10/11/2005 1 overview nsf engineering research center for structured organic composites
TRANSCRIPT
Center for Structured Organic Composites (C-SOC) Rutgers – NJIT – Purdue – UPRM
10/11/2005
22
University-Industry-Government University-Industry-Government PartnershipPartnership
Center for Structured Organic Composites (C-SOC) Rutgers – NJIT – Purdue – UPRM
10/11/2005
33
A Structured Organic Composite A Structured Organic Composite
Center for Structured Organic Composites (C-SOC) Rutgers – NJIT – Purdue – UPRM
10/11/2005
44
C-SOC Vision of Desired StateC-SOC Vision of Desired State
Given active organic substances & administration/delivery requirements,
• Development of structured organic composite product
• Design of associated process• Manufacturing execution will occur via
Model-predictive integrated framework based on fundamental understanding
supported by a minimum of key experiments
Center for Structured Organic Composites (C-SOC) Rutgers – NJIT – Purdue – UPRM
10/11/2005
55
C-SOC MissionC-SOC Mission
1: Develop a scientific foundation for the optimal design of structured organic composites.
2: Develop science and engineering methods for designing, scaling, optimizing and controlling relevant manufacturing processes.
3: Establish effective educational and technology transfer vehicles.
4: Establish effective mechanisms for the inclusion and participation of minorities and women at all levels.
Center for Structured Organic Composites (C-SOC) Rutgers – NJIT – Purdue – UPRM
10/11/2005
66
Development Programs:Test Beds
THRUST 1: Fundamental Knowledge on Materials, Synthesis & Functionalization
Project P1, P2, P3
Develo
pm
en
t P
rog
ram
I:
En
gin
eere
d P
art
icu
late
s
TB2TB2
TB1TB1
Environment /Marketplace
REQUIREMENTS
OUTCOMES
Develo
pm
en
t P
rog
ram
II:
Mic
rocom
posit
es
TB4TB4
TB3TB3
Develo
pm
en
t P
rog
ram
III
:
Macro
com
posit
es
TB6TB6
TB5TB5
PRODUCTS
ManufacturingControl, SynthesisStructuring & Monitoring
PRODUCT IDEAS
Ideas forNew Materials& Applications
THRUST 2: Fundamental Knowledge on Composites, Synthesis & Characterization
P4, P5, P6
Materials Properties &
Synthesis
Required Structure
Required Functionality
THRUST 3: Technology Integration Manufacturing Science P7, P8, P9
Structuring Methods
Thrust Areas:Projects
CSOC Integrated Research PlanCSOC Integrated Research Plan
Center for Structured Organic Composites (C-SOC) Rutgers – NJIT – Purdue – UPRM
10/11/2005
77
Initial Project Line-up
P1
• Thrust 1: Material Synthesis and FunctionalizationFunctionalized Nanoparticles for Tissue Targeting
Functionalized Particles by Nanocoating
Mechanical Strength of Small Organic Crystals• Thrust 2: Composites Synthesis and Characterization
DEM for Realistic Particle Processing Computations
Deagglomeration of Nano- and Micro-agglomerates
Multiscale Computational Tools for Dissolution and Disintegration• Thrust 3: Manufacturing Science
Synthesis and Design of Integrated Composite Manuf. Processes
Real-time Monitoring of Pharmaceutical Manufacturing Processes
MPC Control Strategies for Blending Operations
P2
P3
P4
P5
P6
P7
P8
P9
• Projects focus on basic and enabling research addressing technical gaps and focusing on overcoming technical barriers
Center for Structured Organic Composites (C-SOC) Rutgers – NJIT – Purdue – UPRM
10/11/2005
88
P4: Discrete Element Models for Realistic P4: Discrete Element Models for Realistic Particle Processing ComputationsParticle Processing Computations
• Motivation– Need for correlating system
behavior to process conditions and powder properties
– Need to scale from the particle level to the unit operation level
– Mechanistic understanding for coarse grain models necessary for active control
• Approach– Large scale 3D simulations of
realistic scenarios– Accurate inter-particle
interactionsCarl Wassgren Purdue (Project Leader)
Steve Beaudoin Purdue (Inter-particle force models) Maureen Howley NJIT (DEM-continuum modeling)
Silvina Tomassone Rutgers (DEM-continuum modeling)
Center for Structured Organic Composites (C-SOC) Rutgers – NJIT – Purdue – UPRM
10/11/2005
99
P6: Multiscale Computational Tools for P6: Multiscale Computational Tools for Dissolution and DisintegrationDissolution and Disintegration
• Motivation: – Dissolution and disintegration
profiles are key characteristics of any delivery system.
– Relation between ingredient properties/processing with dissolution profiles is unpredictable.
– Need for methodologies to
accurately predict active release.
• Approach: – Combine, expand and develop
existing multiscale models and simulations techniques (MD, discrete-continuum, FEM).
Mike Harris Purdue (Project Leader)Piero Armenante NJIT (dissolution)
Alberto Cuitiño Rutgers (multiscale modeling) Fernando Muzzio Rutgers (mixing, dissolution)
Center for Structured Organic Composites (C-SOC) Rutgers – NJIT – Purdue – UPRM
10/11/2005
1010
ERC Matrix Organization of ResearchERC Matrix Organization of Research
Thrust I: Materials Synthesis and Functionalization
Thrust II: Composites Synthesis and Characterization
Thrust III: Manufacturing Science
Granular Micro-
composites
Macro-composites
Engineered particulate ingredients
TB 1: Microjet synthesis of
micro-& nano-particles
TB 4: Wetsynthesis of hierarchical
microcomposites
TB 5: Continuous manufacturing
of dry macrocomposites
TB 3:Multicomp particles using in-line liquid-
liquid dispersion
TB 2: Micro-particle synthesis
via impinging jet precipitation
TB 6: Mini-manufacturing :
Controlled Formation of Composites
Thrusts, Development programs and Test beds
Center for Structured Organic Composites (C-SOC) Rutgers – NJIT – Purdue – UPRM
10/11/2005
1111
TB 1: Continuous Particle Synthesis & TB 1: Continuous Particle Synthesis & Coating via Ink-Jet TechnologyCoating via Ink-Jet Technology
Goal: Demonstrate use of micro-jet methods to formuniformly sized particles from solutions/suspensions
Team Leader: Basaran (ChE, Purdue)Members: Glasser (ChE, Rutgers), Khusid (ME, NJIT)
Mitra (Chem, NJIT), Rinaldi (ChE,UPR)
Center for Structured Organic Composites (C-SOC) Rutgers – NJIT – Purdue – UPRM
10/11/2005
1212
TB 6: Mini-Manufacturing System: TB 6: Mini-Manufacturing System: Controlled Formation of CompositesControlled Formation of Composites
Goal: Design & demonstrate compact, dose-on-demand pharmaceutical mini-factory
Team Leader: Reklaitis (ChE, Purdue)Members: Basaran (ChE, Purdue)Khusid (ME, NJIT)Li (Chem, Rutgers)Pinal (IPPH, Purdue) Takhistov (FSci,Rutgers)
Center for Structured Organic Composites (C-SOC) Rutgers – NJIT – Purdue – UPRM
10/11/2005
1313
UG GRADK-12
Rutgers Science Explorer
REU
POST GRAD
Cont Educ. Mod.(Industry)
OU
TR
EA
CH
(EX
PER
IEN
TIA
L)
FO
RM
AL
ED
UC
ATIO
N
Summer Intern. Program
REU
Summer School
EPICS Lab Facilities
M.S.
Ph. D.
HS Modules
HS Teacher Training/CEUs
Certificates
LSAMP / AGEP
LSAMP / AGEP
Minors
Education, Outreach, and Diversity Education, Outreach, and Diversity RoadmapRoadmap
Center for Structured Organic Composites (C-SOC) Rutgers – NJIT – Purdue – UPRM
10/11/2005
1414
Multi-Institutional Leadership TeamMulti-Institutional Leadership Team
• Director: Fernando Muzzio, ChE Rutgers
• Deputy Director: Rex Reklaitis, ChE Purdue (Purdue site leader)
• Material Synthesis & Functionalization Thrust Leader: Raj Dave, ME NJIT (NJIT site leader)
• Composite Synthesis & Characterization Thrust Leader: Alberto Cuitino (Rutgers site leader), ME Rutgers
• Manufacturing Science Thrust Leader: Venkat Venkatasubramanian, ChE Purdue.
• UPR site Leader: Carlos Velazquez, ChE UPRM
• Education Director: Henrik Pedersen ChE Rutgers
• Outreach and Diversity Director: Holly Crawford, Engineering, Rutgers
• Development Program I Coordinator: Piero Armenante, ChE, NJIT
• Development Program II Coordinator: Ken Morris, Pharm, Purdue
• Development Program III Coordinator: Bo Michniak, Pharm, Rutgers
Center for Structured Organic Composites (C-SOC) Rutgers – NJIT – Purdue – UPRM
10/11/2005
1515
Purdue TeamPurdue Team
• Ag & Bio Engr– Narsimhan– Okos*
• Chemical Engr– Agrawal– Basaran*– Beaudoin*– Harris*– Pekny– Ramkrishna*– Reklaitis*– Thomson– Venkatasubramanian*– Won
• Food Science– Nivens
• Industrial Pharmacy– Byrn– Carvajal*– Morris*– Pinal*– Taylor*
• Mechanical Engr– Kim (joint with ChE)– Sojka– Wassgren*
• Discovery Park– Basu– Blau– Joglekar
*Core faculty
Center for Structured Organic Composites (C-SOC) Rutgers – NJIT – Purdue – UPRM
10/11/2005
1616
ERC-SOCERC-SOCIndustry and Nonprofit PartnersIndustry and Nonprofit Partners
IrvineIrvine
ExelusExelus
Center for Structured Organic Composites (C-SOC) Rutgers – NJIT – Purdue – UPRM
10/11/2005
1717
Industry PartnersIndustry Partners
• Roles– Participate in decisions on research & education
directions– Participate in translating findings into practice– Help develop future work force: students & postdocs– Collaborate in specific bilateral technical projects
• Membership levels– Lead Center members
• Abbott, GSK, Lilly, PepsiCo, Pfizer, P&G– Regular Center memberships (three levels)
• Level 1: Regular members (9 so far)• Level 2: Center-wide technology affiliates (3 so far)• Level 3: Single thrust technology affiliates (2 so far)
• Bilateral Projects with industry on specific issues
Center for Structured Organic Composites (C-SOC) Rutgers – NJIT – Purdue – UPRM
10/11/2005
1818
Annual Budget EstimateAnnual Budget Estimate
• NSF $3 MM• University cost-share $0.6 MM• Industry memberships $1 MM• Industry bilateral projects $2
MMe.g., Lilly commitment – $100K membership– $300K/y projects
• Potential for NSF supplements
Center for Structured Organic Composites (C-SOC) Rutgers – NJIT – Purdue – UPRM
10/11/2005
1919
Center StatusCenter Status
C-SOC has passed multiple stage gates• Letter of Intent : Sept 1, 2004• Preproposal: Nov 8, 2004
– Invitation to submit full proposal March 1, 2005• Proposal: June 16, 2005
– Industrial partners: 28 committed– Selection for Site Visit: Sept 20, 2005
• Site Visit: Dec 6-7, 2005– Universities commit to 14 new faculty lines– Univ Puerto Rico commits to $1 million facility cost-share
• Reverse Site Visit: Jan 11, 2006• ERC Panel Positive Recommendation: Jan 18, 2006• Division Director sign-off: April 13, 2006• Completion of NSF approval process: mid-May, 2006