clr, rlr & cds signaling pathways · clr, rlr & cds signaling pathways iкb p50 p65 p50 p65...

Dectin-1

P P

P

P

P

P

Apoptosis

DHX29PKR

NEMO

IKKβIKKα

IкBp50 p65

Ub

ZDHHC1

LSP1

IKKε

CYLD

Bcl3

Bcl3

Anti-inflammatory cytokines

NF-кB

Fucose

DC-SIGN

CNK

KSR1

Raf-1

LSP1

Raf-1

p65

STING

cGAMPc-di-GMPc-di-AMPcGAMP

p65

IKKβIKKα

ISRE7

Type I IFNs IFN-l1 IFN-βIL-2

NF-кB

Pro-inflammatory cytokines

Caspase 8

FADD

DAI

DDX41

TRAF6

TBK1

Pro-Casp-1ASC

Caspase-1

AIM2

pro-IL-1β IL-1β

IFI16cGAS

MRE11

MyD88

IRF1IRF3/7 IRF3/7

ISRE1/7

p50 p65

DHX15

DDX3

IKKεTBK1

IRF3/7

IRF7 IRF7 IRF7

IFN-α

ISRE3/7

Pro-inflammatory cytokines

CLR, RLR & CDS Signaling Pathways

IкBp50 p65

p50 p65 Junc-fos

Pro-inflammatory cytokines

NF-кBNFAT

FcRγ

SykFcRγ

Syk

TBK1

IRF3

IRF3 IRF3

ISRE3

c-di-GMPc-di-AMP

AP1

dsRNA

MAVS

MDA-5 RIG-I

LRRFIP1

Ku70

DHX36

IFIX

dsDNA

β-catenin

Pathogen dsDNA Host dsDNA

LGP2

Mitochondrion

Endoplasmic reticulum

DHX9

High mannose

Dectin-2

NEMO

IKKβIKKα

ERK JNK p38

PLC γ

IP3DAG

RNA Virus

Calcineurin

NFAT

CARD9

MALT1Bcl-10

Ca2+PKCδ

β-Glucan

Syk

DC-SIGN

MAPKs

Mincle

α-Mannose, cord factor

High mannose, α-mannan

NF-кB

RNAPol III

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