PATENT ABSTRACTS

5156958

GENE ENCODING A 30 KILODALTON OUTER

MEMBRANE PROTEIN OF BORDETELLA PERTUSSIS AND METHOD OF RECOMBINANT

PRODUCTION OF SAID PROTEIN

Patricia A Reilly assigned to American Cyanamid Company

The present invention relates to a nucleotide and amino acid sequence of a 30 kilodalton outer membrane protein of Bordetella pertussis. The invention also relates to host cells and vectors comprising the nucleotide sequence. as well as a vaccine composition comprising the substan- tially pure protein.

5156960

MICROBIAL PROCESS FOR THE PRODUCTION OF

IMMUNOSUPPRESSIVE ANTIBIOTICS

nee Bokany Antonia Jekkel, Gabor Ambrus, Eva Toth-Sarudy, Istvan Mihaly, nee Dobos Agota Hulber, Attil Andor, Karol Albrecht, Kalman Konczol, Valeri Szell, nee Joszt Eva Tomori, Imre Moravcsik, Kalman Polya, Jano Erdei, Lajos Kiss, Bela Makadi, Karoly Nagy, Be1 Palotas, nee Konszky Etelk Deli, Karoly Buzasi, nee Antal Aniko Santha Gyorgy Mol- nar, Vilma Szaszhegyesi, Budapest, Hungary as- signed to Biogal Gyogyszergyar

The invention relates to a microbial process for the production of immunosuppressive cyclo- sporine antibiotic complex or of its components, cyclosporine A, cyclosporine Band cyclosporine C, by the aerobic fermentation of a filamentous fungus strain biosynthesizing the above anti- biotic(s) in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the products for- med, which comprises culturing a strain of the novel Tolypocladium varium fungus species pro- ducing the cyclosporine antibiotic complex, pre- ferably tolypocladium varium sp. nov. CY/93, deposited at the National Collection of Agri- cultural and Industrial Microorganisms,

Budapest, Hungary under the number NCAIM(P)F 001005, on a nutrient medium con- taining carbon sources, organic and inorganic nitrogen sources as well as mineral salts, under aerobic conditions, at 25 degrees to 30 degrees C., and, if desired, isolating and purifying the cyclosporine antibiotic complex or its compo- nents produced.

5156961

PROCESS FOR PRODUCING ANTIBIOTICS

Kaname Inoue, Motohide Yamazaki, Richard W Armentrout, Kawasaki, Japan assigned to Shin-Etsu Bio Inc

A method for separation and recovery of poly- meric beads from an antibiotic fermentation broth comprising suspending a mixture of the beads and any inherent mold from the fermenta- tion in an aqueous solution having a specific gravity which is effective to cause the beads to form a discrete layer at or on the surface of the solution, separate and apart from the mold. The separate layer of the beads may then be easily removed from the liquid by a conventional phys- ical methods.

5156965

CATALYTIC ANTIBODIES

Gerald Schochetman, Richard J Massey as- signed to IGEN Inc

A method for increasing the rate of chemical reactions involving the conversion of at least one reactant to at least one product involves con- tacting the reactant with an appropriate mono- clonal antibody under conditions permitting the formulation of a complex between the antibody and the reactant. The complexed reactant is con- verted to the product which is then released from the complex, The monoclonal antibody may em- ploy a cofactor and may be directed to a known substrate of an enzyme. Methods for preparing such monoclonal antibodies are also disclosed.