Analgin | apollo +9191 46 950 950

Analgin | apollo +9191 46 950 950

Analgin

CAS Number : 5907-38-0

Molecular Weight : 333.34 g/mol

Molecular Formula : C13H16N3O4S.Na

Systematic (IUPAC) : Metamizole sodium ; Analgin; Novalgin ; Dipyrone;[(2,3-dihydro-1,5-dimethyl-3-oxo-

2-phenyl-1H-pyrazol-4 -y l)methylamino]methanesulfonte

Application

Analgin is Antipyretic analgesics of Pyrazolones. It indicated for treatment diseases caused by high fever

and various pain. It is also indicated in fever, headache, rheumatic pain, neuralgia and dysmenorrheal ect. It is freely soluble in water and rapidly effect. It is prepared

ampoules .

Package : 25kg/ drum

Period of retest : three years .

Indications

Analgin tablets are used for the treatment of pains of different origin and variable intensity: toothache, headache, arthralgia, neuralgia, myositis, mild to

moderate visceral pain, high fever, not responding to other drugs. Analgin injection is used in cases of acute

and severe pain after operations and traumas, pain associated with neoplastic diseases, colicky pain etc.

Dosage and administration

Ampoules: The ampoules can be administered intramuscularly. The single dose in all age groups is 8 to

16 mg/kg body weight. The dose should be given according to the following scheme: 16 to 31 kg body weight - 250 mg Analgin (1/2 ml); 32 to 46 kg body

weight - 500 mg Analgin (1 ml); 47 - 62 kg body weight - 500 - 750 mg Analgin (1 - 1.5 ml); and over 63 kg body weight - 750 - 1000 mg Analgin (1.5 - 2 ml). In cases of

persistent pain, the dose can be repeated after 6 to 8 hours. Maximum daily dose - 4.0 g Analgin. Analgin

should not be used parenterally for a period longer than 3 days. Tablets: The dosage and duration of the

treatment must be determined according to the severity of the pain syndrome. The common dose in the adults is

250 to 500 mg (1 to 2 tablets) 2 or 3 times daily. The maximum dose is 3 g/24h. In over 15 year-old children

the Analgin dose is 250 mg bid or tid.

Contraindications

Hypersensitivity to metamizole and other pyrazolone derivatives, acute hepatic porphyria, inborn glucose-6-phosphate dehydrogenase deficiency, severe renal or

hepatic diseases, blood diseases (such as aplastic anemia, leucopenia and agranulocytosis), pregnancy

(the first and the last trimester). Parenteral administration of Analgin is contraindicated in under 1

year-old children.

Special warnings and precautions

Analgin is used with increased caution in patients with a history for hypersensitivity to foods and drugs

(particularly to analgesic and nonsteroidal antiinflammatory agents) and also in patients suffering

from bronchial asthma, Quincke’s edema, chronic pulmonary infections. In patients with hypotension and

unstable blood pressure, Analgin should not be used parentarally. If Analgin application is quite necessary,

the blood pressure and the heart rate should be monitored. In cases of prolonged Analgin treatment, regular blood count checks are necessary (differential

count of the white blood cells). The high Analgin doses can influence unfavourably the active attention. Because of this in these cases driving and working with machines

are not advised.

Drug interactions

Analgin potentiates the analgesic and antipyretic action of the nonsteroidal antiinflammatory drugs. The Analgin

effects are potentiated by the tricyclic antidepressants, oral contraceptive agents, allopurinol, alcohol. Analgin decreases the activity of the coumarin anticoagulants

and plasma levels of cyclosporin. The enzyme inductors (barbiturates, glutethimide, phenylbutazone) attenuate

the Analgin effects. Analgin potentiates the effects of the drugs possessing CNS depressant activity. Concurrent administration with chlorpromazine is related with a

risk of severe hypothermia. Analgin can be used in combination with buscolysin, atropin, codein.

Adverse reactions

After prolonged administration very rarely can be observed agranulocytosis, leucopenia and

thrombocytopenia, proteinuria, interstitial nephritis. In sensitive patients rashes, urticaria, Quincke’s edema, asthmatic attacks, and very rarely anaphylactic shock

are possible.

Pharmacological mechanisms

Analgin is a medicine of the pyrazolone group, possessing hard analgesic and antipyretic effects and moderate antiinflammatory activity. Blocking of the

synthesis of endogenous pyrogens - prostaglandins D and E - is the cause for the antipyretic activity and also

for the analgesic action of this drug. The decrease of the prostaglandis production in the periphery (and

respective decrease of nerve endings sensitivity) plays a relatively smaller role. In contrast to the other

nonnarcotic analgesic drugs, Analgin stimulates the release of β-endorphins, explaining its activity in cases

of visceral pain. Analgin has a slight spasmolytic activity on the smooth muscle cells of the biliary and urinary

tracts and also on the muscle of the uterus.

Description

It is an injectable suspension. Each ampoule contains 500mg metamizole sodium. Dosage is given as per by physician. They are stored and protected in a cool dry

place between 15-30 centigrade. Other specs can be provided according to customer's option.

Uses

Used for relieving pain

Used for relieving fever

Used in the treatment of respiratory, gastroenteritic and urogenital diseases, such as: asthma, pneumonia.

This medication is effective in blood poisoning and pyogenic dermatitis.

How to use \ dosage ?

They are used for relieving pain taken as a tablet or 20 drops orally each time, 3 to 4 times a day. In severe pain

1 - 2ml of 50% solution by intramuscularly or intravenous injections 1 -2 times a day. In exceedingly sharp pains: the dose may be increased to 5ml of 50%

solution administered intravenously.

Safety tips

It is used with care and doctor should know about patient deteriorates if any before taking the medication

such as :

Pregnancy

Asthma or chronic lung infection

Any allergy

Unstable blood pressure

Hypertension

NOTE : Not to be used in pregnant women

Common side effects

Diarrhea

Nausea

Rashes

Skin reactions

Red coloration of urine

Drop in blood pressure

Shock

Intolerance

Missed Dose

If you miss a dose take it as soon as you remember. However, if it is nearly time for the next dose, skip the

Missed Dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Storage

Store this medication at room temperature 15–30°C (59–86°F). Keep away from children and excess heat

and moisture (not in the bathroom).

More Information

You may need a dosage adjustment or special monitoring during treatment or you may not be able to take this drug at all if you have kidney or liver infection or if you have gastrointestinal problems. Analgin is in

the FDA pregnancy category C, which means that studies in animals have revealed adverse effects on the fetus

(teratogenic or embryocidal or other) and there are no controlled studies in women, or studies in women and

animals are not available. Also it is not known if Analgin passes into breast milk. Therefore, do not use Analgin

without your doctor`s approval if you are pregnant, likely to become pregnant or breast feeding. Patients

over 65 years of age may be more sensitive to the effects of Analgin. These patients are recommended to take a

lower dose of this drug, as they are more likely to experience side effects.

Warnings/Precautions

Analgin like other NSAID medicines may cause serious problems such as liver damage. Some of the symptoms of liver damage are nausea, vomiting, tiredness, loss of

appetite, itching, and yellow coloring of skin or eyes and dark urine. If you experience these conditions, you should stop taking Analgin and contact your doctor

immediately. Analgin may also cause bleeding stomach ulcers, especially if you take Analgin for a long time or/and if you take large doses of Analgin. Sudden

stomach bleeding is also possible. Contact your doctor immediately if you get a burning stomach pain, black

bowel movements that look like tar, vomit that looks like blood or coffee grounds.

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