addiction to psychoactive drugs...nystagmus, vertical or horizontal n psychosis n hypertension and...
TRANSCRIPT
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Addiction to Psychoactive Drugs
Part 2
Vickie Corbett Ripley, PharmD, CPP, BCPP Coastal Plain Hospital
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Withdrawal
n Dependence possible in 1 month n Dependence likely in 3-4 months n In shorter t ½ drugs, WD in 6-12 hours
peaking in 2-4 days n Alprazolam, lorazepam
n In longer t ½ drugs, WD in 24-36 hours peaking in 4-7 days and lasting 2-4 weeks n Diazepam, clonazepam
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Withdrawal Symptoms
n Anxious mood n Insomnia n Restlessness, irritability n Nausea n Depression n Tension n Seizures
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Treatment of Withdrawal
n Best to taper drug slowly
n Find alternative for treatment of disorder n Pharmacological n Non-pharmacological
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Tapering BZDs
n If symptoms occur, slow the taper n Use longer acting drug to taper n clonazepam
n Decrease dose by no more than 10-25% every 1-2 weeks
n Much inter-individual variability
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Opioids
n Heroin n Morphine (MS Contin) n Codeine (Tylenol #3) n Oxycodone (Percocet, Oxycontin) n Hydrocodone (Lortab, Vicodin)
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Opioids (cont’d)
n Propoxyphene (Darvon) n Tramadol (Ultram) n Methadone n Hydromorphone (Dilaudid) n Fentanyl (Duragesic, Actiq)
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Opioids
n Bind to opioid receptors n Used to relieve pain n Often prescription drugs n Psychological addiction is not common
when used to treat pain n In addiction, used for euphoria and as a
“downer”
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Opioid Intoxication
n Euphoria or dysphoria n Apathy n Motor retardation n Fatigue n Slurred speech n Myosis (pupils constricted)
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Opioid Withdrawal Symptoms
n Begins in 6 to 12 hours n Anxiety n Rhinnorhea n Lacrimation n Sweating n Yawning
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Opioid Withdrawal Symptoms
n Mydriasis (large pupils) n Restlessness, irritability n Shaking, chills, myalgias n Nausea, vomiting, diarrhea n Peak in 48 to 72 hours n Usually resolve in 7 to 10 days
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Withdrawal Treatments
n Clonidine reduces autonomic symptoms n Skeletal muscle relaxers (baclofen) n Smooth muscle relaxers (dicyclomine) n Analgesics (ibuprofen) n Antinausea (promethazine, meclizine) n Antidiarrheal (Imodium)
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Other Drugs
n Methadone and buphrenorphine n Very restricted n May be used to treat withdrawal and as
maintenance to help prevent relapse n Replaces drug in receptors
n Naltrexone n Opioid antagonist, replaces drug in receptors
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Cocaine
n Blocks dopamine and norepinephrine reuptake
n Very addicting n Smoking gives higher levels than
intranasal, leads to dependence quickly
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Cocaine Intoxication: Mild
n Psychological n Euphoria, perception of improved well being,
increased energy and alertness, increased sex drive but decreased performance, improved concentration
n Physical n Mydriasis, tachycardia, hypertension, nausea,
vomiting
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Cocaine Intoxication: Severe
n Psychosis n Hyperthermia n Arrhythmias n Shock n Seizures n Death
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Cocaine Abstinence
n Phase 1 – Crash, occurs in 9 hrs to 4 days n Early - Agitation, depression, anorexia,
craving n Middle - Fatigue, depression, insomnia with
increasing need for sleep, no cravings n Late - Exhaustion, hypersomnolence,
hyperphagia, no craving
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Cocaine Abstinence
n Phase 2 (withdrawal) – occurs in 1-10 wks n Early – Sleep normalized, euthymic mood, low
craving, low anxiety n Middle and late – anhedonia, anergy, anxiety,
high craving
n Phase 3 n Episodic craving usually due to cues
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Methamphetamine
n Stimulant that displaces norepinephrine, dopamine and serotonin
n Causes “adrenalin rush” n Causes mood alteration n Lack of hunger and thirst n Rotten teeth
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Methamphetamine Toxicity
n Severe agitation n Tachycardia n Hypertension n Psychosis n Treat with sedatives and antipsychotics n Monitoring and supportive therapy
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“Ecstasy”
n MDMA (3,4 methylenedioxymethamphetamine) mixed with various other chemicals or drugs
n Synthetic, psychoactive drug n Chemically similar to methamphetamine and
mescaline n Produces feelings of increased energy, euphoria,
emotional warmth, and distortions in time, perception, and tactile experiences
n Considered a “rave” drug
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MDMA (Ecstasy)
n Binds to 5HT transporter to block reuptake n Acts as 5HT to stimulate additional 5HT
release from neurons n Result is a flood and subsequent depletion
of 5HT (also increases NE and Dopamine) n AEs: cognitive impairment, tachycardia,
hyperthermia, depression
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Marijuana
n Often considered innocuous n Medical uses n Increase appetite n Pain control n Anxiety control
n THC – tetrahydrocannabinol n Active ingredient n Stronger than in the past
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Marijuana
n Activates the reward pathway, mediated through cannabinoid and GABA receptors
n Potentiates the effects of cocaine n Euphoria in 10-30 minutes after smoking,
in 30-60 minutes after eating
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Marijuana: Immediate Effects
n Euphoria n Sense of increased well being n Sense of improved functioning n Feeling relaxed n More sociable
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Marijuana Intoxication
n Drowsiness, lethargy n Nausea and vomiting n Impaired motor function, tremor n Memory impairment, cognitive dysfunction n Nystagmus, vertical or horizontal n Psychosis n Hypertension and tachycardia
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Marijuana Intoxication
n Effects may last up to 24 hours due to accumulation of THC in the fatty tissue and then re-release
n Cognitive impairment lasts longer than mood alteration
n Implicated in 11-33 percent of fatal accidents in ages 15-30
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Marijuana in Children/Teens
n Youths aged 12 to 17 have constituted about two-thirds of the new users of marijuana in recent years.
n Research shows that more than 40 percent of teenagers try marijuana before they graduate from high school.
n Additional signs of marijuana use in teens may include the use of masking agents such as eye drops, incense and other deodorants
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Marijuana
n Users are 4 times more likely to experience depression
n Users are 3 times more likely to experience psychotic symptoms
n Increases cognitive dysfunction
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Marijuana Withdrawal
n Restlessness n Decreased appetite, nausea n Irritability n Sleep disturbances n Uncomfortable, not life threatening n Treat supportively
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Marijuana Withdrawal
n Repeated use, even after 3 weeks, leads to psychological and physiological dependence
n Withdrawal symptoms begin in 10 hours, may peak in 48 hours and last 5 – 7 days
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Jimson Weed (Jamestown Weed)
Grows wild Causes delirium and psychosis Bizarre and violent behavior Not able to tell fantasy from reality
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The Newest Threat: Designer Drugs
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What are Designer Drugs? n Synthetic versions of illegal drugs chemically
synthesized in underground labs n Marketed as “Not for Human Consumption” to
avoid FDA regulation n Use has skyrocketed in the past year n Not usually detected by urine drug screen n Chemists are constantly altering the
formulations and creating new chemicals as specific ingredients are being banned by DEA
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Synthetic Cannabinoids
n AKA: Herbal Incense, K2, Spice Gold n Many different combinations of chemicals
(JWH-018 and more than 100 variations) n Sprayed onto a variety of garden herbs n Became available in the US around 2004
via internet and many “head shops” n Dangerous, untested, chemical structures
similar to known carcinogens
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Synthetic Cannabinoids n Binds cannabinoid receptors more tightly
than THC n Binds CB2 (cannabinoid receptor that
helps regulate immune function) n Reported effects: reddening of the eyes,
tachycardia, hypertension, seizures, insomnia, paranoia, dry mouth, headache, psychosis, hallucinations, intoxication
n Addictive potential is unknown
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Bath Salts
n AKA “plant food” n Contain man-made chemicals like mephedrone,
methylone, and methylenedioxypyrovalerone (MDPV), also known as substituted cathinones
n Related to khat, an organic stimulant found in Arab and East African countries that is illegal in the United States
n 2010: Approximately 300 calls to poison control n 2011: Approximately 4700 calls so far
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Bath Salts n Produce effects similar to cocaine or meth n Smoked, inhaled, injected n Reported effects: extreme agitation, violence,
psychosis, hallucinations, paranoia, suicidal ideation, tachycardia, hypertension, kidney failure, hyperthermia, and death (15 confirmed in 2009)
n Effects can last > 1 week n Addictive potential is unknown n Most states list teenagers as primary users
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Update: Federal Ban on Bath Salts
n On September 7, 2011 the US DEA exercised its emergency scheduling authority to temporarily control Mephedrone , MDPV, and Methylone
n Makes possessing and selling these chemicals or the products that contain them illegal in the U.S. for at least one year (effective October 1, 2011)
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Substance Abuse Screening
n All patients should be screened for possible substance abuse
n Ask, obtain a history, nonjudgmental n Use a standard questionnaire n Observe behavior, often bizarre n Observe physical signs n Track marks, rotten teeth, burned fingers
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CAGE
n C – ever felt the need to Cut down others? n A – ever been Annoyed by others’ criticism n G – ever felt Guilty? n E – ever need a morning Eye opener?
n Two positive responses indicate a problem
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Urine Drug Screens
n Amphetamines n Shows up for 2 to 3 days n False positives may be caused by Sudafed,
selegiline, chlorpromazine, trazodone, bupropion, amantadine, ranitidine
n Cocaine n Shows up for 2 to 3 days n False positives by topical cocaine
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Urine Drug Screens
n Marijuana n Shows up 1 to 7 days, up to 30 days n False positives – ibuprofen, naproxen,
efavirenz
n Opiates n Shows up 1 to 3 days, possibly 7 days n False positives – rifampin, poppy seeds,
quinine water, fluoroquinolones
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Prescription Drug Abuse
n Second only to marijuana in frequency of illicit use
n Mostly opioids and sedatives n Patients generally already have addictive
disease and some other substance abuse
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Risk of Prescription Drug Abuse
n Current addiction of history of abuse n Use of controlled drugs in non-prescribed
doses or routes n Use of drugs for reasons other than
indications for which they were prescribed n Younger patients n Patients who work in health care settings
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Characteristics
n Early refills n Pressuring physician or pharmacist for
more n Seeks additional supplies of drugs n Doctor shopping n Exaggeration of symptoms n Dishonesty
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But……..
n Are they drug seeking, or are we under treating????
n Anxiety disorders n Chronic pain
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Short & Long Term Effects of Substance Abuse
n Physical: cardiovascular disease/death; dementia, GI disorders, cirrhosis; ulcers; pancreatitis, diabetes, neurological damage
n Emotional: Anger, fear, guilt, low self-esteem, hostility, suicidal, homicidal
n Mental: Psychosis, neurosis, paranoia, depression, sociopathic disorders, “wet brain dementia”, amnesia, blackouts, confusion
n Spiritual: Dishonesty, mistrust, lack of faith, hate, hopelessness, helplessness, self-centeredness, self-pity
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Consequences of Substance Abuse
n Family: Dysfunction, over/under responsibility, abuse, violence, guilt/blame, separation/divorce, death
n Financial: Bankruptcy, debt, loss of home n Legal: DWI’s, jail/prison, death n Employment: Absenteeism, loss of job, poor job
performance n Social: Isolation, withdrawal, loss of
family/friends n Health: DT’s, blackouts, hypertension, ulcers etc.
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Treatment Goals
n Break the cycle of addiction n Gain and maintain abstinence from all
mind/mood altering substances n Initiate positive changes in lifestyle
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Treatment Approach
n Multidisciplinary Team n Medical detoxification/stabilization n Pain management n Individual/group psychotherapy n Education groups n Relapse Prevention n Family counseling
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Recovery-Wellness
n Is a life-long process n Essential elements of recovery: n Continuing Care support groups n 12-step support groups n Relapse prevention n Outpatient treatment services n Medication management
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Obstacles in Recovery
n “Switching addictions” n “Dry-drunk syndrome” n DENIAL n Self-defeating learned behaviors n Character defects n Dual diagnoses n Living environment
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Recovery
n Requires CHANGE- 3 steps: 1. Conversion- “enough is enough” 2. Decision- to change (what’s it going to take) 3. Action- doing what it takes to make change
happen; must be concrete, practical, focused, & consistent
n PRACTICE, PRACTICE, PRACTICE!
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Relapse Prevention
n Program designed to help individuals avoid lapsing into symptoms of their illness: n Thoughts, feelings, behaviors n People, places, situations n DENIAL n Avoiding change, emotional binging, “secret recovery” n HALT-PLAN
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12-Step Recovery Program
n Essential elements of 12-step recovery: n SUPPORT via fellowship of men & women
who share their experience strength & hope with others that they may solve their common problem & help others recover
n CHANGE via the application & practice of the principles embodied in the 12 steps
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What Are the 12 Steps?
n A group of principles, spiritual in nature, that if practiced as a way of life, can help expel the obsession to drink and/or use drugs, & enable the sufferer to become happily & usefully whole
n These principles, as they are known today, were taken mainly from religion & medicine & some from noting the experiences of the early 12-step groups
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A Suggested Program of Change
n Daily readings/step study n Prayer & meditation n Support group meetings n Sponsorship n Healthcare (and mental health) n Celebration n Evaluation n Family (love & support)
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A Blueprint for Change
n The daily practice of these steps can lead to a SPIRITUAL AWAKENING that results in a personality change sufficient to recover from one’s illness & which revolutionizes one’s whole attitude towards life, towards our fellows, & towards God & His universe.
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Drug Free Campaign
n Parents and families face one of the most difficult battles in today’s society – that of raising drug free children.
n Communication is key! n Teenagers whose parents talk to them on
a regular basis about the dangers of drug use are 42% less likely to use drugs than those whose parents don’t.
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The End?
n NO!! n Recovery n Is n A n Never-ending n Journey!
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Resources
n SAMSHA n http://www.samhsa.gov/
n NIDA – National Instutite on Drug Abuse n http://www.nida.nih.gov/
n American Society of Addiction Medicine n http://www.asam.org/
n National Institute of Mental Health n http://www.nimh.nih.gov/
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Resources for Children/Teens
n Encouragement and Facts for Teens: www.abovetheinfluence.com 1-800-788-2800
n Information on drugs and helping a friend in trouble: www.freevibe.com
n Girls and Boys Town National Hotline: 1-800-448-3000 (24 Hours/7 Days A Week)
n DARE Programs: www.dare.com
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