iv New Patents

ture of binders, based on cellulose and cellulose derivatives in the form of microspheres which are coated with an acrylic resin of defined nature and are compressed together with a disintegrant; the tablets are preferably also coated with a lac- quer layer. As a consequence of the high content of active compound and its delayed release in the body, the therapeutic treatment with ibuprofen can be reduced to a minimum number of intakes and dose units per day.

tion further relates to pharmaceutical composi- tions containing these novel compounds. Finally, this invention relates to methods for treating or preventing diseases characterized by abnormal calcium and phosphate metabolism by utilizing a compound or pharmaceutical com- position of the present invention.

4868166

4868156

PHARMACEUTICAL PREPARATION CONTAINING A

DIPEPTIDE WITH CELL GROWTH REGULATING EFFECT

Kjell Elgjo, Karl-Ludvig Reichelt, Oslo, Norway assigned to Bio-Tech A/S

Method for treatment of abnormally fast rate of cell proliferation in the epidermis, by administra- tion of a dipeptide of the formula See Patent for Chemical Structure wherein R is H or CH3, the pyroglutamic acid moiety being in the L- configuration, and the C-terminal amino acid moiety being in the D-configuration when R is methyl, and the C-terminal carboxyl group may be reduced to -Ch2-OH, or is in amide form -CO- NH2, and cation complexes and physiologically acceptable acid addition salts thereof, the com- plexes being selected from complexes with Zn+ + , Ca+ + , Mg+ + and Mn+ + .

2 2:6,6-DIETHYLEN-3-OXO 17ALPHA-PREGN-4--ENE-21

17ALPHA-CARBOLACTONES, PROCESS FOR THEIR

PRODUCTION & PHARMACEUTICAL

PREPARATIONS CONTAINING THEM

Diete Bittler, Klau Nickisch, Henry Laurent, Rudolf Wiechert, Martin Haberey, Berlin, Federal Republic Of Germany assigned to Schering Aktiengesellschaft

2 2;6,6-diethylene-3-oxo 17alpha-pregn-4-ene- 21 17-carbolactones of general formula I, See Patent for Chemical Structure (I) wherein R1 represents a hydrogen atom or a methyl group, R2 represents a methyl or ethyl group and See Patent for Chemical Structure process for their production and their pharmaceutical use.

4868172

4868164

OCTAHYDRO-PYRIDINE DIPHOSPHONATE COMPOUNDS,

PHARMACEUTICAL COMPOSITIONS, AND METHODS

FOR TREATING ABNORMAL CALCIUM AND PHOSPHATE

METABOLISM

Frank H Ebetino, Kent W Buckingham, Jocelyn E McOsker assigned to Norwich Eaton Pharma- ceuticals Inc

The present invention relates to novel com- pounds having nitrogen-containing, saturated bicyclic cyclopentane-fused rings which are geminally disubstituted with phosphonate groups. Most preferred compounds of the pre- sent invention have the general structure: See Patent for Chemical Structure The present invert-

PHARMACEUTICAL COMPOSITION COMPRISING AN ORGANIC ZINC COMPLEX AND

A PROCESS FOR PREPARING THE ACTIVE SUBSTANCE

Gyula Sebestyen, Istvan Simonyi, Gizell Miholics, Marta Kovacs, Frigye Gorgenyi, Mar- ton Fekete, VagoPal , Istva Seres, Jano Egri, Maria Szeli, Budapest, Hungary assigned to BASF Aktiengesellschaft

The invention refers to a novel pharmaceutical composition having especially antimycotic ac- tivity and comprising the zinc complex of 5- chloro-7-iodo-8-hydroxyquinoline of formula (I) See Patent for Chemical Structure (I) and one or more pharmaceutically acceptable carriers. The pharmaceutical composition of the inven- tion can be used for the effective treatment of mycotic infections on the skin surface, mucous membranes or nails. The complex of formula (I)