274 PATENT ABSTRACTS

4716149

P A R T I A L L Y M O D I F I E D , R E T R O - I N V E R S O N E U R O T E N S I N

A N A L O G S

Fabio Bonelli, Antonell Pessi, Antonio S Verdini, Rome, Italy assigned to Enichem S p A; Eniricerche S p

Pharmacologically active, partially retro- inverso, neurotensin-like peptides lasting longer than the natural hormone, corresponding to the formula See Patent for Chemical Structure wherein R I and R2 are straight or branched (C1- C7) alkyl radicals. The new compounds are use- ful as va=odilating and hypotensive agents.

4716151

T R I P E P T I D E S A N D T H E I R U S E

Pierre Jolles, Daniele Migliore-Samour, Fabienne Parker, Paris, France assigned to Rhone-Poulenc Sante

Tripeptides composed of the amino acids glycine, leucine, and phenylalanine or tyrosine obtainable by fractionation of hydrolysis pro- ducts of human casein or by direct synthesis can be used as immunostimulants.

4716152

P H A R M A C E U T I C A L U S E O F S U B S T I T U T E D O -

A C Y L G L Y C O S I D E S

Bernd-Wieland Kruger, Oswald Lockhoff, Karl G Metzger, Hans-Georg Opitz, Klaus Schaller, Klaus G Stunkel, Hans-Joachi Zeiler, Wupper- tal, Federal Republic Of Germany assigned to Bayer Aktiengesellschaft

Compounds of the formula See Patent jbr Chemical Structure in which X is hydrogen or the radical CH2OR5, R2, R3, R4 and R5 each inde- pendently is hydrogen or the radical See Patent for Chemical Structure Y is oxygen, sulphur, NH or CH2, and R1 and R6 each independently is an optionally substituted hydrocarbon radical having up to 50 carbon atoms, with the proviso that at least one of the radicals RI and/or R6 contains between 9 to 50 carbon atoms, some of which are known, stimulate the immune system's response and antibody production.

4716153

S T A B L E O R A L P R E P A R A T I O N O F M A C R O L I D E A N T I B I O T I C S A N D

M E T H O D F O R S T A B I L I Z I N G T H E S A M E

Masataka Morishita, Masaru Ono, Yukio Sumita, Shizuoka, Japan assigned to Toyo Jozo Company Ltd

Stable oral preparations of 16-membered ring macrolide antibiotics such as SF-837, josamycin, 3"-propionyljosamycin, by incorporating stabilizers showing pH 3-10 in an aqueous medium, such as glycine, and dissolution ac- celerators showing pH 2.5-4 in an aqueous medium such as citric acid or tartaric acid. Coating such dissolution accelerators with a film-forming substance is useful to enhance the stability of the oral preparation of such anti- biotics.

4716154

G E L O F C R O S S L I N K E D H Y A L U R O N I C A C I D F O R U S E A S

A V I T R E O U S H U M O R S U B S T I T U T E

Toma Malson, Bengt L Lindqvist, Uppsala, Sweden assigned to Pharmacia AB

The invention is concerned with a vitreous humor substitute intended for ophthalmological uses and consisting of a gel of crosslinked hyaluronic acid and a method at retinal surgery and after vitrectomy when the vitreous humor completely or partially is exchanged for such a gel.

4716155

P H O S P H O R U S C O N T A I N I N G C O M P O U N D S A N D

H Y P O T E N S I V E U S E T H E R E O F

Donald S Karanewsky, Edward Petrillo as- signed to E R Squibb & Sons Inc

Phosphorus containing compounds of the for- mula See Patent for Chemical Structure wherein X is a substituted or unsubstituted imino or amino acid and A is See Patent for Chemical Structure These compounds possess angiotensin converting enzyme activity and are thus useful as hypertensive agents.