[ product solution ]

AC QU IT Y U P L C S YS T EMS A N D T H I R D - PA RT Y MS

The only inlet you need for mass spectrometry

EXT END YOUR MS SOLUT ION

Waters® ACQUITY UPLC® and nanoACQUITY UPLC® systems, in combination with Waters MS tech-

nologies, chemistries, informatics software, and support services, create a complete system solution

for cutting-edge UPLC®/MS and UPLC/MS/MS applications, yielding the ultimate in chromatographic

resolution, peak capacity and MS sensitivity. Optimal use of UPLC’s sub-2-micron particles results in

narrow peaks, higher signal-to-noise ratios, and shorter run times.

The unprecedented benefits of UPLC technology have driven the need for direct integration of

chromatographic control and data acquisition of ACQUITY UPLC and nanoACQUITY UPLC systems

with non-Waters mass spectrometers.

Extending the ability of UPLC technology to operate seamlessly with other mass spectrometers

provides laboratories with greater analytical performance advantages that result in better use of

existing MS investments.

More resolution, sensitivity, and speed: The power of UltraPerformance LC®, as demonstrated in this HPLC/MS vs. UPLC/MS analysis of the hydroxylated metabolites of Buspirone.

ACQUITY UPLC and

nanoACQUITY UPLC

systems can improve

performance with the

following third-party

MS systems:

Applied Biosystems/

MDS SCIEX:

QSTAR, Q TRAP, and API

series mass spectrometers

Thermo Fisher Scientific:

TSQ Quantum, LTQ Linear Ion

Trap, LTQ FT Hybrid Linear

Trap/Fourier Transform ICR,

and LTQ Orbitrap Hybrid

mass spectrometers

Bruker Daltonics:

esquire/HCT, micrOTOF,

apex, and UltrOTOF series

mass spectrometers

and Bruker BioSpin

NMR spectrometers

HPLC/MS Column: 2.1 x 50, 3.5 μm

Flow rate: 300 μL/min

Analysis time: 5 min

Buspiron, Human T90, QPMS Scan, 50 mm, 40 °C, 300R2HPLC300_BS_MSScan_40C50mm0519008 Sm (Mn, 2x1)

MS2 ES+402

3.95e7

Time

100

%

00.50 1.00 1.50 2.00 2.50 3.00 3.50 4.00 4.50 5.00

3.83

4.09

4.39

3.65

3.35

3.21

MS2 ES+402

3.95e7

Time

100

%

0

Buspiron, Human T90, QPMS Scan, 50 mm, 40 °CQPBS_MSScan_40c50mm0504008 Sm (Mn, 2x1)

0.50 1.00 1.50 2.00 2.50 3.00 3.50 4.00 4.50 5.00

0.910.75

0.69

0.56

UPLC/MS Column: 2.1 x 50, 1.7 μm

Flow rate: 800 μL/min

Analysis time: 1 min

[ product solution ]

Applied Biosystems/MDS SCIEX

Analyst software* supports:

• ACQUITY UPLC and nanoACQUITY UPLC systems

• Q TRAP and API series mass spectrometers

Analyst QS** software supports:

• ACQUITY UPLC and nanoACQUITY UPLC systems

• QSTAR mass spectrometers

*ABI/MDS SCIEX Analyst software will support ACQUITY UPLC and nanoACQUITY UPLC system control in v.1.4.2 with Hotfix. Also offered is the ACQUITY UPLC Instrument Control Options Pack for ABI/MDS SCIEX Analyst software. ACQUITY UPLC systems will run in stand-alone mode under console-based control on the Analyst workstation.

**ABI/MDS SCIEX Analyst QS software will support ACQUITY UPLC and nanoACQUITY UPLC system control in v.2.0 with Hotfix.

E X P E R I ENC E T H E A NA LY T IC A L IM P ROV EM ENT S O F U P L C W IT H T H E MA S S S P EC T ROM E T E RS A N D S O F T WA R E YO U U S E E V E RY DAY

Analyst instrument method page.

Analyst acquisition method page.The ACQUITY UPLC console for easy stand-alone control and execution of UPLC/MS data sets.

ST REAMLINED, STAND-ALONE CONT ROL OF UPLC SYST EMS

Waters has developed a new, stand-alone console software applica-

tion for ACQUITY UPLC and nanoACQUITY UPLC systems, allowing

for flexible instrument method editing and sample set execution.

This ACQUITY UPLC console interfaces with a sample queue manager

capability that can run directly on the same PC workstation operating

third-party data systems, or can alternatively run on a separate,

dedicated PC.

Supported ACQUITY UPLC modules:

n Binary Solvent Manager

n Sample Manager

n Optional Sample Organizer

n Optional Tunable UV Detector

n Optional Photodiode Array Detector

n Optional Evaporative Light Scattering Detector

n Optional Column Manager

Supported nanoACQUITY UPLC modules:

n Binary Solvent Manager

n Sample Manager with Trapping and Heating Module

n Optional Auxiliary Solvent Manager

n Optional Tunable UV Detector

Thermo Fisher Scientific

Xcalibur software† supports:

• ACQUITY UPLC and nanoACQUITY UPLC systems

• TSQ Quantum, LTQ Linear Ion Trap, LTQ FT Hybrid Linear Trap/Fourier

Transform ICR, and LTQ Orbitrap Hybrid mass spectrometers

††Bruker HyStar software control in v.3.2, with an LC driver supplied by Bruker Daltonics, will support the ACQUITY UPLC system.

Bruker Daltonics

HyStar software†† supports:

• ACQUITY UPLC system

• esquire/HCT, micrOTOF, apex, and UltrOTOF series

mass spectrometers

• Bruker BioSpin NMR spectrometers

†Thermo Fisher Scientific Xcalibur software control is available from Thermo Fisher Scientific through an instrument driver that will work with Xcalibur v.2.0, SR2 for ACQUITY UPLC and nanoACQUITY UPLC systems.

E X P E R I ENC E T H E A NA LY T IC A L IM P ROV EM ENT S O F U P L C W IT H T H E MA S S S P EC T ROM E T E RS A N D S O F T WA R E YO U U S E E V E RY DAY

Xcalibur sample set page.

Xcalibur instrument method page.

HyStar acquisition page.

HyStar instrument method page.

[ product solution ]

Waters Corporation 34 Maple Street Milford, MA 01757 U.S.A. T: 1 508 478 2000 F: 1 508 872 1990 www.waters.com

FULL SYST EM INT EGRAT ION

A complete suite of advanced diagnostic capabilities and ease-of-

use tools are available in the ACQUITY UPLC console. The ACQUITY

UPLC BEH column’s eCord™ Information Management Technology

(not supported in nanoACQUITY UPLC system) tracks information

over the life of the column, including certificate of analysis, dates

of installation and usage, number of injections and sample sets, and

maximum temperature and pressure.

Users also have access to the ACQUITY UPLC console calculator to

simplify transfer and optimization of HPLC methods to UPLC methods.

Additionally, state-of-the-art Connections INSIGHT® intelligent

services provides automatic alerts on ACQUITY UPLC system usage

and performance parameters directly to Waters Technical Support

for proactive servicing, to ensure maximum uptime and system

performance.

ACQUIT Y UPLC systems and third-party MS – integration you can rely on

The ACQUITY UPLC console, integrated into non-Waters MS data

systems, provides the ultimate results for improved throughput,

sensitivity, specificity, accuracy, and resolution performance for any

LC/MS laboratory.

Waters, The Science of What’s Possible, ACQUITY, ACQUITY UPLC, nanoACQUITY UPLC, UltraPerformance LC, UPLC, eCord, Connections and Connections INSIGHT are trademarks of Waters Corporation. All other trademarks are the property of their respective owners.

©2007 Waters Corporation. Printed in the U.S.A.April 2007 720002105EN LB-PC

ACQUITY UPLC system.