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12. Protocol/Procedure for– Acutely Toxic Chemicals

Preparation Know the location of the nearest fire extinguisher, eyewash, and safety shower before beginning work. Be sure that a sign is posted that states that the laboratory is a designated area. The nature of the warning may also be posted, e.g. Warning! Acutely Toxic Chemical Work Area. These chemicals are classified as acutely toxic and contact must be minimized at all times. Because of the risks associated with repeated exposures, in addition to immediate exposures, extra care must be taken to prevent contamination of clothing, work surfaces, etc when working with these materials. Some of these materials are flammable or combustible, so avoid open flames and other ignition sources.

Chemical Storage and Disposal

Keep container tightly closed in a cool, dry and well-ventilated place. Any post-reaction waste is to be collected and labeled separately. Also, all the empty containers should be treated and disposed in the same way as hazardous compound. Decontamination of containers in order to use them for other purposes should not be permitted.

Lab-specific Information

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Procedure/Use Scale Engineering Controls/Equipment

PPE (eye, face, gloves, clothing)

Procedure Steps and Special Precautions for this Procedure

1. Using Acutely Toxic Chemicals as reagents.

2 g or less in 50 to 100 mL of solvent

All reactions using these materials must be performed in a properly operating fume hood. Blast shields must be used if the reaction has the potential to generate large quantities of gases or is strongly exothermic

Eye Protection: Wear tight-fitting safety goggles or safety glasses with side shields. Face Protection: The need for face protection is based on the solvents used or if the reaction will be externally heated or if needed. Hand Protection "#$%&'(!)#(*+,&-&.&,/!#%!0.#12!(+,2'&+.!3&,4!(+,2'&+.!-2&$0!56278!

92$2'+.!05&7+$)2:!(low contact): 8 mil minimum Nitrile gloves (unless otherwise specified in the specific MSDS) must be used to prevent incidental contact. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Remove gloves immediately upon contamination and dispose of properly. Wash and dry hands after use. Hand Protection (high contact): For spill handling or for potential

Avoid the formation of dusts with solids. Carefully weigh reagent in an enclosed or vented area. If this is not possible use the tared vessel method and cap the vessel during transport to and from the balance. Use a secondary container for transport of the tared vessel. Immediately move all operations to the fume hood when weighing is complete. In a properly functioning fume hood, add reagent to the reaction vessel. If the reagent is a liquid, dispense and transfer to the reaction vessel using either a syringe or pipettor. Be sure all contaminated reaction vessels and equipment are cleaned and decontaminated before using again or put into storage.

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contact with larger quantities, use double nitrile or heavier gauge nitrile or neoprene gloves (unless otherwise specified in the specific MSDS). Remove gloves immediately upon contamination and dispose of properly. Clothing: Wear fire/flame resistant lab coat (100% cotton based); cotton based clothing/attire; full length pants or equivalent; and close-toed, close-heeled shoes.

Notes Any deviation from this SOP requires approval from PI.

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PPE (eye, face, gloves, clothing)

Procedure Steps and Special Precautions for this Procedure

2. Using Acutely Toxic Chemicals as solvents in reactions, or for extractions

up to 100 mL when used as a reaction solvent no more than 500 mL when using for extractions

All operations using these materials must be performed in a properly operating fume hood. Blast shields must be used if the reaction has the potential to generate large quantities of gases or is strongly exothermic. Open flames and possible sparking and static electricity must be avoided.

Eye Protection: Wear tight-fitting safety goggles or safety glasses with side shields. Face Protection: The need for face protection is based on the volume of solvents used or if the reaction will be externally heated or if needed. Wear a face shield when handling containers that are not behind a lab hood sash or blast shield. Hand Protection (low contact): 8 mil minimum Nitrile gloves must be used to prevent incidental contact. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Remove gloves immediately upon contamination. Wash and dry hands after use. Hand Protection (high contact): Extended contact with many solvents may penetrate lab gloves Use Laminate Film gloves (e.g. Ansell Barrier) for extended contact (such as spill cleanup)

Avoid inhalation of these materials. If a rotary evaporator is used ensure it is vented in the fume hood. If it is necessary to condense the solvent, use an open cold trap system. Pressure can be built up when these solvents are used in closed reaction vessels. Adequate ventilation (e.g. pressure bubbler on Schlenk manifold, or an equilibrating balloon) must be used to prevent dangerous over pressurization. Pressure may be built up if when performing extractions. Adequate ventilation (open the valve frequently during the extraction) has to be used to prevent dangerous over pressurization. The vapor in such a process must be released in a fume hood. If heated, the reaction apparatus has to be fitted with an adequately sized condenser and an adequate flow of cooling water has to be provided to prevent evaporation. Cooling hoses have to be secured with hose clamps to the condenser and the outlet.

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and for any potential contact with solutions containing highly toxic solutes. Extended contact must avoided. Remove gloves immediately upon contamination and dispose of properly. Wash and dry hands after use. Clothing: Wear fire/flame resistant lab coat (100% cotton based); cotton based clothing/attire; full length pants or equivalent; and close-toed, close-heeled shoes.

Notes Any deviation from this SOP requires approval from PI.

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