A designer amphetamine that has become one of the most widely abused drugs in the adolescents

A blending of sympathomimetic amphetamine stimulation with the hallucinogenic effects of mescaline

The drug is popular at “rave “ parties and at dance clubs. Following ingestion, the onset of action is 30 – to 90

minutes, plateau effects are achieved in 2- 3 hours The drug is abused because it induces extreme

euphoria, increased energy, feeling of belongings, heightened sensations, empathy, music appreciation

(3,4,methylenedioxymethamphetamine) Ecstasy

Toxic effects & Major complications Bruxism Trismus Short-term memory loss Confusion Headches Vertigo Ataxia Vomiting Depression&psychological

addiction

Profound hyperthermia Hypertension Seizures Dehydration Hyponatremi Hepatic and renal failure Rhabdomyolysis MI & ICH

Psychological

Euphoria Closeness to others love drug Serotonergic properties Shimmering visual effects

Differential Diagnosis

Amphetamines LSD Phencyclidine abuse

Management

Supportive care, airway management, rapid cooling

Liberal doses of benzodiazepines for tachycardia,hypertension, and agitation

Activated charcoal Toxicology urine screens that are marketed to

detect amphetamines can be negative after ecstacy and desighner amphetamine use

Fluid

Management

Consultation with a local or regional poison center Observation for4 to 6 hours Because of 10 -50% repeat ingestion, families must

be received a kind of instuction about poison prevention

Admission to the hospital(slow release substances and or ingestion of significant amounts of drug

A conservative approach for toxins that can cause potential mortality in small doses (camphor, benzocaine, lomotil, chloroquin, methyl salicylate

All patients with intentional overdoses should undergo psychiatric assessment