancy-European Plan (meals not included) Room rates apply three day prior to, during and three days after the Seminar. Reservations must be received by February 8, 2012, to take advantage of the above rate. Please use attendee code 3545 when making your reservations. After this date, reservation requests will be considered on a space available basis.

Tuition: US $595.00 Physician in PracticeUS $295.00 *Physician in Training, Nurses, Allied Health Care Professionals

*Physicians in Training will need letter of verification from Chief of service. Tuition includes admission to scientific sessions, a course CD and continental breakfasts. After February 20, 2012 and (On-Site) $650.00 for physician in practice and $330 all others.

Services for the Disabled:If special arrangements are required for an individual with a disability to attend this conference, please contact: Gaston Zilleruelo, M.D. (305) 585-6726 and the Alexander All Suite Ocean Front Resort 1-800-327-6121 or (305) 865-6500 no later than February 8, 2012.

For Additional Information, contact:

Division of Continuing Medical EducationUniversity of Miami Miller School of MedicineP.O. Box 016960 (D23-3)Miami, Florida 33101-6960Phone: 305-243-6716 • Fax: 305-243-5613Email: umcme@med.miami.edu

Mail Registration to above address or to register online, visit www.cme.med.miami.edu and click on Register for ConferencesTo register by fax: 305-243-5613Website: http://www.pediatricnephrology.med.miami.edu/SeminarEmail: gzilleruelo@med.miami.edu

S E M I N A R R E G I S T R A T I O N F O R M

ALEXANDER ALL SUITE OCEAN FRONT RESORT5225 COLLINS AVENUE, MIAMI BEACH, FL 33140

Tel: 1- 80 0 - 327- 6121 or (305)865 - 650 0 • Emai l : reservat ions@alexanderhote l .com

H O T E L I N F O R M A T I O N

Registration Cancellation PolicyRefunds will be made only if written notice of cancellation is received prior to February 26, 2012. A $75.00 fee is charged for all refunds. After this date, no refunds will be made. In cases where a course is cancelled due to insufficient registrations, a full tuition refund will be made.

Pediatric Nephrology Seminar XXXIX is an international forum for pediatric and adult nephrologists, pediatricians, internists, general practitioners, renal pathologists, neonatologists, pediatric urologists, transplant surgeons, nurses, nutritionists and allied health professionals to review selected relevant subjects and share new scientific materials. The content is basic, the approach is clinical. Conceptual and practical problems are featured in a balance of formal presentations followed by informal discussions. Topics covered relate research advances to the understanding of mechanisms of renal disease and clinical diagnosis and management. All registrants have opportunities to be involved in a dynamic exchange of information, experience, and insight.

Specific topics selected for Pediatric Nephrology Seminar XXXIX include a total of 9 Sessions covering evolving concepts about developmental nephrology and genetic origens of kidney disease, renal tubular disorders affecting magnesium, phosphate and uric acid handling, biomarkers of tubular injury, cystinosis, hypertension and new developments in vascular biology, approach to evaluation and management of renovascular hypertension in the young child, new developments on bone disease, Vitamin D analogs, FGF-23 and the kidney, on-going challenges in chronic kidney disease, and the effects of systemic diseases on the kidneys. There will be a Session devoted to Fellowship Training Issues and Research Initiatives and two

separate workshops dealing with diagnostic and therapeutic challenges in Dialysis and Transplantation. There will be one interactive Session on Clinico-Pathologic correlations and two special State of the Art presentations will cover New Mechanisms of Progressive Kidney Disease and Transplantation Update 2012.

The Seminar will take place over a 3 day period and will deal with a diverse array of current nephrologic and urologic issues ranging from basic science to clinical practice. There will be a total of 22 distinguished Guest Faculty including the President and Secretary-Treasurer of the American Society of Pediatric Nephrology, several ASPN Council Members, the Secretary General of IPNA and the ALANEPE General Secretary and 13 Local Faculty. Each presentation will last 20 minutes and will be carefully timed to permit maximum opportunity of discussion by participants and faculty.

Upon completion of the Seminar, participants should be able to define the various etiologies and physiologic conditions relating to these subjects, select appropriate diagnostic procedures, understand that which may occur as a result of the disease process or treatment, and indicate appropriate therapy. In addition, those able to do basic or clinical research focused on pediatric nephrology challenges, will be stimulated by those knowledgeable about research issues and be informed about support sources.

ACCREDITATIONThe University of Miami Leonard M. Miller School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

CREDIT DESIGNATIONUniversity of Miami Leonard M. Miller School of Medicine designates this live activity for a maximum of 16.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

OBJECTIVES• Identify recent discoveries in basic, translational and clinical research in selected areas of pediatric nephrology• Assess diagnostic tools in the approach to children with renal tubular disorders• Assess the impact of genetic and epigenetic effects on kidney function and the long term effects of prematurity on adult onset diseases• Evaluate pathogenesis, complications and management of infants and children with hypertension• Assess newer roles and interactions of FGF-23 and Vit D on bone diseases, cardiovascular effects and the kidneys• More effectively manage children with CKD, dialysis and renal transplant and its complications• Explain the process of how to apply for research funds and publish manuscripts• Assess the information obtained from kidney biopsies and its clinical correlation• Assess the importance of the use of emotional intelligence in the work place and establish a new practice• Review the effects of systemic conditions on the kidney and the impact of newer therapies

Founded by: José Strauss, M.D. Program Director: Gastón Zilleruelo, M.D.

Organizing Committee: Gastón Zilleruelo, M.D., Carolyn Abitbol, M.D., Michael Freundlich, M.D., Jayanthi Chandar, M.D., Steven Lipshultz, M.D., Maritza Luna-Hair, MHSA, Linda Davidson, MHA

COURSE DESCRIPTION

FACULTY DISCLOSURES AND CONFLICTS OF INTERESTAll conflicts of interest of any individuals in a position to control the content of this CME activity will be identified and resolved prior to this educational activity being provided. Disclosure about provider and faculty relationships, or the lack thereof, will be provided to learners.

GRANTS AVAILABLEAttention: Medical Students/Physicians in Training/Young FacultyGrants are available for Medical Students/Trainees/Young Faculty. To apply download the grant application from our website:http://www.pediatricnephrology.med.miami.edu/seminar and submit completed application form to:Gaston Zilleruelo, M.D., Program Director, Fax: (305)585-7025, Email:gzilleruelo@med.miami.edu

APPLICATION MUST BE RECEIVED BY JANUARY 7, 2012.

M I A M I B E A C H , F L THE ALEXANDERALL SUITE OCEAN FRONT RESORT5225 COLLINS AVENUEMIAMI BEACH, FL 33140

M A R C H 8 - M A R C H 11, 2 01 2For More Information call 305-243-6716 | Visit us at http://pediatricnephrology.med.miami.edu/seminar

PEDIATRIC NEPHROLOGY SEMINAR XXXIXT hirty Ninth

Department Of PediatricsDivision of Pediatric NephrologyP.O. Box 016960 (M-714)Miami, Florida 33101

_____________PRST STD

US Postage PAID

Miami, FLPermit No. 438

PEDIATRIC NEPHROLOGY SEMINAR XXXIXMarch 8 - March 11, 2012THE ALEXANDER ALL SUITE OCEAN FRONT RESORTMIAMI BEACH, FLORIDA

Sponsored by the

Presented by The Division of Pediatric Nephrology, Department of Pediatrics

PROGRAM DIRECTOR: GASTON E. ZILLERUELO, M.D.

THURSDAY MARCH 8, 20126:00-8:00 P.M Registration

FRIDAY MARCH 9, 20127:00-8:00 A.M. Registration. Continental Breakfast.

8:00-8:10 A.M. Introduction. Opening Remarks. Gaston E. Zilleruelo, M.D.

SESSION 1: Developmental Nephrology/ Genetic Origins of Kidney Disease

MODERATOR: CAROLYN L. ABITBOL, M.D.

8:10-8:30 A.M. The Death of Nephrons: Buried Alive or Decapitation? Robert L. Chevalier, M.D.

8:30-8:50 A.M. Relevance of Genetic Testing in NS William E. Smoyer, M.D.

8:50-9:10 A.M. Fabry’s Disease Olaf Bodamer, M.D., Ph.D.

9:10-9:30 A.M. Of Mice and Men: the Curious Story of ACE-inhibitor Fetopathy Robert L. Chevalier, M.D.

9:30-9:50 A.M. Role of Epigenetics in Kidney Disease Olaf Bodamer, M.D., Ph.D.

9:50-10:10 A.M. Long-term Effects of the Preemie Kidney Carolyn L. Abitbol, M.D.

10:10-10:30 A.M. Panel Discussion

10:30-11:00 A.M. Break and Visit Exhibits

SESSION 2: Tubular Disorders/Biomarkers of Renal Disease

MODERATOR: VERA KOCH, M.D.

11:00-11:20 A.M. Magnesium Wasting Syndromes Uri S. Alon, M.D.

11:20-11:40 A.M. Phosphorus: Friend or Foe? Adrian Spitzer, M.D.

11:40-12:00 P.M. Pathogenic Roles of Uric Acid F. Bruder Stapleton, M.D.

12:00-12:20 P.M. Biomarkers of Tubular Injury Richard Cote, M.D.

12:20-12:40 P.M. Hypophosphatemic Rickets Uri S. Alon, M.D.12:40-1:00 P.M. Cystinosis: A Novel Therapy Robert Mak, M.D., Ph.D.

1:00-1:30 P.M. Panel Discussion

1:30-2:30 P.M. Meet the Professors Luncheon

SESSION 3: Workshop on Dialysis Challenges

MODERATOR: BRADLEY A. WARADY, M.D.

3:00-3:30 P.M. Special Presentation: An Integrated View of the Physiology of Progressive Chronic Kidney Disease H. William Schnaper, M.D.

3:30-5:30 P.M. Growth challenges in ESRD: NAPRTCS Richard N. Fine, M.D.

AKI: When to indicate dialysis? Which modality? Stuart L. Goldstein, M.D.

Tandem HD/TPE Guido Filler, M.D., Ph.D.

PD Challenges Bradley A. Warady, M.D.

HD Challenges Stuart L. Goldstein, M.D.

5:30-7:30 P.M. WELCOME RECEPTION

SATURDAY MARCH 10, 20127:30-8:00 A.M. Registration. Continental Breakfast.

SESSION 4: Bone Disease, Vit D Analogs, FGF-23 and the Kidneys

MODERATOR: MICHAEL FREUNDLICH, M.D.

8:00-8:20 A.M. New Roles of FGF-23 in Bone Metabolism Isidro B. Salusky, M.D.

8:20-8:40 A.M. FGF-23 and the Heart Wacharee Seeherunvong, M.D.

8:40-9:00 A.M. FGF-23 Post-renal Transplantation Myles Wolf, M.D.

9:00-9:20 A.M. Long-term effects of Idiopathic Hypercalciuria Michael Freundlich, M.D.

Program PEDIATRIC NEPHROLOGY SEMINAR 2012

9:20-9:40 A.M. Vit D and its role in Diabetic Nephropathy Robert Mak, M.D., Ph.D.

9:40-10:00 A.M. Vit D Receptor Activators and the Progression of CKD Michael Freundlich, M.D.

10:00-10:30 A.M. Panel Discussion

10:30-10:45 A.M. Break and Visit Exhibits

10:45-11:00 A.M. The Jose Strauss Visiting Professor Award

SESSION 5: Hypertension and Vascular Biology

MODERATOR: JOSEPH T. FLYNN, M.D.

11:00-11:20 A.M. Neonatal Hypertension: An Update Joseph T. Flynn, M.D.

11:20-11:40 A.M. Hypertension from Endothelial Injury Frederick J. Kaskel, M.D., Ph.D.

11:40-12:00 P.M. Renovascular Hypertension: An Approach to Management Julie R. Ingelfinger, M.D.

12:00-12:20 P.M. Hypertensive Crisis Joseph T. Flynn, M.D.

12:20-12:40 P.M. Cardiac Biomarkers in Kidney Diseases Steven E. Lipshultz, M.D.

12:40-1:00 P.M. Use of ABPM in Masked Hypertension Mark Mitsnefes, M.D.

1:00-1:30 P.M. Panel Discussion

1:30-2:30 P.M. Meet the Professors Luncheon

SESSION 6: Workshop on Transplant Challenges

MODERATOR: RICHARD N. FINE, M.D.

3:00-3:30 P.M. Special Presentation: Current Status of Tolerance in Clinical Organ Transplantation Richard N. Fine, M.D.

3:30-5:30 P.M. BK and PTLD Challenges Vikas R. Dharnidharka, M.D., M.P.H.

Role of Proteinuria Post-Renal Transplantation Jayanthi Chandar, M.D.

Latin-American Registry for Transplantation Nelson Orta, M.D.

Recurrence of FSGS: New Developments George W. Burke, III, M.D.

3 Best Fellows Abstracts Presentations

SUNDAY MARCH 11, 20127:00-8:00 A.M. Registration. Continental Breakfast.

SESSION 7: Research and Training Initiatives

MODERATOR: WILLIAM E. SMOYER, M.D.

8:00-8:40 A.M. Manuscript Writing Interactive Session Julie R. Ingelfinger, M.D.

8:40-9:00 A.M. Development and Use of Emotional Intelligence in the Work Place John Mahan, M.D.

9:00-9:20 A.M. Transition From Training to Practice William E. Smoyer, M.D.

9:20-9:45 A.M. NIH Research Initiatives: An Update Marva Moxey-Mims, M.D.

9:45-10:15 A.M. Break. Visit Exhibits

SESSION 8: Clinico-Pathologic Correlations

MODERATOR: JAYANTHI CHANDAR, M.D.

10:15-10:30 A.M. Taxonomy of Podocytopathies H. William Schnaper, M.D.

10:30-11:30 A.M. Interactive Case Presentations Jayanthi Chandar, M.D., Rafael Valenzuela, M.D. and Monica Garcia-Buitrago, M.D.

SESSION 9: The Kidney in Systemic Diseases

MODERATOR: RAMON EXENI, M.D.

11:30-11:50 A.M. Sickle Cell Nephropathy Ofelia Alvarez, M.D.

11:50-12:10 P.M. SLE Nephritis: Early versus Late Rituximab? Carolyn L. Abitbol, M.D.

12:10-12:30 P.M. Use of Angiotensin Blockade in CKD Guido Filler, M.D., Ph.D.

12:30-12:50 P.M. New Approaches on the Management of HUS/aHUS Frederick J. Kaskel, M.D., Ph.D.

12:50-1:30 P.M. Panel Discussion

ADJOURN

Program PEDIATRIC NEPHROLOGY SEMINAR 2012

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ACKNOWLEDGEMENTSENDORSEMENTS

CAROLYN L. ABITBOL, M.D. Professor of Pediatrics, Medical Director, Pediatric Dialysis Unit, Division of Pediatric Nephrology, Department of Pediatrics, Leonard Miller School of Medicine, University of Miami, Miami, FL

OFELIA ALVAREZ, M.D. Professor of Clinical Pediatrics, Division of Hematology Oncology, Department of Pediatrics, Leonard Miller School of Medicine, University of Miami, Miami, FL

OLAF BODAMER, M.D., PH.D. Professor of Human Genetics, Biochemistry and Molecular Biology, Director, Division of Clinical and Translational Genetics, Dr. John T. MacDonald Foundation, Department of Human Genetics, Leonard Miller School of Medicine, University of Miami, Miami, FL

GEORGE BURKE, M.D. Professor of Surgery and Director, Division of Kidney Pancreas Transplantation, Leonard Miller School of Medicine, University of Miami, Miami, FL

JAYANTHI CHANDAR, M.D. Associate Professor of Clinical Pediatrics, Division of Pediatric Nephrology, Department of Pediatrics, Leonard Miller School of Medicine, University of Miami, Miami, FL

RICHARD COTE, M.D., FRCPATH, FCAP Professor and Chair Department of Pathology, Director, Biomedical Nantechnology Institute, Leonard Miller School of Medicine, University of Miami, Miami, FL

MICHAEL FREUNDLICH, M.D. Professor of Clinical Pediatrics, Division of Pediatric Nephrology, Consultant in Pediatric Nephrology, Pediatric Specialty Centers, Miami-Dade and Broward Counties, FL

MONICA GARCIA-BUITRAGO, M.D. Assistant Professor of Clinical Pathology, Department of Pathology, Leonard Miller School of Medicine, University of Miami, Nephropathologist, UM/JMH, Miami, FL

STEVEN E. LIPSHULTZ, M.D. George Batchelor Professor and Chairman, Department of Pediatrics, Chief of Staff Holtz Children’s Hospital, Leonard Miller School of Medicine, University of Miami, Miami, FL

WACHAREE SEEHERUNVONG, M.D. Assistant Professor of Pediatrics, Division of Pediatric Nephrology, Department of Pediatrics, Leonard Miller School of Medicine, University of Miami, Miami, FL

RAFAEL VALENZUELA, M.D., PH.D. Professor of Pathology, Department of Pathology, Chief, Pathology and Laboratory Medicine Service, Veterans Affairs Medical Center, Nephropathologist, VA/JMH/UM

MYLES WOLF, M.D. Associate Professor of Medicine, Department of Internal Medicine, Leonard Miller School of Medicine, University of Miami, Miami,FL

GASTON E. ZILLERUELO, M.D. Professor of Pediatrics, Director, Division of Pediatric Nephrology, Department of Pediatrics, Program Director, Pediatric Nephrology Seminars, Leonard Miller School of Medicine, University of Miami, Miami, FL

AMGEN

GENZYME CORPORATION

URI S. ALON, M.D. Professor of Pediatrics and Director, Bone and Mineral Disorders Clinic, Section of Nephrology, Children’s Mercy Hospital and Clinics, University of Missouri at Kansas City School of Medicine, Kansas City, MO

ROBERT L. CHEVALIER, M.D. David Harrison Professor of Pediatrics, University of Virginia, Charlottesville, VA

VIKAS R. DHARNIDHARKA, M.D., M.P.H. Chief Division of Pediatric Nephrology, Fellowship Program Training Director, Medical Director, Pediatric Kidney Transplant Program, Associate Professor of Pediatrics, University of Florida, Gainesville, FL

RAMON EXENI, M.D. Pediatric Nephrology Department, Hospital de Niños de San Justo and Director of Pediatric Nephrology Fellowship, University of Buenos Aires, Argentina

GUIDO FILLER, M.D. Professor of Pediatrics, Chair Department of Pediatrics, Children’s Hospital, London Health Science Centre, University of Western Ontario, Ontario, Canada

RICHARD N. FINE, M.D. Professor of Pediatrics and Dean School of Medicine, State University of NY at Stonybrook

JOSEPH T. FLYNN, M.D., MS Professor of Pediatrics, Division of Nephrology, Seattle Children’s Hospital, University of Washington, Seattle, WA

STUART L. GOLDSTEIN, M.D. Professor of Pediatrics, Division of Nephrology and Hypertension & The Heart Institute, Director, The Center for Acute Care Nephrology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

FREDERICK J. KASKEL, M.D., PH.D. Professor of Pediatrics and Director of Pediatric Nephrology, Department of Pediatrics, Children’s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY

VERA KOCH, M.D. Professor of Pediatric Nephrology, Instituto da Crianza do Hospital das Clinicas, University of Sao Paulo, School of Medicine, Brazil, Secretary General ALANEPE

JULIE R. INGELFINGER, M.D. Professor of Pediatrics, Harvard Medical School; Senior Consultant in Pediatric Nephrology, MassGeneral Hospital for Children at Massachusetts General Hospital; Deputy Editor, The New England Journal of Medicine, Boston, MA

JOHN D. MAHAN, M.D. Professor, Department of Pediatrics, Program Director, Pediatric Residency Program, Program Director, Pediatric Nephrology Fellowship Program, Vice Chair for Education, The Ohio State University COM

ROBERT MAK, M.D., PH.D. Professor and Chief, Director of Fellowship Program, Division of Pediatric Nephrology. University of California at San Diego

MARK MITSNEFES, M.D., MS Associate Professor of Pediatrics, Division of Nephrology and Hypertension, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

MARVA MOXEY-MIMS, M.D. Deputy Director of Clinical Research, Director Pediatric Nephrology and Renal Centers Programs NIH, NIDDK, DKUH, Bethesda, MD

NELSON ORTA, M.D. Service of Pediatric Nephrology, Children’s Hospital of Valencia, Professor of Pediatrics and Pediatric Nephrology, University of Carabobo, Valencia, Venezuela, President of Latin American Association of Pediatric Nephrology (ALANEPE)

ISIDRO B. SALUSKY, M.D. Professor of Pediatrics, Associate Dean of Clinical Research, Director Pediatric Dialysis Program, Director, General Clinical Research Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, Secretary General of the International Pediatric Nephrology Association

H. WILLIAM SCHNAPER, M.D. Professor of Pediatrics, Vice Chair, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL

WILLIAM E. SMOYER, M.D. Vice President, Clinical Translational Research, Director, Center for Clinical and Translational Research, The Research Institute at Nationwide Children’s Hospital, The Ohio State University, Columbus, OH

ADRIAN SPITZER, M.D. Clinical Professor of Pediatrics, Albert Einstein College of Medicine, Bronx, NY

F. BRUDER STAPLETON, M.D. Professor and Chair, Ford/Morgan Endowed Chair of Pediatrics, Associate Dean, University of Washington School of Medicine, Chief Academic Officer/Senior Vice President, Seattle Children’s

BRADLEY A. WARADY, M.D. Professor of Pediatrics, University of Missouri-Kansas City School of Medicine, Associate Chairman of Pediatrics, Academic Affairs, Chief Section of Pediatric Nephrology, Director of Dialysis and Transplantation, The Mercy Children’s Hospital, Kansas City, MO