ageing brain, environmental factors and metabolism
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Ageing Brain, environmental factors and metabolism. Based on the Nature review: Recruiting adaptive cellular stress responses for successful brain ageing By Alexis M. Stranahan & Mark P. Mattson. Brain structures highly affected by oxidative stress. - PowerPoint PPT PresentationTRANSCRIPT
Ageing Brain, environmental factors and metabolism
Based on the Nature review: Recruiting adaptive cellular stress responses for successful brain ageingBy Alexis M. Stranahan & Mark P. Mattson
Brain structures highly affected by oxidative stress
Neurodegenerative disorders have a logarithmic increase in prevalence with
respect to aging
The Selective neural vulnerability phenomena is based on
morphological
-high energy requirements -reliance on axonal support for sustained function - large cell area.- High numbers of AMPA and NMDA receptors.- Low levels of Calcium binding proteins- Dysfunction and death of neurons adversley affects both the
pre- and post- synaptic neurons.
Ion dysregulation via stimulation of glutamate receptors
“programed” cell death
Role of Mitochondria in synaptic plasticity
AD oxidative damage
Obesity and cognitive cognition
Physical exercise and SNRI synergistic effect
Beneficial molecular changes due to hormesis
Phytochemicals vs. refined sugars
Factors mediating Neurodegenerative disease upon aging
Promoting adaptive mechanism against neurodegenerative disorders
Thanks for listening