1.8 1.6 1.4 1.2 1.0 0.8 0.6 0.4 0.2 0

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A 1. 8 1. 6 1. 4 1. 2 1. 0 0. 8 0. 6 0. 4 0. 2 0 I II III (N=26) (N=18) (N=36) NORE1A mRNA level (NORE1A/GAPDH) P < 0.05 P < 0.05 WD MD PD (N=25) (N=46) (N=9) P < 0.05 P < 0.05 1. 8 1. 6 1. 4 1. 2 1. 0 0. 8 0. 6 0. 4 0. 2 0 I II III (N=26) (N=18) (N=36) NORE1B mRNA level (NORE1B/GAPDH) P < 0.05 WD MD PD (N=25) (N=46) (N=9) P < 0.05 P < 0.05 P < 0.05 B Percentage of specimens (%) 80 70 60 50 40 30 20 10 0 NORE1A level Wild type K-R as Mutant K-Ras 30 Normal Low (N=49) (N=31) 19 20 11 80 70 60 50 40 30 20 10 0 NORE1B level Wild type K-R as Mutant K-Ras 34 Normal Low (N=55) (N=25) 21 16 9

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P < 0.05. P < 0.05. P < 0.05. P < 0.05. P < 0.05. P < 0.05. P < 0.05. P < 0.05. 1.8 1.6 1.4 1.2 1.0 0.8 0.6 0.4 0.2 0. 1.8 1.6 1.4 1.2 1.0 0.8 0.6 0.4 0.2 0. NORE1A mRNA level ( NORE1A/GAPDH ). NORE1B mRNA level ( NORE1B/GAPDH ). WD MD PD - PowerPoint PPT Presentation

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Page 1: 1.8 1.6 1.4 1.2 1.0 0.8 0.6 0.4 0.2 0

A

1.8

1.6

1.4

1.2

1.0

0.8

0.6

0.4

0.2

0 I II III

(N=26) (N=18) (N=36)

NO

RE

1A m

RN

A le

vel (

NO

RE

1A/G

AP

DH

)

P < 0.05

P < 0.05

WD MD PD

(N=25) (N=46) (N=9)

P < 0.05

P < 0.05

1.8

1.6

1.4

1.2

1.0

0.8

0.6

0.4

0.2

0 I II III

(N=26) (N=18) (N=36)

NO

RE

1B m

RN

A le

vel (

NO

RE

1B/G

AP

DH

)

P < 0.05

WD MD PD

(N=25) (N=46) (N=9)

P < 0.05

P < 0.05

P < 0.05

B

Per

ce

nta

ge

of

sp

ecim

en

s (

%) 80

70

60

50

40

30

20

10

0

NORE1A level

Wild type K-RasMutant K-Ras

30

Normal Low(N=49) (N=31)

19

20

11

80

70

60

50

40

30

20

10

0

NORE1B level

Wild type K-RasMutant K-Ras

34

Normal Low(N=55) (N=25)

21

16

9