arginine cardio

© Arginine Benefits LLC, 2013Author: Dr. Rainer Böger Page 1

Arginine Cardio: Evidence-based reduction of blood pressure (1)

L-Arginine is the precursor of Nitric Oxide

L-Citrulline potentiates the bioavailability of L-arginine

Arginine Cardio is the L-Arginine supplement that has the highest L-citrullineContent

Nitric Oxide causes vasodilation and thereby reduces blood pressure.

© Arginine Benefits LLC, 2013Author: Dr. Rainer Böger Page 2

Arginine Cardio: Evidence-based reduction of blood pressure (2)

L-Arginine is not being marketed by pharmaceutical industrywith a multi million dollar budget for promotion.

Clinical trials with L-arginine to lower blood pressure have been performedby independent academic research institutions, with small research budgets.

Therefore, patient numbers in clinical trials with L-arginine are comparatively small.

However, there is a recent meta-analysis summarizing clinical trials with L-arginine.

© Arginine Benefits LLC, 2013Author: Dr. Rainer Böger Page 3

Dong et al.; American Heart Journal 2011

11 randomized, double-blind, placebo-controlled trials involving 387 participants with oral L-arginine intervention ranging from 4 to 24 g/d

[…] Compared with placebo, L-arginine intervention significantly lowered systolic blood pressure by 5.39 mm Hg (95% CI −8.54 to −2.25, P = .001) anddiastolic BP by 2.66 mm Hg (95% CI −3.77 to −1.54, P = .001).

Arginine Cardio: Evidence-based reduction of blood pressure (3)

© Arginine Benefits LLC, 2013Author: Dr. Rainer Böger Page 4

Dong et al.; American Heart Journal 2011L-Arginine better Placebo better

© Arginine Benefits LLC, 2013Author: Dr. Rainer Böger Page 5

Dong et al.; American Heart Journal 2011L-Arginine better Placebo better

© Arginine Benefits LLC, 2013Author: Dr. Rainer Böger Page 6

Dong et al.; American Heart Journal 2011

© Arginine Benefits LLC, 2013Author: Dr. Rainer Böger Page 7

Arginine Cardio: Evidence-based reversal of atherosclerosis (1)

Nitric Oxide has been known to protect from atherosclerosis ever sincethe Nobel Prize for Medicine was awarded for this finding in 1998.

L-Arginine is the precursor of Nitric Oxide. Animal experiments have unequivocally proven in different models and in various laboratories around the world that L-arginine can reverse atheroslcerosis.

Whilst no big, multinational studies could be performed with L-arginine due tolack of funding from public sources, multiple studies have shown reversal ofendothelial dysfunction, the early clinical sign of atherosclerosis, by L-arginine.

We have a collection of case reports that show reversal of atherosclerotic plaquein humans during a few months of L-arginine intake.

© Arginine Benefits LLC, 2013Author: Dr. Rainer Böger Page 8

Böger et al., Atherosclerosis 1995; 117: 273 – 284

Study A: Prevention of Plaque Build-Up

Design:

0 8 weeks

Control

Cholesterol

Cholesterol + L-Arginine

Results:

Cholesterol

Cholesterol; treated with L-arginineCONTROL CHOLESTEROL

051015202530354045505560

Car

otid

intim

al p

laqu

e ar

ea

[%

of t

otal

intim

a]

*

CHOL.+ L-ARGININE

#

(0)

A. carotis

© Arginine Benefits LLC, 2013Author: Dr. Rainer Böger Page 9

Böger et al., Circulation 1997; 96: 1282-1290

Study B: Stopping the Progression of Plaque Build-Up

Design:

0 10 weeks

Control

Cholesterol

Results:

164

Cholesterol + L-Arginine

Cholesterol

Cholesterol + Lovastatin

Control

0 weeks164

Intim

al p

laqu

e ar

ea(c

arot

id a

rter

y) [%

]

0

50

40

30

20

10

-92%

„Dietary L-arginine completely suppressed the aggravation of intimal plaque formation during the second part of the study Lovastatin treatment significantly reduced the progression of plaque formation but did not completely block it.“

© Arginine Benefits LLC, 2013Author: Dr. Rainer Böger Page 10

Candipan et al., Arterioscler. Thromb. Vasc. Biol. 1996; 16: 44-50

Study C: Reversal of Pre-Existing Plaque

Design:

0 18 weeks

Cholesterol

Results:

2310

Cholesterol

Cholesterol + L-Arginine

0 weeks2310

Intim

al p

laqu

e ar

ea(c

arot

id a

rter

y) [%

]

0

75

60

45

30

15

„This is the first demonstration that restoration of NO activity can induce regression of preexisting intimal lesions and provides evidence that L-arginine therapy may be of potential clinical benefit “

Cholesterol

1814

© Arginine Benefits LLC, 2013Author: Dr. Rainer Böger Page 11

© Arginine Benefits LLC, 2013Author: Dr. Rainer Böger Page 12

© Arginine Benefits LLC, 2013Author: Dr. Rainer Böger Page 13