1st year mbbs curriculum (3rd module)

1

1st Year MBBS Curriculum

(3rd Module)

CMH INSTITUTE OF MEDICAL SCIENCES (CIMS)

BAHAWALPUR

2

Sr. No. Topics Page No.

1. Calendar of 1st Year MBBS Class 4

2. Weekly Time Table 5

3. Module Theme 6

4. Teaching Hours 8

5.

Department of Anatomy

a. Faculty

b. Recommended books

c. General Anatomy

d. Embryology

e. Histology

f. Gross Anatomy (upper limb)

g. Histology (Practical)

9

10

11

13

17

18

21

6.

Department of Physiology

a. Faculty


c. Lectures

23

24

25

3

d. Practical 30

7.

Department of Biochemistry

a. Faculty


c. Lectures

d. Practical

33

34

35

39

4

CALENDAR OF 1ST YEAR MBBS CLASS (2018 / 2019)

Events Class

1st Year

Start of Session 06 Feb 2019 (Wed)

1st Module

Duration: 10 Week

From: 06 Feb 2019(Wed)

To: 21 April 2019 (Sun)

End Module Exam: 15 April 2019 (Mon) To 21 April 2019 (Sat)

2nd Module

Duration: 10 Week

From: 22 April 2019 (Mon)

To: 21 July 2019 (Sun)

End Module Exam: 15 July 2019 (Mon) To 20 July 2019 (Sat)

3rd Module

Duration: 08 Week

From: 22 July 2019 (Mon)

To: 29 Sep 2019 (Sun)

End Module Exam: 14 Sep 2019 (Sat) To 20 Sep 2019 (Fri)

Sports Week 25 March 2019 (Mon) To 29 March 2019 (Fri)

There will be ½ day Activity in the morning before sports activities

Summer Vacation & Eid ul Fitr Leave 18 May 2019 (Sat) To 16 June 2019 (Sun) (30 Days)

Eid ul Azha Leave 10 Aug 2019 (Sat) To 18 Aug 2019 (Sun) (09 Days)

Prep Leave Pre-Annual Exam 21 Sep 2019 (Sat) To 27 Sep 2019 (Fri) (07 Days)

Pre-Annual Exam 28 Sep 2019 (Sat) To 05 Oct 2019 (Sat)

Prep Leave Annual Exam 06 Oct 2019 (Sun) To 31 Oct 2019 (Thur) (26 Days)

Annual Exam 01 Nov 2019 (Fri) To 16 Nov 2019 (Sat)

Post Prof Leave 17 Nov 2019 (Sun) To 24 Nov 2019 (Sun) (08 Days)

5

WEEKLY TIME TABLE

1st YEAR MBBS CLASS (THIRD MODULE)

2018 / 2019

Days 0800-0930 0935-1030 1030-

1100 1105-1200 1205-1300

1300-

1315 1315-1500

Mon

Demo &

Dissection

Gross Anatomy

Physiology

Lecture

TE

A B

RE

AK

General Anatomy

Lecture

Biochemistry

Lecture

PR

AY

ER

BR

EA

K

Batch-A

Practical

Anatomy

Batch-B

Practical

Physio

Batch-C

Practical

Biochem

Tue

Demo &

Dissection

Gross Anatomy

Physiology

Lecture

Embryology

Lecture

Biochemistry

Lecture

Batch-A

Practical

Biochem

Batch-B

Practical

Anatomy

Batch-C

Practical

Physio

Wed

Demo &

Dissection

Gross Anatomy

Physiology

Lecture

Histology

Lecture

Biochemistry

Lecture

Batch-A

Practical

Physio

Batch-B

Practical

Biochem

Batch-C

Practical

Anatomy

Thurs

Demo &

Dissection

Gross Anatomy

Physiology

Lecture Clinical Physiology Clinical Anatomy

Batch-1

Tutorial (Physio)

Batch-2

Tutorial (Biochem)

Fri

Demo &

Dissection

Gross Anatomy

Batch-1

Tutorial (Biochem)

Batch-2

Tutorial (Physio)

Physiology

Lecture Islamiat Lecture

1300-1400

FRI PRAYER

1400-1500

Behavioral Sciences

6

MODULE THEME

BLOCKS THEMES

ANATOMY PHYSIOLOGY BIOCHEMISTRY

1. Lower Limb 2. Respiratory System

1. Lower Limb 2. Respiratory System

Learning outcomes

ANATOMY PHYSIOLOGY BIOCHEMISTRY

Gross anatomy

Lower Limb General Anatomy

Skin Fascia

Vertebral column

Nervous system-II Embryology

Birth defects

Body cavities

Respiratory system

Muscular System

Skeletal system except head and neck

Development of limbs Histology

Respiratory system

Physiology of respiration

Deep sea physiology

Aviation/space physiology

High altitude physiology Exercise physiology

7

MODULE THEME

Code Y1M3

Name Anatomy

Duration 10 weeks

Broad Themes of Module (Theme: a subject that is being integrated a majority of time of module)

Lower Limb Respiratory System

Subject Themes

Gross anatomy

Lower Limb General Anatomy

Skin Fascia Vertebral column Nervous system-II Embryology

Birth defects Body cavities Respiratory system Muscular System Skeletal system except head and neck Development of limbs Histology Respiratory system

Prerequisite Module Y1M1 & Y1M2

8

TEACHING HOURS

Total Weeks/Hours: 8 weeks/ 280 Hours (0800-1500)

Anatomy :

o Demos : 40 5/Week 60 hours

o practical: 08 1/Week 36 hours

o Histo Lectures: 08 1/Week 8 Hours

o Embryo Lectures : 08 1/Week 8 Hours

o GA Lectures : 08 1/Week 8 Hours

Total 120 hours

Physiology :

o Lectures : 40 5/Week 40 Hours

o Practical: 08 1/Week 36 Hours

Total 76 hours

Biochemistry :

o Lectures : 24 3/Week 24 hours

o practical: 08 1/Week 36 hours

Total 60 hours

CBLs :

o CBLs : 8 1/Week 12 hours

Med Education: 4 hours

Medicine: 4 hours

Surgery: 4 hours

Radiology: 2 hours

9

DEPARTMENT OF ANATOMY

S.No Faculty Course

1. Professor: Dr. Fareed Alvi Histology

2. Associate Professor: Dr. Alina Saqib Embryology

3. Assistant Professor: Dr. Fareha Shan General Anatomy

Lecturers

1. Dr. Asima Kashif Gross Anatomy

2. Dr. Ayesha Nasrullah Gross Anatomy

3. Dr. Rabbia Farooq Gross Anatomy

4. Dr. Abdullah Histology practical

5. Dr.Fareha Asghar Gross Anatomy

10

RECOMMENDED BOOKS (ANATOMY)

Gross Anatomy

o Cunningham’s Manual of Practical Anatomy vol. I- 15th edition, 1986.

o Clinical Anatomy by Regions. Richard S. Snell, 9th edition, 2012.

o Netter Atlas of Human Anatomy. 5th edition 2011.

o Reference Books

Clinically Oriented Anatomy. Keith L Moore, 6th edition, 2010.

Gray’s Anatomy. 40th edition, 2008.

General Anatomy

o General Anatomy. Dr. Laiq Hussain, 3rd edition, 2011.

o Understanding General Anatomy. Professor Tassaduq Hussain, 14th edition, 2014.

Embryology

o Langman’s Medical Embryology. 12th edition, 2012.

Histology

o Medical Histology. Dr. Laiq Hussain, 5th edition, 2015. o Reference Books

Basic Histology. Junqueira, 13th edition, 2013.

DiFiore’s Atlas of Histology. 12th edition, 2013.

Manual/Practical Copies

o Histology Manual by Prof Athar Maqbool

o Gross Anatomy – Plain Copy (Sketch Book)

11

ANATOMY

Third Module (1 x Lecture / Week) Subject: General Anatomy

Lectures Week General Anatomy Learning Objectives

1. I. Skin

Describe the components of integumentary system.

List the functions of integumentary system

List the two main parts of skin.

List its layers with their general features.

2. II. Facia

Name appendages of skin.

Describe their general features.

Define cleavage lines? Describe their clinical importance.

3. III. Vertebral column Describe the anatomy of vertebral column with reference to:

Number of vertebrae in different regions

4. IV. Defects of vertebral column. Name different types of defects of vertebral column

Describe defects in the curvature of vertebral column

5. V. Nervous system-I

Describe division of nervous system on gross anatomical basis

Name components of central and peripheral nervous system.

Describe their general features

Define autonomic nervous system (ANS). Enlist the differences between

autonomic and somatic nervous system

6. VI. Autonomic nervous system

List the main divisions of ANS? Describe differences of its two main

divisions in tabulated form.

Explain cranial parasympathetic ganglia.

Describe their general features.

12

7. VII. Autonomic nervous system II Define enteric nervous system.

List general features.

13

ANATOMY

Third Module (1 x Lecture / Week) Subject: Embryology

Lectures Week Embryology Learning Objectives

1. I.

Birth defects

Name types of birth abnormalities & define each of them with at least one example

describe principles of teratology

Classify teratogens with associated human malformations in tabulated form

List numerical & structural chromosomal abnormalities

Discuss the following numerical chromosomal abnormalities:

Trisomy 21

Trisomy 18

Trisomy 13

Klinefelter syndrome

Turner syndrome

2. II.

Development of body

cavities

Explain transformation of single intraembryonic coelom into pericardial, pleural and

peritoneal cavities

List development sources of diaphragm

Describe development of diaphragm

Discuss positional changes of diaphragm with reference to age of fetus

Explain the innervation of diaphragm with reference to its developmental sources

Analyze clinical scenarios regarding:

Ventral body wall defects

Diaphragmatic hernias

3. III.

Development of

respiratory system

Describe the development of the following:

Larynx

Trachea

Bronchi

Lungs

14

Describe different stages of lung maturation

List factors responsible for normal lung maturation

List the postnatal changes that occur in lungs

Analyze clinical scenarios regarding:

Various types of tracheoesophageal fistulas

Respiratory distress syndrome

4. IV.

Development of

skeletal system

Describe histogenesis of cartilage

Describe histogenesis of bone

Explain development of joints

Describe development of vertebral column

Define spina bifida. Enlist its different types. Give embryological basis of bifid spine

alongwith methods of prenatal assessment in this anomaly

Explain development of ribs and sternum with congenital defects

Discuss embryological basis and associated birth defects of:

Klippel feil syndrome

Accessory ribs

Fused ribs

Hemivertebra

Rachiscisis

15

5. V.

Development of

muscular system

Describe development of skeletal musculature

Define lateral somitic frontier. List the structures whose borders are defined by lateral

somitic frontier.

Enumerate the muscles derived from primaxial and abaxial domains

recognize the innervation of axial skeletal muscles

List the developmental source of:

Head muscles

Limb muscles

Cardiac muscles

Smooth muscles

Discuss the following clinical anomalies:

Poland sequence

Prune belly syndrome

6. VI.

Development of limbs

Describe the formation of limb buds

Define apical ectodermal ridge and discuss its role in limb development including digits

Describe limb growth and development

Discuss rotation of limbs during development. Describe the relationship between rotation

of limbs & cutaneous nerve supply of limbs

Differentiate between development of upper and lower limbs

7. VII.

Limb defects and

chromosomal

abnormalities

Discuss development of limb musculature

Describe the various types of limb defects.

Explain their embryological basis

Discuss the following structural chromosomal abnormalities:

Cri-du-chat syndrome

Angelman’s syndrome

Prader-willi syndrome

Miler-dieker syndrome

Define mosaicism & discuss its embryological basis

Describe critical periods of prenatal human development

16

Name invasive and noninvasive approaches for assessing growth & development of fetus

in utero

17

ANATOMY

Third Module (1 x Lecture / Week) Subject: Histology

Lectures Week Histology Learning Objectives

1. I. Respiratory system

List the main divisions of respiratory passage along with the structures

constituting each

2. II.

Respiratory and olfactory

epithelium

Define respiratory and olfactory epithelium

List the cells comprising respiratory & olfactory epithelium.

3. III.

Nasopharynx Describe extension, epithelium, mucosa, and muscles of nasopharunx

4. IV. Larynx Describe histological structure of nasopharynx

Explain the layer of larynx

5. V. Trachea, Bronchi

Differentiate various parts of bronchial tree on the basis of lining epithelium,

presence of cilia, glands, cartilage, smooth muscles, and elastic fibers

6. VI. Phrynx Describe the extension and histological features of phrynx

7. VII. Pleura, Lungs

Explain the layers of plura

Describe the Epithelium and stroma of pleura

Differentiate various parts of bronchial tree on the basis of lining epithelium,

presence of cilia, glands, cartilage, smooth muscles, and elastic fibers

18

ANATOMY

Third Module (5 x Demos / Week) Subject: Gross Anatomy (Lower Limb)

Lectures Week Topics

1.

I.

Hip bone

2. Gluteal Region

3. Vasculature of Gluteal Region

4. Femur

5. Anterior fascial Compartment of Thigh

6. Medial fascial Compartment of Thigh

7. The back of the thigh

8.

SUBSTAGE -1

9. Gluteal Region

10. Thigh, Hip Bone, Femur

11.

II.

Hip joint

12. Bones of leg

13. Popliteal fossa

19

14. Fascial compartments of leg

15. Knee joint

16.

Proximal & distal Tibiofibular joints

17. SUBSTAGE – 2

18.

III.

Hip joint, Bones of leg

19. Popliteal fossa

20. Fascial compartments of leg

21.

IV.

Ankle joint

22. Articulated foot

23. Sole of foot

24. The dorsum of foot

25. Cutaneous innervations of lower limb

26.

V.

Blood supply of lower limb

27. SUBSTAGE – 3

28. Ankle joint, Foot, Knee joint

29. Cutaneous innervations of lower limb

20

30. Blood supply of lower limb

31.

VI.

Lymphatic drainage of lower limb

32. Surface marking

33. Final Stage

21

ANATOMY

Third Module (1 x Practical / Week) Subject: Histology Practical

S.No Week Practical Learning Objectives

1. I.

Respiratory system Skill:

Identify and draw the different parts of respiratory system.

Focus the prepared slide at different magnifications.

2. II.

Respiratory and olfactory

epithelium

Skill:

Identify respiratory and olfactory epithelium

Identify the different shapes of cells.

Draw a labeled diagram of different types of cells.

3. III.

Nasopharynx Skill:

Identify the epithelia of nasopharynx.

Draw a labeled diagram of different layers of nasophrynx.

4. IV.

Larynx Skill:

Identify the epithelia

Draw labeled diagram histological features of lyrnx.

Identify mucous and serousa with haematoxylin and eosin.

Draw a labeled diagram of layers of larynx

22

5. V.

Trachea, Bronchi

Skill:

Identify various parts of bronchial tree on the basis of lining epithelium, presence

of cilia, glands, cartilage, smooth muscles, and elastic fibers.

6. VI.

Phrynx Skill:

Identify different types of layers microscopically.

Draw a labeled diagram showing the histological structure of different types of

layers with hematoxylin and eosin.

7. VII. Pleura, Lungs

Skill:

Identify different types of layers microscopically.

Draw a labeled diagram showing the histologic structure of pleura.

Identify various parts of bronchial tree on the basis of lining epithelium, presence

of cilia, glands, cartilage, smooth muscles, and elastic fibers.

23

DEPARTMENT OF PHYSIOLOGY

S.No Faculty Course

1 Professor: Dr. Shafiq Ahmad Iqbal Lectures

2 Associate Professor: Dr. Rukhsana Mirza Lectures

3. Assistant Professor: Dr. Jazib Andleeb Lectures

4 Assistant Professor: Dr. Sara Sadiq Lectures

Lecturers

1 Dr. Khalid Mehmood Arif Practicals & Tutorials

2 Dr. Amber Javaid Practicals & Tutorials

3 Dr. Amna Riaz Practicals & Tutorials

24

RECOMMENDED BOOKS (PHYSIOLOGY)

Kim E. Barrett, Susain M.Barman Ganongls Review of Medical Physiology 24th Edition McGrowhill.

Bruce M.Koeppon, Bruce A.Stanton Berne & Cevy Physiology 6th Edition Raj Kamal Electric Press, Kundli, Haryana

ELSEVIER 2010.

John E. Hall Guyton & Hall Text Book of Medical Physiology 13th Edition Canada ELSEVIER 2016.

Lecture Notes Kaplan

USMLE step -1 Kaplan.

USMLE First Aid.

Fundamental / Introduction of biochemistry by Mackee Mackee.

25

PHYSIOLOGY

Third Module (5 x Lectures / Week, 1 Clinical Lecture / week for Vertical Integration)

Lectures Week Topics Learning Objectives

1.

I.

Introduction to Respiratory System I Describe the functional anatomy of respiratory tract

Describe the functions of various parts of respiratory system

Give the overall view of respiratory system in homeostasis.

2.

Pulmonary Mechanics I

Explain the non-respiratory functions of respiratory tract

Describe the functions of respiratory muscles.

3.

Pulmonary Mechanics I

Describe the role of different respiratory muscles during inspiration and

expiration

Describe the role of Bucket handle movement and Pump handle

movement in controlling the chest diameters.

4.

Pulmonary Mechanics II

Describe the various pressures acting on lungs and chest wall

Explain the change in pleural, alveolar and transpulmonary pressures

during each phase of respiration.

Define Compliance with its normal value for the lung and chest wall

compliance

Draw and label the compliance diagram

the concept of work of breathing

5. Surfactant role on surface tension

Describe the composition and synthesis of surfactant

Describe the role of surfactant in reducing alveolar surface tension

Describe the abnormalities relates to deficiency of surfactant

26

6.

II.

Lung Volumes and Capacities

Define Lung Volumes and Capacities along with its normal value

Explain the spirogram showing lung volumes and capacities

Differentiate between obstructive and restrictive lung disorders

7. Pulmonary Circulation

Describe the physiological anatomy of pulmonary vessels

Describe the pressures in pulmonary vessels

Describe the pressure differences b/w pulmonary & systemic circulation

8. Pulmonary Capillary dynamics

Describe the role of starling forces in maintenance of equilibrium across

the pulmonary capillary and interstitum

Explain the role of pulmonary safety factor to prevent edema

9.

Abnormalities of Pulmonary Capillary

dynamics

Describe the Pulmonary edema and Plural effusion along with its etiology

and pathophysiology.

10. Gas laws and Partial pressure of gases

Describe different gas laws

Explain the changes in partial pressure of gases from atmospheric air to

different phases of breathing

11.

III.

Respiratory Membrane & Diffusion of

Gases

Describe the structure and layers of respiratory membrane

Describe the diffusing capacity through respiratory membrane

Describe the factors affecting gas diffusion through respiratory

membrane

12.

Oxygen transport

List the forms of oxygen transport

Describe the mechanics of oxygen diffusion from blood to tissue fluid

Describe the mechanics of oxygen diffusion from tissue fluid in to cell

13. Oxygen-hemoglobin Dissociative curve

Explain the normal oxygen-hemoglobin dissociation curve

Explain the role of factors that shift oxygen-hemoglobin dissociation

curve

27

14.

Carbon dioxide transport

List the various chemical form in which CO2 is transported in blood

Explain the normal CO2 dissociation curve

Explain the concept of haldane effect

15. Hypoxia and Hypercapnia

Define Hypoxia and Hyper-capnia

Describe the types and causes of hypoxia

Describe the effect of hypoxia and hyper-capnia on body

various causes of hypoxia

To know the effects of hypoxia on the body

To study the role of oxygen therapy in different types of hypoxia

16.

IV.

Pulmonary circulation Va /Q

Describe ventilation perfusion ratio

Explain the concept of shunted blood

Describe the abnormalities of ventilation perfusion ratio in lung diseases

17.

Nervous regulation of respiration

List different group of neurons composing respiratory center

Describe the control of inspiration and respiratory rhythm

Explain the role of pneumotaxic center in respiration

Describe the regulatory mechanism of hering-breuer inflation reflex

18.

Chemical regulation of respiration

Describe the central chemosensitive area & its stimulation by CO2 and

H+

Explain the role of peripheral chemoreceptors for control of respiration

Describe the composite effects of PCO2, pH, & PO2 on alveolar

ventilation

19. Test ----

20.

Regulation of respiration during

exercise Describe oxygen consumption and pulmonary ventilation during exercise

Describe the respiratory changes during exercise

28

List the factors that control respiration during exercise

21.

V.

Abnormal breathing pattern

Describe the different Abnormal breathing pattern

Describe the mechanism of Cheyne-Stokes Breathing

Describe the types and mechanism of sleep apnea.

22. Arterial blood gases and pH

Explain the role of arterial blood gases and pH in diagnosis of different

lung abnormalities

23. Respiratory disease I

Define emphysema

Describe etiology and pathophysiology of emphysema

Describe the physiological effects of chronic emphysema

Define pneumonia and atelectasis

24. Respiratory disease II

Define pneumonia and atelectasis

Describe the etiology and pathophysiology of pneumonia and atelectasis

25. Respiratory disease III

Define tuberculosis and asthma

Describe the etiology and pathophysiology of tuberculosis and asthma

26.

VI.

Acclimatization at High altitude

Describe the mechanism of acclimatization of the body to low O2

List the cause of natural acclimatization in natives of High Altitude

Explain the principles of acclimatization

27.

Hazards at High Altitude

Describe the change in composition of air at high altitude

Describe the effects of low oxygen pressure on the body

Describe the change of alveolar PO2 at different elevations

28. Space physiology

Describe the effects of acceleratory forces on the body in aviation and

space physiology.

Describe physiological Challenges of Weightlessness (Microgravity)

29

29. Deep sea diving I

Describe the effect of high partial pressures of individual gases on the

body

Describe the Symptoms, etiology and pathophysiological mechanism

Decompression Sickness

30. Deep sea diving II

Describe the components, uses and mechanism of self-contained

underwater Breathing apparatus (scuba) diving

Explain the special physiological problems in submarines

31.

VII.

Test (FORMATIVE ASSESSEMENT) SEQ’s

32. Revision of Respiratory system Important topics / Muddy points will be discussed.

33. Revision of Respiratory system Important topics / Muddy points will be discussed.

34. Test (FORMATIVE ASSESSEMENT) SEQ’s


36.

VIII.

Test (FORMATIVE ASSESSEMENT) SEQ’s




40.

Assessment week Theory, OSPE & practical assessment.

30

PHYSIOLOGY

Third Module (1 x Practical / Week) Subject: Physiology Practical

Demonstration Week Practical Learning Objectives

1. I.

Examination of the chest related to respiratory system

Knowledge:

Describe the steps of examination of chest

List symptoms and signs of respiratory diseases

Skill:

Perform inspection, palpation, percussion and auscultation of respiratory system

2. II.

Auscultation of breath

sounds

Knowledge:

List the causes of abnormal breath sounds.

Skill:

Perform the Auscultation of breath sounds.

3. III.

Cardio Pulmonary Resuscitation

Knowledge:

Describe cardio Pulmonary arrest.

Describe the aims, indication and importance of Cardio Pulmonary Resuscitation.

Describe the ABC of Cardio Pulmonary Resuscitation.

Skill:

31

Perform Cardio Pulmonary Resuscitation on the subject.

4. IV.

Spirometry: Lung volumes

and capacities

Knowledge:

Define various respiratory volumes and capacities.

Describe variation in Lung volumes and capacities in case of obstructive and

restrictive diseases.

Skill:

Measure the Lung volumes and capacities by using Spirometer.

5. V.

Spirometry: FEV1 and

FVC

Knowledge:

Define various FEV1 and FVC

Describe variation in FEV1 and FVC in case of obstructive and restrictive

diseases.

Skill:

Measure the FEV1 and FVC by using Spirometer.

6. VI.

PEFR Peak Expiratory

Flow Rate

Knowledge:

Define Peak Expiratory Flow Rate

Describe the methodology of Peak Expiratory Flow Rate

Skill:

Perform Peak Expiratory Flow Rate by using peak flow meter

32

7. VII. Revision of practical’s -----

33

DEPARTMENT OF BIOCHEMISTRY

S.No Faculty Course

1. Professor: Dr. Jariya Kalsoom

Lecturers:

1. Dr. Ahmed Malik Practical’s

2. Dr. Rafia Nadeem Practical’s

3. Dr. Faisal Shahzad Practical’s

34

RECOMMANDED BOOKS (BIOCHEMISTRY)

Ser Author Of Book Title of Book Edition

1. Michael A. Lieberman Biochemistry Molecular Biology & Genetics 6th

2. Michael A. Lieberman Mark’s Essentials of Medical Biochemistry 2nd

3. Michael A. Lieberman Mark’s Basic Medical Biochemistry A Clinical Approach 4th

4. Stuart H. Ralston Davidson’s Principles and Practice of Medicine (Vol: 01) 23rd

5. Stuart H. Ralston Davidson’s Principles and Practice of Medicine (Vol: 02) 23rd

6. Maxine A. Papadakis Current Medical Diagnosis and Treatment (Vol: 01) 57th

7. Maxine A. Papadakis Current Medical Diagnosis and Treatment (Vol: 02) 57th

8. J Koolman K.H. Roehm Color Atlas of Biochemistry 2nd

9. Roger L. Miesfeld Biochemistry 1st

10. Kaplan Biochemistry and Medical Genetics 1st

11. Nalini Chandar Lippincott’s IIIustrated Reviews Cell and Molecular Biology 1st

12. Michael A. Lieberman Lippincott’s IIIustrated Q&A Review of Biochemistry 1st

13. Rebecca James Perumcheril Self Assessment and Review of Biochemistry 2nd

35

BIOCHEMISTRY

Third Module (4 x Lectures / Week) Subject: Biochemistry

Lecture Week Topics Learning Objectives

1.

I.

Classification of vitamins C

Classify vitamins

State RDA for vitamin C

List sources of vitamin C

Mention active form of vitamin C

Describe functions of vitamin C in body

Explain the biochemical basis anemia in vitamin C deficiency

Describe the causes and sign symptoms of scurvy

2.

Vitamin B2 riboflavin

State RDA for vitamin B2

List sources of vitamin B2

Mention active form of vitamin B2

Describe functions of vitamin B2in body Describe the causes and sign symptoms of deficiency of B2

3.

B9 Folic acid




Describe functions of vitamin B9 in body

Describe the causes and sign symptoms of deficiency of B9

Describe folate trap hypothesis Describe role of folate in one carbon metabolism

4.

B12 Cobalamine






Describe the absorption of B12

36

5.

II.

Vitamin B3 Niacin






6.

Vitamin B7 Biotin

Vitamin B6 Pyridoxine











7.

Vitamin B5 pantothenic acid

Vitamin B1 thiamine











8.

Vitamin A State RDA for vitamin A

List sources of vitamin A

Mention active form of vitamin A

Describe functions of vitamin A in body

Describe the causes and sign symptoms of deficiency of A

Describe the causes and sign symptoms of toxicity of vitamin A

37

9.

III.

Vitamin D State RDA for vitamin D

List sources of vitamin D

Mention active form of vitamin D

Describe functions of vitamin D in body

Describe the causes and sign symptoms of deficiency of D

Describe the causes and sign symptoms of toxicity of vitamin D

10.

Vitamin E State RDA for vitamin E

List sources of vitamin E

Mention active form of vitamin E

Describe functions of vitamin E in body

Describe the causes and sign symptoms of deficiency of E

Describe the causes and sign symptoms of toxicity of vitamin E

11.

Vitamin K State RDA for vitamin K

List sources of vitamin K

Mention active form of vitamin K

Describe functions of vitamin K in body

Describe the causes and sign symptoms of deficiency of K

Describe the causes and sign symptoms of toxicity of vitamin K

12.

Balanced diet & biochemical

importance of carbohydrates,

fats & protein in diet

Define balanced diet

Describe the biochemical importance of carbohydrates in diet

Describe the biochemical importance of proteins in diet

Describe the biochemical importance of lipids in diet

13.

IV.

RDA, BMR, Caloric

requirements

Define RDA and describe its biomedical importance

Define BMR and describe its biomedical importance

Identify caloric requirements for different age groups and physiological states

14.

Estimation of caloric

requirements

Estimation of caloric requirements

15.

Specific nutritional

requirements:

(Pregnancy, lactation,

newborn)

Explain specific nutritional requirements in: Pregnancy, lactation, newborn

Recommend diet plans for pregnant and lactating females and newborns

38

16.

Carbohydrates & glycemic

index

Describe effect of carbohydrate rich diet on glycemic index

Define glycemic index

Describe biomedical importance of glycemic index

17.

V.

Proteins & nitrogen balance Describe the role of proteins in maintaining the nitrogen balance

Define nitrogen balance

18. Revisions ________



39

BIOCHEMISTRY

Third Module (1 x Practical / Week) Subject: Biochemistry

Demonstration Week Practical Learning Objectives

1.

I.

Physical & chemical properties of

urine

Knowledge:

Describe the physical and chemical properties of urine

Skill:

Interpretation of the physical and chemical properties of urine

2.

II.

Test for urine abnormalities

(benedict’s test, sulphosalicyclic

acid test & heat coagulation test)

Knowledge:

Describe the abnormalities of urine

Skill:

Detection of abnormalities in urine

3.

III.

Test for urine abnormal constituents

in urine (benedict’s test,

sulphosalicyclic acid test & heat

coagulation test)

Knowledge:

Describe the abnormal constituents in urine

Skill:

Detection of abnormal constituents in urine

4.

IV.

Tests for bio salts in urine

Knowledge:

Describe the significance of bio salts in urine

Skill:

Detection of bio salts in urine

40

5.

V.

Test for detection of bile pigments

in urine

Knowledge:

Describe the significance of bile pigments in urine

Skill:

Detection of bile pigments in urine

6.

VI.

Test for detection of ketone bodies

in urine

Knowledge:

Describe the significance of ketone bodies in urine

Skill:

Detection of ketone bodies in urine

7.

VII.

Test for detection of bilirubin in

urine

Knowledge:

Describe the significance of bilirubin in urine

Skill:

Detection of bilirubin in urine

8.

VIII.

Analyzing the urine report

Knowledge:

Describe the significance of urine report

Skill:

Interpretation of urine report

1st year mbbs curriculum (3rd module)

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