ahs13 grayson wheatley - what is optimal health? complexity science, chaos theory and its impact on...
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An ancestral lifestyle relies on alignment of nutrition, physical activity and sleep for achieving optimal health and well-being. New research in complexity science - a rapidly evolving body of work that studies dynamic networking systems - has cast doubt on the effectiveness of how we measure expected outcomes in health and medicine. Complex systems may better explain human health by focusing not on single data elements as “cause-and-effect” but on the interactions among complex biological systems. The implications of complexity science and chaos theory on leading an ancestral lifestyle and achieving optimal health will be discussed.TRANSCRIPT
What is Optimal Health?
Complexity Science, Chaos Theory and its Impact on Ancestral Health
Grayson H. Wheatley, MDPhoenix, Arizona
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Disclaimer
The comments and statements in this presentation are solely my own and in no way
represent my employer.
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“Typical Day”
Why Am I Here?
AHS 2012
Heart Disease Prevention and the Ancestral Diet
Decrease inflammation (biomarkers)
Prevent/slow heart disease
Ancestral Diet
Optimal Health
What is “Optimal Health”?
Do we know it when we see it?
How do we measure it?
How do we achieve it?
Ancestral Health
Diet
ExerciseSleep
nutrientdense
absenceof
processed foods
duration
quality
intensity
functional
AncestralHealth
ChaosTheory?
“Alongside relativity and quantum mechanics, it is being
hailed as the twentieth century's third revolution.”
The Butterfly Effect: This effect grants the power to cause a
hurricane in China to a butterfly flapping its wings in
New Mexico.
Small changes in the initial conditions….lead to drastic
changes in the results1988
www.artdevanyonline.com
Foundational Principles“The human mind has a
trusty device for simplifying a complex world: reduce to
averages and identify trends.”
“… our culture encodes a strong bias either to neglect or ignore
variation. We tend to focus instead on measures of central
tendency, and as a result we make some terrible mistakes,
often with considerable practical import.”
1996
Variation is the NATURE of Life
www.fractalsciencekit.com
Fractal
- iterative pattern of nesting
sequences.
“self-similarity”
Fractal Anatomy
Heart Rate
Heart Rate Variability
Heart Rate Variability
“A Healthy Complexity”
A. Goldberger. Nature 1999; 399:461
Heart Rate Variability (HRV)
Age related entropy in HRV
Do we need to re-design pacemakers?
www.heart-valve-surgery.com
www.pbs.org
HRV as a tool to monitor overtraining
myithelte.com
http://www.bioforcehrv.com/
Esko HyvärinenTampere University of Technology,,Ragnar Granit Institute
Sensatex, Inc
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Corventis
npr.org
“Smart Band-aids”
Diet
ExerciseSleep
HRV and Ancestral Health
Diet
ExerciseSleep
HRV and Ancestral Health
?
Omega-3 polyunsaturated fatty acids (PUFA) may modulate autonomic control of the heart.
Omega-3 PUFA is abundant in the brain and other nervous tissue as well as incardiac tissue.
Studies have demonstrated a positive association between cellular content of omega-3 PUFA and HRV
Supplementation with omega-3 PUFA seems to increase HRV
Could be a possible explanation for decreased risk of arrhythmic events and sudden cardiac death sometimes observed after omega-3 PUFA supplementation.
Diet
ExerciseSleep
HRV and Ancestral Health
Diet
ExerciseSleep?
HRV and Ancestral Health
HRV and Ancestral Health
Diet
ExerciseSleep
HRV and Ancestral Health
“Anticipatory Medicine”
signal complexity health
Heart beatsSleep apneaBrain wavesGait pattern
“We’re developing and refining computational tools to pull useful information out of extremely complex data sets.” – Ary Goldberger, MD, Wyss Institute, Boston, MA
AncestralHealth
ChaosTheory
Heart rate variability
Modifying factors
“Fractal Physiology”
Fractal breathingFractal gaitFractal temperatureFractal neurons
Where Medicine Went Wrong. Bruce J. West. World Scientific 2006
www.gastropatienteducation.com www.pcsd.k12.ny.us
Fractal Gut
www.pcsd.k12.ny.us
Fractal Gut
en.wikipedia.org
www.theglutenfreefoodslist.com
Loss of villi secondary to gluten sensitivity.
LOSS OF FRACTAL ARCHITECTURE
Sign of disease
Claude Bernard (1813-1878)
www.nndb.com
“Constancy of internal mileu is the essential condition to a free life.”
-Introduction to Experimental Medicine (1865)
Homeostasis-Greek words “same” and “steady”-Resistance to change-General property of all highly complex systems
hajbio.wordpress.com
Regulation of Calcium
bio1152.nicerweb.com
Law of Frequency of Errors
Normal distribution is not compatible with complexity science and chaos
Vital Signs
Heart rate 89 beats per minuteRespiratory rate 18 breaths per minuteTemperature 98.9 degress FBlood pressure 128/78 mmHg
Does not capture or reflect variability in the system.
Circulation 2009; 120: 118-125
Chris Masterjohn – AHS 2012
Framingham Heart Study
Inverse Power-Law Distribution
Inverse power-law
“Simple Systems”
“Complex Systems”
Pareto Principle (80/20 rule)
Inverse power –law distribution
Ubiquitous in the real world
Ubiquitous in Medicine
Differences between physical sciences and life sciences
“The few are important and determine the properties of complex systems and the many are irrelevant and readily replaceable.” – Bruce J. West
www.managerwise.com
HRV – Inverse Power-Law
Optimal Health
Measures of health (i.e. laboratory values, vital signs) fail to capture intrinsic variability in our health
A certain level of random variation is an essential part of health
Loss of randomness to biologic functions reflects disease and ageing
Ancestral Health + Chaos
Diet
ExerciseSleep
DietPromote and support variability
Intermittent calorie intake
Intermittent supplement intakeDoses and frequency
Diversified nutrients
Avoid anti-nutrients
Ancestral Health
Diet
ExerciseSleep
Exercise
Robert Dos Remedios
www.pponline.o.uk
Ancestral Health
Diet
ExerciseSleep
Sleep
Quality and duration
VariabilityBedtimeWaking-upDuration
Measurements
Attention to sleep cycle
Wheatley AHS2012 56
Thank you!