a promising chemotherapy agent, gd@c82(oh)22

Tianjin Medical University Cancer Institute & Hospital

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A Promising Chemotherapy Agent, Gd@C82(OH)22

Ning ZhangTianjin Medical University Cancer Institute and Hospital

UICC 2008


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Chemotherapies have always been

accompanied with serious side effects.

Can nanoparticles provide a new approach to

design low toxic therapeutic agents?


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Treatments with Gd@C82(OH)22 Inhibit hepatoma growth in a mouse model

Nano Lett Vol 5, pg 2050 Gd@C82(OH)22 inhibits tumor growth in a breast tumor model.

0.28 mg/kg1.20mg/kg


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Gd@C82(OH)22 doesn’t show cytotoxicity


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Treatments with Gd@C82(OH)22 reduced blood supply to tumors


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Treatments with Gd@C82(OH)22 reduced blood vessel density


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Treatments with Gd@C82(OH)22 induced a massive leukocyte infiltration in tumors.


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Gd@C82(OH)22 induced iDC maturation and TH-1 response.


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TreatmentsMetastasis

Rate

Salineq.d. ×20 day

66.7%

C60(C(COOH)2)2

(0.4 mg/kg, n = 10)

34.2%

C60(OH)20 (0.4

mg/kg, n = 10)38.0%

Gd@C82(OH)22 ，0.35mg/kg

q.d. ×20 day4.3 %

Treatments with Gd@C82(OH)22 cancer cell chemotaxis and metastasis


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Summary

1. Treatment with Gd@C82(OH)22 inhibits tumor growth without detectable toxicity.

2. Gd@C82(OH)22 doesn’t show cytotoxicity.

3. Gd@C82(OH)22 inhibits blood supply to tumor tissues.

4. Gd@C82(OH)22 induced tumor immunity.

5. Gd@C82(OH)22 inhibits cancer cell chemotaxis

Blood supply

Tumor immunity

Metastasis


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Chinese AcademyInstitute of High Energy

Physics

Tianjin Cancer Institute and

Hospital

Research Center for Cancer Nanotechnology

National Center of Nanotechnology


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Acknowledgements

Nanosafety Lab, Chinese Academy of ScienceDr. Yuliang Zhao, DirectorDr. Gengmei XingHuan Meng

Laboratory of Molecular Immunoregulation, NCIDr. Joost Oppenheim, ChiefDr. De Yang

Dr. Yujie MaDr. Guoguang YingDr. Ruifang Niu


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Gd@C82(OH)22 induced a dendritic cell maturation


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HR (100 ug/ml)-treated DCs migrated to SLC but not Rantes, suggesting the HR-treated DCs were mature DCs.

Gd@C82(OH)22 induced a dendritic cell to express CCR7 receptors


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T cell cytokine production in response to Gd@C82(OH)22 -treated DCs


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Treatments with Gd@C82(OH)22 disrupted the integrity of capillary blood vessels in tumors.

a promising chemotherapy agent, gd@c82(oh)22

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