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Table of content Biocenter Research News 3Science & Society 10Graduations & News 12Upcoming Events & Seminars 13Recent Publications 15

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BIOCENTER

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Editorial Dear members of the Biocenter! Summer has gone and the third BNL is finally here. I am sure you have long been waiting for it J I hope you had an enjoyable summer break and the chance to start refreshed into the new academic year. I know, this asks for extra efforts and poses a challenge to those who are involved in teaching or support the execution of our curriculum by other means, but also for the many active researchers who teach, as they may need to downgrade on what they like to do most, i.e., science. Don´t give in, you´ll get through this J. Looking at the collection of mypoint news related to the publication of exciting research findings that accumulated since the last BCNL, I have to say, I am impressed by what has been achieved in such a short period of time. I do not only want to congratulate those who managed to publish their latest research, but clearly also those who managed again to attract research funding in the season of drought to sustain their work or organized other academic events and meetings. As a short preview of what will happen next in terms of social events, I would like to draw your attention to the upcoming “open” Christmas Party, scheduled for December 18th this year. I hope you will join in again and contribute, as in the past. We will organize drinks and music, to make it another memorable social event at the Biocenter. I hope to see you all there. On behalf of all involved, Andreas

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Biocenter Research News

Division of Bioinformatics

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Mit Hilfe der Hochschulraum-Strukturmittel wurde es möglich die „Austrian Platform for Preciscion Oncology“ unter der Leitung von ZLATKO TRAJANOSKI, Direktor der Sektion für Bioinformatik am Innsbrucker Biozentrum zu fördern. Präzisionsonkologie ist eine personalisierte Form der Krankheitsbetrachtung, bei der individuelle Mutationsmuster eines/r Patienten/in ausgewertet werden, um die verfügbaren Medikamente und Therapien optimal für die Behandlung zu nutzen. Die Entwicklung einer Infrastruktur für die Präzisionsonkologie stellt jedoch eine große Herausforderung dar, da Expertisen in unterschiedlichen Fachgebieten wie der Labordiagnostik, Onkologie, Zelluläre und Molekulare Biologie sowie Bioinformatik benötigt werden. Die Medizinischen Universitäten in Innsbruck, Graz und Wien haben deshalb komplementäre Expertisen gebündelt und entwickeln eine Plattform für Präzisionsonkologie. The Austrian Government will support the Austrian Platform for Preciscion Oncology, headed by ZLATKO TRAJANOSKI, head of the Bioinformatics at the Biocenter. Within this program, the private mutation spectrum of cancer patients shall be defined to optimize treatment. This idea requires adequate infrastructure, perfect logistics and the collaboration with other medical universities in Austria in Graz and Vienna who will provide their complementary expertise. Read more: https://www.i-med.ac.at/mypoint/news/711150.html

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picture by MUI Mit den Entscheidungen der beiden letzten Vergabesitzung des FWF-Kuratoriums im Mai und im Juni fördert der Österreichische Wissenschaftsfonds FWF ein neues internationales Forschungsprojekt mit Beteiligung von ZLATKO TRAJANOSKI, Direktor der Sektion für Bioinformatik am Biozentrum Innsbruck. Personalisierte Krebsprognose im Visier: Das vorrangige Ziel dieses Projekts ist es, durch einen systemmedizinischen Ansatz personalisierte Krebsprognosen zu erstellen. Vor dem Hintergrund des begrenzten Verständnisses jener Mechanismen, die auf molekularer Ebene für die Ausprägung des Phänotyps verantwortlich sind und der Schwierigkeit, genetische Fehlbildungen zu Krankheits-Phänotypen und ihren räumlichen und zeitlichen Eigenschaften zuzuordnen, sollen mithilfe der Kombination genetischer Daten wie auch der modernen Systembiologie neue Möglichkeiten geschaffen werden, diese vielschichtigen, auf Mutationen basierenden genetischen Effekte zu untersuchen. ZLATKO TRAJANOSKI has received funding from the FWF to participate in an international project aiming to predict cancer treatment responses and prognoses by a systems approach in combination with available genetic data from cancer patients. Read more: https://www.i-med.ac.at/mypoint/news/711479.html Division of Genomics & RNomics

picture by MUI Neue Biomarker-Methode zur Früherkennung der chronischen Nierenerkrankung unter der Leitung von ALEXANDER HÜTTENHOFER und Gert Meyer (Innere Medizin IV). Unter den vielen neuen Erkenntnissen zu chronischen Nierenerkrankungen, die aus dem inzwischen abgeschlossenen Forschungsprojekt SysKID (Systems biology towards novel chronic kidney disease diagnosis and treatment) hervorgingen, findet sich auch eine neue, von ForscherInnen der Sektion für Genomik und RNomik und der Univ.-Klinik für Innere Medizin IV etablierte Biomarker-Methode. Die daraus generierten Antikörper aus

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Nukleinsäuren erleichtern Früherkennung und Prävention. Together with clinician scientists from the Department of Internal Medicine IV, ALEXANDER HÜTTENHOFER and his crew from the Division of Genomics and RNomik, spearheaded the development of new biomarkers and diagnostics for the early recognition of chronic kidney disease. This project was part of a former EU-network program funded by the European Union, SysKID, that is now completed. Read more: https://www.i-med.ac.at/mypoint/news/711694.html Division of Genomics & RNomics and Biological Chemistry

picture by MUI In der Kuratoriumssitzung vom 2. Oktober 2017 genehmigte der Wissenschaftsfonds vier Einzelprojekte an der Medizinischen Universität Innsbruck. Zwei davon kommen aus dem Biozentrum, das Forschungsvorhaben „Is there a code behind the code?“ von MATTHIAS ERLACHER von der Sektion für Genomik und RNomik und das Projekt „AGMO: Einfluss auf die Adipozytendifferenzierung“ von KATRIN WATSCHINGER von der Sektion für Biologische Chemie. Die Projekte werden auf Basis der Förderempfehlung des FWF im Rahmen der Kooperationsvereinbarung „Matching Funds“ vom Land Tirol ko-finanziert. On 2nd October 2017, the Science Fund approved four individual projects at the Medical University of Innsbruck. Two research projects will be implemented at the Biocenter. The project of MATTHIAS ERLACHER, Division for Genomics and RNomics, "Is there a code behind the code?" and KATRIN WATSCHINGER’S project „AGMO: Influence on adipocyte differentiation”. They are co-funded by the province of Tyrol based on the FWF funding recommendation under the "Matching Funds" cooperation agreement. Read more: https://www.i-med.ac.at/mypoint/news/713435.html Division of Biological Chemistry SEBASTIAN FÜHRER hat seine Masterarbeit "Towards NMR structural analysis of a protein complex formed by the Spred1-EVH1 domain and Neurofibromin’s GAP related domain" bei THERESIA DUNZENDORFER angefertigt. Diese wurde von der Gesellschaft Österreichischer Chemiker (GÖCH) unter die 5 besten Chemie-Diplomarbeiten 2017 gereiht und somit mit dem GÖCH-Förderungspreises 2017 ausgezeichnet. Die Verleihung des Preises fand im September in Salzburg statt. SEBASTIAN FÜHRER completed his master thesis "Towards NMR structural analysis of a protein complex formed by the Spred-EVH1 domain and Neurofibromin's GAP related domain" under supervision of THERESIA DUNZENDORFER. His work was ranked among the 5 best chemistry diploma

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theses in 2017 by the GÖCH and received the GÖCH-award 2017. The award ceremony took place in September in Salzburg.

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Division of Clinical Biochemistry

picture by MUI Die MitarbeiterInnen der Core Facility „Protein Micro-Analysis“ (Projektleiter: HERBERT LINDNER) arbeiten im Hintergrund vieler erfolgreicher Forschungsprojekte an der Medizinischen Universität Innsbruck. Zuletzt wurde das breite Spektrum an analytischen Methoden der zentralen Serviceeinrichtung dazu genutzt, Proben von BrustkrebspatientInnen auf Aluminium zu untersuchen – eine besondere Herausforderung. Ermöglicht wurde die Studie zu aluminiumhaltigen Deodorants durch die interdisziplinäre Zusammenarbeit am Medizinstandort Innsbruck. Die Sektion für Medizinische Statistik und Information, die Univ.-Klinik für Gynäkologie und Geburtshilfe, die Sektion für Klinische Biochemie und die Univ.-Klinik für Plastische, Rekonstruktive und Ästhetische Chirurgie waren maßgeblich an dieser Studie beteiligt. In the background of many successful research projects at the Medical University Innsbruck you find the members of the Core Facility "Protein Micro-Analysis”, led by HERBERT LINDNER. The wide range of analytical methods used by the central service facility has been recently also used to study samples of

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breast cancer patients with the aim to trace aluminum. The study on aluminum-containing deodorants were just possible by the interdisciplinary collaboration between the Department of Medical Statistics and Information, the Department of Gynecology and Obstetrics, the Department of Clinical Biochemistry and the Department of Plastic, Reconstructive and Aesthetic Surgery. Read more: https://www.i-med.ac.at/mypoint/news/711779.html Division of Molecular Biology

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FABIO GSALLER wurde im Rahmen der 51. Jahrestagung der „Deutschsprachigen Mykologischen Gesellschaft“ (DMykG) in Münster (D) ausgezeichnet. Er erhielt den Nachwuchsförderpreis für klinische Mykologie, dieser Preis ging damit zum zweiten Mal in Folge nach Innsbruck. FABIO GSALLER received the Young Scientist award for Clinical Mycology at the 51st Annual Meeting of the German Mycological Society (DMykG) in Münster (D). Read more: https://www.i-med.ac.at/mypoint/news/711950.html

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Forscher um ALEXANDRA LUSSER von der Sektion für Molekularbiologie am Biozentrum der Medizinischen Universität und Ronald Micura vom Institut für Organische Chemie der Universität Innsbruck haben ein neues Verfahren entwickelt, mit dem Entstehung und Abbau der Boten-RNA in der Zelle sehr einfach und rasch ermittelt werden kann. Researchers led by ALEXANDRA LUSSER from the Department of Molecular Biology at the Biocenter of the Medical University and Ronald Micura from the Institute of Organic Chemistry at the University of

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Innsbruck developed a new method to detect very easy and fast the formation and decay of mRNA in the cell. A nice example for a collaboration “across borders”. Read more: https://www.i-med.ac.at/mypoint/thema/712983.html Division of Biological Chemistry and Cell Biology: In einer vom Fonds für Wissenschaft und Forschung (FWF) geförderten Kooperation gelang den Forschungsgruppen von LUKAS HUBER, KLAUS SCHEFFZEK und weiteren KollegInnen des Biozentrums nun die Aufklärung der dreidimensionalen Struktur des LAMTOR Komplexes und seiner Bedeutung für die Signalübertragung, womit eine Tür zur Entwicklung neuer Therapieansätze geöffnet werden könnte. Die wegweisenden Erkenntnisse aus Innsbruck wurden soeben im renommierten Fachjournal SCIENCE veröffentlicht. Herzlichen Glückwunsch! In a cooperative effort funded by the Austrian Science Fund (FWF), the research groups lead by LUKAS HUBER, KLAUS SCHEFFZEK and other colleagues of the Biocenter now succeeded in elucidating the three-dimensional structure of the LAMTOR complex and its importance for signal transduction, thus opening the door to the development of new therapeutic approaches could be opened. This report was published in SCIENCE, one of the world's most respected science magazines. Respect!

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Crystal Structure of the Human Lysosomal mTORC1 Scaffold Complex and its Impact on Signaling.Mariana E.G. de Araujo, Andreas Naschberger, Barbara G. Fürnrohr, Taras Stasyk, Theresia Dunzendorfer-Matt, Stefan Lechner, Stefan Welti, Leopold Kremser, Giridhar Shivalingaiah, Martin Offterdinger, Herbert H. Lindner, Lukas A. Huber, Klaus Scheffzek. Science 21 Sep 2017. http://dx.doi.org/10.1126/science.aao1583 Read more: https://www.i-med.ac.at/mypoint/news/712624.html

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Division of Cell Biology:

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Neue Erkenntnisse zur Ursache einer Durchfallerkrankung bei Säuglingen und Kleinkindern brachte die Forschungsarbeit unter der Leitung von LUKAS HUBER und Thomas Müller, Pädieatrie I: International vernetzte Teamarbeit und die vorbildliche Zusammenarbeit zwischen Grundlagen- und klinischer Forschung haben die Entschlüsselung eines weiteren Gendefektes für die Mikrovillus Einschlusserkrankung (MVID) ermöglicht. Darüber hinaus konnte die Ursache für chronische Durchfälle bei einer weiteren Seltenen Krankheit (FHL5) geklärt werden.

New findings on the cause of diarrhea in infants and toddlers brought research led by the teams of LUKAS HUBER and Thomas Müller, Pediatrics I: International net- and teamwork and the efficient collaboration between basic and clinical research have shed new insights into the cause of diarrhea in infants and toddlers by deciphering another genetic defect for microvillus inclusion disease (MVID). In addition, the cause of chronic diarrhea in another rare disease, caused by mutations in the FHL5 gene could be clarified. Read more: https://www.i-med.ac.at/mypoint/news/713129.html

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Science & Society • Life Sciences: ÖGMBT annual meeting 2017

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Ende September fand im CCB Innsbruck die neunte Jahrestagung der Österreichischen Gesellschaft für Molekulare Biowissenschaften und Biotechnologie (ÖGMBT) in Kooperation mit dem achten „Life Sciences Meeting Innsbruck“ statt. Die Tagung wurde von einem Team von WissenschafterInnen des Biozentrums der Medizinischen Universität Innsbruck und des Center for Moleculare Biosciences Innsbruck (CMBI) der Leopold Franzens Universität Innsbruck gemeinsam mit der ÖGMBT organisiert. Die Jahrestagung 2018 unter dem Titel „10 years life, science & molecules“ wird vom 17. bis 20. September in Wien stattfinden. Save the date!! In cooperation with the 8th “Life Sciences Meeting Innsbruck” the 9th Annual Meeting of the Austrian Society for Molecular Biosciences and Biotechnology (ÖGMBT) took place end of September. The conference was organized by a team of scientists from the Biocenter, led by David Teis, and the Center for Molecular Biosciences Innsbruck (CMBI) together with ÖGMBT. The 2018 Annual Conference titled "10 years life, science & molecules" will take place in Vienna from the 17th to 20th September 2018. Save the date!! Read more: https://www.i-med.ac.at/mypoint/news/712828.html MICHAELA WILLI von der Sektion für Bioinformatik hat den “Awward of Excellence” für die Beste Dissertation des vergangenen Studienjahres erhalten. MICHAELA WILLI from the Division of Bioinformatics received the „Award of Excellence“ for the best dissertation of the past academic year.

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GABRIELE WERNER-FELMAYER von der Sektion Biologische Chemie ist seit 1. Juli 2017 ein Mitglied der Bioethikkommission im Bundeskanzleramt. Since 1st of July 17 GABRIELE WERNER-FELMAYER from the Division of Biological Chemistry is a member of the bioethicscommission of the chancellor.

picture by © Bundeskanzleramt Österreich Read more: https://www.bundeskanzleramt.gv.at/mitglieder-bioethik • Open door day at eight Universities in Tyrol

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Der Tiroler Hochschultag fand im Oktober am CCB statt und gab SchülerInnen die Möglichkeit, sich über das Studienangebot zu informieren. The Tyrolean University Day, which took place in October, offers pupils the opportunity to get information about the study program. Read more: https://www.i-med.ac.at/mypoint/news/713268.html

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Graduations & News Graduations & Habilitations GERLINDE KARBON and Laura von Raffay who performed her master studies at the Div. of Dev. Immunology defended with success. SELMA TUZLAK defended her PhD Thesis at the Division of Dev. Immunology. Congrats! HUBERT HACKL from the Division of Bioinformatics habilitated. Congratulation! News: KATJA SCHÖLER from the Division of Dev. Immunology received a DOC-scholarship from the ÖAW for the duration of 30 month. Welcome Gaia! LOURDES ROCAMORA REVERTE from the Division of Dev. Immunology gave birth on the 3rd of November to a baby girl.

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Upcoming Events & Seminars CCB LECTURE SERIES (STARTED ON 2ND OF OCOTBER 2017)

CCB Lecture Series 2017/18 02. Oktober 2017 JULIA VON BLUME – Max Plank Institute of Biochemistry, Martinsried, DE

Cargo sorting during protein secretion (FWF Lecture)

16. Oktober 2017 CHRISTIAN UNGERMANN – University of Osnabrück, DE Control of endosome-lysosome maturation and fusion by Rab GTPases

(MUI Lecture) 20. November 2017 AURELIEN ROUX – University of Geneva, CH Coupled dynamics and mechanics of the Escrt-III complex

(MUI Lecture)

11. Dezember 2017 DAVID KOMANDER – University of Cambridge, UK Cracking the ubiquitin code

(ÖGMBT Lecture) 29. Jänner 2018 THOMAS LANGER – University of Cologne, DE

Proteolytic control of mitochondrial dynamics and cell survival (MUI Lecture)

19. Februar 2018 MARKUS LANDTHALER – MDC Berlin, DE Exploring regulatory protein-mRNA interactions

(FWF Lecture) 24. April 2018 JOHANNA JOYCE – L‘Université de Lausanne, Lausanne, CH

T cell exclusion, immune privilege, and the tumor microenvironment (Aperim Lecture)

22. Mai 2018 ANDREA ABLASSER – Ecole Polytechnique Fédérale de Lausanne (EPFL), CH Intracellular DNA sensing pathways during infection and beyond (Krebshilfe Lecture)

11. Juni 2018 SNEZHANA OLIFERENKO – Francis Crick Institute, London. UK A comparative approach to understanding mitotic division (MUI Lecture)

All guests are welcome

Seminars held at 5:00 PM in the CCB Seminar Room M 01.470 Klaus Scheffzek Andreas Villunger Ludger Hengst

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BIOCENTER SEMINARS (STARTED ON 6TH OF OCOTBER 2017)

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Recent Publications 1: Rammer M, Webersinke G, Haitchi-Petnehazy S, Maier E, Hackl H, Charoentong P, Malli T, Steinmair M, Petzer AL, Rumpold H. MicroRNAs and their role for T stage determination and lymph node metastasis in early colon carcinoma. Clin Exp Metastasis. 2017 Nov 13. doi: 10.1007/s10585-017-9863-9. [Epub ahead of print] PubMed PMID: 29134398. 2: Garrigues S, Gandía M, Popa C, Borics A, Marx F, Coca M, Marcos JF, Manzanares P. Efficient production and characterization of the novel and highly active antifungal protein AfpB from Penicillium digitatum. Sci Rep. 2017 Nov 7;7(1):14663. doi: 10.1038/s41598-017-15277-w. PubMed PMID: 29116156. 3: Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, Ademowo OS, Afonso CB, Andreadou I, Antelmann H, Antunes F, Aslan M, Bachschmid MM, Barbosa RM, Belousov V, Berndt C, Bernlohr D, Bertrán E, Bindoli A, Bottari SP, Brito PM, Carrara G, Casas AI, Chatzi A, Chondrogianni N, Conrad M, Cooke MS, Costa JG, Cuadrado A, My-Chan Dang P, De Smet B, Debelec-Butuner B, Dias IHK, Dunn JD, Edson AJ, El Assar M, El-Benna J, Ferdinandy P, Fernandes AS, Fladmark KE, Förstermann U, Giniatullin R, Giricz Z, Görbe A, Griffiths H, Hampl V, Hanf A, Herget J, Hernansanz-Agustín P, Hillion M, Huang J, Ilikay S, Jansen-Dürr P, Jaquet V, Joles JA, Kalyanaraman B, Kaminskyy D, Karbaschi M, Kleanthous M, Klotz LO, Korac B, Korkmaz KS, Koziel R, Kračun D, Krause KH, Křen V, Krieg T, Laranjinha J, Lazou A, Li H, Martínez-Ruiz A, Matsui R, McBean GJ, Meredith SP, Messens J, Miguel V, Mikhed Y, Milisav I, Milković L, Miranda-Vizuete A, Mojović M, Monsalve M, Mouthuy PA, Mulvey J, Münzel T, Muzykantov V, Nguyen ITN, Oelze M, Oliveira NG, Palmeira CM, Papaevgeniou N, Pavićević A, Pedre B, Peyrot F, Phylactides M, Pircalabioru GG, Pitt AR, Poulsen HE, Prieto I, Rigobello MP, Robledinos-Antón N, Rodríguez-Mañas L, Rolo AP, Rousset F, Ruskovska T, Saraiva N, Sasson S, Schröder K, Semen K, Seredenina T, Shakirzyanova A, Smith GL, Soldati T, Sousa BC, Spickett CM, Stancic A, Stasia MJ, Steinbrenner H, Stepanić V, Steven S, Tokatlidis K, Tuncay E, Turan B, Ursini F, Vacek J, Vajnerova O, Valentová K, Van Breusegem F, Varisli L, Veal EA, Yalçın AS, Yelisyeyeva O, Žarković N, Zatloukalová M, Zielonka J, Touyz RM, Papapetropoulos A, Grune T, Lamas S, Schmidt HHHW, Di Lisa F, Daiber A. Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162]. Redox Biol. 2017 Oct 26. pii: S2213-2317(17)30747-4. doi: 10.1016/j.redox.2017.10.001. [Epub ahead of print] PubMed PMID: 29107648. 4: Liccardi G, Fava LL. Fiat Lux: illuminating the cell cycle. Cell Death Discov. 2017 Jul 17;3:17042. doi: 10.1038/cddiscovery.2017.42. eCollection 2017. PubMed PMID: 29104761; PubMed Central PMCID: PMC5512176. 5: Trixl L, Amort T, Wille A, Zinni M, Ebner S, Hechenberger C, Eichin F, Gabriel H, Schoberleitner I, Huang A, Piatti P, Nat R, Troppmair J, Lusser A. RNA cytosine methyltransferase Nsun3 regulates embryonic stem cell differentiation by promoting mitochondrial activity. Cell Mol Life Sci. 2017 Nov 4. doi: 10.1007/s00018-017-2700-0. [Epub ahead of print] PubMed PMID: 29103146. 6: Misslinger M, Gsaller F, Hortschansky P, Müller C, Bracher F, Bromley MJ, Haas H. The cytochrome b(5) CybE is regulated by iron availability and is crucial for azole resistance in A. fumigatus. Metallomics. 2017 Oct 26. doi: 10.1039/c7mt00110j. [Epub ahead of print] PubMed PMID: 29072765. 7: Safra M, Sas-Chen A, Nir R, Winkler R, Nachshon A, Bar-Yaacov D, Erlacher M, Rossmanith W, Stern-Ginossar N, Schwartz S. The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution. Nature. 2017 Nov 9;551(7679):251-255. doi: 10.1038/nature24456. Epub 2017 Oct 25. PubMed PMID: 29072297.

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8: Quarta S, Camprubí-Robles M, Schweigreiter R, Matusica D, Haberberger RV, Proia RL, Bandtlow CE, Ferrer-Montiel A, Kress M. Sphingosine-1-Phosphate and the S1P(3) Receptor Initiate Neuronal Retraction via RhoA/ROCK Associated with CRMP2 Phosphorylation. Front Mol Neurosci. 2017 Oct 10;10:317. doi: 10.3389/fnmol.2017.00317. eCollection 2017. PubMed PMID: 29066950; PubMed Central PMCID: PMC5641356. 9: Ottina E, Peperzak V, Schoeler K, Carrington E, Sgonc R, Pellegrini M, Preston S, Herold MJ, Strasser A, Villunger A. DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice. Nat Commun. 2017 Oct 18;8(1):1028. doi: 10.1038/s41467-017-01022-4. PubMed PMID: 29044097; PubMed Central PMCID: PMC5647323. 10: Sass G, Nazik H, Penner J, Shah H, Ansari SR, Clemons KV, Groleau MC, Dietl AM, Visca P, Haas H, Déziel E, Stevens DA. Studies of Pseudomonas aeruginosa mutants indicate pyoverdine as the central factor in inhibition of Aspergillus fumigatus biofilm. J Bacteriol. 2017 Oct 16. pii: JB.00345-17. doi: 10.1128/JB.00345-17. [Epub ahead of print] PubMed PMID: 29038255. 11: Adell MAY, Migliano SM, Upadhyayula S, Bykov YS, Sprenger S, Pakdel M, Vogel GF, Jih G, Skillern W, Behrouzi R, Babst M, Schmidt O, Hess MW, Briggs JA, Kirchhausen T, Teis D. Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding. Elife. 2017 Oct 11;6. pii: e31652. doi: 10.7554/eLife.31652. PubMed PMID: 29019322; PubMed Central PMCID: PMC5665648. 12: Stasyk T, Huber LA. DIGE-Based Phosphoproteomic Analysis. Methods Mol Biol. 2018;1664:79-86. doi: 10.1007/978-1-4939-7268-5_7. PubMed PMID: 29019126. 13: Forero A, Rivero O, Wäldchen S, Ku HP, Kiser DP, Gärtner Y, Pennington LS, Waider J, Gaspar P, Jansch C, Edenhofer F, Resink TJ, Blum R, Sauer M, Lesch KP. Cadherin-13 Deficiency Increases Dorsal Raphe 5-HT Neuron Density and Prefrontal Cortex Innervation in the Mouse Brain. Front Cell Neurosci. 2017 Sep 26;11:307. doi: 10.3389/fncel.2017.00307. eCollection 2017. PubMed PMID: 29018333; PubMed Central PMCID: PMC5623013. 14: Welters MJP, Ma W, Santegoets SJ, Goedemans R, Ehsan I, Jordanova ES, van Ham VJ, van Unen V, Koning F, van Egmond SI, Charoentong P, Trajanoski Z, van der Velden LA, van der Burg SH. Intratumoral HPV16-specific T-cells constitute a type 1 oriented tumor microenvironment to improve survival in HPV16-driven oropharyngeal cancer. Clin Cancer Res. 2017 Oct 10. pii: clincanres.2140.2017. doi: 10.1158/1078-0432.CCR-17-2140. [Epub ahead of print] PubMed PMID: 29018052. 15: Filipek PA, de Araujo MEG, Vogel GF, De Smet CH, Eberharter D, Rebsamen M, Rudashevskaya EL, Kremser L, Yordanov T, Tschaikner P, Fürnrohr BG, Lechner S, Dunzendorfer-Matt T, Scheffzek K, Bennett KL, Superti-Furga G, Lindner HH, Stasyk T, Huber LA. LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning. J Cell Biol. 2017 Oct 9. pii: jcb.201703061. doi: 10.1083/jcb.201703061. [Epub ahead of print] PubMed PMID: 28993467. 16: Shah NM, Herasimtschuk AA, Boasso A, Benlahrech A, Fuchs D, Imami N, Johnson MR. Changes in T Cell and Dendritic Cell Phenotype from Mid to Late Pregnancy Are Indicative of a Shift from Immune Tolerance to Immune Activation. Front Immunol. 2017 Sep 15;8:1138. doi: 10.3389/fimmu.2017.01138. eCollection 2017. PubMed PMID: 28966619; PubMed Central PMCID: PMC5605754. 17: Mathai AJ, Lowry CA, Cook TB, Brenner LA, Brundin L, Groer MW, Peng X, Giegling I, Hartmann AM, Konte B, Friedl M, Fuchs D, Rujescu D, Postolache TT. Reciprocal moderation by Toxoplasma gondii seropositivity and blood phenylalanine - tyrosine ratio of their associations with trait aggression. Pteridines. 2016 Dec;27(3-4):77-85. doi: 10.1515/pterid-2016-0006. Epub 2016 Oct 21. PubMed PMID:

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