DTL Partner Advisory Committee meeting

Utrecht, 13 November 2015

Professor in Personalized Healthcare Head Radboud Center for Proteomics, Glycomics and Metabolomics Coordinator Radboud Technology Centers Senior Scientist Integrator - Biomarkers

Prof Alain van Gool

alain.vangool@radboudumc.nl

• Nijmegen, The Netherlands

• Mission: “To have a significant impact on healthcare”

• Strategic focus on Personalized Healthcare through “the patient as partner”

• Core activities:

• Patient care

• Research

• Education

• 11.000 colleagues

• 52 departments

• 3.300 students

• 1.000 beds

Radboud university medical center

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Radboud campus: - Radboudumc - Radboud University - Hogeschool Arnhem Nijmegen - Max Planck Institute - Multiple companies

Orientation across the spectrum from molecule to man to population

Ori

enta

tio

n a

cro

ss

the

spec

tru

m o

f d

isea

ses

PI

Research Theme

Te

chn

olo

gy

C

ente

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Research support by Technology

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Radboudumc Technology Infrastructure

Get organised:

1. What technological expertise do we have and should we have ?

2. How should we organise this ?

3. How will we communicate this ?

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External role

Internal role

• Knowledge hub for technological expertise • Maximise use of available technical capabilities and knowledge (‘duurzaamheid’) • Advise scientists with technological expertise • Advise management on strategic investments and opportunities • Drive innovations by working with each other, research theme’s and Valorisation

• Easy access to Radboudumc’s technological expertise • Represent Radboudumc as one in external technology networks • Increase funding (grants, contract research)

Internal / external role

Radboudumc Technology Centers

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Technology Platforms UMC St Radboud

(Potential) Technology Platforms

Genomics

RPC

CMBI PRIME

MIC

CDL

CRCN

Radboud Biobank Malaria lab

Flow cytometry

TR&CT

TNU

MITeC

PDRC

December 2013

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Inventory phase

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Radboudumc Technology Centers

Genomics

Bioinformatics Animal studies

Flow cytometry

Translational neuroscience

Image-guided treatment

Imaging

Microscopy

Biobank

Data stewardship

Proteomics Glycomics

Metabolomics

Radboudumc Technology

Centers

GMP products

Clinical trials

January 2014

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Repositioning phase

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Radboudumc Technology Centers Improving phase

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Feb-Oct 2014

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Radboudumc Technology Centers Improving phase

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Feb-Oct 2014

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www.radboudumc.nl/research/technologycenters

Genomics

Bioinformatics

Animal studies

Stem cells

Translational neuroscience

Image-guided treatment

Imaging

Microscopy

Biobank

Health economics

Mass Spectrometry

Radboudumc Technology

Centers Investigational

products

Clinical studies

EHR-based research

Statistics

Human performance

Data stewardship

Molecule

Flow cytometry

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Implementation phase

Nov 2014 -

About 250 dedicated people working in 18 Technology Centers, ~1600 users (internal, external), ~140 consortia www.radboudumc.nl/research/technologycenters/

• Proteins • Metabolites • Drugs • PK-PD

• Preclinical • Clinical

• Behavioural • Preclinical

• Animal facility • Systematic review

• Cell analysis • Sorting

• Pediatric • Adult • Phase 1, 2, 3, 4

• Vaccines • Pharmaceutics • Cyclotron • Radio-isotopes • Malaria parasites

• Management • Analysis • Sharing • Cloud computing

• DNA • RNA

• Internal • External

• Early HTA • Evidence-based

surgery • Field lab

• Statistics • Biological • Structural

• Preclinical • Clinical • Economic

viability • Decision

analysis

• Experimental design • Biostatistical advice

• Electronic Health Records • Big Data • Best practice

• In vivo • Functional

diagnostics

• iPSC • Organoids

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Visibility

• Logo

• Key figures • Website • Leaflets

• Lectures

Combination of • Science • Business • Innovation • Impact in health www.radboudumc.nl/research/technologycenters/

(1H2015: 1.900 unique visitors, 26.000 page views)

Users Radboudumc Technology Centers

Internal researchers (often with external collaborators)

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External researchers (direct collaborations, public-private)

External fee for service (public-private)

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Working together on the Radboud campus

(Spin-out) companies

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Radboud Research Facilities • Shared facilities across Radboud campus, also made part of Gelderland facilities • Initiated by funding 6.2M Eur Gelderland + 6.2M Eur Radboud University/ Radboudumc

www.ru.nl/radboudresearchfacilities/ 15

Working with other networks Region, nation, Europe, world

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Next steps

• Collaboration • Organisation of individual RTC’s • Interactions/collaborations/cross-selling between RTC’s • Research themes – Technology centers

• Networks • Local/regional/national/international

• Support • Cash, kind

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Use lessons learned for DTL?

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• Visualize DTL infrastructure 2.0 • Who, what, where? • Speciality? Quality? Accessibility? • Branding !! (eg. SciLifeLab)

• Define functional networks

• Coalition of the willing: based on mutual interest to collaborate (1+1=3) • E.g. Biobanks – facilities – data stewardship

• Funding should not be main driver

• Focus and get support • Define overarching theme and/or specialised focus areas

• E.g. Personalized Medicine & Health resp. Microscopy • Join forces in getting funding (NL (eg. NWO), EU (eg. ESFRI’s))

• Next steps

• Collaboration. Joined integrated D-T-L strategy. Focus. Action.