centre for drug design and discovery · 2010-01-08 · centre for drug design and discovery is the...

CENTRE FOR DRUG DESIGN AND DISCOVERY

is the investment fund

and technology transfer

platform for early phase

innovative drug discovery

and target validation!

MISSION CD3 STRATEGY

TargetIdentifi-cation

TargetValidation

AssayDevelop-ment

ScreeningHit identi-fication

Hit-to-Lead

LeadOptimiza-tion

Pre-clinicalstudies

Clinicalstudies

CD3 CLOSES THE GAP BETWEEN “ACADEMIC” BIOMEDICAL RESEARCH AND INDUSTRY

UNIVERSITIES – RESEARCH INSTITUTES – SMALL BIOTECHS

CD3

• new targets• new approaches and insights• biology expertise• biological assays (transfer)• support in hit-to-lead process• mechanism-of-action studies• in vivo POC

• assay optimisation and HTS• high quality compound libraries• in silico drug design & screening• pharma medicinal chemistry• preliminary ADME-Tox• in vivo POC• project coordination and follow-up• IP support • … everything missing to reach goals

PHARMA – BIOTECHINDUSTRY

• final lead optimisation• pre-clinical development• clinical development• project planning• production• commercialisation• marketing

1. “Screening projects”start = specific target or innovation

2. “Rational design projects”start = target with structural information

3. “Development or Hit-to-Lead projects”start = hit compounds

Exceptionally4. “Target identification or validation projects”start = non-drug like compound or non-validated target

FOUR TYPES OF PROJECTS WITH

DIFFERENT STARTING POINTS

SELECTION PROCESS

WITH INVESTMENT

COMMITTEE &

SCIENTIFIC ADVISORY

BOARD

www.lrd.kuleuven.be/CD3

Number

of

projectsCD3 team

SAB

IC

PARTNERS

CONTACT Centre for Drug Design and Discovery, CD3Minderbroedersstraat 12, B-3000 Leuven, BE

Tel +32-16-32 65 23patrick.chaltin@lrd.kuleuven.be

“Stimulating and optimizing the transformation of

innovative European academic

research results into small

molecule drugs”

“Supplement innovative

biomedical research witheverything lacking for

professional small molecule

drug discovery in order to

develop drug lead compoundswith in vivo POC”

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