advancing neuromodulation research · originally developed at the university of michigan,...

Advancing neuromodulation research

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Originally developed at the University of Michigan, NeuroNexus’ suite of commercialized technologies has, for over a decade, led to hundreds of publications from research labs all around the world. Our products include conventional and high-density leads, recording and stimulation systems, and software for data analytics.

Our products have been used in a wide variety of animal models from fruit fly to rodent to non-human primates. NeuroNexus is currently working to make our state-of-the-art technologies and systems available for human clinical research.

NeuroNexus is the global leader in neuroscience research. Now expanding into clinical research.

Next page, clockwise from top left: Matrix Array™, Vector Array™,

SmartBox™, Quad-fiber Optoelectrode. See the NeuroNexus Research

Product Catalog at neuronexus.com for more information.

Currently not available for sale

NeuroNexus is an official NIH BRAIN Initiative® partner.

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NeuroNexus is at the intersection of neuroscience, technology, and clinical drivers.

Science drivers: NeuroNexus powers leading-edge neuroscience research around the world

Technology drivers: NeuroNexus continually

innovates neural interfaces to meet the needs of

both scientific and clinical research

Clinical drivers: NeuroNexus is uniquely

positioned to translate new technologies into innovative neuromodulation systems

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• High resolution thin-film technologies utilizing silicon and polymer materials

• Draw from our design tools and libraries for advanced thin-film neural interfaces

• Translation of leading-edge concepts into commercial solutions

• Computational modeling and analysis of neural interface devices and systems

• Rapid prototyping

• Resources and expertise for testing and validation

• Collaboration and networking with leaders in the clinical and neuroscience fields

Core Technologies and Competencies

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NeuroNexus offers a custom lead design service that provides unique access to a virtually unlimited design space. Almost any feature of a lead can be tailored to suit your application - and all it takes to get started is a sketch.

Each custom lead includes:

• Consultation with our engineering team to validate feasibility of your proposed design

• Translation of your design into a CAD layout

• Formal design review with our technical team

• State-of-the-art microfabrication of your design

• Packaging and testing of the fabricated devices

• Ability to imprint text (such as your name) on the lead

Custom Design

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NeuroNexus offers both conventional and high density lead technologies.

• History of clinical use• Robust mechanical properties• Body compliant

• High channel count, high density• Ultra flexible• Can be integrated into form factors of

conventional systems• Customizable shape and electrode coverage

Conventional Lead Technologies

High Density Lead Technologies

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Images not to scale.

SPECIFICATIONS

LEADS FOR BRAIN/SPINAL CORD SURFACE

Conventional HD

Substrate

Electrode Material

Silicone/Polyurethane, millimeter thickness

Platinum Iridium

Electrode Coverage Millimeter spatial resolution

Maximum current mA

Regulatory Status FDA Approved

Number of Channels 8, 12

Thin-film, micron thickness

Platinum

Micron spatial resolution

µA - mA

In Process

16, 32, 64+, customizable

Impedance kΩ range kΩ - MΩ range

Flexibility Body compliant Ultra-flexible

Usage Stimulation Stimulation, Sensing (ECoG, µECoG, CAP)

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Images not to scale.

LEADS FOR DEEP BRAIN MAPPING OR STIMULATION

SPECIFICATIONS Conventional HD - Stimulation HD - Mapping

Substrate

Electrode Material

Silicone, millimeter thickness

Platinum Iridium

Electrode Coverage Millimeter spatial resolution

Maximum current mA

Regulatory Status FDA Approved

Number of Channels 8, 12

Thin-film with silicone/polyurethane backing

Platinum

Micron spatial resolution

µA - mA

In Process

24, 48, customizable

Impedance kΩ range kΩ - MΩ range

Usage Stimulation Stimulation, Sensing (AP, LFP)

Thin-film combined with conventional wire

Platinum

Micron spatial resolution

µA - mA

In Process

16, 32, customizable

kΩ - MΩ range

Stimulation, Sensing (AP, LFP)

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SPECIFICATIONS

INTRACORTICAL LEADS

HD

Substrate Material

Electrode Material

Silicon

Iridium

Electrode Resolution < 50 µm, customizable

Usage Stimulation (electrical and optical), Sensing (Action potential, Field potential)

Regulatory Status In Process

Number of Channels 64, 128

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Images not to scale.

NERVE LEADS

SPECIFICATIONS Conventional HD

Substrate

Electrode Material

Silicone/Polyurethane, millimeter thickness

Platinum Iridium

Electrode Coverage Millimeter spatial resolution

Maximum current mA

Regulatory Status FDA Approved

Number of Channels 2-3

Polyimide, micron thickness

Platinum

Micron spatial resolution

µA - mA

In Process

12, 24, customizable

Impedance kΩ range kΩ - MΩ range

Flexibility Flexible Ultra-flexible

Usage Sensing Sensing, Stimulation

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Clinical SmartBox™ Platform - Recording Module*

• State-of-the-art technology, affordable pricing

• Record up to 256 channels simultaneously

• Up to 30 kHz sampling rate per channel

• 16-bit ADC resolution, 15 µV smallest detectable signal

• Electrode diagnostic (impedance check) and site conditioning mode

• Wide variety of signals supported: EEG, EMG, action potential, field potential, pulsation

• Portable with optional battery pack - take your recording system and laptop with you, and record from anywhere

• DAC out for audio monitoring

• Arrives ready to go, with minimal setup required; Laptop included

The NeuroNexus SmartBox™ is a portable control and data acquisition system.

Above: SmartBox™

Inset: GUI

*Available in 2016

LEARN MOREVisit our YouTube channel to learn more about our products: youtube.com/TheNeuroNexus

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Images not to scale.

Clinical SmartBox™ Platform - Stimulation Module*

• Can be integrated to perform simultaneous recording and stimulation

• 25 stimulation channels with independent constant current sources

• Stimulate up to 15 mA

• Highly flexible programming to support advanced stimulation protocol

• Wirelessly controlled (up to 1 meter range)

• Can be battery powered (2 weeks of operation with typical usage)

• Arbitrary waveform generation

• Implantable, wearable, and desktop versions available

*Available in 2016

Desktop Stimulation Module

WearableStimulation Module

Implantable Stimulation Module

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Surgical Consultation & Neural AnalyticsAdapting to new technology and techniques can be difficult. NeuroNexus staff engineers and scientists have decades of combined experience, and we can help you reduce your ramp-up time so you can focus on your research.

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655 Fairfield Ct., Ste. 100 / Ann Arbor, MI 48108, USA

neuronexus.com / +1.734.913.8858 (Phone) / +1.734.786.0069 (Fax)

N O T E S

Currently not available for sale

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