2-3. recent advances in ftir - dhi seminar tlri 15 oct 2015 · agenda `infrared analysis of milk `...
TRANSCRIPT
Ded
icat
ed A
naly
tica
l Sol
utio
ns
RECE
NT
ADVA
NCE
S IN
FTI
R DH
I Sem
inar
TLR
I, Ta
iwan
15
Oct
ober
201
5 St
een
Kold
-Chr
isten
sen,
Inte
rnat
iona
l Mar
ket M
anag
er, F
OSS
, Den
mar
k
Ded
icat
ed A
naly
tica
l Sol
utio
ns
2 2
AGEN
DA
Infra
red
anal
ysis
of m
ilk
Mid
infra
red
spec
tros
copy
M
easu
rem
ent o
f min
or c
ompo
nent
s
Targ
eted
and
non
-targ
eted
ana
lyse
s
A v
ision
of f
utur
e ap
plic
atio
ns
Ded
icat
ed A
naly
tica
l Sol
utio
ns
3
MID
IR S
PECT
RA O
F LI
QU
ID M
ILK
0.0
0.1
0.2
0.3
0.4 1
00
01
10
01
20
01
30
01
40
01
50
01
60
0
wav
enu
mb
er
absorbance
Ded
icat
ed A
naly
tica
l Sol
utio
ns
4
MIL
K AD
ULT
ERAT
ION
0.0
0.1
0.2
0.3
0.4 1
000
1100
1200
1300
1400
1500
1600
wave
num
ber
absorbance
am
moniu
m s
ulp
hate
ure
am
ela
min
e
Ded
icat
ed A
naly
tica
l Sol
utio
ns
5 5
WH
AT C
AN F
T-IR
OFF
ER U
S TO
DAY?
MIR
spec
tros
copy
has
sinc
e 19
70’s
offe
red
rapi
d an
alys
is of
mai
n co
nstit
uent
s fa
t, pr
otei
n, la
ctos
e, so
lids &
solid
s-no
n-fa
t
FT-IR
spec
tros
copy
is th
e st
ate-
of-t
he-a
rt m
etho
d fo
r ac
quiri
ng M
IR sp
ectr
a an
alyz
ing:
Co
nven
tiona
l par
amet
ers
fat,
prot
ein
(tru
e &
cru
de),
case
in, l
acto
se, s
olid
s, u
rea,
citr
ic
acid
, fre
e fa
tty
acid
s, P
H, F
PD
New
par
amet
ers
Fatt
y Ac
ids P
rofil
ing
Keto
sis sc
reen
ing
(BHB
and
Ace
tone
) Ad
ulte
rant
s Sc
reen
ing
Ded
icat
ed A
naly
tica
l Sol
utio
ns
6
THE
USE
OF
TARG
ETED
& U
NTA
RGET
ED
CALI
BRAT
ION
MO
DEL
S
Mel
amin
e cr
isis (
2008
) with
cont
amin
ated
milk
pow
der
Liqu
id m
ilk d
elib
erat
ely
adul
tera
ted
for e
cono
mic
gai
n Co
llabo
rativ
e pr
ojec
t bet
wee
n Fo
nter
ra, A
rla a
nd F
OSS
Re
sulte
d in
dev
elop
men
t of t
arge
ted
and
unta
rget
ed m
odel
s for
det
ectin
g m
ilk
adul
tera
tion
at e
cono
mic
leve
ls
In 2
014
we
have
rele
ased
FTI
R m
odel
s usin
g ab
norm
al sp
ectr
um m
odul
e (A
SM) a
s wel
l as
targ
eted
mod
els f
or sp
ecifi
c ad
ulte
rant
s
Ded
icat
ed A
naly
tica
l Sol
utio
ns
7
FOSS
CO
MM
ITM
ENT
IN T
ESTI
NG
AG
AIN
ST M
ILK
ADU
LTER
ATIO
N
FOSS
star
ted
in th
e ni
netie
s with
Infra
red
anal
ysis
agai
nst s
impl
e an
d k
now
n ad
ulte
rant
s. S
uch
as te
sts
for s
cree
ning
for a
dded
wat
er.
As th
e ad
ulte
ratio
n sc
hem
es b
ecam
e m
ore
com
plex
FO
SS d
evel
oped
new
tool
s for
mak
ing
scre
enin
g m
odel
s aga
inst
unk
now
n ad
ulte
rant
s.
Toda
y w
e of
fer ”
out o
f the
box
” sc
reen
ing
mod
el
agai
nst a
bnor
mal
ities
in th
e m
ilk a
s wel
l as o
fferin
g m
any
targ
eted
cal
ibra
tions
aga
inst
spec
ific
adul
tera
nts.
With
in 3
0 se
c th
e da
iry p
lant
can
scre
en th
e m
ilk fo
r an
y un
know
n ad
ulte
rant
s or a
naly
ze fo
r wel
l-kno
wn
adul
tera
nts s
uch
as M
elam
ine
or C
IP a
gent
by
mea
ns
of in
frare
d an
alyz
ers
Ded
icat
ed A
naly
tica
l Sol
utio
ns
8
Milk
qua
lity
is te
sted
bef
ore
unlo
adin
g.
But m
ilk a
dulte
ratio
n is
rare
ly te
sted
at
the
plat
form
.
Milk
Adu
ltera
tion
is a
grow
ing
prob
lem
.
Adut
erat
ion
can
be d
elib
erat
e or
cau
sed
by a
ccid
ent.
MIL
K AD
ULT
ERAT
ION
Ded
icat
ed A
naly
tica
l Sol
utio
ns
9
SCRE
ENIN
G F
OR
MIL
K AD
ULT
ERAT
ION
Uni
nten
tiona
l dev
iatio
ns
Caus
ed b
y ac
cide
nts o
r fai
lure
s.
Agen
t in
the
cow
s fee
d th
at is
tran
spor
ted
on to
the
milk
Cl
eani
ng a
gent
W
ater
In
tent
iona
l dev
iatio
ns
Driv
en b
y ec
onom
ic g
ains
:
amou
nt (w
eigh
t and
/or v
olum
e)
milk
fat c
onte
nt
milk
pro
tein
con
tent
dr
y m
atte
r con
tent
th
e to
tal b
acte
rial c
ount
s and
som
atic
cel
l cou
nts
Ded
icat
ed A
naly
tica
l Sol
utio
ns
10
NO
RMAL
VS
ABN
ORM
AL S
PECT
RUM
FTIR
spec
tra
from
nat
ural
raw
milk
sam
ples
is a
uni
que
finge
r prin
t of n
orm
al m
ilk
Raw
milk
sam
ple
Ded
icat
ed A
naly
tica
l Sol
utio
ns
11
11
UN
TARG
ETED
SCR
EEN
ING
MO
DEL
You
can
scre
en a
ll m
ilk sa
mpl
es a
gain
st a
bnor
mal
ities
. It
will
not
tell
you
wha
t is i
n th
e m
ilk o
nly
if it
is no
rmal
milk
or n
ot.
Adva
ntag
es u
ntar
gete
d m
odel
allo
ws y
ou sc
reen
ing
for a
n un
limite
d nu
mbe
r of u
nkno
wn
pote
ntia
l ad
ulte
rant
s with
in 1
0 - 3
0 se
c.
Ded
icat
ed A
naly
tica
l Sol
utio
ns
12
READ
Y TO
USE
MO
DEL
FO
R TH
E M
ILKO
SCAN
FT1
Read
y to
use
mod
el to
scre
en
agai
nst a
bnor
mal
milk
in ra
w c
ow
milk
.
Befo
re st
artin
g th
e sc
reen
ing
of
your
milk
you
nee
d to
con
sider
; N
umbe
r of f
alse
pos
itive
and
ne
gativ
e re
sults
How
to m
ake
conf
irmat
ory
test
s
Wha
t to
do w
ith th
e m
ilk in
the
truc
k
Ded
icat
ed A
naly
tica
l Sol
utio
ns
13
The
outp
ut fr
om th
e m
odel
is a
n AS
M S
core
.
If AS
M sc
ore>
thre
shol
d, th
e ne
w
sam
ple
is cl
assif
ied
as a
bnor
mal
NU
MBE
R O
F FA
LSE
POSI
TIVE
AN
D
NEG
ATIV
E RE
SULT
S
2 4 6 8
True
Pos
itive
(adu
ltera
ted)
False
Pos
itive
(not
adu
ltera
ted)
True
Neg
ativ
e (n
ot a
dulte
rate
d)
False
Neg
ativ
e (a
dulte
rate
d)
Thre
shol
d =
3
ASM score D
edic
ated
Ana
lyti
cal S
olut
ions
14
The
grap
h sh
ows t
he e
ffect
of
chan
ging
the
thre
shol
d in
the
mod
el.
A th
resh
old
on 3
cor
resp
onds
to
a fa
lse p
ositi
ve ra
te o
f 1.5
%
whe
reas
a th
resh
old
on 5
co
rres
pond
s to
a fa
lse p
ositi
ve
rate
of 0
.4%
.
NU
MBE
R O
F FA
LSE
POSI
TIVE
AN
D N
EGAT
IVE
RESU
LTS
24
68
1001234
Thre
shol
d
Percentage of false positives
Ded
icat
ed A
naly
tica
l Sol
utio
ns
15
WH
AT C
AN B
E SC
REEN
ED A
GAI
NST
W
ITH
TH
E U
NTA
RGET
ED M
OD
EL ?
The
tabl
e sh
ows t
he L
imit
of D
ecte
ctio
n fo
r the
adu
ltera
nts w
hich
cou
ld b
e de
tect
ed a
s abn
orm
al b
y th
e m
odel
.
The
LoD´
s cor
resp
ond
to a
thre
shol
d of
3.
Adul
tera
nt
LoD
L
oD A
dulte
rant
Lo
D L
oD A
dulte
rant
Lo
D
Alla
ntoi
n
300
ppm
C
yanu
ric a
cid
17
0 pp
m
Sod
ium
bic
arbo
nate
40
0 pp
m
Am
idou
rea
5
00 p
pm
Cyr
omaz
ine
30
0 pp
m
Sod
ium
hyd
roxi
de
0.06
%
Am
inot
riazin
e 8
00 p
pm
Dic
yand
iam
ide
30
0 pp
m
Sod
ium
nitr
ite
200
ppm
Am
mon
ium
nitr
ate
20
0 pp
m
For
mal
dehy
de
400
ppm
T
hiou
rea
50
0 pp
m
Am
mon
ium
sulp
hate
30
0 pp
m
Hyd
roxy
prol
ine
90
0 pp
m
Triu
ret
800
ppm
Biu
ret
600
ppm
M
alto
dext
rine
11
00 p
pm
3-a
min
otria
zole
11
00 p
pm
CIP
age
nt
1%
Mel
amin
e 3
00 p
pm
4-
amin
otria
zole
14
00 p
pm
Ded
icat
ed A
naly
tica
l Sol
utio
ns
16
Scre
en fo
r al
l unk
now
n ad
ulte
rant
s
Scre
en fo
r sp
ecifi
c ad
ulte
rant
s
SECU
RITY
SCR
EEN
ING
IN 3
0 SE
CON
DS
Rapi
d in
expe
nsiv
e sc
reen
ing
of y
our m
ilk
Conf
irmat
ory
test
Actio
n pl
an
Secu
re d
airy
pr
oduc
ts
Unt
arge
ted
mod
el
Targ
eted
m
odel
s
Ded
icat
ed A
naly
tica
l Sol
utio
ns
17
FOSS
GO
OD
PRO
DU
CT
- A S
TRO
NG
VIS
ION
Tool
s to
secu
re a
n ef
fect
ive
and
safe
supp
ly c
hain
Scre
en th
e fe
ed fo
r abn
orm
aliti
es
Scre
en th
e m
ilk &
dai
ry p
rodu
ct
for a
bnor
mal
ities