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  • Adapalene | apollo +9191 46 950 950

    Adapalene | apollo +9191 46 950 950

    Adapalene

    CAS Number : 106685-40-9 Molecular Weight : 412.52 g/mol Molecular Formula : C28H28O3

    Systematic (IUPAC) : 6-[3-(adamantan-1-yl)-4- methoxyphenyl]

    naphthalene-2-carboxylic acid

    Type : small molecule

    Description : Adapalene is a topical retinoid primarily used in the treatment of acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. It is currently marketed by Galderma under the trade

    names Differin in some countries, and Adaferin in India.

    Categories : Dermatologic Agents

    Taxonomy

  • Kingdom : Organic

    Classes : Retinoids

    Substructures Hydroxy Compounds

    Benzyl Alcohols and Derivatives Naphthalenes

    Acetates Benzoates

    Phenols and Derivatives Ethers

    Benzene and Derivatives Biphenyl and Derivatives

    Carboxylic Acids and Derivatives Adamantanes

    Aromatic compounds Anisoles

    Benzoyl Derivatives Retinoids

    Cyclooctane and Derivatives Phenyl Esters

    Pharmacology

    Indication : For the topical treatment of comedo, papular and pustular acne (acne vulgaris) of the face,

    chest or back.

    Pharmacodynamics : Adapalene is a chemically stable retinoid-like compound. Biochemical and

    pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation,

    keratinization, and inflammatory processes all of which represent important features in the pathology of acne

    vulgaris.

  • Mechanism of action : Mechanistically, adapalene binds to specific retinoic acid nuclear receptors (gamma and beta) and retinoid X receptors but does not bind to the cytosolic receptor protein. Although the exact mode of action of adapalene is unknown, it is suggested that topical adapalene may normalize the differentiation of

    follicular epithelial cells resulting in decreased microcomedone formation.

    Absorption : Absorption of adapalene through human skin is low. Only trace amounts (

  • Uses This medication is used to treat acne. It may decrease the number and severity of acne pimples and promote quick healing of pimples that do develop. Adapalene belongs to a class of medications called retinoids. It works by affecting the growth of cells and decreasing

    swelling and inflammation.

    How To Use? Wash your hands before applying this medication.

    Gently clean the affected skin with a mild or soapless cleanser and pat dry. Use your fingertips to apply a small amount of medication in a thin layer, usually once daily at bedtime, or as directed by your doctor. A gauze pad or cotton swab can be used to apply the solution.Use this medication on the skin only. Do not apply to the inner lip area or inside the nose/mouth. Do not apply to cut, scraped, sunburned, or eczema-affected skin.Avoid

    getting this medication in your eyes. If this medication gets into your eyes, flush with large amounts of water. Call your doctor if eye irritation develops. Wash your hands after using the medication to avoid accidentally

    getting it in your eyes.During the first few weeks of using adapalene, your acne might appear worse because the medication is working on pimples forming inside the

    skin. It may take up to 8-12 weeks to notice results from this medication.Use it regularly in order to get the most benefit from it. To help you remember, use it at the same time each day. Do not use a larger amount or use it more

    frequently than recommended. Your skin will not improve any faster, and it will increase the risk of

    developing redness, peeling and pain.This medication is available in different strengths and forms (e.g., gel,

    cream, solution). The best type of medication for you to

  • use will depend on the condition of your skin and your response to therapy. Inform your doctor if your

    condition persists or worsens.

    Why is this medication prescribed? Adapalene is used to treat acne. Adapalene is in a class of medications called retinoid-like compounds. It works by stopping pimples from forming under the surface of

    the skin.

    How should this medicine be used? Adapalene comes as a gel, a solution (liquid), and a

    cream to apply to the skin. The solution comes in a glass bottle with an applicator and as individual pledgets

    (medicated wipes for one time use). It is usually applied once a day at bedtime. Follow the directions on your prescription label carefully, and ask your doctor or

    pharmacist to explain any part you do not understand. Apply adapalene exactly as directed. Do not apply more or less of it or apply it more often than prescribed by your doctor. Applying more adapalene or applying

    adaplene more often than recommended will not speed up or improve results, but it may irritate your skin.

    Adapalene controls acne but does not cure it. Your acne may get worse during the first few weeks of treatment, and it may take 8-12 weeks or longer before you feel the full benefit of adapalene. Pimples can take 6-8 weeks to form under the skin, and during the first weeks of your treatment, adapalene may bring these pimples to the skin surface. Continue to use adapalene even if your acne worsens or you do not see much improvement at first. Do not stop using adapalene without talking to

    your doctor. Do not apply adapalene to skin that is sunburned,

    broken, or covered with eczema (a skin disease). If you

  • have any of these conditions, do not apply adapalene until your skin has healed.

    Be careful not to get adapalene in your eyes, nose, or mouth. If you do get adapalene in your eyes, wash them with plenty of water and call your doctor. Your eyes may

    become irritated, swollen, or infected. To use the cream, gel, or solution, follow these steps: Gently wash the affected skin with a mild soap or

    soapless cleanser and pat dry with a soft towel. Do not use harsh or abrasive cleansers, and do not scrub your

    skin vigorously. Ask your doctor or pharmacist to recommend a gentle cleanser.

    If you are using the gel or cream, use your fingers to spread a thin film of medication over the affected area. If you are using a pledget, remove it from the foil pouch

    and gently wipe the entire affected area. If you are using the glass bottle of solution, apply a thin layer to the

    affected area using the applicator provided. You may feel a slight warmth or stinging in the place

    where you applied adapalene. This feeling is normal and should go away by itself in a short time.

    If you used a pledget, throw it away after use. Do not save it to use again.

    Other uses for this medicine This medication may be prescribed for other uses; ask

    your doctor or pharmacist for more information.

    What special precautions should I follow? Before taking adapalene,

    tell your doctor and pharmacist if you are allergic to adapalene or any other medications.

    tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or

  • using. Be sure to mention all skin care products including soaps, cleansers, moisturizers, and cosmetics. Many skin care products can irritate your skin if you use them with adapalene. This is especially likely if you use products that are harsh, dry out the skin, or contain alcohol, spices, lime rind, sulfur, resorcinol, salicylic

    acid, or alpha hydroxy acid. If you have been using these products, your doctor may want you to wait for your skin to return to normal before you begin using adapalene. tell your doctor if you have or have ever had eczema or

    cancer. tell your doctor if you are pregnant, plan to become

    pregnant, or are breast-feeding. If you become pregnant while using adapalene, call your doctor.

    plan to avoid unnecessary or prolonged exposure to real and artificial sunlight and to wear protective clothing, sunglasses, and sunscreen with an SPF of 15 or higher, especially if you sunburn easily. Also avoid prolonged exposure to cold or wind. Adapalene may make your

    skin sensitive to sunlight or extreme weather. do not use hot wax to remove unwanted hair during your

    treatment with adapalene.

    What special dietary instructions should I follow?

    Unless your doctor tells you otherwise, continue your normal diet.

    What should I do if I forget a dose? Apply the missed dose as soon as you remember it.

    However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not apply a double dose to make up for a missed one.

    What side effects can this medication cause?

  • Adapalene may cause side effects. The following symptoms are likely to affect your skin during the first 2- 4 weeks of treatment. Tell your doctor if any of these

    symptoms are severe or do not go away: redness scaling dryness

    burning or stinging itching

    Medications that are similar to adapalene have caused tumors in laboratory animals who were given the

    medications and exposed to real or artificial sunlight. It is not known whether adapalene increases the risk of tumors in humans. Protect yourself from sunlight and sunlamps while taking adapalene, and talk to your doctor ab

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