acrin fall meeting 2008 mitchell schnall md, phd professor of radiology university of pennsylvania...

ACRIN Fall Meeting 2008

Mitchell Schnall MD, PhDProfessor of RadiologyUniversity of PennsylvaniaACRIN Network Chair

State of ACRIN : 10 years of investment


1. Strategies for Imaging Surveillance of Populations at High Risk for Cancer

2. Imaging Approaches to the Characterization of Disease in Order to Guide Targeted Therapy

3. Biomarkers of Therapeutic Response for Implementation in Clinical Trials and Clinical Care

Primary Scientific Objectives


ACRIN ORGANIZATION: 1999

Data and Safety Monitoring Committee

Network ChairNetwork Deputy Chair

Advisory Panel

Vice ChairModalities

Vice ChairBasic Sciences

Vice Chair for Institutional

Participants

Vice ChairIndustry/Insurers

Vice ChairPublications

Urinary

GYN

Breast

Head & Neck

CNS

Musculoskeletal

Lung

Pediatrics

Heart & Vasculature

Receptor Delivery Sys

Nuc MedPET/Spect

Ultrasound

Conventional/CT

Psychophysics

MRI/MRS

GI

Design & Analysis

NetworkAdministration

Biostatistical & DataManagement Center

Vice ChairDisease Sites

Functional/Meta-bolic Imaging

InterventionalMin Invasive

Image & InfoTech

Outcomes andQuality of Life

Economics and Cost Impact

Oncologic Pathology

Quality Contol

Medical Specialties

Advisory Comm.

SpecialPopulations

Physics &Engineering

InstitutionalParticipants

Vice ChairMethods

Scientific Committees


ACRIN Organizational Chart

Institutional Participants CommitteeVice Chair

Chris Comstock, MDUCSD

Institutional Participants CommitteeVice Chair

Chris Comstock, MDUCSD

Media / Publications and

DisseminationCommitteeVice Chair

Laurie Fajardo, MDUniversity of Iowa

Media / Publications and

DisseminationCommitteeVice Chair

Laurie Fajardo, MDUniversity of Iowa

Special PopulationsElizabeth Patterson, MD

Special PopulationsElizabeth Patterson, MD

Research AssociatesWendy Smith, RT

Rhode Island Hospital

Research AssociatesWendy Smith, RT

Rhode Island Hospital

Quality ControlMitchell Schnall, MD, PhDUniversity of Pennsylvania

Quality ControlMitchell Schnall, MD, PhDUniversity of Pennsylvania

Patient AdvocacyBarbara LeStage, MHP

Patient AdvocacyBarbara LeStage, MHP

Outcomes & Economics Core

LaboratoryWilliam Black, MD

Dartmouth Medical School

Outcomes & Economics Core

LaboratoryWilliam Black, MD

Dartmouth Medical School

Advisory PanelHal Kundel, MD

University of Pennsylvania

Advisory PanelHal Kundel, MD

University of PennsylvaniaLeadership Council

Mitchell Schnall, MD, PhDUniversity of Pennsylvania

Leadership CouncilMitchell Schnall, MD, PhD

University of Pennsylvania

Biostatistical & Data Management Center

Brown UniversityChair

Constantine Gatsonis, PhD

Deputy Chair Jeffrey Blume, PhD.

Biostatistical & Data Management Center

Brown UniversityChair

Constantine Gatsonis, PhD

Deputy Chair Jeffrey Blume, PhD.

Steering Committee

Network ChairMitchell Schnall, MD,

PhDUniversity of Pennsylvania

Deputy Chairs Anat/Fxn ImagingDenise Aberle, MD

UCLA

Molecular ImagingBarry Siegel, MD

Washington University

Steering Committee

Network ChairMitchell Schnall, MD,

PhDUniversity of Pennsylvania

Deputy Chairs Anat/Fxn ImagingDenise Aberle, MD

UCLA

Molecular ImagingBarry Siegel, MD


AbdominalFergus Coakley, MDUniv Calif San Francisco

AbdominalFergus Coakley, MDUniv Calif San Francisco

Head/Neck/CNSGreg Sorensen, MD

Massachusetts General Hosp

Head/Neck/CNSGreg Sorensen, MD

Massachusetts General Hosp

BreastEtta Pisano, MD

University North Carolina

BreastEtta Pisano, MD

University North Carolina

ThoracicCaroline Chiles, MDWake Forest University

ThoracicCaroline Chiles, MDWake Forest University

Gynecological Gynecological

Disease SiteCommittees

Scientific SupportCommittees

Experimental ImagingDavid Mankoff, MD

University of Washington

Experimental ImagingDavid Mankoff, MD

University of Washington

InformaticsDaniel Rubin

Stanford University

InformaticsDaniel Rubin

Stanford University

Core Laboratory

PET/Nuc MedicineBarry Siegel, MD


MR/CTMark Rosen, MD, PhDUniversity of Pennsylvania

Core Laboratory

PET/Nuc MedicineBarry Siegel, MD


MR/CTMark Rosen, MD, PhDUniversity of Pennsylvania

Ultrasound Working Group

Barry Goldberg, MDThomas Jefferson University

Ultrasound Working Group

Barry Goldberg, MDThomas Jefferson University

NCIJim Tatum, MD

Cancer Imaging Program

NCIJim Tatum, MD

Cancer Imaging Program

Network AdministrationCharles Apgar

ACR Philadelphia

Network AdministrationCharles Apgar

ACR Philadelphia

Data & Safety Monitoring Committee

Daniel Sargent, PhDMayo Clinic

Data & Safety Monitoring Committee

Daniel Sargent, PhDMayo Clinic

SupportCommittees


Scientific ProgressACRIN Trial Status by Disease Site

Disease Site OpenedCompleted

AccrualIn

DevelopmentClosed

Unsuccessfully

Breast 1 4 1 0

Abdominal 2 4 1 2

GYN 1 1 1 0

CNS/Head and Neck

1 2 2 0

Thoracic 2 1 1 1

EISC 0 0 2 0


ACRIN Success

117 sites have participated ACRIN trials Over 76,500patients have been accrued to

ACRIN trials Over 20 million images have been collected

into the ACRIN database Over 70 abstract presented

10 ACRIN research presentation scheduled at RSNA 2008 Over 50 Scientific publications

3 NEJM/1JAMA


The National CTC Trial Results Make it to Times Square


Extending ACRIN’s Impact

Awarded RO1 for establishing VIEW Imaging core lab services to the cooperative groups Partner with QARC and CALGB

Established ACRIN PA Supported by PA tobacco fund Cartilage Assessment Radial DCE MRI Amyloid imaging Coronary CTA

*Developed the ACRIN Cardiovascular Committee ACRIN “projects”

*initiative supported by the ACRIN Fund for Imaging Innovation


Challenges

Strong scientific pipeline Balance in the research portfolio Focus on imaging science Engagement of clinical community

Maintaining accrual Build publication record


Case Accrual


Cost per case has been increasing

Assuming 6 committees:

73 cases/committee/year


Primary Scientific Objectives

Presentation to Steering Committee Written Concept Trial PI / Committee Chair Present

ACRIN SCIENTIFIC COMMITTEESReview Idea Impact Feasibility Strategy

Develop Concept Assemble Experts Symposium at Fall Meeting Define Imaging Approach Identify Collaborators

ACRIN STEERING COMMITTEEReview with Respect to: Scientific Impact Generalizability of Technology Feasibility Cost

IndividualInvestigators

Committee Members

CooperativeGroups

Trial Ideas

OutcomeEconomics

Biostatistics

Steering Committee Response Approve for Development and CTEP Concept Submission Disapprove Request Revision

PatientAdvocacy

SpecialPopulations

INPUT from ACRIN Resources

ImagingCore Lab


Committee Meeting

Publications

Patient Accrual

Protocol Pipeline

acrin fall meeting 2008 mitchell schnall md, phd professor of radiology university of pennsylvania...

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